Saccharomyces cerevisiae possesses the genetic characteristics of eukaryotes and the metabolic characteristics of prokaryotes, is easy to culture, and has high homology to genomes and higher eukaryotes. It is a model organism of functional genomics, modern molecular biology and cell biology. We use S. cerevisiae as a model organism to study the molecular mechanisms of DNA damage repair and aging in eukaryotes after expose to ionizing radiation, and provide a theoretical basis for the treatment of diseases such as cancer.

1) Biochemical process of eukaryotic DNA and subcellular structure damage caused by ionizing radiation and the corresponding principle of action of vital regulatory factors;

2) DNA damage repair pathway and corresponding regulation mechanisms;

2019-- Present: Vice Director of Dept. of Biophysics,  Institute of Modern Physics, Chinese Academy of Sciences

2016-  National Institute of Quantum and Radiological Science and Technology, Research Scholar

2012--Present: Associate prof., Dept. of Biophysics, IMP, CAS

2009--2012: Assistant Prof., Dept. of Biophysics,  IMP, CAS

2006--2009: Research Assistant, Dept. of Biophysics,  IMP, CAS

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1. [1]    Jie Bai, Zihan Gong, Meng Shu, Hui Zhao, Fanyu Ye, Chenglun Tang, Song Zhang, Bo Zhou, Dong Lu, Xiang Zhou, Qinlu Lin, Jun Liu, Increased Water-Soluble Yellow Monascus Pigment Productivity via Dual Mutagenesis and Submerged Repeated-Batch Fermentation of Monascus purpureus, Frontiers in Microbiology, 2022.13:914828, DOI: 10.3389/fmicb.2022.914828

[2]    Dan Zhao, Jiani Yang,  Guojing Zhang, Dong Lu, Shuang Zhang,  Weidong Wang, Lei Yan, Potential and whole‑genome sequence‑based mechanism of elongated‑prismatic magnetite magnetosome formation in Acidithiobacillus ferrooxidans BYM, World Journal of Microbiology and Biotechnology, 2022, 38:121, DOI:10.1007/s11274-022-03308-2

[3]    Nan Ding, Zhiang Shao, Fangyun Yuan, Pei Qu, Ping Li, Dong Lu, Jufang Wang， Qianzheng Zhu, Chk1inhibition hinders the restoration of H3.1K56 and H3.3K56 acetylation and reprograms gene transcription after DNA damage repair. Frontiers in Oncology, 2022,12:862592, DOI: 10.3389/fonc.2022.862592

[4]    Xin Li, Lei Chen, Haitao Zhou, Shaobin Gu, Ying Wu, Bing Wang, Miaomiao Zhang, Nan Ding, Jiaju Sun, Xinyue Pang^※, Dong Lu^※，LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli, International Journal of Radiation Biology, 2021, 97(12):1731–1740, DOI: 10.1080/09553002.2021.1987565

[5]    Dan Zhao, Jian Yang, Tao Liu, Dong Lu, Shuang Zhang, Lei Yan, Yongqing Ni, Complete genome sequence analysis of Acidithiobacillus ferrivorans XJFY6S-08 reveals environmental adaptation to alpine acid mine drainage, Current Microbiology, 2021, 78: 1488-1498, DOI: 10.1007/s00284-021-02423-x

[6]    Yue Gao, Xiang Zhou, Miaomiao Zhang, Yajun Liu, Xiaopeng Guo, Cairong Lei, Wenjian Li, Dong Lu^※, Response characteristics of the membrane integrity and physiological activities of the mutant strain Y217 under exogenous butanol stress, Applied Microbiology and Biotechnology, 2021, 105(6): 2455-2472, DOI: 10.1007/s00253-021-11174-5

[7]    Yue Gao, Miaomiao Zhang, Xiang Zhou, Xiaopeng Guo, Cairong Lei, Wenjian Li, Dong Lu^※, Effects of carbon ion beam irradiation on butanol tolerance and production of Clostridium acetobutylicum, Frontiers in Microbiology, 2020, 11: 602774, DOI: 10.3389/fmicb.2020.602774

[8]    Ruiyuan Liu, Wenjian Li, Dong Lu, Jiangang Li, Ying Qu, Wenjie Jin, Xicun Dong, Variation in RNA-editing sites of chloroplast protein-coding genes in early-maturity mutant induced by carbon-ion beam in Sweet Sorghum, Plant Breeding. 2020,139: 762-778, DOI: 10.1111/pbr.12823

[9]    Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Dong Lu^※, Wenjian Li, Libin Zhou, Repair characteristics and time-dependent effects in response to heavy-ion beam irradiation in Saccharomyces cerevisiae: a comparison with X-ray irradiation, Applied Microbiology and Biotechnology, 2020, 104: 4043–4057, DOI: 10.1007/s00253-020-10464-8

[10] Nan Ding, Junrui Hua, Jinpeng He, Dong Lu, Wenjun Wei, Yanan Zhang, Heng Zhou, Liying Zhang, Yongqi Liu, Guangming Zhou, Jufang Wang, The role of MiR-5094 as a proliferation suppressor during cellular radiation response via downregulating STAT5b, Journal of Cancer, 2020, 11: 2222-2233, DOI: 10.7150/jca.39679

[11] Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Guozhen Cao, Dong Lu^※, Wenjian Li, Quantitative multi-omics analysis of the effects of mitochondrial dysfunction on lipid metabolism in Saccharomyces cerevisiae, Applied Microbiology and Biotechnology, 2020, 104: 1211–1226, DOI: 10.1007/s00253-019-10260-z

[12] Yue Gao, Miaomiao Zhang, Xiaopeng Guo, Wenjian Li, Dong Lu^※, The biological mechanisms of butanol tolerance and the application of solvent-tolerant bacteria for environmental protection, Journal of Chemical Technology & Biotechnology, 2020, 95: 1290–1297, DOI: 10.1002/jctb.6255

[13] Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Wenjian Li, Dong Lu^※, “Saddle-Shaped” Dose-Survival Effect, Is it a general and valuable phenomenon in microbes in response to heavy ion beam irradiation?  Annals of Microbiology, 2019, 69(3): 221-232, DOI: 10.1007/s13213-019-1442-7

[14] Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Guozhen Cao, Yang Yang, Dong Lu^※, Wenjian Li, A genome-wide view of mutations in respiration-deficient mutants of Saccharomyces cerevisiae selected following carbon ion beam irradiation, Applied Microbiology and Biotechnology, 2019, 103: 1851-1864, DOI: 10.1007/s00253-019-09626-0

[15] Xiaopeng Guo, Miaomiao Zhang, Ruiyuan Liu, Yue Gao, Yang Yang, Wenjian Li, Dong Lu^※, Repair characteristics and time-dependent effects in Saccharomyces cerevisiae cells after X-ray irradiation, World Journal of Microbiology and Biotechnology, 2019, 35: 1. DOI:10.1007/s11274-018-2566-9

[16] Miaomiao Zhang, Xiaopeng Guo, Ruiyuan Liu, Liang Ma, Yue Gao, Dong Lu^※, Wenjian Li, Lipidomics studies on mitochondrial damage of Saccharomyces cerevisiae induced by heavy ion beam radiation, Chinese Journal of Analytical Chemistry, 2018, 46(11): 1714–1723, DOI: 10.1016/S1872-2040(18)61123-5

[17] Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Wenjian Li, Dong Lu^※, Determining survival fractions of Saccharomyces cerevisiae in response to ionizing radiation in liquid culture, Journal of Radiation Research, 2018, 59(6): 760-764, DOI: 10.1093/jrr/rry070

[18] Miaomiao Zhang, Guozhen Cao, Xiaopeng Guo, Yue Gao, Wenjian Li, Dong Lu^※, A comet assay for DNA damage and repair after exposure to carbon-ion beams or X-rays in Saccharomyces cerevisiae, Dose-Response, 2018, 16(3):1-9, DOI: 10.1177/1559325818792467

[19] Huidan Zhang, Dong Lu, Xin Li, Yingang Feng, Qiu Cui and Xiaojin Song, Heavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield in Mortierella alpine, BMC Biotechnology, 2018, 18: 23, DOI: 10.1186/s12896-018-0437-y

[20] Xin Li, Jie Wang, Zhouliang Tan, Liang Ma, Dong Lu, Wenjian Li, Jufang Wang, Cd resistant characterization of mutant strain irradiated by carbon-ion beam, Journal of Hazardous Materials, 2018, 353(5): 1-8, DOI: 10.1016/j.jhazmat.2018.03.036

已指导学生

剡倩  硕士研究生  071011-生物物理学  

现指导学生

雷彩荣  博士研究生  071011-生物物理学  

王娅娟  硕士研究生  071011-生物物理学  

任军乐  硕士研究生  071011-生物物理学  

董子毅  博士研究生  071011-生物物理学  

贾承霖  硕士研究生  086000-生物与医药  

赵晶茹  博士研究生  071011-生物物理学