博士后，专业硕士和学位硕士

2004-03--2007-03   天津大学   博士

2017-至今   中国科学院大学化学学院   副教授

2014-2016  中国科学院大学化学与化工学院   讲师
2011-2014  北京大学医学部   博士后
2007-2009  日本甲南大学先端生命工学研究所(FIBER)   博士后

[1] 吴丽. Self-Assembly Nanostructure Induced by Regulation of G-Quadruplex DNA Topology via a Reduction-Sensitive Azobenzene Ligand on Cells. Biomacromolecules[J]. 2023, [2] Yan, Liang, Ke, Yongqi, Wang, Yu, Yang, Jingkui, He, Yujian, Wu, Li. Effect of Mini-PEGs Modification on the Enzymatic Digestion of D-Amino Acid-Containing Peptides under the Action of PROK. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2023, 29(16): https://www.doi.org/10.1002/chem.202203524.
[3] Wang, Yu, Ji, Heming, Ma, Jian, Luo, Hang, He, Yujian, Tang, Xinjing, Wu, Li. Reversible On-Off Photoswitching of DNA Replication Using a Dumbbell Oligodeoxynucleotide. MOLECULES[J]. 2022, 27(24): http://dx.doi.org/10.3390/molecules27248992.
[4] Kan, Yuhe, Jin, Zhaoyang, Ke, Yongqi, Lin, Dao, Yan, Liang, Wu, Li, He, Yujian. Replicative bypass studies of L-deoxyribonucleosides in Vitro and in E. coli cell. SCIENTIFIC REPORTS[J]. 2022, 12(1): http://dx.doi.org/10.1038/s41598-022-24802-5.
[5] Luo, Hang, Wu, Li, He, Yujian, Qin, Chong, Tang, Xinjing. Major Advances in Emerging Degrader Technologies. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2022, 10: http://dx.doi.org/10.3389/fcell.2022.921958.
[6] Wu, Ya, Bu, Xinya, Ke, Yongqi, Sun, Huaming, Li, Jingyao, Chen, Lu, Cui, Wei, He, Yujian, Wu, Li. Insight into the Stereocontrol of DNA Polymerase-Catalysed Reaction by Chiral Cobalt Complexes. ADVANCED SYNTHESIS & CATALYSIS[J]. 2022, 364(16): 2760-2771, http://dx.doi.org/10.1002/adsc.202200418.
[7] 卜新雅, 陈露, 阚玉贺, 雷华军, 何裕建, 封禄田, 吴丽. 手性氨基酸对DNA链式聚合反应的影响. 中国科学院大学学报[J]. 2021, 38(3): 306-313, http://lib.cqvip.com/Qikan/Article/Detail?id=7104572335.
[8] Lin, Dao, Kan, Yuhe, Yan, Liang, Ke, Yongqi, Zhang, Yang, Luo, Hang, Tang, Xinjing, Li, Xiangjun, He, Yujian, Wu, Li. Redox manipulation of enzyme activity through physiologically active molecule. ISCIENCE[J]. 2021, 24(9): http://dx.doi.org/10.1016/j.isci.2021.102977.
[9] Li, Yasi, Ti, Mengru, Li, Zhongqiu, Zhang, Yang, Wu, Li, He, Yujian. Comparative study on the removal of different-type organic pollutants on three-dimensional hexagonal-tungsten trioxide/reduced graphene oxide nanorod arrays: adsorption and visible light photodegradation. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS[J]. 2021, 32(2): 2268-2282, https://www.webofscience.com/wos/woscc/full-record/WOS:000604333400009.
[10] 吴亚, 史俊, 吴丽. 有机合成协同思政教育的课程体系构建探索. 大学化学[J]. 2021, 36(3): 179-185, http://lib.cqvip.com/Qikan/Article/Detail?id=7104444679.
[11] Li, Yasi, Ti, Mengru, Zhao, Dongxu, Zhang, Yang, Wu, Li, He, Yujian. Facile synthesis of nitrogen-vacancy pothole-rich few-layer g-C3N4 for photocatalytic nitrogen fixation into nitrate and ammonia. JOURNAL OF ALLOYS AND COMPOUNDS[J]. 2021, 870: http://dx.doi.org/10.1016/j.jallcom.2021.159298.
[12] Ti, Mengru, Li, Yasi, Li, Zhongqiu, Zhao, Dongxu, Wu, Li, Yuan, Longfei, He, Yujian. A ratiometric nanoprobe based on carboxylated graphitic carbon nitride nanosheets and Eu3+ for the detection of tetracyclines. ANALYST[J]. 2021, 146(3): 1065-1073, https://www.webofscience.com/wos/woscc/full-record/WOS:000615961900037.
[13] Yan, Liang, Ke, Yongqi, Kan, Yuhe, Lin, Dao, Yang, Jingkui, He, Yujian, Wu, Li. New insight into enzymatic hydrolysis of peptides with site-specific amino acid D-isomerization. BIOORGANIC CHEMISTRY[J]. 2020, 105: http://dx.doi.org/10.1016/j.bioorg.2020.104389.
[14] Kan, Yuhe, Chen, Lu, Lin, Dao, Bu, Xinya, Mo, Mengwu, Yan, Liang, Yang, Zhenjun, Yuan, Longfei, Wu, Li, He, Yujian. Replication of DNA Containing Mirror-Image Thymidine in E. coli Cells. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2020, 33(9): 2276-2285, https://www.webofscience.com/wos/woscc/full-record/WOS:000575336300025.
[15] 陈露, 季禾茗, 莫蒙武, 雷华军, 卜新雅, 何裕建, 封禄田, 吴丽. 偶氮苯修饰的发夹DNA对RNA转录的光调控. 中国科学院大学学报[J]. 2020, 37(3): 416-423, http://lib.cqvip.com/Qikan/Article/Detail?id=7102144160.
[16] Liu, Qingju, Ke, Yongqi, Kan, Yuhe, Tang, Xinjing, Li, Xiangjun, He, Yujian, Wu, Li. Compatibility and Fidelity of Mirror-Image Thymidine in Transcription Events by T7 RNA Polymerase. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 21: 604-613, http://dx.doi.org/10.1016/j.omtn.2020.06.023.
[17] Wu Li. Mutation analysis of L-thymidine-induced replication products using restriction enzyme mediated assay. Current Protocol in Nucleic Acid Chemistry. 2020, [18] Yang, Xu, Yang, Kunhao, Wu, Li, Yang, Jingkui, He, Yujian. Fe3O4 nanoparticles functionalized with poly(ethylene glycol) for the selective separation and enrichment of Au(iii). NEW JOURNAL OF CHEMISTRY[J]. 2020, 44(4): 1313-1319, https://www.webofscience.com/wos/woscc/full-record/WOS:000509895700017.
[19] 雷华军, 莫蒙武, 孔德佳, 何裕建, 郑鹏武, 吴丽. 生物体系中还原裂解氮氮双键的研究进展. 中国科学:化学[J]. 2019, 256-265, https://www.sciengine.com/doi/10.1360/N032018-00142.
[20] Lei, Huajun, Mo, Mengwu, He, Yujian, Wu, Ya, Zhu, Wufu, Wu, Li. Bioactivatable reductive cleavage of azobenzene for controlling functional dumbbell oligodeoxynucleotides. BIOORGANIC CHEMISTRY[J]. 2019, 91: 103106-, http://dx.doi.org/10.1016/j.bioorg.2019.103106.
[21] Mo, Mengwu, Kong, Dejia, Ji, Heming, Lin, Dao, Tang, Xinjing, Yang, Zhenjun, He, Yujian, Wu, Li. Reversible Photocontrol of Thrombin Activity by Replacing Loops of Thrombin Binding Aptamer using Azobenzene Derivatives. BIOCONJUGATE CHEMISTRY[J]. 2019, 30(1): 231-241, https://www.webofscience.com/wos/woscc/full-record/WOS:000456350800024.
[22] Li, Zhongqiu, Ti, Mengru, Yang, Kunhao, Li, Xiangjun, Wu, Li, He, Yujian. Colorimetric detection of iron (II) using 4-mercaptobenzoic acid and 3,3 ',5, 5 '-tetramethylbenzidine modified silver nanoparticles. MICROCHEMICAL JOURNAL[J]. 2019, 151: http://dx.doi.org/10.1016/j.microc.2019.104254.
[23] Yuhe Kan, Zhikun Zhang, Kunhao Yang, Mengru Ti, Yongqi Ke, Li Wu, Jingkui Yang, Yujian He. Influence of D-Amino Acids in Beer on Formation of Uric Acid. FOOD TECHNOLOGY AND BIOTECHNOLOGY[J]. 2019, 57(3): 418-425, https://doaj.org/article/13ee37de225a4710a74ac7b7dfad2abc.
[24] Li, Zhongqiu, Yang, Kunhao, Lv, Yueguang, Wang, Qingnan, Li, Chang, Wu, Li, He, Yujian. A rapid pretreatment of PVC products for high-throughput and visual detection of trace heavy metals. MONATSHEFTE FUR CHEMIE[J]. 2019, 150(11): 1903-1910, https://www.webofscience.com/wos/woscc/full-record/WOS:000494183000001.
[25] 季禾茗, 孔德佳, 莫蒙武, 雷华军, 陈露, 赵瑞琪, 王威, 何裕建, 封禄田, 吴丽. 偶氮苯修饰的DNA对引物延伸的光调控. 中国科学院大学学报[J]. 2019, 36(1): 38-47, http://lib.cqvip.com/Qikan/Article/Detail?id=6100179307.
[26] 孔德佳, 莫蒙武, 季禾茗, 雷华军, 陈露, 李元昊, 何裕建, 汤新景, 郑鹏武, 吴丽. 偶氮苯作用的核酸开关在生物体内的可逆光调控. 中国科学：化学[J]. 2018, 48(7): 698-711, http://lib.cqvip.com/Qikan/Article/Detail?id=676033609.
[27] Yang, Kunhao, Li, Zhongqiu, Lv, Yueguang, Yu, Chuyi, Wang, Peilong, Su, Xiaoou, Wu, Li, He, Yujian. Graphene and AuNPs based electrochemical aptasensor for ultrasensitive detection of hydroxylated polychlorinated biphenyl. ANALYTICA CHIMICA ACTA[J]. 2018, 1041: 94-101, http://dx.doi.org/10.1016/j.aca.2018.08.047.
[28] 刘庆菊, 何裕建, 吴丽, 李向军. D-氨基酸诱导的酿酒酵母细胞内活性氧的累积. 中国科学院大学学报[J]. 2018, 35(4): 473-480, http://lib.cqvip.com/Qikan/Article/Detail?id=675644908.
[29] Zhang, Liangliang, Liang, Duanwei, Wang, Yuan, Li, Dong, Zhang, Jinhao, Wu, Li, Feng, Mengke, Yi, Fan, Xu, Luzheng, Lei, Liandi, Du, Quan, Tang, XinJing. Caged circular siRNAs for photomodulation of gene expression in cells and mice. CHEMICAL SCIENCE[J]. 2018, 9(1): 44-51, https://www.webofscience.com/wos/woscc/full-record/WOS:000418376400005.
[30] Yang, Kunhao, Pan, Long, Gong, Lingling, Liu, Qingju, Li, Zhongqiu, Wu, Li, He, Yujian. Colorimetric and visual determination of Au(III) ions using PEGylated gold nanoparticles. MICROCHIMICA ACTA[J]. 2018, 185(2): [31] Liu, Qingju, Zhao, Chuanfang, Huang, Jincheng, Chen, Li, Yang, Kunhao, Gong, Lingling, Du, Yuguo, Yu, Chuyi, Wu, Li, Li, Xiangjun, He, Yujian. Enantioselectivity of D-amino acid oxidase in the presence of ionic liquids. RSC ADVANCES[J]. 2017, 7(54): 34110-34117, https://www.webofscience.com/wos/woscc/full-record/WOS:000405279100052.
[32] Wu Li. Mirror-image thymidine discriminates against incorporation of dNTP into DNA and repairs itself by DNA polymerases. Bioconjugate Chemistry. 2017, [33] Qingju Liu, Li Chen, Zhikun Zhang, Bibai Du, Yating Xiao, Kunhao Yang, Lingling Gong, Li Wu, Xiangjun Li, Yujian He. PH-Dependent Enantioselectivity of D-amino Acid Oxidase in Aqueous Solution. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/366929d02861413da266a82bc9d372c9.
[34] Gong, Lingling, Du, Bibai, Pan, Long, Liu, Qingju, Yang, Kunhao, Wang, Wei, Zhao, Hong, Wu, Li, He, Yujian. Colorimetric aggregation assay for arsenic(III) using gold nanoparticles. MICROCHIMICA ACTA[J]. 2017, 184(4): 1185-1190, https://www.webofscience.com/wos/woscc/full-record/WOS:000397497900025.
[35] Wu, Ya, Wu, Li. Acid generation by 1,4-bis(phenylsulfonyloxy)benzene and their photochemical mechanism. MONATSHEFTE FUR CHEMIE[J]. 2017, 148(4): 675-682, https://www.webofscience.com/wos/woscc/full-record/WOS:000398172300007.
[36] Pan, Long, Xu, MengYing, Liu, ZiLu, Du, BiBai, Yang, KunHao, Wu, Li, He, Peng, He, YuJian. Facile method for the synthesis of Fe3O4@ HCP core-shell porous magnetic microspheres for fast separation of organic dyes from aqueous solution. RSC ADVANCES[J]. 2016, 6(53): 47530-47535, https://www.webofscience.com/wos/woscc/full-record/WOS:000377253400040.
[37] Wu, Li, He, Yujian, Tang, Xinjing. Photoregulating RNA Digestion Using Azobenzene Linked Dumbbell Antisense Oligodeoxynucleotides. BIOCONJUGATE CHEMISTRY[J]. 2015, 26(6): 1070-1079, http://www.corc.org.cn/handle/1471x/2376393.
[38] Wu, Li, Wu, Ya, Jin, Hongwei, Zhang, Liangren, He, Yujian, Tang, Xinjing. Photoswitching properties of hairpin ODNs with azobenzene derivatives at the loop position. MEDCHEMCOMM[J]. 2015, 6(3): 461-468, https://www.webofscience.com/wos/woscc/full-record/WOS:000351095400011.
[39] Wu, Li, Pei, Fen, Zhang, Jinhao, Wu, Junzhou, Feng, Mengke, Wang, Yuan, Jin, Hongwei, Zhang, Liangren, Tang, Xinjing. Synthesis of Site-Specifically Phosphate-Caged siRNAs and Evaluation of Their RNAi Activity and Stability. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2014, 20(38): 12114-12122, https://www.webofscience.com/wos/woscc/full-record/WOS:000341831600021.
[40] Wu, Li, Wang, Yuan, Wu, Junzhou, Lv, Cong, Wang, Jie, Tang, Xinjing. Caged circular antisense oligonucleotides for photomodulation of RNA digestion and gene expression in cells. NUCLEIC ACIDS RESEARCH[J]. 2013, 41(1): 677-686, https://www.webofscience.com/wos/woscc/full-record/WOS:000312889900088.
[41] Wang, Yuan, Wu, Li, Wang, Peng, Lv, Cong, Yang, Zhenjun, Tang, Xinjing. Manipulation of gene expression in zebrafish using caged circular morpholino oligomers. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(21): 11155-11162, https://www.webofscience.com/wos/woscc/full-record/WOS:000313349100051.
[42] Wu Li. Reversible stability switching of a hairpin DNA via a molecularly designed photo-responsive linker unit. Chemical Communications. 2009, [43] Ji Yuzhuo, Yang Jiali, Wu Li, Yu Lijia, Tang Xinjing. Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification. ANGEWANDTE CHEMIE[J]. http://dx.doi.org/10.1002/ange.201510921.

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（ 1 ） 光敏感核酸分子的设计、合成及细胞内基因表达的光控制, 主持, 国家级, 2012-02--2014-01
（ 2 ） 磷酸二酯骨架修饰的光敏感siRNA的合成及其对基因表达的光调控, 主持, 国家级, 2014-01--2016-12
（ 3 ） 偶氮苯修饰的四倍体对凝血酶的光调控, 主持, 部委级, 2015-06--2017-06
（ 4 ） 二氧化碳起泡体系研发与测试, 主持, 院级, 2016-02--2017-04
（ 5 ） 用于重要贸易产品快速检测的低成本传感 芯片的研究-快速取样技术研究和芯片功能 化研究, 参与, 国家级, 2016-06--2020-12
（ 6 ） 非紫外的核酸开关对 RNA 降解和细胞内基 因表达的可逆控制, 主持, 市地级, 2014-06--2015-06
（ 7 ） 偶氮苯修饰的 TBA 活性的可逆光调控, 主持, 市地级, 2015-06--2016-06
（ 8 ） 偶氮苯修饰的核酸对生物体内基因表达的可逆光调控, 主持, 国家级, 2018-01--2021-12
（ 9 ） 非天然核苷对遗传 信息传递的影响, 主持, 省级, 2019-01--2021-12
（ 10 ） 含L-胸苷的DNA模板指导的引物延伸和转录, 主持, 研究所（学校）, 2018-01--2019-12
（ 11 ） 核苷类似物对遗传信息传递的影响, 主持, 市地级, 2018-01--2020-12
（ 12 ） 偶氮苯氧化还原开关对功能核酸的特异性调控, 主持, 部委级, 2021-05--2022-12

已指导学生

柯咏琪  硕士研究生  0703Z1-化学生物学  

现指导学生

罗航  硕士研究生  085204-材料工程  

王昱  硕士研究生  0703Z1-化学生物学  

马健  硕士研究生  085600-材料与化工  

陈红佳  硕士研究生  070305-高分子化学与物理