Li Wenjun ,Ph.D, Associate Professor, Shenzhen Institute of advanced technology, Chinese Academy of Sciences


Address: 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, P.R.China

Postal Code: 518055

Research Areas

1.  Biological Applications of click chemistry / biorthogonal chemistry

2. Bionics nanorobot and  Natural Intelligent Nano-materials in tumor theranostic 

3. Development and application of Novel immuno-therapy for tumor


2007.09 ~ 2012.07   Shandong University,   Medicinal Chemistry,   Ph.D

2003.09 ~ 2007.07   Dalian University of Technology, Pharmaceutical Engineering, B.S.


Work Experience

2018.02 ~          Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Associate professor

2012.07 ~ 2018.02   Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Assistant professor

Teaching Experience

化学生物学进展 (Advances in Chemical biology)

纳米生物学实验课 (Nanobiology and Experiment Course)

纳米技术导论 (Introduction of Nanotechnology)

生物材料综合实验课 (Biomaterials and Experiment Course)



(1)Membrane-anchoring clickable Iridium(III) nanosonosensitizer in situ evokes PANoptosis for augmented tumor sono-immunotherapy, Nano Today, 2024, 56: 0-102270  通讯作者

(2)In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy, Adv. Funct. Mater., 2022, 2022(2202603): 1-11  通讯作者

(3)In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy . ADVANCED FUNCTIONAL MATERIALS[J] , 2022 , 32(29) . 通讯作者

(4)Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor, Bioactive Materials, 2021, 第 1 作者
(5) Bio‐Orthogonal T Cell Targeting Strategy for Robustly Enhancing Cytotoxicity against Tumor Cells, Small, 2019, 第 1 作者
(6) T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy, Advanced science, 2019, 第 1 作者
(7) Enzyme and pH dual-responsive hyaluronic acid nanoparticles mediated combination of photodynamic therapy and chemotherapy, International Journal of Biological Macromolecules, 2019, 通讯作者
(8) In Situ Bioorthogonal Metabolic Labeling for Fluorescence Imaging of Virus Infection In Vivo, Small, 2017, 第 2 作者
(9) Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment, and Real-Time Monitoring Based on Fluorescence Resonance Energy Transfer, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 6 作者
(10) Dual-modal imaging-guided highly efficient photothermal therapy using heptamethine cyanine-conjugated hyaluronic acid micelles, BIOMATERIALS SCIENCE, 2017, 第 5 作者
(11) Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation, Journal of Materials Chemistry B, 2017, 第 1 作者
(12) umor-targeting and hyaluronidase activatable nanoparticles for tumor tracer and photochemistry therapy, Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 第 1 作者
(13) Living Cells Multi-Lifetime Encoding Based on Lifetime-Tunable Lattice-Strained Quantum Dots, ACS Appl. Mater. Interfaces, 2016, 第 3 作者
(14) Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy, Biomaterials, 2016, 第 1 作者
(15) Long-decay near-infrared-emitting dopedquantum dots for lifetime-based in vivo pH imaging, ChemComm, 2015, 第 7 作者
(16) Current drug research on PEGylation with small molecular agents, Progress in polymer science, 2013, 第 1 作者
(17) Synthesis, Influence of Molecular Weight of PEG on Pharmaceutics and Anti-HIV Activity in Vitro, Int J Biol Macromol, 2012, 第 1 作者
(18) Synthesis, influence of polymer molecular weight on drug release and anti-HIV activity of PEGylated AZT conjugates, Antiviral Research, 2011, 第 1 作者
(19) In Vitro and In Vivo Release Kinetics, and Anti-HIV Activity of A Sustained-Release Prodrug (mPEG-AZT) of 3′-Azido-3′-deoxythymidine (AZT, Zidovudine), ChemMedChem, 2011, 第 1 作者


( 1 ) 一种纳米靶向载药技术及其制备方法和一种抗癌药物及其制备方法, 发明, 2015, 第 2 作者, 专利号: 201510960716

( 2 ) 纳米载药胶束和抗癌药物及其制备方法, 发明, 2013, 第 2 作者, 专利号: 201310589848

( 3 ) 胆碱类似物及其制备方法和应用、由染料分子标记的四嗪探针及其制备方法和应用, 发明, 2013, 第 2 作者, 专利号: 201310752617

( 4 ) 对细胞进行原位标记的方法和应用, 发明, 2014, 第 5 作者, 专利号: 201410154914

( 5 ) 由染料分子标记的四嗪探针及其制备方法, 发明, 2013, 第 2 作者, 专利号: 201610348541

( 6 ) 聚合物、光响应胶束、光响应载药胶束及其制备方法, 发明, 2014, 第 3 作者, 专利号: 201410182216

( 7 ) 一种纳米载药胶束、纳米抗癌药物及其制备, 发明, 2016, 第 3 作者, 专利号: 201611241607

( 8 ) 一种用于具有细胞膜结构的生物体的荧光标记, 发明, 2013, 第 4 作者, 专利号: 201310754554

( 9 ) (2-(2-氧基-4-硫代嘧啶)乙氧基)甲基膦酸酯类衍生物及其制备与应用, 发明, 2012, 第 2 作者, 专利号: 201210330501

( 10 ) (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备, 发明, 2012, 第 2 作者, 专利号: 201210330875

( 11 ) 促进生物体相互作用的方法及应用, 发明, 2018, 第 2 作者, 专利号: CN201811450846.X

( 12 ) 单糖类似物及包含其的分子探针和该分子探针的应用, 发明, 2018, 第 2 作者, 专利号: CN201811446431.5

Research Interests

Click chemistry / biorthogonal chemistry

Bionics nanorobot 

Natural Intelligent Nano-materials 

Tumor mmuno-therapy


(1)点击化学在病毒示踪和细胞治疗的前沿研究   中国化学会第32届学术年会   蔡林涛,潘宏,李文军,张鹏飞,郑明彬   2021-04-16
(2)Paired bioorthogonal glycometabolic labeling for enhancing T cell targeting and cytotoxicity against lymphoma cells   2018-10-15
(3)Visual tracking of enterovirus infection behavior by bioorthogonal Near-infrared Quantum Dots   2017-07-29
(4)酶敏感纳米胶束的对肿瘤的活体示踪及光动力治疗研究   2016 中国化学会   2016-07-01
(5)Tumor-targeting and hyaluronidase activatable nanoparticles for tumor tracer and photochemistry therapy   2015-04-07


Long-term and stable cooperative relations have been established with ICMCB, Shandong University, Shenzhen Hospital of The University of Hong Kong, Shenzhen Longgang People's Hospital and Shenzhen Third People's Hospital.



梁振国  硕士研究生  0703Z1-化学生物学  

张旭  硕士研究生  086000-生物与医药  

马财兵  硕士研究生  086000-生物与医药  


王子茜  硕士研究生  086000-生物与医药  

沙依拜·沙比提  博士研究生  0703Z1-化学生物学  

柯莹莹  硕士研究生  086000-生物与医药  

赫弈然  硕士研究生  086000-生物与医药