Biology of systematic aging

2012-09--2018-06 PhD, University of Chinese Academy of Sciences

2008-09--2012-06 Bachelor of Henan Normal University

​

2021-08~ present, Associate Researcher Level 3, Institute of Zoology, Chinese Academy of Sciences

2021-06~ present, Beijing Institute of Stem Cell and Regenerative Medicine, to a researcher

2020-02~2021-08, Assistant Researcher, Institute of Zoology, Chinese Academy of Sciences

2018-08~2020-01, Assistant Researcher, Institute of Biophysics, Chinese Academy of Sciences

   

（1） Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland, Nature Aging, 2024, 第 4 作者
（2） Decoding aging-dependent regenerative decline across tissues at single-cell resolution, CELL STEM CELL, 2023, 第 23 作者
（3） Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging, Protein & Cell, 2023, 第 17 作者
（4） The Aging Biomarker Consortium represents a new era for aging research in China, NATURE MEDICINE, 2023, 第 36 作者
（5） Biomarkers of aging, Biomarkers of aging, SCIENCE CHINA-LIFE SCIENCES, 2023, 第 87 作者
（6） Determining a multimodal aging clock in a cohort of Chinese women, MED, 2023, 第 21 作者
（7） Degeneration Directory: a multi-omics web resource for degenerative diseases, PROTEIN & CELL, 2023, 第 10 作者
（8） CHIT1-positive microglia drive motor neuron aging in the primate spinal cord, Nature, 2023, 第 10 作者
（9） CRISPR-based screening identifies XPO7 as a positive regulatorof senescence, CRISPR-based screening identifies XPO7 as a positive regulator of senescence, PROTEIN & CELL, 2023, 第 9 作者
（10） A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body, The Innovation, 2023, 第 2 作者
（11） Decoding aging hallmarks at the single-cell level, Annual Review of Biomedical Data Science, 2023, 第 1 作者
（12） Single-cell transcriptomic atlas of mouse cochlear aging, Protein & Cell, 2023, 第 6 作者
（13） Lineage Landscape: a comprehensive database that records lineage commitment across species, Nucleic Acids Research, 2022, 第 3 作者
（14） Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration, Protein & Cell, 2022, 第 6 作者
（15） Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging, Protein & Cell, 2022, 第 6 作者
（16） Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice, Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice, Protein & Cell, 2022, 第 6 作者
（17） Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues., Cell Stem Cell, 2022, 第 1 作者
（18） The landscape of aging, Science China Life Sciences, 2022, 第 27 作者
（19） A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis, Protein & Cell, 2022, 第 7 作者
（20） Regeneration Roadmap: database resources for regenerative biology, Nucleic Acids Research, 2022, 第 4 作者
（21） Single-cell transcriptomic atlas of primate cardiopulmonary aging, Cell Research, 2021, 第 1 作者
（22） A single-cell transcriptomic atlas of primate pancreatic islet aging, National Science Review, 2021, 第 8 作者
（23） Single-nucleus transcriptomic landscape of primate hippocampal aging, Single-nucleus transcriptomic landscape of primate hippocampal aging, Protein & Cell, 2021, 第 5 作者
（24） Aging Atlas: a multi-omics database for aging biology, Nucleic Acids Research, 2021, 第 6 作者
（25） A single-cell transcriptomic landscape of the lungs of patients with COVID-19, Nature Cell Biology, 2021, 第 3 作者
（26） A Single-Cell Transcriptomic Atlas of Human Skin Aging, Developmental Cell, 2021, 第 6 作者
（27） Genomic evidence for two phylogenetic species and long-term population bottlenecks in red pandas, Science Advances, 2020, 第 6 作者
（28） A human circulating immune cell landscape in aging and COVID-19, A human circulating immune cell landscape in aging and COVID-19, Protein & Cell, 2020, 第 8 作者
（29） Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging, Cell, 2020, 第 1 作者
（30） Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis, Protein & Cell, 2020, 通讯作者
（31） A single-cell transcriptomic landscape of primate arterial aging, Nature Communications, 2020, 通讯作者
（32） Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells, Protein & Cell, 2019, 第 7 作者
（33） Low-dose quercetin positively regulates mouse healthspan, Protein & Cell, 2019, 第 5 作者
（34） Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis, Protein & Cell, 2019, 第 8 作者
（35） Patterns and effects of GC3 heterogeneity and parsimony informative sites on the phylogenetic tree of genes, Gene, 2018, 第 1 作者
（36） Walking in a heterogeneous landscape: Dispersal, gene flow and conservation implications for the giant panda in the Qinling Mountains, Evolutionary Applications, 2018, 第 7 作者
（37） Seasonal Variation in Nutrient Utilization Shapes Gut Microbiome Structure and Function in Wild Giant Pandas, Proc. R. Soc. B., 2017, 第 7 作者
（38） A natural communication system on genome evolution, Science China Life Sciences, 2017, 第 4 作者
（39） Comparative Genomics Reveals Convergent Evolution Between the Bamboo-Eating Giant and Red Pandas, Proceedings of the National Academy of Sciences of the United States of America, 2017, 第 3 作者

（1） Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland, Nature Aging, 2024, 第 4 作者
（2） Decoding aging-dependent regenerative decline across tissues at single-cell resolution, CELL STEM CELL, 2023, 第 23 作者
（3） Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging, Protein & Cell, 2023, 第 17 作者
（4） The Aging Biomarker Consortium represents a new era for aging research in China, NATURE MEDICINE, 2023, 第 36 作者
（5） Biomarkers of aging, Biomarkers of aging, SCIENCE CHINA-LIFE SCIENCES, 2023, 第 87 作者
（6） Determining a multimodal aging clock in a cohort of Chinese women, MED, 2023, 第 21 作者
（7） Degeneration Directory: a multi-omics web resource for degenerative diseases, PROTEIN & CELL, 2023, 第 10 作者
（8） CHIT1-positive microglia drive motor neuron aging in the primate spinal cord, Nature, 2023, 第 10 作者
（9） CRISPR-based screening identifies XPO7 as a positive regulatorof senescence, CRISPR-based screening identifies XPO7 as a positive regulator of senescence, PROTEIN & CELL, 2023, 第 9 作者
（10） A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body, The Innovation, 2023, 第 2 作者
（11） Decoding aging hallmarks at the single-cell level, Annual Review of Biomedical Data Science, 2023, 第 1 作者
（12） Single-cell transcriptomic atlas of mouse cochlear aging, Protein & Cell, 2023, 第 6 作者
（13） Lineage Landscape: a comprehensive database that records lineage commitment across species, Nucleic Acids Research, 2022, 第 3 作者
（14） Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration, Protein & Cell, 2022, 第 6 作者
（15） Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging, Protein & Cell, 2022, 第 6 作者
（16） Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice, Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice, Protein & Cell, 2022, 第 6 作者
（17） Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues., Cell Stem Cell, 2022, 第 1 作者
（18） The landscape of aging, Science China Life Sciences, 2022, 第 27 作者
（19） A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis, Protein & Cell, 2022, 第 7 作者
（20） Regeneration Roadmap: database resources for regenerative biology, Nucleic Acids Research, 2022, 第 4 作者
（21） Single-cell transcriptomic atlas of primate cardiopulmonary aging, Cell Research, 2021, 第 1 作者
（22） A single-cell transcriptomic atlas of primate pancreatic islet aging, National Science Review, 2021, 第 8 作者
（23） Single-nucleus transcriptomic landscape of primate hippocampal aging, Single-nucleus transcriptomic landscape of primate hippocampal aging, Protein & Cell, 2021, 第 5 作者
（24） Aging Atlas: a multi-omics database for aging biology, Nucleic Acids Research, 2021, 第 6 作者
（25） A single-cell transcriptomic landscape of the lungs of patients with COVID-19, Nature Cell Biology, 2021, 第 3 作者
（26） A Single-Cell Transcriptomic Atlas of Human Skin Aging, Developmental Cell, 2021, 第 6 作者
（27） Genomic evidence for two phylogenetic species and long-term population bottlenecks in red pandas, Science Advances, 2020, 第 6 作者
（28） A human circulating immune cell landscape in aging and COVID-19, A human circulating immune cell landscape in aging and COVID-19, Protein & Cell, 2020, 第 8 作者
（29） Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging, Cell, 2020, 第 1 作者
（30） Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis, Protein & Cell, 2020, 通讯作者
（31） A single-cell transcriptomic landscape of primate arterial aging, Nature Communications, 2020, 通讯作者
（32） Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells, Protein & Cell, 2019, 第 7 作者
（33） Low-dose quercetin positively regulates mouse healthspan, Protein & Cell, 2019, 第 5 作者
（34） Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis, Protein & Cell, 2019, 第 8 作者
（35） Patterns and effects of GC3 heterogeneity and parsimony informative sites on the phylogenetic tree of genes, Gene, 2018, 第 1 作者
（36） Walking in a heterogeneous landscape: Dispersal, gene flow and conservation implications for the giant panda in the Qinling Mountains, Evolutionary Applications, 2018, 第 7 作者
（37） Seasonal Variation in Nutrient Utilization Shapes Gut Microbiome Structure and Function in Wild Giant Pandas, Proc. R. Soc. B., 2017, 第 7 作者
（38） A natural communication system on genome evolution, Science China Life Sciences, 2017, 第 4 作者
（39） Comparative Genomics Reveals Convergent Evolution Between the Bamboo-Eating Giant and Red Pandas, Proceedings of the National Academy of Sciences of the United States of America, 2017, 第 3 作者

(1) Systematic analysis of health and aging regulation 2023 Sports and Health Academic Conference, Sports and Public Health Branch of the Chinese Biophysical Society 2023-10-24

(2) Systematic analysis of aging and health regulation 2023 Academic Summit of the National Clinical Medical Research Center for Geriatric Diseases and the 13th Golden Sands Geriatric Medicine Forum - Youth Forum on Basic Research on Aging 2023-06-09

(3) Analysis of the system of long-term aerobic exercise to regulate body aging 2023 Chinese Aging Science Conference 2023-04-23

(4) Analysis of markers of Systemic Aging and its intervention in the first China Aging Markers Conference 2022-11-27

(5) Single cell Atlas reveals the restorative effect of allosymbiosis on aging. 11th Annual Meeting of Chinese Stem Cells 2021-12-12

(6) Analysis of the regulation of biological system Aging at the single-cell level 2021 (4th) Single-Cell Multi-omics Research and Clinical Application Summit 2021-11-19

(1) Cell Press 2022 Most Popular Chinese Papers, Other, 2022

(2) Cell Press 2020 Most Popular Chinese Papers, Other, 2021

(3) Outstanding Scientific and Technological Achievement Award, Chinese Academy of Sciences, Provincial, 2020

(4) Top Ten Advances in Life Sciences in China, Provincial, 2020

(5) Top Ten Scientific Advances in China, Provincial, 2020