1、脑机接口检测调控芯片微系统

2、脑机接口智能算法

3、离体神经芯片与神经计算

   

0809Z1-生物电子学

脑机接口微电极阵列和芯片微系统

2005-09--2010-06   中国科学院电子学研究所   博士
2000-09--2004-06   北方工业大学   学士

研究生

博士

   

2022-11~现在, 中国科学院空天信息创新研究院, 特聘研究骨干
2016-07~现在, 中国科学院空天信息创新研究院, 副研究员
2010-07~2016-07,中国科学院电子学研究所, 助理研究员

2024-05-20-今,中国人工智能学会会员,
2023-02-15-今,中国神经科学学会脑机接口分会会员,
2018-03-31-今,中国电子学会生物医学电子学分会会员,
2016-11-30-今,中国研究型医院学会移动医疗专业委员会青年委员会委员,

   

（1） 优秀职工, 研究所（学校）, 2021
（2） The 19th IEEE International Conference on Nanotechnology 唯一最佳会议论文奖, 其他, 2019
（3） 中国生物医学工程联合学术年会生物电子与传感器分论坛最佳论文奖, 其他, 2018

（ 1 ） 三维精准电刺激诱导休眠的神经信息检测双面微电极阵列, 发明专利, 2023, 第 3 作者, 专利号: 202310508489.2

（ 2 ） 一种用于临床脑功能定位的多位点钨丝微电极, 发明专利, 2023, 第 3 作者, 专利号: 202310394130.7

（ 3 ） 用于非人灵长类动物脑深部核团双模功能定位和精准电刺激的神经微探针, 发明专利, 2023, 第 3 作者, 专利号: 202310326745.6

（ 4 ） 一种双脑区神经元长期检测微电极阵列及多向驱动系统, 发明专利, 2022, 第 3 作者, 专利号: 201111455961.2

（ 5 ） 头戴式多脑区神经检测调控微系统及微纳电极阵列模块, 发明专利, 2021, 第 3 作者, 专利号: 202111601891.2

（ 6 ） 穴位电针装置及系统, 发明专利, 2021, 第 3 作者, 专利号: CN113648219A

（ 7 ） 多模式神经刺激调控与同步检测系统, 发明专利, 2021, 第 5 作者, 专利号: CN112842366A

（ 8 ） 单细胞水平脑功能定位的微纳电极阵列芯片及其制备方法, 发明专利, 2021, 第 8 作者, 专利号: CN112716497A

（ 9 ） 颅内皮层神经信息检测电极、电极阵列及其制备方法, 2021, 第 6 作者, 专利号: CN107485386B

（ 10 ） 神经调控检测集成系统及方法, 2020, 第 4 作者, 专利号: CN107468235B

（ 11 ） 电化学检测系统, 2020, 第 4 作者, 专利号: CN106419851B

（ 12 ） 一种微纳阵列传感器及其制备方法, 2015, 第 8 作者, 专利号: CN103630571B

（ 13 ） 微电极阵列植入式芯片及其制备方法, 2016, 第 8 作者, 专利号: CN103829938B

（ 14 ） 神经信号检测器, 2015, 第 3 作者, 专利号: CN103505197B

（ 15 ） 一种神经信息检测系统, 2015, 第 4 作者, 专利号: CN103417205B

（ 16 ） 超痕量疾病标志物快速检测仪, 2012, 第 1 作者, 专利号: CN101995481B

（ 17 ） 可佩戴式无创血糖快速检测仪, 发明专利, 2010, 第 1 作者, 专利号: CN101461712B

（ 18 ） 一种临床用检测调控一体化多位点钨基微电极阵列及制备方法, 发明专利, 2024, 第 3 作者, 专利号: 202410396894.4

（ 19 ） 基于微电极阵列的生物智能辅助迷宫路径规划装置和方法, 发明专利, 2023, 第 4 作者, 专利号: 202311476000.4

（ 20 ） 一种微流控生物互联神经网络芯片及其制备方法, 发明专利, 2024, 第 4 作者, 专利号: 202410566580.4

   

（1） Deep brain implantable microelectrode arrays for functional localization and detection of the subthalamic nucleus in rats with Parkinson’s Disease, Bio-design and manufacturing, 2024, 第 12 作者  通讯作者
（2） High-performance bidirectional microelectrode array for assessing sevoflurane anesthesia effects and in situ electrical stimulation in deep brain regions, ACS Sensors, 2024, 第 11 作者  通讯作者
（3） Real-time precise targeting of the subthalamic nucleus via transfer learning in a rat model of Parkinson’s Disease based on microelectrode arrays, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2024, 第 9 作者  通讯作者
（4） High-throughput microelectrode arrays for precise functional localization of the globus pallidus internus, Cyborg and Bionic Systems, 2024, 第 9 作者  通讯作者
（5） Wireless closed-loop deep brain stimulation using microelectrode array probes, Journal of Zhejiang University-SCIENCE B, 2024, 第 8 作者  通讯作者
（6） Using human-induced pluripotent stem cell derived neurons on microelectrode arrays to model neurological disease: a review, Advanced Science, 2023, 第 9 作者
（7） Impaired spatial firing encoding of neurons in medial entorhinal cortex of the epileptic rat using microelectrode arrays, Research, 2023, 第 11 作者  通讯作者
（8） Integrated three-electrode dual-mode detection chip for place cell analysis: dopamine facilitates the role of place cells in encoding spatial locations of novel environments and rewards, ACS Sensors, 2023, 第 13 作者  通讯作者
（9） PtNPs/Short MWCNT-PEDOT: PSS-Modified Microelectrode Array to Detect Neuronal Firing Patterns in the Dorsal Raphe Nucleus and Hippocampus of Insomnia Rats, Micromachines, 2022, 第 2 作者
（10） Sensitive detection of electrophysiology and dopamine vesicular exocytosis of hESC-derived dopaminergic neurons using multifunctional microelectrode array, Biosensors and Bioelectronics, 2022, 第 7 作者
（11） Single-neuron detection of place cells remapping in short-term memory using motion microelectrode arrays, Biosensors and Bioelectronics, 2022, 第 8 作者
（12） PtNPs/PEDOT:PSS-Modified Microelectrode Arrays Reveal Electrophysiological Activities of Different Neurons in Medial Amygdala of Mice Under Innate Fear, Frontiers in Neuroscience, 2022, 第 12 作者
（13） Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex, Microsystems & Nanoengineering, 2022, 第 11 作者
（14） Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for medial entorhinal cortex, Microsystems & Nanoengineering, 2022, 第 13 作者  通讯作者
（15） PDMS-Parylene Hybrid, Flexible Micro-ECoG Electrode Array for Spatiotemporal Mapping of Epileptic Electrophysiological Activity from Multicortical Brain Regions, ACS APPLIED BIO MATERIALS, 2021, 第 0 作者
（16） SWCNTs/PEDOT:PSS-Modified Microelectrode Arrays for Dual-Mode Detection of Electrophysiological Signals and Dopamine Concentration in the Striatum under Isoflurane Anesthesia, ACS SENSORS, 2021, 第 10 作者
（17） Research on the Specificity of Electrophysiological Signals of Human Acupoints Based on the 90-Day Simulated Weightlessness Experiment on the Ground, IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, 2021, 第 3 作者
（18） Synchronous beta oscillation of epileptiform activities detected by microelectrode arrays in the awake and anesthetized mice, SENSORS AND ACTUATORS A-PHYSICAL, 2021, 第 9 作者
（19） Cellular-Scale Microelectrode Arrays to Monitor Movement-Related Neuron Activities in the Epileptic Hippocampus of Awake Mice, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2021, 第 7 作者
（20） Multi-level neural stimulation and dual-mode neural signal detection system based on implantable microelectrode array (MEA), 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, 第 1 作者
（21） Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson's Disease, BIOSENSORS-BASEL, 2020, 第 6 作者
（22） 神经电调控-双模信号检测系统与活体大鼠脑深部核团实验验证, Neural Electrostimulation-Detection System and Experimental Validation of Deep Brain Nuclei in Vivo, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2019, 第 7 作者
（23） Microelectrode Arrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firings under Deep Brain Stimulation in Rat Models of Parkinson's Disease, ACS SENSORS, 2019, 第 9 作者
（24） High Frequency Stimulation of Subthalamic Nucleus Synchronously Modulates Primary Motor Cortex and Caudate Putamen Based on Dopamine Concentration and Electrophysiology Activities Using Microelectrode Arrays in Parkinson’s Disease Rats, SENSORS AND ACTUATORS B-CHEMICAL, 2019, 第 6 作者
（25） Functional localization in the brain of a cynomolgus monkey based on spike pattern recognition with machine learning, JOURNAL OF AMBIENT INTELLIGENCE AND HUMANIZED COMPUTING, 2019, 第 1 作者
（26） Fei Gao, Guihua Xiao, Yilin Song, Mixia Wang, Ziyue Li, Yu Zhang, ShengweiXu, JingyuXie, Xinxia Cai. Recording of neural activity under modulation of caged compounds photolysis in seizures rat using microelectrode arrays, IEEE Transactions on Biomedical Engineering.2019 66(11):3080-3087, IEEE Transactions on Biomedical Engineering, 2019, 
（27） An integrated system for synchronous detection of neuron spikes and dopamine activities in the striatum of Parkinson monkey brain, JOURNAL OF NEUROSCIENCE METHODS, 2018, 第 5 作者
（28） Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson's disease using nano-based microelectrode arrays, MICROSYSTEMS & NANOENGINEERING, 2018, 第 3 作者
（29） Bio-electrochemical microelectrode arrays for glutamate and electrophysiology detection in hippocampus of temporal lobe epileptic rats, ANALYTICAL BIOCHEMISTRY, 2018, 第 6 作者
（30） A microelectrode array electrodeposited with reduced graphene oxide and Pt nanoparticles for norepinephrine and electrophysiological recordings, JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2017, 第 6 作者
（31） Research on Neural Information Detecting System Measuring Neuroelectricity in Hippocampus in Vivo and Dopamine in Vitro Based on Microelectrode Array, 2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2016, 第 1 作者
（32） Simultaneous recording of brain extracellular glucose, spike and local field potential in real time using an implantable microelectrode array with nano-materials, NANOTECHNOLOGY, 2016, 第 7 作者
（33） 基于双模检测仪器的大鼠神经放电和神经化学信号同步检测研究, Synchronous Detection of Rat Neural Spike Firing and Neurochemical Signals Based on Dual-mode Recording Instrument, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2016, 第 5 作者
（34） A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain, BIOSENSORS & BIOELECTRONICS, 2016, 第 3 作者
（35） 用于在体神经递质检测的可佩戴式无线电化学检测仪, A Wearable Wireless Electrochemical Instrument Used for In-vivo Neurotransmitter Detection, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2015, 第 3 作者
（36） Planar Microelectrode Chip for Synchronous Simulative Neurochemical and Neuroelectrial Monitoring, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2013, 第 5 作者

（1） Compendium of In-Vivo Monitoring in Real-time Molecular Neuroscience, World Scientific Publishing Co. Inc., 2019-11, 第 5 作者
（2） 智能传感器导论, 中国科学技术出版社, 2022-11, 第 其他 作者

   

（ 1 ） 微电极阵列及其记录系统研究, 负责人, 国家任务, 2022-11--2025-10
（ 2 ） 微纳传感器智能精准功能定位帕金森靶点的关键技术与装置, 负责人, 国家任务, 2020-01--2023-12
（ 3 ） 基于微纳电极与嵌入式系统的脑-机交互接口技术研究, 负责人, 国家任务, 2022-08--2025-12
（ 4 ） 睡眠-觉醒脑神经电活动高分辨感测与电刺激方法研究, 参与, 国家任务, 2023-01--2027-12
（ 5 ） 神经再生功能信息原位探测纳米生物传感技术, 参与, 国家任务, 2020-01--2024-12
（ 6 ） 神经芯片, 负责人, 国家任务, 2023-07--2025-10
（ 7 ） 脑机接口新器件与系统前沿交叉研判项目, 参与, 国家任务, 2023-01--2023-12

（1）基于微电极阵列的脑重大疾病细胞水平神经信息检测与调控   第六届细胞生物信息学研讨会   2023-11-28
（2）细胞水平智能脑功能定位系统研究   第五届细胞生物信息学研讨会   2023-02-23
（3）Multi-level neural stimulation and dual-mode neural signal detection system based on implantable microelectrode array (MEA)    2020-07-20
（4）Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non-human Primate of Parkinson’s Disease using Implantable Microelectrode Arrays   2018-07-17
（5）Research on neural information detecting system measuring neuroelectricity in hippocampus in vivo and dopamine in vitro based on microelectrode array   2016-08-17