基本信息
薛愿超 男 博导 生物物理研究所
电话:15652394680 ,010-64888447
电子邮件:xueyuanchao@hotmail.com
单位名称:中国科学院生物物理所,中国科学院核酸生物学重点实验室
通信地址:北京市朝阳区大屯路15号
邮政编码:100101

研究领域

RNA结合蛋白,非编码RNA,细胞转分化

招生信息

生物化学与分子生物学、生物信息学、细胞生物学

招生专业
071010-生物化学与分子生物学
招生方向
RNA结合蛋白和非编码RNA与细胞命运决定

教育背景

   
学历
2000-2004  信阳师范学院, 获理学学士学位

2004-2009  武汉大学, 获理学博士学位

2010-2015  美国加州大学圣地亚哥分校博士后
学位

博士

专利与奖励

2015年度中组部“青年****”、2015年度“国家优秀青年科学基金

专利成果
[1] 薛愿超, 吉蕾. PTBP1抑制剂及其在制备促进细胞向神经分化及转分化的药物中的应用. ZL202311049388.X, 2023-09-19.
[2] 薛愿超, 苏瑞宝, 曹唱唱. 一种鉴定RNA结合蛋白靶位点的方法LACE-seq及试剂盒和应用. CN: CN113215234A, 2021-08-06.
[3] 薛愿超, 蔡兆奎, 曹唱唱. 一种捕获RNA原位高级结构及相互作用的方法. CN: CN111909991B, 2021-08-03.
[4] 薛愿超, 蔡兆奎, 曹唱唱. 一种高效切割SARS-CoV-2基因组的siRNA及其应用. CN: CN112574960A, 2021-03-30.
[5] 薛愿超, 苏瑞宝, 王磊. 一种利用微量临床穿刺样本进行染色质免疫共沉淀文库制备的方法及其应用. CN: CN111440843A, 2020-07-24.
[6] 薛愿超, 付向东. 一种控制人神经细胞重编程的信号通路及其应用. CN: CN105950557A, 2016-09-21.

出版信息

   
发表论文
[1] Wang, Peng, Wang, Qiushi, Chen, Lianwan, Cao, Zheng, Zhao, Hailian, Su, Ruibao, Wang, Ning, Ma, Xiaojing, Shan, Jin, Chen, Xinyan, Zhang, Qi, Du, Baochen, Yuan, Zhiheng, Zhao, Yanmei, Zhang, Xiaorong, Guo, Xuejiang, Xue, Yuanchao, Miao, Long. RNA-binding protein complex AMG-1/SLRP-1 mediates germline development and spermatogenesis by maintaining mitochondrial homeostasis in Caenorhabditis elegans. SCIENCE BULLETIN[J]. 2023, 第 17 作者  通讯作者  68(13): 1399-1412, http://dx.doi.org/10.1016/j.scib.2023.05.029.
[2] Zhang, Yigan, Zhang, Jinyue, Xue, Yuanchao. ADAR1: a mast regulator of aging and immunity. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2023, 第 3 作者  通讯作者  8(1): 323-324, http://dx.doi.org/10.1038/s41392-022-01276-5.
[3] Lv, Yue, Lu, Gang, Cai, Yuling, Su, Ruibao, Liang, Liang, Wang, Xin, Mu, Wenyu, He, Xiuqing, Huang, Tao, Ma, Jinlong, Zhao, Yueran, Chen, ZiJiang, Xue, Yuanchao, Liu, Hongbin, Chan, WaiYee. RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits. PROTEIN & CELL[J]. 2023, 第 13 作者  通讯作者  14(1): 51-63, http://dx.doi.org/10.1093/procel/pwac040.
[4] Liang, Liang, Cao, Changchang, Ji, Lei, Cai, Zhaokui, Wang, Di, Ye, Rong, Chen, Juan, Yu, Xiaohua, Zhou, Jie, Bai, Zhibo, Wang, Ruoyan, Yang, Xianguang, Zhu, Ping, Xue, Yuanchao. Complementary Alu sequences mediate enhancer-promoter selectivity. NATURE[J]. 2023, 第 14 作者  通讯作者  619(7971): 868-+, http://dx.doi.org/10.1038/s41586-023-06323-x.
[5] Su, Jianzhong, Yuan, Jian, Xu, Liangde, Xing, Shilai, Sun, Mengru, Yao, Yinghao, Ma, Yunlong, Chen, Fukun, Jiang, Longda, Li, Kai, Yu, Xiangyi, Xue, Zhengbo, Zhang, Yaru, Fan, Dandan, Zhang, Ji, Liu, Hui, Liu, Xinting, Zhang, Guosi, Wang, Hong, Zhou, Meng, Lyu, Fan, An, Gang, Yu, Xiaoguang, Xue, Yuanchao, Yang, Jian, Qu, Jia, Myopia Associated Genetics. Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population. CELL REPORTS[J]. 2023, 第 11 作者42(5): http://dx.doi.org/10.1016/j.celrep.2023.112510.
[6] Ye, Rong, Hu, Naijing, Cao, Changchang, Su, Ruibao, Xu, Shihan, Yang, Chen, Zhou, Xiangtian, Xue, Yuanchao. Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation. MOLECULAR CELL[J]. 2023, 第 8 作者  通讯作者  83(8): 1311-+, http://dx.doi.org/10.1016/j.molcel.2023.03.001.
[7] Guo, Jing, Zhao, Hailian, Zhang, Jue, Lv, Xiangjiang, Zhang, Shen, Su, Ruibao, Zheng, Wei, Dai, Jing, Meng, Fei, Gong, Fei, Lu, Guangxiu, Xue, Yuanchao, Lin, Ge. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition. ADVANCED SCIENCE[J]. 2023, 第 12 作者  通讯作者  10(11): https://doaj.org/article/aee0f18d25734a11bd9f4c41a80415f2.
[8] Fan, YuJie, Ding, Zhan, Zhang, Yu, Su, Ruibao, Yue, JiaLe, Liang, AnMin, Huang, QiWei, Meng, YanRan, Li, Muwang, Xue, Yuanchao, Xu, YongZhen. Sex-lethal regulates back-splicing and generation of the sex-differentially expressed circular RNAs. NUCLEIC ACIDS RESEARCH[J]. 2023, 第 10 作者51(10): 5228-5241, http://dx.doi.org/10.1093/nar/gkad280.
[9] Chao, Shanshan, Zhang, Fei, Yan, Huiwen, Wang, Liuyang, Zhang, Liwen, Wang, Zhi, Xue, Ruixin, Wang, Lei, Wu, Zhenzhen, Jiang, Bing, Shi, Guizhi, Xue, Yuanchao, Du, Junfeng, Bu, Pengcheng. Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis. EMBO REPORTS[J]. 2023, 第 12 作者24(8): http://dx.doi.org/10.15252/embr.202256416.
[10] Li, Hui, Zhao, Hailian, Yang, Chunhui, Su, Ruibao, Long, Min, Liu, Jinliang, Shi, Lanying, Xue, Yuanchao, Su, YouQiang. LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice. ADVANCED SCIENCE[J]. 2023, 第 8 作者  通讯作者  10(18): https://doaj.org/article/307283679a674b4bbd4a9b6845e07d8a.
[11] Yang, Zhigang, Dong, Ping, Cao, Jiankun, Lin, Na, Ma, Shize, Cao, Rui, Cai, Lei, Wang, Lei, Cao, Changchang, Xue, Yuanchao, Pan, Jing, Li, Xiu, Wang, Kang, Liu, Qiwei, Li, Chen, Gong, Fuxing, Fu, Xin, Xiao, Ran. NOVA1 prevents overactivation of the unfolded protein response and facilitates chromatin access during human white adipogenesis. NUCLEIC ACIDS RESEARCH[J]. 2023, 第 10 作者51(13): 6981-6998, http://dx.doi.org/10.1093/nar/gkad469.
[12] Zhang, Chong, Wang, Dongpeng, Hao, Yajing, Wu, Shuheng, Luo, Jianjun, Xue, Yuanchao, Wang, Di, Li, Guohong, Liu, Lihui, Shao, Changwei, Li, Huiyan, Yuan, Jinfeng, Zhu, Maoxiang, Fu, XiangDong, Yang, Xiao, Chen, Runsheng, Teng, Yan. LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly. MOLECULAR CELL[J]. 2022, 第 6 作者82(21): 4018-+, http://dx.doi.org/10.1016/j.molcel.2022.09.022.
[13] Xu, Bingbing, Zhu, Yanda, Cao, Changchang, Chen, Hao, Jin, Qiongli, Li, Guangnan, Ma, Junfeng, Yang, Siwy Ling, Zhao, Jieyu, Zhu, Jianghui, Ding, Yiliang, Fang, Xianyang, Jin, Yongfeng, Kwok, Chun Kit, Ren, Aiming, Wan, Yue, Wang, Zhiye, Xue, Yuanchao, Zhang, Huakun, Zhang, Qiangfeng Cliff, Zhou, Yu. Recent advances in RNA structurome. SCIENCE CHINA-LIFE SCIENCES. 2022, 第 18 作者  通讯作者  65(7): 1285-1324, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7300716&detailType=1.
[14] Wang, Di, Ye, Rong, Cai, Zhaokui, Xue, Yuanchao. Emerging roles of RNA-RNA interactions in transcriptional regulation. WILEY INTERDISCIPLINARY REVIEWS-RNA. 2022, 第 4 作者  通讯作者  http://dx.doi.org/10.1002/wrna.1712.
[15] Gu, Zhongru, Pan, Shengkai, Lin, Zhenzhen, Hu, Li, Dai, Xiaoyang, Chang, Jiang, Xue, Yuanchao, Su, Han, Long, Juan, Sun, Mengru, Ganusevich, Sergey, Sokolov, Vasiliy, Sokolov, Aleksandr, Pokrovsky, Ivan, Ji, Fen, Bruford, Michael W, Dixon, Andrew, Zhan, Xiangjiang. Climate-driven flyway changes and memory-based long-distance migration. NATURE[J]. 2021, 第 7 作者591(7849): 259-+, http://dx.doi.org/10.1038/s41586-021-03265-0.
[16] Zhang, Jinyang, Hou, Lingling, Zuo, Zhenqiang, Ji, Peifeng, Zhang, Xiaorong, Xue, Yuanchao, Zhao, Fangqing. Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long. NATURE BIOTECHNOLOGY[J]. 2021, 第 6 作者39(7): 836-845, http://dx.doi.org/10.1038/s41587-021-00842-6.
[17] Cao, Changchang, Cai, Zhaokui, Xiao, Xia, Rao, Jian, Chen, Juan, Hu, Naijing, Yang, Minnan, Xing, Xiaorui, Wang, Yongle, Li, Manman, Zhou, Bing, Wang, Xiangxi, Wang, Jianwei, Xue, Yuanchao. The architecture of the SARS-CoV-2 RNA genome inside virion. NATURE COMMUNICATIONS[J]. 2021, 第 14 作者  通讯作者  12(1): https://doaj.org/article/9e50f430b49c49a7bdba77035d1bc6ef.
[18] Cao, Changchang, Cai, Zhaokui, Ye, Rong, Su, Ruibao, Hu, Naijing, Zhao, Hailian, Xue, Yuanchao. Global in situ profiling of RNA-RNA spatial interactions with RIC-seq. NATURE PROTOCOLS[J]. 2021, 第 7 作者  通讯作者  16(6): 2916-2946, http://dx.doi.org/10.1038/s41596-021-00524-2.
[19] Liu, Jingjing, You, Menghao, Yao, Yingpeng, Ji, Ce, Wang, Zhao, Wang, Fang, Wang, Di, Qi, Zhihong, Yu, Guotao, Sun, Zhen, Guo, Wenhui, Liu, Juanjuan, Li, Shumin, Jin, Yipeng, Zhao, Tianyan, Xue, HaiHui, Xue, Yuanchao, Yu, Shuyang. SRSF1 plays a critical role in invariant natural killer T cell development and function. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 第 17 作者18(11): 2502-2515, http://dx.doi.org/10.1038/s41423-021-00766-w.
[20] Su, Ruibao, Fan, LiHua, Cao, Changchang, Wang, Lei, Du, Zongchang, Cai, Zhaokui, Ouyang, YingChun, Wang, Yue, Zhou, Qian, Wu, Ligang, Zhang, Nan, Zhu, Xiaoxiao, Lei, WenLong, Zhao, Hailian, Tian, Yong, He, Shunmin, Wong, Catherine C L, Sun, QingYuan, Xue, Yuanchao. Global profiling of RNA-binding protein target sites by LACE-seq. NATURE CELL BIOLOGY[J]. 2021, 第 19 作者  通讯作者  23(6): 664-+, 
[21] Qian, Hao, Kang, ***, Hu, Jing, Zhang, Dongyang, Liang, Zhengyu, Meng, Fan, Zhang, Xuan, Xue, Yuanchao, Maimon, Roy, Dowdy, Steven F, Devaraj, Neal K, Zhou, Zhuan, Mobley, William C, Cleveland, Don W, Fu, XiangDong. Reversing a model of Parkinson's disease with in situ converted nigral neurons. NATURE[J]. 2020, 第 8 作者582(7813): 550-+, http://dx.doi.org/10.1038/s41586-020-2388-4.
[22] Li, Yaoyi, Song, Yawei, Xu, Wei, Li, Qin, Wang, Xinxiu, Li, Kuan, Wang, Juehan, Liu, Zicong, Velychko, Sergiy, Ye, Rong, Xia, Qing, Wang, Lei, Guo, Rong, Dong, Xiaotao, Zheng, Zhikai, Dai, Yushuang, Li, Haojie, Yao, Mingze, Xue, Yuanchao, Schoeler, Hans R, Sun, Qianwen, Yao, Hongjie. R-loops coordinate with SOX2 in regulating reprogramming to pluripotency. SCIENCE ADVANCES[J]. 2020, 第 19 作者6(24): http://dx.doi.org/10.1126/sciadv.aba0777.
[23] Xue, Yuanchao, Chen, Runsheng, Qu, Lianghu, Cao, Xiaofeng. Noncoding RNA: from dark matter to bright star. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 第 1 作者63(4): 463-468, https://www.sciengine.com/doi/10.1007/s11427-020-1676-5.
[24] Cai, Zhaokui, Cao, Changchang, Ji, Lei, Ye, Rong, Wang, Di, Xia, Cong, Wang, Sui, Du, Zongchang, Hu, Naijing, Yu, Xiaohua, Chen, Juan, Wang, Lei, Yang, Xianguang, He, Shunmin, Xue, Yuanchao. RIC-seq for global in situ profiling of RNA-RNA spatial interactions. NATURE[J]. 2020, 第 15 作者  通讯作者  582(7812): 432-+, http://dx.doi.org/10.1038/s41586-020-2249-1.
[25] Ye, Rong, Cao, Changchang, Xue, Yuanchao, Du, X. Enhancer RNA: biogenesis, function, and regulation. SPOTLIGHT ON CHINA: RNA. 2020, 第 11 作者64(6): 883-894, http://dx.doi.org/10.1042/EBC20200014.
[26] Hu, Jing, Gao, Chen, Wei, Chaoliang, Xue, Yuanchao, Shao, Changwei, Hao, Yajing, Gou, LanTao, Zhou, Yu, Zhang, Jianlin, Ren, Shuxun, Chen, Ju, Wang, Yibin, Fu, XiangDong. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 4 作者116(13): 6172-6180, 
[27] Li, Zonghong, Zhou, Maoge, Cai, Zhaokui, Liu, Hongyang, Zhong, Wen, Hao, Qiang, Cheng, Dongwan, Hu, Xihao, Hou, Junjie, Xu, Pingyong, Xue, Yuanchao, Zhou, Yifa, Xu, Tao. RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation. NUCLEIC ACIDS RESEARCH[J]. 2018, 第 11 作者46(22): 12052-12066, https://www.webofscience.com/wos/woscc/full-record/WOS:000456714000035.
[28] Juan Chen, Zhaokui Cai, Meizhu Bai, Xiaohua Yu, Chao Zhang, Changchang Cao, Xihao Hu, Lei Wang, Ruibao Su, Di Wang, Yingpeng Yao, Rong Ye, Baidong Hou, Yang Yu, Shuyang Yu, Jinsong Li, Yuanchao xue. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. 细胞研究:英文版[J]. 2018, 第 17 作者28(10): 981-995, http://lib.cqvip.com/Qikan/Article/Detail?id=676732340.
[29] Hu Jing, Qian Hao, Xue Yuanchao, Fu Xiangdong. PTB/nPTB: master regulators of neuronal fate in mammals. 生物物理学报:英文版[J]. 2018, 第 3 作者4(4): 204-214, http://lib.cqvip.com/Qikan/Article/Detail?id=676327038.
[30] Zhang, Kai, Zhang, Xiaorong, Cai, Zhiqiang, Zhou, Jie, Cao, Ran, Zhao, Ya, Chen, Zonggui, Wang, Dehe, Ruan, Wen, Zhao, Qian, Liu, Guangqiao, Xue, Yuanchao, Qin, Yan, Zhou, Bing, Wu, Ligang, Nilsen, Timothy, Zhou, Yu, Fu, XiangDong. A novel class of microRNA-recognition elements that function only within open reading frames. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2018, 第 12 作者25(11): 1019-+, http://202.127.25.143/handle/331003/3372.
[31] Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu. PTB/nPTB: master regulators of neuronal fate in mammals. 生物物理学报:英文版[J]. 2018, 第 3 作者4(4): 204-214, http://lib.cqvip.com/Qikan/Article/Detail?id=676327038.
[32] Chen, Juan, Cai, Zhaokui, Bai, Meizhu, Yu, Xiaohua, Zhang, Chao, Cao, Changchang, Hu, Xihao, Wang, Lei, Su, Ruibao, Wang, Di, Yao, Yingpeng, Ye, Rong, Hou, Baidong, Yu, Yang, Yu, Shuyang, Li, Jinsong, Xue, Yuanchao. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. CELL RESEARCH[J]. 2018, 第 17 作者  通讯作者  28(10): 981-995, http://202.127.25.143/handle/331003/3502.
[33] Burkholder, Nathaniel Tate, Mayfield, Joshua E, Yu, Xiaohua, Irani, Seema, Arce, Daniel K, Jiang, Faqin, Matthews, Wendy L, Xue, Yuanchao, Zhang, Yan Jessie. Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST). JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 第 8 作者293(43): 16851-16861, http://dx.doi.org/10.1074/jbc.RA118.004722.
[34] Liu, Chang, Xin, Ying, Xu, Le, Cai, Zhaokui, Xue, Yuanchao, Liu, Yong, Xie, Daoxin, Liu, Yule, Qi, Yijun. Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses. DEVELOPMENTAL CELL[J]. 2018, 第 5 作者44(3): 348-+, http://dx.doi.org/10.1016/j.devcel.2017.12.002.
[35] 赵爽, 陈月琴, 薛愿超, 周宇, 刘默芳. RNA-蛋白质机器在哺乳动物遗传信息表达中的调控功能与机制. 中国基础科学[J]. 2018, 第 3 作者20(3): 8-12, http://lib.cqvip.com/Qikan/Article/Detail?id=676330462.
[36] Xue, Yuanchao, Qian, Hao, Hu, Jing, Zhou, Bing, Zhou, Yu, Hu, Xihao, Karakhanyan, Aziz, Pang, Zhiping, Fu, XiangDong. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. NATURE NEUROSCIENCE[J]. 2016, 第 1 作者  通讯作者  19(6): 807-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000376744600011.
[37] Lim, Su Min, Choi, Won Jun, Oh, KiWook, Xue, Yuanchao, Choi, Ji Young, Kim, Sung Hoon, Nahm, Minyeop, Kim, YoungEun, Lee, Jinhyuk, Noh, MinYoung, Lee, Seungbok, Hwang, Sejin, Ki, ChangSeok, Fu, XiangDong, Kim, Seung Hyun. Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION[J]. 2016, 第 4 作者11(1): http://dx.doi.org/10.1186/s13024-016-0075-6.
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指导学生

现指导学生

蔡兆奎  博士研究生  071010-生物化学与分子生物学