研究主要涉及污染物的环境暴露和人群健康效应，目前利用多模型（体外细胞模型、动物暴露实验以及人群流行病学数据），结合分析化学和分子生物学技术手段，研究污染物的生物代谢过程以及健康效应。整合外源污染物的暴露剂量、形态以及生物体的内源（表观）遗传背景，探索污染物暴露和遗传信息对有健康效应的环境与基因的交互作用，甄别环境污染物的毒性形态以及明确易感人群的基因形态，从而为降低人群的暴露风险提供科学指导方案

   

083001-环境科学

环境污染物监测和人群健康风险评估，环境暴露易感人群（表观）遗传特征甄别

2016-09--2019-06   中国科学院大学   博士
2007-09--2010-06   上海海洋大学   硕士
2003-09--2007-07   海南大学（原华南热带农业大学）   学士

博士研究生

博士

   

2020-01~现在, 中国科学院城市环境研究所, 副研究员
2018-12~2020-01,University of Central Lancashire, 访问学者
2013-01~2019-12,中国科学院城市环境研究所, 助理研究员
2010-07~2012-12,中国科学院城市环境研究所, 研究实习员

   

（ 1 ） ALDH2基因多态性检测试剂盒及检测方法, 发明专利, 2021, 第 1 作者, 专利号: CN113174438A

   

[1] Tian, Meiping, Morais, Camilo L M, Shen, Heqing, Pang, Weiyi, Li Xu, Huang, Qingyu, Martin, Francis L. Direct identification and visualisation of real-world contaminating microplastics using Raman spectral mapping with multivariate curve resolution-alternating least squares. JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 第 1 作者422: http://dx.doi.org/10.1016/j.jhazmat.2021.126892.
[2] Tian, Meiping, Wu, Shuangshan, Wang, YiXin, Liu, Liangpo, Zhang, Jie, Shen, Heqing, Lu, Yanyang, Bao, Huaqiong, Huang, Qingyu. Associations of environmental phthalate exposure with male steroid hormone synthesis and metabolism: An integrated epidemiology and toxicology study. JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 第 1 作者  通讯作者  436: http://dx.doi.org/10.1016/j.jhazmat.2022.129213.
[3] Tian, Meiping, Wang, YiXin, Wang, Xiaofei, Wang, Heng, Liu, Liangpo, Zhang, Jie, Nan, Bingru, Shen, Heqing, Huang, Qingyu. Environmental doses of arsenic exposure are associated with increased reproductive-age male urinary hormone excretion and in vitro Leydig cell steroidogenesis. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 第 1 作者  通讯作者  408: http://dx.doi.org/10.1016/j.jhazmat.2020.124904.
[4] Zhang, Xi, Zhang, Jie, Wu, Yan, Nan, Bingru, Huang, Qingyu, Du, Xiaoyan, Tian, Meiping, Liu, Liangpo, Xin, Yuntian, Li, Yanbo, Duan, Junchao, Chen, Rui, Sun, Zhiwei, Shen, Heqing. Dynamic recovery after acute single fine particulate matter exposure in male mice: Effect on lipid deregulation and cardiovascular alterations. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 第 7 作者414: http://dx.doi.org/10.1016/j.jhazmat.2021.125504.
[5] Tian, Meiping, Zhao, Benhua, Martin, Francis L, Morais, Camilo L M, Liu, Liangpo, Huang, Qingyu, Zhang, Jie, Shen, Heqing. Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure. ENVIRONMENT INTERNATIONAL[J]. 2020, 第 1 作者  通讯作者  134: https://doaj.org/article/28d3374825454c9f82d1b870a75b3fb6.
[6] Tian, Meiping, Liu, Liangpo, Zhang, Jie, Huang, Qingyu, Shen, Heqing. Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: A pilot study. CHEMOSPHERE[J]. 2019, 第 1 作者220: 459-467, http://dx.doi.org/10.1016/j.chemosphere.2018.12.155.
[7] Tian, Meiping, Zhang, Xi, Liu, Liangpo, Martin, Francis L, Wang, Heng, Zhang, Jie, Huang, Qingyu, Wang, Xiaofei, Shen, Heqing. Phthalate side-chain structures and hydrolysis metabolism associated with steroidogenic effects in MLTC-1 Leydig cells. TOXICOLOGY LETTERS[J]. 2019, 第 1 作者  通讯作者  308: 56-64, http://dx.doi.org/10.1016/j.toxlet.2019.03.013.
[8] Meiping Tian. Phthalate side chain structures and hydrolysis metabolism associated with their steroidogenesis effects in MLTC-1 Leydig cells. Toxicology letters. 2019, 第 1 作者
[9] Tian, Meiping, Huang, Qingyu, Wang, Heng, Martin, Francis L, Liu, Liangpo, Zhang, Jie, Shen, Heqing. Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumour cells. REPRODUCTIVE TOXICOLOGY[J]. 2019, 第 1 作者83: 54-62, http://dx.doi.org/10.1016/j.reprotox.2018.11.006.
[10] Tian, Meiping, Liu, Liangpo, Wang, Heng, Wang, Xiaofei, Martin, Francis L, Zhang, Jie, Huang, Qingyu, Shen, Heqing. Phthalates Induce Androgenic Effects at Exposure Levels That Can Be Environmentally Relevant in Humans. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS[J]. 2018, 第 1 作者5(5): 232-236, https://www.webofscience.com/wos/woscc/full-record/WOS:000431927300002.
[11] Du, Xiaoyan, Tian, Meiping, Wang, Xiaoxue, Zhang, Jie, Huang, Qingyu, Liu, Liangpo, Shen, Heqing. Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water. ENVIRONMENTAL POLLUTION[J]. 2018, 第 2 作者234: 590-600, http://dx.doi.org/10.1016/j.envpol.2017.11.083.
[12] Wu, Yan, Zhang, Jie, Peng, Siyuan, Wang, Xiaofei, Luo, Lianzhong, Liu, Liangpo, Huang, Qingyu, Tian, Meiping, Zhang, Xueqin, Shen, Heqing. Multiple elements related to metabolic markers in the context of gestational diabetes mellitus in meconium. ENVIRONMENT INTERNATIONAL[J]. 2018, 第 8 作者121: 1227-1234, http://dx.doi.org/10.1016/j.envint.2018.10.044.
[13] Gorrochategui, Eva, Li, Junyi, Fullwood, Nigel J, Ying, GuangGuo, Tian, Meiping, Cui, Li, Shen, Heqing, Lacorte, Silvia, Tauler, Roma, Martin, Francis L. Diet-sourced carbon-based nanoparticles induce lipid alterations in tissues of zebrafish (Danio rerio) with genomic hypermethylation changes in brain. MUTAGENESIS[J]. 2017, 第 5 作者32(1): 91-103, https://www.webofscience.com/wos/woscc/full-record/WOS:000397070600009.
[14] Tian, Meiping, Zhao, Benhua, Zhang, Jie, Martin, Francis L, Huang, Qingyu, Liu, Liangpo, Shen, Heqing. Association of environmental benzoapyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case-control study. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2016, 第 1 作者541: 1243-1252, http://dx.doi.org/10.1016/j.scitotenv.2015.10.003.
[15] 张洁, 木晓丽, 王晓雪, 黄清育, 田美平, 刘良坡, 申河清. 砷对DNA甲基化影响的研究进展. 环境与健康杂志[J]. 2014, 第 5 作者31(3): 269-276, https://d.wanfangdata.com.cn/periodical/hjyjkzz201403032.
[16] 彭思远, 张洁, 田美平, 王展林, 申河清. 液相色谱-串联质谱法测定生物样本全基因组DNA甲基化. 分析化学[J]. 2012, 第 3 作者40(8): 1201-1206, http://lib.cqvip.com/Qikan/Article/Detail?id=42882233.

   

（ 1 ） 微生物菌、黄腐酸协同发酵制备土壤酸化改良剂, 负责人, 地方任务, 2021-08--2024-08
（ 2 ） 塑料制品光老化过程中形成的持久性自由基和微塑料对肝细胞毒性研究, 负责人, 地方任务, 2022-07--2025-06
（ 3 ） 塑料光老化介导的微(纳)塑料形成和光解产物释放对雄性生殖内分泌的干扰研究, 负责人, 国家任务, 2024-01--2027-12

（1）邻苯二甲酸酯水解代谢与内分泌干扰效应   2017年环境与公共健康学术会议   2017-11-10
（2）邻苯二甲酸酯水解代谢与生殖毒性   第九届全国环境化学大会   2017-10-09