基本信息
王曼丽 女 博导 中国科学院武汉病毒研究所
电子邮件: Wangml@wh.iov.cn
通信地址: 湖北省武汉市武昌小洪山中区44号
邮政编码: 430071
研究领域
长期从事昆虫病毒和虫媒布尼亚病毒的感染机理研究,特别是在病毒入侵机制和抗病毒药物研究中取得了一系列创新性的研究成果。截至目前,共发表SCI研究论文60余篇。其中,第一作者和通讯作者SCI论文30余篇,包括Cell Research (1)、Small (1)、Philosophical Transactions B (1)、Journal of Virology (9)等。近期的研究重点为病毒入侵细胞的分子机制、病毒与媒介/宿主昆虫免疫系统的互作机制、病毒的致病机制和抗病毒药物。
招生信息
重要新发病毒的感染机理、致病机制和抗病毒药物。
招生专业
071005-微生物学
招生方向
分子病毒学,生物工程技术
教育背景
2002-09--2008-09 中国科学院武汉病毒研究所 博士学位1998-09--2002-07 武汉工业学院 学士学位
学历
研究生学历
学位
2009年获微生物学博士学位
工作经历
工作简历
2011-09~现在, 中国科学院武汉病毒研究所, 副研究员2008-10~2011-08,中国科学院武汉病毒研究所, 助理研究员2007-03~2007-10,荷兰wageningen大学, 访问学者
教授课程
文献阅读《分子病毒学》第四讲《分子病毒学》第五讲
专利与奖励
奖励信息
(1) 病毒所青年年度人物, 研究所(学校), 2015(2) 中国科学院卢嘉锡青年人才奖, , 院级, 2012(3) 中国科学院优秀博士学位论文, , 院级, 2010(4) 湖北省优秀博士学位论文, , 省级, 2010
专利成果
[1] 商雨, 胡志红, 邓菲, 王曼丽, 王华林. 一种杆状病毒基因组的合成方法及其在重组杆状病毒构建中的应用. CN: CN106754896B, 2019-09-17.[2] 王华林, 王曼丽, 干盈盈, 邓菲, 胡志红. 表达gp64基因的新型基因工程重组病毒的构建方法. 中国: CN102382803A, 2012-03-21.[3] 王华林, 董思聪, 王曼丽, 沈姝, 邓菲, 胡志红. 用于提高杆状病毒对哺乳动物细胞转导效率的方法. 中国: CN102199629A, 2011.09.28.
出版信息
发表论文
[1] Wang, Xi, Burdzhiev, Nikola T T, Hu, Hengrui, Li, Yufeng, Li, Jiang, Lozanova, Vesela V V, Kandinska, Meglena I I, Wang, Manli. Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection In Vitro. VIRUSES-BASEL[J]. 2023, 第 8 作者 通讯作者 15(2): http://dx.doi.org/10.3390/v15020502.[2] Han Xiao, Hengrui Hu, Yijia Guo, Jiang Li, Le Wen, WenBo Zeng, Manli Wang, MinHua Luo, Zhihong Hu. Construction and characterization of a synthesized herpes simplex virus H129-Syn-G2. VIROLOGICA SINICA[J]. 2023, 第 7 作者38(3): 373-379, http://dx.doi.org/10.1016/j.virs.2023.03.005.[3] Shiyu Dai, Yuan-Qin Min, Qi Li, Kuan Feng, Zhenyu Jiang, Zhiying Wang, Cunhuan Zhang, Fuli Ren, Yaohui Fang, Jingyuan Zhang, Qiong Zhu, Manli Wang, Hualin Wang, Fei Deng, Yun-Jia Ning. Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins. NATURE COMMUNICATIONS[J]. 2023, 第 12 作者14(1): http://dx.doi.org/10.1038/s41467-023-43206-1.[4] Dai, Shiyu, Min, YuanQin, Li, Qi, Feng, Kuan, Jiang, Zhenyu, Wang, Zhiying, Zhang, Cunhuan, Ren, Fuli, Fang, Yaohui, Zhang, Jingyuan, Zhu, Qiong, Wang, Manli, Wang, Hualin, Deng, Fei, Ning, YunJia. Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins. NATURE COMMUNICATIONS[J]. 2023, 第 12 作者14(1): http://dx.doi.org/10.1038/s41467-023-43206-1.[5] Li, Xiao, Hu, Hengrui, Liu, Wanlin, Zhang, Qiyu, Wang, Yujie, Chen, Xingjuan, Zhu, Yunping, Hu, Zhihong, Wang, Manli, Ma, Jie, Leng, Ling. SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts. STEM CELL RESEARCH & THERAPY[J]. 2023, 第 9 作者 通讯作者 14(1): http://dx.doi.org/10.1186/s13287-023-03603-1.[6] Wang, Xiao, Xu, Mingyue, Ke, Huanhuan, Ma, Longda, Li, Liushuai, Li, Jiang, Deng, Fei, Wang, Manli, Hu, Zhihong, Liu, Jia. Construction and Characterization of Severe Fever with Thrombocytopenia Syndrome Virus with a Fluorescent Reporter for Antiviral Drug Screening. VIRUSES-BASEL[J]. 2023, 第 8 作者 通讯作者 15(5): http://dx.doi.org/10.3390/v15051147.[7] HanXiao, HengruiHu, YijiaGuo, JiangLi, LeWen, WenBoZeng, ManliWang, MinHuaLuo, ZhihongHu. Construction and characterization of a synthesized herpes simplex virus H129-Syn-G2. Virologica Sinica[J]. 2023, 第 7 作者 通讯作者 38(3): 373-379, https://www.virosin.org/article/doi/10.1016/j.virs.2023.03.005.[8] Wang, Qianran, Peng, Lu, Nie, Yanqiu, Shu, Yanni, Zhang, Huajun, Song, Zidan, Li, Yufeng, Hu, Hengrui, Li, Liushuai, Wang, Xi, Liu, Jia, Li, Jiang, Shi, Zhengli, Deng, Fei, Guo, Yu, Zhou, Yiwu, Yan, Bing, Hu, Zhihong, Wang, Manli. Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo. VIROLOGICA SINICA[J]. 2023, 第 19 作者 通讯作者 38(2): 257-267, http://dx.doi.org/10.1016/j.virs.2022.12.007.[9] Guo, Yijia, Hu, Hengrui, Xiao, Han, Deng, Fei, Li, Jiang, Wang, Manli, Hu, Zhihong. Successful Rescue of Synthetic AcMNPV with a similar to 17 kb Deletion in the C1 Region of the Genome. VIRUSES-BASEL[J]. 2022, 第 6 作者 通讯作者 14(12): [10] Yin, Jiayi, Fu, Yan, Rao, Guibo, Li, Zhiqiang, Tian, Kexing, Chong, Tingting, Kuang, Kai, Wang, Manli, Hu, Zhihong, Cao, Sheng. Structural transitions during the cooperative assembly of baculovirus single-stranded DNA-binding protein on ssDNA. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 8 作者50(22): 13100-13113, http://dx.doi.org/10.1093/nar/gkac1142.[11] Kuang, Wenhua, Zhang, Huanyu, Cai, Yan, Zhang, Guilin, Deng, Fei, Li, Hailong, Hu, Zhihong, Guo, Yu, Wang, Manli, Zhou, Yiwu, Gong, Peng. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. JOURNAL OF VIROLOGY[J]. 2022, 第 9 作者96(6): http://dx.doi.org/10.1128/jvi.02085-21.[12] Shen, Shu, Zhang, Yaxian, Yin, Zhiyun, Zhu, Qiong, Zhang, Jingyuan, Wang, Tiantian, Fang, Yaohui, Wu, Xiaoli, Bai, Yuan, Dai, Shiyu, Liu, Xijia, Jin, Jiayin, Tang, Shuang, Liu, Jia, Wang, Manli, Guo, Yu, Deng, Fei. Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases. BMC MEDICINE[J]. 2022, 第 15 作者20(1): http://dx.doi.org/10.1186/s12916-022-02558-z.[13] 尹梦伊, kuang wenhua, 王倩然, 汪习, 袁传飞, 林哲, Huanyu Zhang, 邓菲, JIANG, HAOBO, 龚鹏, 邹振, 胡志红, 王曼丽. Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity. Nature Communications[J]. 2022, 第 13 作者 通讯作者 null(null): [14] 王倩然, Zou, Zhen, 王曼丽, 胡志红. The Micrococcus luteus infection activates a novel melanization pathway of cSP10, cSP4, and cSP8 in Helicoverpa armigera. Insect Biochemistry and Molecular Biology[J]. 2022, 第 3 作者 通讯作者 [15] Li, Zhiqiang, Zhang, Huanyu, Li, Zhuorui, Fu, Yan, Wang, Xi, Li, Jiang, Wang, Kangxiaoya, Wang, Zhiying, Zhang, Tao, Wang, Manli, Hu, Zhihong, Cao, Sheng. Structural Characterization of Per Os Infectivity Factor 5 (PIF5) Reveals the Essential Role of Intramolecular Interactions in Baculoviral Oral Infectivity. JOURNAL OF VIROLOGY[J]. 2022, 第 10 作者96(14): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327705/.[16] Boezen, Dieke, Ali, Ghulam, Wang, Manli, Wang, Xi, van der Werf, Wopke, Vlak, Just M, Zwart, Mark P. Empirical estimates of the mutation rate for an alphabaculovirus. PLOS GENETICS[J]. 2022, 第 3 作者18(6): https://doaj.org/article/20a5e9edc2164c479854485b9b3aa053.[17] Wang, Xi, Chen, Cheng, Zhang, Nan, Chen, Qingxiu, Zhang, Fenghua, Liu, Xijia, Li, Fang, Shi, ZhengLi, Vlak, Just M, Wang, Manli, Hu, Zhihong. Functional Peroral Infectivity Complex of White Spot Syndrome Virus of Shrimp. JOURNAL OF VIROLOGY[J]. 2022, 第 10 作者 通讯作者 96(24): [18] DaheYang, JunWang, XiWang, FeiDeng, QingyunDiao, ManliWang, ZhihongHu, ChunshengHou. Genomics and proteomics of Apis mellifera filamentous virus isolated from honeybees in China. Virologica Sinica[J]. 2022, 第 6 作者37(4): 483-490, https://www.virosin.org/article/doi/10.1016/j.virs.2022.02.007.[19] Kuang, Wenhua, Zhang, Huanyu, Cai, Yan, Zhang, Guilin, Deng, Fei, Li, Hailong, Zhou, Yiwu, Wang, Manli, Gong, Peng, Guo, Yu, Hu, Zhihong. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales). JOURNAL OF VIROLOGY[J]. 2022, 第 8 作者96(7): http://dx.doi.org/10.1128/jvi.02173-21.[20] Wang, Qianran, Cao, Ruiyuan, Li, Liushuai, Liu, Jia, Yang, Jingjing, Li, Wei, Yan, Linjie, Wang, Yanming, Yan, Yunzheng, Li, Jiang, Deng, Fei, Zhou, Yiwu, Wang, Manli, Zhong, Wu, Hu, Zhihong. In vitro and in vivo efficacy of a novel nucleoside analog H44 against Crimean-Congo hemorrhagic fever virus. ANTIVIRAL RESEARCH[J]. 2022, 第 13 作者 通讯作者 199: http://dx.doi.org/10.1016/j.antiviral.2022.105273.[21] Zhang, Huanyu, Kuang, Wenhua, Fu, Congcong, Li, Jiang, Wang, Manli, Hu, Zhihong. AC81 Is a Putative Disulfide Isomerase Involved in Baculoviral Disulfide Bond Formation. JOURNAL OF VIROLOGY[J]. 2022, 第 5 作者 通讯作者 96(24): http://dx.doi.org/10.1128/jvi.01167-22.[22] MingyueXu, BoWang, FeiDeng, HualinWang, ManliWang, ZhihongHu, JiaLiu. Establishment of a Reverse Genetic System of Severe Fever with Thrombocytopenia Syndrome Virus Based on a C4 Strain. Virologica Sinica[J]. 2021, 第 5 作者 通讯作者 36(5): 958-967, https://www.virosin.org/article/doi/10.1007/s12250-021-00359-x.[23] Xu, Mingyue, Wang, Bo, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong, Liu, Jia. Establishment of a Reverse Genetic System of Severe Fever with Thrombocytopenia Syndrome Virus Based on a C4 Strain (Jul, 10.1007/s12250-021-00359-x, 2021). VIROLOGICA SINICA. 2021, 第 5 作者 通讯作者 36(6): 1683-1683, http://dx.doi.org/10.1007/s12250-021-00420-9.[24] Pan, Yongbing, Du, Jianhui, Liu, Jia, Wu, Hai, Gui, Fang, Zhang, Nan, Deng, Xiaojie, Song, Gang, Li, Yufeng, Lu, Jia, Wu, Xiaoli, Zhan, ShanShan, Jing, Zhaofei, Wang, Jiong, Yang, Yimin, Liu, Jianbang, Chen, Ying, Chen, Qin, Zhang, Huanyu, Hu, Hengrui, Duan, Kai, Wang, Manli, Wang, Qisheng, Yang, Xiaoming. Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries. CELL DISCOVERY[J]. 2021, 第 22 作者 通讯作者 7(1): http://dx.doi.org/10.1038/s41421-021-00295-w.[25] Leng, Ling, Cao, Ruiyuan, Ma, Jie, Lv, Luye, Li, Wei, Zhu, Yunping, Wu, Zhihong, Wang, Manli, Zhou, Yiwu, Zhong, Wu. Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 第 8 作者 通讯作者 6(1): 229-231, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791959/.[26] Liu, Jia, Li, Yufeng, Liu, Qian, Yao, Qun, Wang, Xi, Zhang, Huanyu, Chen, Rong, Ren, Liang, Min, Juan, Deng, Fei, Yan, Bing, Liu, Liang, Hu, Zhihong, Wang, Manli, Zhou, Yiwu. SARS-CoV-2 cell tropism and multiorgan infection. CELL DISCOVERY. 2021, 第 14 作者 通讯作者 7(1): https://doaj.org/article/3715a80a1d6044f5af696ca036fe44a5.[27] Yuan, Chuanfei, Xing, Longsheng, Wang, Manli, Hu, Zhihong, Zou, Zhen. Microbiota modulates gut immunity and promotes baculovirus infection in Helicoverpa armigera. INSECT SCIENCE[J]. 2021, 第 3 作者28(6): 1766-1779, http://dx.doi.org/10.1111/1744-7917.12894.[28] Fu, Dan, Zhang, Guangshun, Wang, Yuhui, Zhang, Zheng, Hu, Hengrui, Shen, Shu, Wu, Jun, Li, Bo, Li, Xin, Fang, Yaohui, Liu, Jia, Wang, Qiao, Zhou, Yunjiao, Wang, Wei, Li, Yufeng, Lu, Zhonghua, Wang, Xiaoxiao, Nie, Cui, Tian, Yujie, Chen, Da, Wang, Yuan, Zhou, Xingdong, Wang, Qisheng, Yu, Feng, Zhang, Chen, Deng, Changjing, Zhou, Liang, Guan, Guangkuo, Shao, Na, Lou, Zhiyong, Deng, Fei, Zhang, Hongkai, Chen, Xinwen, Wang, Manli, Liu, Louis, Rao, Zihe, Guo, Yu. Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes. PLOS BIOLOGY[J]. 2021, 第 34 作者 通讯作者 19(5): http://dx.doi.org/10.1371/journal.pbio.3001209.[29] TongChen, XiaoyanDuan, HengruiHu, YuShang, YangboHu, FeiDeng, HualinWang, ManliWang, ZhihongHu. Systematic Analysis of 42 Autographa Californica Multiple Nucleopolyhedrovirus Genes Identifies An Additional Six Genes Involved in the Production of Infectious Budded Virus. Virologica Sinica[J]. 2021, 第 8 作者 通讯作者 36(4): 762-773, https://www.virosin.org/article/doi/10.1007/s12250-021-00355-1.[30] He, Bing, Liu, Shuning, Wang, Yuanyuan, Xu, Mengxin, Cai, Wei, Liu, Jia, Bai, Wendi, Ye, Shupei, Ma, Yong, Hu, Hengrui, Meng, Huicui, Sun, Tao, Li, Yanling, Luo, Huanle, Shi, Mang, Du, Xiangjun, Zhao, Wenjing, Chen, Shoudeng, Yang, Jingyi, Zhu, Haipeng, Jie, Yusheng, Yang, Yuedong, Guo, Deyin, Wang, Qiao, Liu, Yuwen, Yan, Huimin, Wang, Manli, Chen, YaoQing. Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 第 27 作者6(1): 1833-1844, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6999795&detailType=1.[31] He, Lihong, Shao, Wei, Li, Jiang, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Systematic analysis of nuclear localization of Autographa californica multiple nucleopolyhedrovirus proteins. JOURNAL OF GENERAL VIROLOGY[J]. 2021, 第 7 作者 通讯作者 102(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000635958900004.[32] YuShang, HengruiHu, XiWang, HualinWang, FeiDeng, ManliWang, ZhihongHu. Construction and Characterization of a Novel Bacmid AcBac-Syn Based on a Synthesized Baculovirus Genome. Virologica Sinica[J]. 2021, 第 6 作者 通讯作者 36(6): 1566-1574, https://www.virosin.org/article/doi/10.1007/s12250-021-00449-w.[33] Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong, Gengfu Xiao . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research[J]. 2020, 第 1 作者https://www.nature.com/articles/s41422-020-0282-0.[34] Zhang, Huanyu, Kuang, Wenhua, Chen, Cheng, Shang, Yu, Ma, Xiaoyan, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong. Per Os Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. JOURNAL OF VIROLOGY[J]. 2020, 第 8 作者 通讯作者 94(15): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375385/.[35] Xi Wang, Ruiyuan Cao, Huanyu Zhang, Jia Liu, Mingyue Xu, Hengrui Hu, Yufeng Li, Lei Zhao, Wei Li, Xiulian Sun, Xinglou Yang, Zhengli Shi, Fei Deng, Zhihong Hu, Wu Zhong, Manli Wang. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. CELL DISCOVERY[J]. 2020, 第 16 作者6(1): 1-5, http://dx.doi.org/10.1038/s41421-020-0169-8.[36] LeikeZhang, JiaLiu, RuiyuanCao, MingyueXu, YanWu, WeijuanShang, XiWang, HuanyuZhang, XiamingJiang, YuanSun, HengruiHu, YufengLi, GangZou, MinZhang, LeiZhao, WeiLi, XiaojiaGuo, XiaomeiZhuang, XingLouYang, ZhengLiShi, FeiDeng, ZhihongHu, GengfuXiao, ManliWang, WuZhong. Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2In Vitro. Virologica Sinica[J]. 2020, 第 24 作者 通讯作者 35(6): 776-784, https://www.virosin.org/article/doi/10.1007/s12250-020-00288-1.[37] 胡志红. Per os Infectivity Factor 5 (PIF5) Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. Journal of Virology. 2020, [38] Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong, Manli Wang. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery[J]. 2020, 第 10 作者https://www.nature.com/articles/s41421-020-0156-0.[39] Wang, Qianran, Yin, Mengyi, Yuan, Chuanfei, Liu, Xijia, Hu, Zhihong, Zou, Zhen, Wang, Manli. Identification of a Conserved Prophenoloxidase Activation Pathway in Cotton Bollworm Helicoverpa armigera. FRONTIERS IN IMMUNOLOGY[J]. 2020, 第 7 作者 通讯作者 11: https://doaj.org/article/c42b39d1faf04d7394916bff3f8cccff.[40] Liu, Xiaoping, Wang, Hanzhong, Liu, Xiaoqian, Li, Yong, Chen, Jing, Zhang, Jun, Wang, Xi, Shen, Shu, Wang, Hualin, Deng, Fei, Wang, Manli, Guan, Wuxiang, Hu, Zhihong. Genomic and transcriptional analyses of novel parvoviruses identified from dead peafowl. VIROLOGY[J]. 2020, 第 11 作者539: 80-91, http://dx.doi.org/10.1016/j.virol.2019.10.013.[41] Yuan, Chuanfei, Wu, Jia, Peng, Yun, Li, Yufeng, Shen, Shu, Deng, Fei, Hu, Zhihong, Zhou, Jinlin, Wang, Manli, Zou, Zhen. Transcriptome analysis of the innate immune system of Hyalomma asiaticum. JOURNAL OF INVERTEBRATE PATHOLOGY[J]. 2020, 第 9 作者 通讯作者 177: http://dx.doi.org/10.1016/j.jip.2020.107481.[42] Yimeng Li, Liangbo Hu, Tong Chen, Meng Chang, Fei Deng, Zhihong Hu, Hualin Wang, Manli Wang, Joanna L Shisler. Host AAA+ ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. JOURNAL OF VIROLOGY. 2020, 第 8 作者94(6): [43] Liu, Jia, Li, Yufeng, Liu, Liang, Hu, Xudong, Wang, Xi, Hu, Hengrui, Hu, Zhihong, Zhou, Yiwu, Wang, Manli. Infection of human sweat glands by SARS-CoV-2. CELL DISCOVERY. 2020, 第 9 作者 通讯作者 6(1): http://dx.doi.org/10.1038/s41421-020-00229-y.[44] Cao, Ruiyuan, Hu, Hengrui, Li, Yufeng, Wang, Xi, Xu, Mingyue, Liu, Jia, Zhang, Huanyu, Yan, Yunzheng, Zhao, Lei, Li, Wei, Zhang, Tianhong, Xiao, Dian, Guo, Xiaojia, Li, Yuexiang, Yang, Jingjing, Hu, Zhihong, Wang, Manli, Zhong, Wu. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS INFECTIOUS DISEASES[J]. 2020, 第 17 作者 通讯作者 6(9): 2524-2531, http://dx.doi.org/10.1021/acsinfecdis.0c00522.[45] Li, Yimeng, Hu, Liangbo, Chen, Tong, Chang, Meng, Deng, Fei, Hu, Zhihong, Wang, Hualin, Wang, Manli. Host AAA plus ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. JOURNAL OF VIROLOGY[J]. 2020, 第 8 作者 通讯作者 94(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000518387200013.[46] Li, Shufen, Wang, Yun, Hou, Dianhai, Guan, Zhenqiong, Shen, Shu, Peng, Ke, Deng, Fei, Chen, Xinwen, Hu, Zhihong, Wang, Hualin, Wang, Manli. Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization. VIROLOGY[J]. 2019, 第 11 作者 通讯作者 535: 200-209, http://dx.doi.org/10.1016/j.virol.2019.07.006.[47] Shao, Wei, He, Lihong, Chen, Qingxiu, Li, Jiang, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Functional Characterization of the Group I Alphabaculovirus Specific Gene ac73. VIROLOGICA SINICA[J]. 2019, 第 8 作者 通讯作者 34(6): 701-711, http://lib.cqvip.com/Qikan/Article/Detail?id=7100725498.[48] Zhang, LeiKe, Wang, Bo, Xin, Qilin, Shang, Weijuan, Shen, Shu, Xiao, Gengfu, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. JOURNAL OF VIROLOGY[J]. 2019, 第 10 作者 通讯作者 93(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000466417500011.[49] Wang, Xi, Shang, Yu, Chen, Cheng, Liu, Shurui, Chang, Meng, Zhang, Nan, Hu, Hengrui, Zhang, Fenghua, Zhang, Tao, Wang, Zhiying, Liu, Xijia, Lin, Zhe, Deng, Fei, Wang, Hualin, Zou, Zhen, Vlak, Just M, Wang, Manli, Hu, Zhihong. Baculovirus Per Os Infectivity Factor Complex: Components and Assembly. 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Unraveling the Entry Mechanism of Baculoviruses and Its Evolutionary Implications. JOURNAL OF VIROLOGY[J]. 2014, 第 1 作者88(4): 2301-2311, http://dx.doi.org/10.1128/JVI.03204-13.[107] Ning Yunjia, Wang Manli, Deng Maping, Shu Shen, Wei Liu, Cao Wuchun, Fei Deng, Wang Yanyi, Hu Zhihong, Wang Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 第 2 作者6(4): 324-337, https://explore.openaire.eu/search/publication?articleId=od_______267::5e91f3dc5958c3d82b8b79f04162209d.[108] Wang Manli, Hu Zhihong. Bats as Animal Reservoirs for the SARS Coronavirus: Hypothesis Proved After 10 Years of Virus Hunting. 中国病毒学:英文版[J]. 2013, 第 1 作者315-317, http://lib.cqvip.com/Qikan/Article/Detail?id=48282114.[109] ManliWang, ZhihongHu. Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting. Virologica Sinica[J]. 2013, 第 1 作者28(6): 315-317, https://www.virosin.org/article/doi/10.1007/s12250-013-3402-x.[110] LiminLiao, DianhaiHou, HuachaoHuang, ManliWang, FeiDeng, HualinWang, ZhihongHu, TaoZhang. Identification of the Epitopes of Monoclonal Antibodies against P74 ofHelicoverpa armigeraNucleopolyhedrovirus. Virologica Sinica[J]. 2013, 第 4 作者28(6): 360-367, https://www.virosin.org/article/doi/10.1007/s12250-013-3393-7.[111] Yin, Feifei, Wang, Manli, Tan, Ying, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Betabaculovirus F proteins showed different efficiencies when rescuing the infectivity of gp64-null Autographa californica nucleopolyhedrovirus. VIROLOGY[J]. 2013, 第 2 作者436(1): 59-66, http://dx.doi.org/10.1016/j.virol.2012.10.017.[112] Song, Jingjiao, Wang, Manli, Huang, Huachao, Luo, Xin, Deng, Fei, Wang, Hualin, Hu, Zhihong. Functional studies of per os infectivity factor 3 of Helicoverpa armigera nucleopolyhedrovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 第 2 作者93: 374-382, [113] Shen, Shu, Gan, Yinyin, Wang, Manli, Hu, Zhihong, Wang, Hualin, Deng, Fei. Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 第 3 作者93: 2705-2711, https://www.webofscience.com/wos/woscc/full-record/WOS:000313027500020.[114] Song, Jingjiao, Wang, Manli, Huang, Huachao, Luo, Xin, Deng, Fei, Wang, Hualin, Hu, Zhihong. Functional studies of per os infectivity factor 3 of Helicoverpa armigera nucleopolyhedrovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 第 2 作者93: 374-382, https://www.webofscience.com/wos/woscc/full-record/WOS:000300139500017.[115] Shen, Shu, Gan, Yinyin, Wang, Manli, Hu, Zhihong, Wang, Hualin, Deng, Fei. Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 第 3 作者93: 2705-2711, https://www.webofscience.com/wos/woscc/full-record/WOS:000313027500020.[116] Huang, Huachao, Wang, Manli, Deng, Fei, Wang, Hualin, Hu, Zhihong. ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex. VIROLOGY[J]. 2012, 第 2 作者427(2): 217-223, http://dx.doi.org/10.1016/j.virol.2012.01.022.[117] Huachao Huang, Manli Wang, Fei Deng, Hualin Wang, Zhihong Hu. ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex. VIROLOGY[J]. 2012, 第 2 作者427(2): 217-223, http://dx.doi.org/10.1016/j.virol.2012.01.022.[118] ZhaoruiZhou, ManliWang, FeiDeng, TianxianLi, ZhihongHu, HualinWang. Production of CCHF Virus-Like Particle by a Baculovirus-Insect Cell Expression System. Virologica Sinica[J]. 2011, 第 2 作者26(5): 338-346, https://www.virosin.org/article/doi/10.1007/s12250-011-3209-6.[119] Dong, Sicong, Wang, Manli, Qiu, Zhijuan, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Autographa californica Multicapsid Nucleopolyhedrovirus Efficiently Infects Sf9 Cells and Transduces Mammalian Cells via Direct Fusion with the Plasma Membrane at Low pH. JOURNAL OF VIROLOGY[J]. 2010, 第 2 作者84(10): 5351-5359, http://www.corc.org.cn/handle/1471x/2375694.[120] Wang, Manli, Yin, Feifei, Shen, Shu, Tan, Ying, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Partial Functional Rescue of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus Infectivity by Replacement of F Protein with GP64 from Autographa californica Multicapsid Nucleopolyhedrovirus. JOURNAL OF VIROLOGY[J]. 2010, 第 1 作者84(21): 11505-11514, http://www.corc.org.cn/handle/1471x/2375674.[121] Dong, Sicong, Wang, Manli, Qiu, Zhijuan, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Autographa californica Multicapsid Nucleopolyhedrovirus Efficiently Infects Sf9 Cells and Transduces Mammalian Cells via Direct Fusion with the Plasma Membrane at Low pH. JOURNALOFVIROLOGY[J]. 2010, 第 2 作者84(10): 5351-5359, http://www.corc.org.cn/handle/1471x/2375694.[122] Wang, Manli, Tuladhar, Era, Shen, Shu, Wang, Hualin, van Oers, Monique M, Vlak, Just M, Westenberg, Marcel. Specificity of Baculovirus P6.9 Basic DNA-Binding Proteins and Critical Role of the C Terminus in Virion Formation. JOURNAL OF VIROLOGY[J]. 2010, 第 1 作者84(17): 8821-8828, http://www.corc.org.cn/handle/1471x/2375721.[123] Wang, Manli, Tan, Ying, Yin, Feifei, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. The F-like protein Ac23 enhances the infectivity of the budded virus of gp64-null Autographa californica multinucleocapsid nucleopolyhedrovirus pseudotyped with baculovirus envelope fusion protein F. JOURNAL OF VIROLOGY[J]. 2008, 第 1 作者82(19): 9800-9804, http://www.corc.org.cn/handle/1471x/2375446.[124] Wang, Manli, Tan, Ying, Yin, Feifei, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. The F protein of Helicoverpa armigera single nucleopolyhedrovirus can be substituted functionally with its homologue from Spodoptera exigua multiple nucleopolyhedrovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2008, 第 1 作者89: 791-798, http://www.corc.org.cn/handle/1471x/2375513.[125] Yin, Feifei, Wang, Manli, Tan, Ying, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. A functional F analogue of Autographa californica nucleopolyhedrovirus GP64 from the Agrotis segetum granulovirus. JOURNAL OF VIROLOGY[J]. 2008, 第 2 作者82(17): 8922-8926, http://www.corc.org.cn/handle/1471x/2375452.[126] Tan, Ying, Jiang, Ling, Wang, Manli, Yin, Feifei, Deng, Fei, Liu, Maili, Hu, Zhihong, Wang, Hualin. Mutagenesis and nuclear magnetic resonance analyses of the fusion peptide of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus F protein. JOURNAL OF VIROLOGY[J]. 2008, 第 3 作者82(16): 8138-8148, http://dx.doi.org/10.1128/JVI.00368-08.[127] Han Xiao, Hengrui Hu, Yijia Guo, Jiang Li, Le Wen, WenBo Zeng, Manli Wang, MinHua Luo, Zhihong Hu. Construction and characterization of a synthesized herpes simplex virus H129-Syn-G2. VIROLOGICA SINICA. 第 7 作者http://dx.doi.org/10.1016/j.virs.2023.03.005.[128] Shu Shen, Yaxian Zhang, Zhiyun Yin, Qiong Zhu, Jingyuan Zhang, Tiantian Wang, Yaohui Fang, Xiaoli Wu, Yuan Bai, Shiyu Dai, Xijia Liu, Jiayin Jin, Shuang Tang, Jia Liu, Manli Wang, Yu Guo, Fei Deng. Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases. BMC MEDICINE. 第 15 作者20(1): http://dx.doi.org/10.1186/s12916-022-02558-z.
发表著作
《Insect Molecular Virology》Caister Academic Press;2019.01;参编第九章
科研活动
科研项目
( 1 ) 杆状病毒口服感染分子机制的研究, 参与, 国家级, 2012-01--2016-12( 2 ) 重要病毒转录复制蛋白复合体的结构功能研究, 主持, 国家级, 2013-01--2017-12( 3 ) 宿主细胞因子Integrin在杆状病毒入侵哺乳动物细胞中的功能及其作, 主持, 国家级, 2014-01--2017-12( 4 ) 中科院青年创新促进会, 主持, 国家级, 2013-01--2016-12( 5 ) 关键宿主因子Hsp90介导的昆虫细胞actin核内聚合在杆状病毒BV形成中的作用机制, 主持, 国家级, 2016-01--2019-12( 6 ) 杆状病毒感染昆虫中肠的作用机理研究, 参与, 部委级, 2016-08--2020-12( 7 ) P4实验室高端用户培育计划, 主持, 部委级, 2018-08--2019-12( 8 ) 2019-nCoV药物筛选与评价研究, 参与, 国家级, 2020-01--2020-12( 9 ) 定向项目, 参与, 国家级, 2019-01--2023-12
参与会议
(1)Functional Rescue of an F-null HearNPV by two Naturally Non-functional Envelope Proteins Disclose the Evolutionary Track of Baculoviridae 第29届美国病毒学会年会 Manli Wang, Feifei Yin, Ying Tan, Fei Deng, Just M Vlak2, Johannes A. Jehle, Zhihong Hu and Hualin Wang 2010-07-17(2)The F-like protein of group I NPVs enhances the production and infectivity of the budded virus of gp64-null AcMNPV pseudotyped with the envelope fusion protein F of group II NPVs 第41届国际无脊椎动物病理学年会 Manli Wang, Ying Tan, Feifei Yin, Fei Deng, Zhihong Hu, Just M Vlak and Hualin Wang 2008-08-03
指导学生
已指导学生
邹梓姣 硕士研究生 085238-生物工程
张楠 硕士研究生 071005-微生物学
李忆梦 博士研究生 071005-微生物学
袁传飞 博士研究生 100102-免疫学
王博 博士研究生 100103-病原生物学
邵伟 博士研究生 071005-微生物学
胡亮波 博士研究生 071005-微生物学
汪习 博士研究生 071005-微生物学
陈诚 硕士研究生 071005-微生物学
现指导学生
李玉凤 硕士研究生 085238-生物工程
马小燕 硕士研究生 071005-微生物学