基本信息
陈卓  女  博导  中国科学院福建物质结构研究所
电子邮件: zchen@fjirsm.ac.cn
通信地址: 福建省福州市杨桥西路155号
邮政编码: 350001

研究领域

分子药理学和治疗学领域,主要聚焦于

1)        肿瘤早期筛查及靶向治疗;

2)        光动力抗感染;

3)        心脑血管疾病相关药物靶标发现;

4)        代谢性疾病等重大疾病的药物研发。


招生信息


招生专业
071010-生物化学与分子生物学
招生方向
酞菁光敏剂的靶向性抗肿瘤光动力学效应及其介导的肿瘤诊疗一体化
光敏剂光动力抗菌作用研究
新型纳米荧光生物标记材料对肿瘤标志物的检测及靶向生物成像

工作经历

   
社会兼职
2018-12-01-2023-12-31,福建省药理学会, 理事
2017-05-01-2022-05-31,福建省生物化学与生物学会, 常务理事
2013-12-31-2021-12-30,《中国医药导报》, 编委

教授课程

Practical course in Molecular Cell Biology
药理学

专利与奖励

   
奖励信息
(1) 省引才“****”创新类, 省级, 2018
(2) 中科院海西院“****”, 研究所(学校), 2018
(3) 巾帼建功先进个人, 研究所(学校), 2017
(4) Danida Fellowship, 国家级, 2012
专利成果
[1] 周山勇, 马恩, 黄丽冰, 杨鸿艺, 叶斯哲, 张云, 陈卓, 陈学元. 一种宽波段时间分辨荧光免疫分析装置及分析方法. CN: CN113075175A, 2021-07-06.

[2] 陈卓, 郭晗晗, 宋晓荣, 陈学元, 周山勇. 一种基于稀土纳米材料荧光放大的循环肿瘤细胞检测试剂盒及其应用. CN: CN112034160A, 2020-12-04.

[3] 黄明东, 李世杰, 袁彩, 陈卓, 陈锦灿, 雪光浦, 郑科. 去除血清白蛋白及其融合蛋白中杂质的方法. CN: CN106046149B, 2019-12-24.

[4] 黄明东, 李睿, 陈卓, 胡萍, 陈锦灿, 周山勇, 袁彩, 陈松. 用于光学成像和光动力治疗的肿瘤靶向融合蛋白药物载体. CN: CN104800855B, 2019-10-29.

[5] 黄明东, 陈卓, 徐芃, 陈锦灿, 周山勇, 胡萍, 陈学元. 靶向表达尿激酶受体的肿瘤的光敏剂及其制备方法和用途. CN: CN104069492B, 2019-05-28.

[6] 黄明东, 陈锦灿, 陈卓, 胡萍. 一种可用于光动力抗菌的纤维素材料及其制备方法. 中国: CN106637992A, 2017-05-10.

[7] 黄明东, 陈卓, 郑科, 李睿, 袁彩. 一种白蛋白与蒽环霉素类抗癌药的分子复合物及其制备方法. 中国: CN106177972A, 2016.12.07.

[8] 陈学元, 周山勇, 郑伟, 马恩, 黄明东, 陈卓, 涂大涛. 一种稀土纳米材料溶解增强时间分辨荧光免疫分析方法. 中国: CN103969432A, 2014.08.06.

[9] 陈学元, 周山勇, 郑伟, 马恩, 黄明东, 陈卓, 涂大涛. 一种氟化钇锂纳米复合材料及其制备方法和在光动力学治疗中的应用. 中国: CN103980904A, 2014-08-13.

[10] 黄明东, 周山勇, 胡萍, 陈锦灿, 陈卓. 五聚赖氨酸酞菁锌在制备杀菌药物中的应用. 中国: CN102755647A, 2012-10-31.

[11] 黄明东, 周山勇, 陈卓, 陈锦灿, 胡萍. 肿瘤靶向光敏免疫偶联物的制备方法及其应用. 中国: CN102585003A, 2012-07-18.

[12] 黄明东, 徐芃, 陈卓, 陈锦灿, 周山勇, 胡萍, 陈学元. 一种具有肿瘤靶向性的光敏剂及其制备方法. 中国: CN102321159A, 2012-01-18.

出版信息

   
发表论文
[1] 刘若湄, 冯艳辉, 李卓, 卢珊, 关天用, 李幸俊, 刘䶮, 陈卓, 陈学元. A novel near-infrared responsive lanthanide upconversion nanoplatform for drug delivery based on photocleavage of cypate. Acta Chim. Sinica[J]. 2022, 80(4): 423-427, http://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A22010001.
[2] He, Chen, Zhang, Lei, Liu, Wenzhen, Huang, Yunmei, Hu, Ping, Dai, Tao, Xu, Jianhua, Chen, Zhuo. Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086. DYES AND PIGMENTS[J]. 2021, 189: http://dx.doi.org/10.1016/j.dyepig.2021.109258.
[3] Wang, Huanhuan, Pan, Xiaohong, Wang, Yaqi, Liu, Wenzhen, Dai, Tao, Yuan, Binbin, Chen, Xueyuan, Chen, Zhuo. A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy. SCIENCE CHINA-MATERIALS[J]. 2021, 64(10): 2601-2612, http://dx.doi.org/10.1007/s40843-021-1652-2.
[4] 戴涛, 叶发荣, 胡萍, 潘小宏, 陈锦灿, 黄云梅, 王欢欢, 张蕾, 黄明东, 刘见永, 苏建强, 陈学元, 陈卓. 一种基于大肠杆菌驱动药物递送系统增强光动力治疗的肿瘤靶向策略. 中国科学:材料科学(英文版)[J]. 2021, 64(1): 232-240, http://lib.cqvip.com/Qikan/Article/Detail?id=7103798294.
[5] 王乐, 张志强, 陈建松, 陈卓. 循环肿瘤细胞上皮-间质转化对肿瘤发生发展的影响及其临床应用潜力. 福建医科大学学报[J]. 2021, 55(02期): 157-161, [6] Dai, Tao, Ye, Farong, Hu, Ping, Pan, Xiaohong, Chen, Jincan, Huang, Yunmei, Wang, Huanhuan, Zhang, Lei, Huang, Mingdong, Liu, Jianyong, Su, Jianqiang, Chen, Xueyuan, Chen, Zhuo. A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system. SCIENCE CHINA-MATERIALS[J]. 2021, 64(1): 232-240, https://www.webofscience.com/wos/woscc/full-record/WOS:000547355300002.
[7] Lin, Yunfeng, Chen, Zhuo, Hu, Chaohua, Chen, ZheSheng, Zhang, Lei. Recent progress in antitumor functions of the intracellular antibodies. DRUG DISCOVERY TODAYnull. 2020, 25(6): 1109-1120, http://dx.doi.org/10.1016/j.drudis.2020.02.009.
[8] Li, Linlin, Chen, Dan, Zheng, Ke, Jiang, Libin, Dai, Tao, Yang, Ling, Jiang, Longguang, Chen, Zhuo, Yuan, Cai, Huang, Mingdong. Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(4): 4221-4230, http://dx.doi.org/10.1021/acsami.9b18396.
[9] Liu, Wenzhen, Zhang, Yuxiang, You, Wenwu, Su, Jianqiang, Yu, Shaohua, Dai, Tao, Huang, Yunmei, Chen, Xueyuan, Song, Xiaorong, Chen, Zhuo. Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistant Acinetobacter baumannii based on lanthanide nanoparticles. NANOSCALE[J]. 2020, 12(26): 13948-13957, https://www.webofscience.com/wos/woscc/full-record/WOS:000547632900045.
[10] Hu, Ping, Shang, Le, Chen, Jincan, Chen, Xuzheng, Chen, Chun, Hong, Wanjin, Huang, Mingdong, Xu, Peng, Chen, Zhuo. A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2020, 8(3): 504-514, https://www.webofscience.com/wos/woscc/full-record/WOS:000508846000013.
[11] Ke, Jianxi, Lu, Shan, Li, Zhuo, Shang, Xiaoying, Li, Xingjun, Li, Renfu, Tu, Datao, Chen, Zhuo, Chen, Xueyuan. Multiplexed intracellular detection based on dual-excitation/dual-emission upconversion nanoprobes. NANO RESEARCH[J]. 2020, 13(7): 1955-1961, http://lib.cqvip.com/Qikan/Article/Detail?id=7102716205.
[12] Wang, Dong, Yang, Yongshuai, Wang, Yu, Proulle, Valerie, Andreasen, Peter A, Hong, Wanjin, Chen, Zhuo, Huang, Mingdong, Xu, Peng. Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis. BIOMEDICINE & PHARMACOTHERAPY[J]. 2020, 130: http://dx.doi.org/10.1016/j.biopha.2020.110528.
[13] Wang, Dong, Liu, Wenzhen, Wang, Le, Wang, Yu, Liao, Christopher Kai, Chen, Jincan, Hu, Ping, Hong, Wanjin, Huang, Mingdong, Chen, Zhuo, Xu, Peng. Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating photodynamic therapy, photothermal therapy, and enzyme inhibition. ACTA BIOMATERIALIA[J]. 2020, 113: 541-553, http://dx.doi.org/10.1016/j.actbio.2020.06.021.
[14] Liu, Jihao, Chen, Zhuo, Huang, Mingdong, Tang, Shuzhi, Wang, Qianchao, Hu, Ping, Gupta, Pranav, Ashby, Charles R, Chen, ZheSheng, Zhang, Lei. Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells. EXPERIMENTAL CELL RESEARCH[J]. 2020, 391(1): http://dx.doi.org/10.1016/j.yexcr.2020.111987.
[15] Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, ZheSheng Chen. The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer. Molecular Cancer[J]. 2020, 19(1): 1-18, http://dx.doi.org/10.1186/s12943-019-1112-1.
[16] Zhang Lei, Chen Zhuo. Research Progress of Structure Based Antitumor Drug Design. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2020, 39(12): 2085-2090, http://lib.cqvip.com/Qikan/Article/Detail?id=7103737695.
[17] Sun, Jing, Zhang, Yuxiang, Su, Jianqiang, Dai, Tao, Chen, Jincan, Zhang, Lei, Wang, Huanhuan, Liu, Wenzhen, Huang, Mingdong, Chen, Zhuo. Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression. DYES AND PIGMENTS[J]. 2020, 179: http://dx.doi.org/10.1016/j.dyepig.2020.108392.
[18] Lian, Wei, Tu, Datao, Hu, Ping, Song, Xiaorong, Gong, Zhongliang, Chen, Tao, Song, Jibin, Chen, Zhuo, Chen, Xueyuan. Broadband excitable NIR-II luminescent nano-bioprobes based on CuInSe2 quantum dots for the detection of circulating tumor cells. NANO TODAY[J]. 2020, 35: http://dx.doi.org/10.1016/j.nantod.2020.100943.
[19] Li, Xiuxiu, Chen, Zhuo, Zhang, Guomin, Lu, Hongwei, Qin, Peng, Qi, Ming, Yu, Ying, Jiao, Bingke, Zhao, Xianfeng, Gao, Qiang, Wang, Hao, Wu, Yunyu, Ma, Juntao, Zhang, Liyan, Wang, Yongli, Deng, Lingwei, Yao, Shanguo, Cheng, Zhukuang, Yu, Diqiu, Zhu, Lihuang, Xue, Yongbiao, Chu, Chengcai, Li, Aihong, Li, Shigui, Liang, Chengzhi. Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 63(11): 1688-1702, http://lib.cqvip.com/Qikan/Article/Detail?id=7104062130.
[20] Tang, Shuzhi, Liu, Wenzhen, Pan, Xiaohong, Liu, Libin, Yang, Yongshuai, Wang, Dong, Xu, Peng, Huang, Mingdong, Chen, Zhuo. Specific inhibition of plasminogen activator inhibitor 1 reduces blood glucose level by lowering TNF-a. LIFE SCIENCES[J]. 2020, 246: http://dx.doi.org/10.1016/j.lfs.2020.117404.
[21] Zhang, Lei, Li, Yidong, Wang, Qianchao, Chen, Zhuo, Li, Xiaoyun, Wu, Zhuoxun, Hu, Chaohua, Liao, Dan, Zhang, Wei, Chen, ZheSheng. The PI3K subunits, P110 alpha and P110 beta are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer. MOLECULAR CANCER[J]. 2020, 19(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000513723900001.
[22] Shen, Chen, Du, Huilong, Chen, Zhuo, Lu, Hongwei, Zhu, Fugui, Chen, Hong, Meng, Xiangzhao, Liu, Qianwen, Liu, Peng, Zheng, Lihua, Li, Xiuxiu, Dong, Jiangli, Liang, Chengzhi, Wang, Tao. The Chromosome-Level Genome Sequence of the Autotetraploid Alfalfa and Resequencing of Core Germplasms Provide Genomic Resources for Alfalfa Research. MOLECULAR PLANT[J]. 2020, 13(9): 1250-1261, http://lib.cqvip.com/Qikan/Article/Detail?id=7103401570.
[23] Zhuo Chen. Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating multiple therapeutic mechanisms. Acta Biomaterialia. 2020, [24] Peng, Hua, Wang, Kai, Chen, Zhuo, Cao, Yinghao, Gao, Qiang, Li, Yan, Li, Xiuxiu, Lu, Hongwei, Du, Huilong, Lu, Min, Yang, Xin, Liang, Chengzhi. MBKbase for rice: an integrated omics knowledgebase for molecular breeding in rice. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(D1): D1085-D1092, https://www.webofscience.com/wos/woscc/full-record/WOS:000525956700139.
[25] Yan, Shufeng, Guo, Hanhan, Su, Jianqiang, Chen, Jincan, Song, Xiaorong, Huang, Mingdong, Zhang, Juncheng, Chen, Zhuo. Effects of hydroxyl radicals produced by a zinc phthalocyanine photosensitizer on tumor DNA. DYES AND PIGMENTS[J]. 2020, 173: http://dx.doi.org/10.1016/j.dyepig.2019.107894.
[26] Peng, Shuangzhou, Xue, Guangpu, Chen, Shanli, Chen, Zhuo, Yuan, Cai, Li, Jinyu, Huang, Mingdong. tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity. THROMBOSIS AND HAEMOSTASIS[J]. 2019, 119(1): 77-86, https://www.webofscience.com/wos/woscc/full-record/WOS:000454595900010.
[27] 委娇娇, 郑伟, 商晓颖, 李仁富, 黄萍, 刘, 宫仲亮, 周山勇, 陈卓, 陈学元. 基于Mn2+激活氟化钙纳米荧光探针的时间分辨荧光生物分析(英文). 中国科学:材料科学(英文版). 2019, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SCMA201901014&DbName=CJFDLAST2019&DbCode=CJFQ&yx=&pr=&URLID=&bsm=QKK0203;.
[28] Wang, Dong, Yang, Yongshuai, Jiang, Longguang, Wang, Yu, Li, Jinyu, Andreasen, Peter A, Chen, Zhuo, Huang, Mingdong, Xu, Peng. Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(4): 2172-2183, https://www.webofscience.com/wos/woscc/full-record/WOS:000460365600032.
[29] Yan, Shufeng, Huang, Qingqing, Song, Xiaorong, Chen, Zhuo, Huang, Mingdong, Zhang, Juncheng. A series of photosensitizers with incremental positive electric charges for photodynamic antitumor therapy. RSC ADVANCES[J]. 2019, 9(42): 24560-24567, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000480277000057.
[30] 杨永帅, 贾玉华, 蔡良知, 徐芃, 戴涛, 陈锦灿, 胡萍, 黄明东, 陈卓. 酞菁光敏剂抗小鼠宫颈癌的光动力学实验. 福州大学学报:自然科学版. 2019, 47(6): 859-864, http://lib.cqvip.com/Qikan/Article/Detail?id=7100523546.
[31] Wang, Yu, Wang, Sen, Nie, Xinyi, Yang, Kunlong, Xu, Peng, Wang, Xiuna, Liu, Mengxin, Yang, Yongshuai, Chen, Zhuo, Wang, Shihua. Molecular and structural basis of nucleoside diphosphate kinase-mediated regulation of spore and sclerotia development in the fungus Aspergillus flavus. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(33): 12415-12431, http://dx.doi.org/10.1074/jbc.RA119.007505.
[32] Yu Wang, Sen Wang, Xinyi Nie, Kunlong Yang, Peng Xu, Xiuna Wang, Mengxin Liu, Yongshuai Yang, Zhuo Chen, Shihua Wang. Molecular and structural basis of nucleoside diphosphate kinase–mediated regulation of spore and sclerotia development in the fungus Aspergillus flavus. Journal of Biological Chemistry. 2019, 294(33): 12415-12431, http://dx.doi.org/10.1074/jbc.RA119.007505.
[33] Chen, Jingyi, Yang, Ling, Chen, Jincan, Liu, Wenzhen, Zhang, Di, Xu, Peng, Dai, Tao, Shang, Le, Yang, Yongshuai, Tang, Shuzhi, Zhang, Yuxiang, Lin, Huajian, Chen, Zhuo, Huang, Mingdong. Composite of silver nanoparticles and photosensitizer leads to mutual enhancement of antimicrobial efficacy and promotes wound healing. CHEMICAL ENGINEERING JOURNAL[J]. 2019, 374: 1373-1381, http://dx.doi.org/10.1016/j.cej.2019.05.184.
[34] Guo, Hanhan, Song, Xiaorong, Lei, Wen, He, Cheng, You, Wenwu, Lin, Qingzhong, Zhou, Shanyong, Chen, Xueyuan, Chen, Zhuo. Direct Detection of Circulating Tumor Cells in Whole Blood Using Time-Resolved Luminescent Lanthanide Nanoprobes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(35): 12195-12199, [35] Ke, Jianxi, Lu, Shan, Shang, Xiaoying, Liu, Yan, Guo, Hanhan, You, Wenwu, Li, Xingjun, Xu, Jin, Li, Renfu, Chen, Zhuo, Chen, Xueyuan. A Strategy of NIR Dual‐Excitation Upconversion for Ratiometric Intracellular Detection. Advanced Science[J]. 2019, 6(22): n/a-n/a, https://doaj.org/article/5a21835e8fc44375bd0e6daa31466548.
[36] Gao, Yu, Li, Renfu, Zheng, Wei, Shang, Xiaoying, Wei, Jiaojiao, Zhang, Meiran, Xu, Jin, You, Wenwu, Chen, Zhuo, Chen, Xueyuan. Broadband NIR photostimulated luminescence nanoprobes based on CaS:Eu2+, Sm3+ nanocrystals. CHEMICAL SCIENCE[J]. 2019, 10(21): 5452-5460, https://www.webofscience.com/wos/woscc/full-record/WOS:000474412700025.
[37] Wei, Jiaojiao, Zheng, Wei, Shang, Xiaoying, Li, Renfu, Huang, Ping, Liu, Yan, Gong, Zhongliang, Zhou, Shanyong, Chen, Zhuo, Chen, Xueyuan. Mn2+-activated calcium fluoride nanoprobes for time-resolved photoluminescence biosensing. SCIENCE CHINA-MATERIALS[J]. 2019, 62(1): 130-137, https://www.webofscience.com/wos/woscc/full-record/WOS:000455325400014.
[38] Zhuo Chen. Direct detection of circulating tumor cells in whole blood based on time-resolved luminescent lanthanide nanoprobes. Angew. Chem. Int. Ed.. 2019, [39] Yan S, Huang Q, Chen J, Song X, Chen Z, Huang M, Xu P, Zhang J. Tumor-targeting photodynamic therapy based on folate-modified polydopamine nanoparticles. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2019, 14: 6799-6812, [40] Li, Shijie, Yuan, Cai, Chen, Jincan, Chen, Dan, Chen, Zhuo, Chen, Wenlie, Yan, Shufeng, Hu, Ping, Xue, Jinping, Li, Rui, Zheng, Ke, Huang, Mingdong. Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release. THERANOSTICS[J]. 2019, 9(3): 884-899, [41] 刘吉昊, 唐述志, 胡立宏, 黄明东, 陈卓. 靶向纤溶酶原激活物抑制剂1的肿瘤治疗研究进展. 生物化学与生物物理进展[J]. 2019, 46(7): 663-672, http://lib.cqvip.com/Qikan/Article/Detail?id=83728387504849574855484851.
[42] Liu JiHao, Tang ShuZhi, Hu LiHong, Huang MingDong, Chen Zhuo. Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICSnull. 2019, 46(7): 663-672, [43] Song, Xiaorong, Li, Shihua, Guo, Hanhan, You, Wenwu, Shang, Xiaoying, Li, Renfu, Tu, Datao, Zheng, Wei, Chen, Zhuo, Yang, Huanghao, Chen, Xueyuan. Graphene-Oxide-Modified Lanthanide Nanoprobes for Tumor-Targeted Visible/NIR-II Luminescence Imaging. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(52): 18981-18986, https://www.webofscience.com/wos/woscc/full-record/WOS:000495085500001.
[44] Li, Shijie, Li, Linlin, Chen, Zhuo, Xue, Guangpu, Jiang, Longguang, Zheng, Ke, Chen, Jincan, Li, Rui, Yuan, Cai, Huang, Mingdong. A novel purification procedure for recombinant human serum albumin expressed in Pichia pastoris. PROTEIN EXPRESSION AND PURIFICATION[J]. 2018, 149: 37-42, http://dx.doi.org/10.1016/j.pep.2018.04.012.
[45] Yan, Shufeng, Chen, Jincan, Cai, Liangzhi, Xu, Peng, Zhang, Yaxin, Li, Shijie, Hu, Ping, Chen, Xueyuan, Huang, Mingdong, Chen, Zhuo. Phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(38): 6080-6088, http://dx.doi.org/10.1039/c8tb01884g.
[46] Zhang, Yuxiang, Huang, Ping, Wang, Dong, Chen, Jincan, Liu, Wenzhen, Hu, Ping, Huang, Mingdong, Chen, Xueyuan, Chen, Zhuo. Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles. NANOSCALE[J]. 2018, 10(33): 15485-15495, http://dx.doi.org/10.1039/c8nr01967c.
[47] 黄明东, 刘大锋, 袁彩, 陈静怡, 陈卓. 两亲性光敏剂五聚赖氨酸酞菁锌的抗菌机理. 福建农林大学学报:自然科学版[J]. 2018, 47(5): 626-632, http://lib.cqvip.com/Qikan/Article/Detail?id=7000845470.
[48] Zhuo Chen. House-hold light source for potent photodynamic antimicrobial effect and wound healing in infective animal model. Biomedical Optics Express. 2018, [49] Zhuo Chen. A Smart Photosensitizer: Tumor-triggered Oncotherapy by Self-Assembly Photodynamic Nanodots. ACS Applied Materials & Interfaces. 2018, [50] Yan, Shufeng, Song, Xiaorong, Liu, Yan, Dai, Tao, Huang, Mingdong, Chen, Xueyuan, Chen, Zhuo. An efficient synergistic cancer therapy by integrating cell cycle inhibitor and photosensitizer into polydopamine nanoparticles. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(17): 2620-2629, https://www.webofscience.com/wos/woscc/full-record/WOS:000431421800014.
[51] Ullah, Azeem, Zhang, Yuxiang, Iqbal, Zafar, Zhang, Yaxin, Wang, Dong, Chen, Jincan, Hu, Ping, Chen, Zhuo, Huang, Mingdong. Household light source for potent photodynamic antimicrobial effect and wound healing in an infective animal model. BIOMEDICAL OPTICS EXPRESS[J]. 2018, 9(3): 1006-1019, http://dx.doi.org/10.1364/BOE.9.001006.
[52] Liu, Dafeng, Li, Linsen, Chen, Jincan, Chen, Zhuo, Jiang, Longguang, Yuan, Cai, Huang, Mingdong. Dissociation of zinc phthalocyanine aggregation on bacterial surface is key for photodynamic antimicrobial effect. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2018, 22(9-10): 925-934, http://dx.doi.org/10.1142/S1088424618500888.
[53] 邓静泽, 黄明东, 陈卓, 张明鑫, 陈锦灿, 李林森. 水溶性寡聚赖氨酸锌酞菁的合成及其光动力学活性. 沈阳药科大学学报[J]. 2018, 35(11): 936-942, http://lib.cqvip.com/Qikan/Article/Detail?id=676840226.
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[55] Zhuo Chen. A long-acting PAI-1 inhibitor reduce thrombus formation. Thrombosis and Haemostasis. 2017, [56] Chen, Jincan, Wang, Weijie, Hu, Ping, Wang, Dong, Lin, Fan, Xue, Jingping, Chen, Zhuo, Iqbal, Zafar, Huang, Mingdong. Dual antimicrobial actions on modified fabric leads to inactivation of drug-resistant bacteria. DYES AND PIGMENTS[J]. 2017, 140: 236-243, http://dx.doi.org/10.1016/j.dyepig.2017.01.032.
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[58] Zhang, Zaizhong, He, Yang, Tu, Xiaohuang, Huang, Sheng, Chen, Zhuo, Wang, Lie, Song, Jingxiang. Mapping of DNA Hypermethylation and Hypomethylation induced by Folate Deficiency in Sporadic Colorectal Cancer and Clinical Implication Analysis of Hypermethylation Pattern in CBS Promoter. CLINICAL LABORATORY[J]. 2017, 63(4): 733-748, https://www.webofscience.com/wos/woscc/full-record/WOS:000398985100011.
[59] Zhuo Chen. Dual antimicrobial mechanisms of a material leads to an inactivation of drug-resistant bacteria. Dyes and Pigments. 2017, [60] 李世杰, 袁彩, 郑科, 陈锦灿, 雪光浦, 陈卓, 黄明东. 一种新颖的除去重组人血清白蛋白杂质的方法. 福建师范大学学报(自然科学版)[J]. 2017, 65-72, [61] Wang, Dong, Zhang, Yuxiang, Yan, Shufeng, Chen, Zihan, Deng, Yicai, Xu, Peng, Chen, Jincan, Liu, Wenzhen, Hu, Ping, Huang, Mingdong, Chen, Zhuo. An effective zinc phthalocyanine derivative against multidrug-resistant bacterial infection. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2017, 21(3): 205-210, http://dx.doi.org/10.1142/S1088424617500298.
[62] Zhuo Chen. Effects of a combination therapy with a compound Chinese medicine and an enteral nutrition powder in the treatment of mice with chronic obstructive pulmonary diseases. China Medical Herald. 2017, [63] Peng, Shuangzhou, Xue, Guangpu, Gong, Lihu, Fang, Chao, Chen, Jingfei, Yuan, Cai, Chen, Zhuo, Yao, Lishan, Furie, Bruce, Huang, Mingdong. A long-acting PAI-1 inhibitor reduces thrombus formation. THROMBOSIS AND HAEMOSTASIS[J]. 2017, 117(7): 1338-1347, https://www.webofscience.com/wos/woscc/full-record/WOS:000404671700014.
[64] Zhuo Chen. A novel method of removing impurities from recombinant human serum albumin. Journal of Fujian Normal University. 2017, [65] Xu, Peng, Jia, Yuhua, Yang, Yongshuai, Chen, Jincan, Hu, Ping, Chen, Zhuo, Huang, Mingdong. Photodynamic Oncotherapy Mediated by Gonadotropin-Releasing Hormone Receptors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 60(20): 8667-8672, https://www.webofscience.com/wos/woscc/full-record/WOS:000414114300029.
[66] Wang, Huiqi, Tu, Datao, Xu, Jin, Shang, Xiaoying, Hu, Ping, Li, Renfu, Zheng, Wei, Chen, Zhuo, Chen, Xueyuan. Lanthanide-doped LaOBr nanocrystals: controlled synthesis, optical spectroscopy and bioimaging. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2017, 5(25): 4827-4834, https://www.webofscience.com/wos/woscc/full-record/WOS:000404613200002.
[67] 邓宜材, 黄明朝, 陈丽, 叶永佺, 游锦惠, 苏标堃, 陈卓, 董芳. 血管紧张素转换酶Ⅱ在肺栓塞大鼠肺动脉中的表达及其对肺动脉血管的影响. 中国医药导报. 2017, 14(32): 4-7, http://lib.cqvip.com/Qikan/Article/Detail?id=673812262.
[68] 陈卓, 顾飞腾, 朱建林, 陈月媛, 张再重, 涂小煌. 术前外周血中性粒细胞和淋巴细胞比值与结直肠癌术后病理的相关性分析. 临床医药文献杂志(电子版). 2017, 4(82): 16193-16195, http://lib.cqvip.com/Qikan/Article/Detail?id=7000661759.
[69] Zhuo Chen. Secretion and effects of angiotensin-converting enzyme 2 on pulmonary vascular remodeling in pulmonary embolism rats. China Medical Herald. 2017, [70] Zhou, Zhihao, Zheng, Wei, Kong, Jintao, Liu, Yan, Huang, Ping, Zhou, Shanyong, Chen, Zhuo, Shi, Jianlin, Chen, Xueyuan. Rechargeable and LED-activated ZnGa2O4 : Cr3+ near-infrared persistent luminescence nanoprobes for background-free biodetection. NANOSCALE[J]. 2017, 9(20): 6846-6853, http://ir.sic.ac.cn/handle/331005/25404.
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[72] Rui Li, Ke Zheng, Cai Yuan, Zhuo Chen, Mingdong Huang. Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials. Nanotheranostics. 2017, 1(4): 346-357, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646738/.
[73] Zhuo Chen. Application of polymerase chain reaction technology in food microbe examination. Journal of Fujian Medical University. 2016, [74] Bag, Partha Pratim, Wang, Dong, Chen, Zhuo, Cao, Rong. Outstanding drug loading capacity by water stable microporous MOF: a potential drug carrier. CHEMICAL COMMUNICATIONS[J]. 2016, 52(18): 3669-3672, [75] Zhuo Chen. Outstanding drug loading capacity by water stable microporous 2D MOF: A potential drug carrier. Chemical Communications. 2016, [76] Liu, Yongsheng, Zhou, Shanyong, Zhuo, Zhu, Li, Renfu, Chen, Zhuo, Hong, Maochun, Chen, Xueyuan. In vitro upconverting/downshifting luminescent detection of tumor markers based on Eu3+-activated core-shell-shell lanthanide nanoprobes. CHEMICAL SCIENCE[J]. 2016, 7(8): 5013-5019, https://www.webofscience.com/wos/woscc/full-record/WOS:000380893900028.
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[113] Botkjaer, Kenneth A, Fogh, Sarah, Bekes, Erin C, Chen, Zhuo, Blouse, Grant E, Jensen, Janni M, Mortensen, Kim K, Huang, Mingdong, Deryugina, Elena, Quigley, James P, Declerck, Paul J, Andreasen, Peter A. Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies. BIOCHEMICAL JOURNAL[J]. 2011, 438: 39-51, http://dx.doi.org/10.1042/BJ20110129.
[114] 陈卓. 肿瘤靶向性酞菁光敏剂的研究. 2011, [115] Chen, Jincan, Chen, Zhuo, Zheng, Yuqian, Zhou, Shanyong, Wang, Jundong, Chen, Naisheng, Huang, Jinling, Yan, Fuhua, Huang, Mingdong. Substituted zinc phthalocyanine as an antimicrobial photosensitizer for periodontitis treatment. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2011, 15(4): 293-299, http://dx.doi.org/10.1142/S1088424611003276.
[116] Zhuo Chen. Zinc Pentalysine β-carbonyl-phthalocyanine: An Effective Tumor-targeting Photosensitizer for Photodynamic Therapy. ChemMedChem. 2010, [117] Chen, Zhuo, Zhou, Shanyong, Chen, Jincan, Deng, Yicai, Luo, Zhipu, Chen, Hongwei, Hamblin, Michael R, Huang, Mingdong. Pentalysine beta-Carbonylphthalocyanine Zinc: An Effective Tumor-Targeting Photosensitizer for Photodynamic Therapy. CHEMMEDCHEM[J]. 2010, 5(6): 890-898, http://dx.doi.org/10.1002/cmdc.201000042.
[118] Zhu, Lili, Yuan, Cai, Chen, Zhuo, Wang, Wanyu, Huang, Mingdong. Expression, purification and characterization of recombinant Jerdonitin, a P-II class snake venom metalloproteinase comprising metalloproteinase and disintegrin domains. TOXICON[J]. 2010, 55(2-3): 375-380, http://dx.doi.org/10.1016/j.toxicon.2009.08.016.
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发表著作
(1) Tumor specific imaging and photodynamic therapy targeting on urokinase receptor, CRC Press, Taylor & Francis Group, 2017-12, 第 3 作者

科研活动

   
科研项目
( 1 ) 酞菁锌偶合物抗菌作用研究, 主持, 国家级, 2012-01--2015-12
( 2 ) 核受体/间质蛋白酶在闽台高发恶性肿瘤发病和防治中的作用与机制研究, 主持, 国家级, 2015-01--2018-12
( 3 ) 稀土荧光慢性病诊断(子课题:肿瘤标志物体外诊断试剂盒研制), 主持, 部委级, 2013-01--2017-12
( 4 ) 上转换纳米靶向光敏剂及其在肿瘤诊疗一体化中的应用, 主持, 国家级, 2016-01--2019-12
( 5 ) 系列酞菁光敏剂抗肿瘤活性研究, 主持, 国家级, 2010-01--2012-12
( 6 ) 化学新药“光汰净”的抗菌活性实验研究, 主持, 省级, 2013-01--2015-12
( 7 ) 基于纳米稀土荧光标记材料的FRET生物检测, 主持, 国家级, 2009-06--2012-05
( 8 ) 基于结构的抗肿瘤药物设计及其药学研究, 主持, 省级, 2009-03--2011-12
( 9 ) 稀土上转换纳米材料介导的光动力学抗深部组织耐药菌感染研究, 主持, 国家级, 2020-01--2023-12
( 10 ) 福建省引进高层次创业创新人才-陈卓, 主持, 省级, 2018-08--2021-07
( 11 ) 基于高效光敏剂的耐药菌及耐药基因的环境污染控制, 主持, 市地级, 2018-12--2020-11
( 12 ) 稀土清洁高效分离和均衡高质利用——肿瘤检测与诊断试剂盒, 主持, 市地级, 2017-01--2020-12
( 13 ) 茉莉花提取物在安神助眠功效方面的研究, 参与, 院级, 2020-11--2022-12
( 14 ) PAI-1抑制剂在调节糖脂代谢中的作用及其机制, 主持, 省级, 2020-09--2023-08
( 15 ) 循环肿瘤细胞的异质性在转移性乳腺癌中的作用, 主持, 研究所(学校), 2020-01--2021-12

成果转移转化