纳米药学

纳米-(微)生物表界面互作

纳米免疫效应

物理化学

纳米科学与技术

纳米生物医学/纳米生物材料

纳米免疫

0703J1-纳米科学与技术
0703Z1-化学生物学
0703Z2-生物无机化学

纳米药物递送系统
纳米材料的免疫学效应

   

2021-03~现在, 国家纳米科学中心, 研究员
2017-07~2021-03,西北大学, 教授

2022-07-06-今,Frontiers in Chemistry编辑部, 评论编辑
2022-07-05-今,Frontiers in Bioengineering and Biotechnology编辑部, 客座副主编
2022-03-28-今,Rare Metals杂志编辑部, 客座编辑
2020-09-20-今,中国药学会纳米药物专业委员会, 青年委员
2018-10-15-今,中国环境诱变剂学会生物标志物专业委员会, 青年委员

纳米生物技术

   

（1） 北京市科技新星, 市地级, 2022
（2） 中国科学院****, 院级, 2020
（3） 中国科协青年人才托举工程, , 部委级, 2018

（ 1 ） 一种二烷基酰基半胱氨酸二肽及制备方法和应用, 发明专利, 2023, 第 1 作者, 专利号: CN116715721A

（ 2 ） 一种载有核酸分子的酸响应聚合物修饰的铋单质纳米片及其制备方法和应用, 发明专利, 2021, 第 2 作者, 专利号: CN112315975A

（ 3 ） 一种雷公藤红素/盐酸阿霉素自组装纳米药物及其制备方法和应用, 专利授权, 2018, 第 5 作者, 专利号: CN107929290A

（ 4 ） 一种双pH响应的两亲性共聚物及其制备方法和用途, 专利授权, 2017, 第 4 作者, 专利号: CN106317416A

（ 5 ） 一种Cu 3 BiS 3 纳米药物及其制备方法和应用, 发明专利, 2016, 第 2 作者, 专利号: CN105833298A

（ 6 ） 一种金钆复合纳米材料、制备方法及其用途, 专利授权, 2016, 第 2 作者, 专利号: CN105641696A

   

[1] Zhang, Xu, Shi, Kejian, Mao, Jiahui, Mao, Kerou, Jia, Yangrui, Zhang, Jiakun, Wang, Qingzhen, Bai, Ru, Gao, Fene, Liu, Shihui, Guo, Mengyu, Qin, Fenglan, Li, Shengmin, Chen, Chunying, Zhou, Huige, Liu, Jing, Chen, Fulin. Ultra-strong penetrating and GSH-responsive oral drug delivery system improved therapeutic effect of gemcitabine for pancreatic tumors. NANO TODAY[J]. 2024, 第 16 作者  通讯作者  54: http://dx.doi.org/10.1016/j.nantod.2023.102048.
[2] Advanced Materials. 2024,   通讯作者  
[3] Angew. Chem. Int. Ed.. 2023,   通讯作者  
[4] Liu, Jing, Guo, Mengyu, Chen, Chunying. Nano-bio interactions: A major principle in the dynamic biological processes of nano-assemblies. ADVANCED DRUG DELIVERY REVIEWS. 2022, 第 1 作者186: http://dx.doi.org/10.1016/j.addr.2022.114318.
[5] Liu, Jing, Guo, Mengyu, Chen, Chunying. Nano-bio interactions: A major principle in the dynamic biological processes of nano-assemblies. ADVANCED DRUG DELIVERY REVIEWS. 2022, 第 1 作者186: http://dx.doi.org/10.1016/j.addr.2022.114318.
[6] Zhou, Huige, Guo, Mengyu, Li, Jiayang, Qin, Fenglan, Wang, Yuqing, Liu, Tao, Liu, Jing, Sabet, Zeinab Farhadi, Wang, Yaling, Liu, Ying, Huo, Qing, Chen, Chunying. Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 第 7 作者143(4): 1846-1853, http://dx.doi.org/10.1021/jacs.0c10245.
[7] Wang, Longwei, Li, Bo, You, Zhen, Wang, Aizhu, Chen, Xuanyu, Song, Gaojing, Yang, Ling, Chen, Dan, Yu, Xin, Liu, Jing, Chen, Chunying. Heterojunction of Vertically Arrayed MoS2 Nanosheet/N-Doped Reduced Graphene Oxide Enabling a Nanozyme for Sensitive Biomolecule Monitoring. ANALYTICAL CHEMISTRY[J]. 2021, 第 10 作者  通讯作者  93(32): 11123-11132, http://dx.doi.org/10.1021/acs.analchem.1c01550.
[8] Qin, Fenglan, Zhou, Huige, Li, Jiayang, Liu, Jing, Wang, Yaling, Bai, Ru, Liu, Shihui, Manman, Ma, Liu, Tao, Gao, Fene, Du, Peiyao, Lu, Xiaoquan, Chen, Chunying. Hypoxia and pH co-triggered oxidative stress amplifier for tumor therapy. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2021, 第 4 作者905: http://dx.doi.org/10.1016/j.ejphar.2021.174187.
[9] Guo, JinCheng, An, Qiao, Guo, Mengyu, Xiao, Yating, Li, Bo, Gao, Fene, Wang, Yuqing, Li, Jiayang, Wang, Yaling, Liu, Ying, Meng, Huan, Guo, Jia, Liu, Jing. Oxygen-independent free radical generation mediated by core-shell magnetic nanocomposites synergizes with immune checkpoint blockade for effective primary and metastatic tumor treatment. NANO TODAY[J]. 2021, 第 13 作者  通讯作者  36: http://dx.doi.org/10.1016/j.nantod.2020.101024.
[10] Angew. Chem. Int. Ed.. 2021,   通讯作者  
[11] Liu, Tao, Bai, Ru, Zhou, Huige, Wang, Rongqi, Liu, Jing, Zhao, Yuliang, Chen, Chunying. The effect of size and surface ligands of iron oxide nanoparticles on blood compatibility. RSC ADVANCES[J]. 2020, 第 5 作者10(13): 7559-7569, http://dx.doi.org/10.1039/c9ra10969b.
[12] Liu Jing. Defect-Rich Adhesive Molybdenum Disulfde/rGO Vertical Heterostructures with Enhanced Nanozyme Activity for Smart Bacterial Killing Application. Advanced Materials. 2020, 第 1 作者  通讯作者  
[13] Advanced Materials. 2020,   通讯作者  
[14] Xu, Mengzhen, Zhang, Can Yang, Wu, Junguang, Zhou, Huige, Bai, Ru, Shen, Ziyi, Deng, Fangling, Liu, Ying, Liu, Jing. PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 第 9 作者  通讯作者  11(6): 5701-5713, http://dx.doi.org/10.1021/acsami.8b13059.
[15] Tang, Jinglong, Guo, Mengyu, Wang, Peng, Liu, Jing, Xiao, Yating, Cheng, Wenting, Gao, Jinling, Hu, Wenquan, Miao, Qing Robert. Gd-Metallofullerenol nanoparticles cause intracellular accumulation of PDGFR-alpha and morphology alteration of fibroblasts. NANOSCALE[J]. 2019, 第 4 作者11(11): 4743-4750, http://www.corc.org.cn/handle/1471x/2160633.
[16] Wang, Longwei, Zhang, Xiao, Yu, Xin, Gao, Fene, Shen, Ziyi, Zhang, Xiaolei, Ge, Shenguang, Liu, Jing, Gu, Zhanjun, Chen, Chunying. An All-Organic Semiconductor C3N4/PDINH Heterostructure with Advanced Antibacterial Photocatalytic Therapy Activity. ADVANCED MATERIALS[J]. 2019, 第 8 作者  通讯作者  31(33): https://www.webofscience.com/wos/woscc/full-record/WOS:000481909600016.
[17] Liu Jing. The adjuvant effect of C60(OH)22 nanoparticles promoting both humoral and cellular immune responses to HCV recombinant proteins. Materials Science & Engineering C. 2019, 第 1 作者
[18] Wang, Song, Zhang, JianHua, Wang, Huan, Yang, Lu, Hong, Shuai, Yu, Bo, Guo, JinCheng, Liu, Jing, Zhu, YanBing. A novel multidimensional signature predicts prognosis in hepatocellular carcinoma patients. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2019, 第 8 作者  通讯作者  234(7): 11610-11619, 
[19] Advanced Materials. 2019,   通讯作者  
[20] Li, Zhenglin, Hu, Shaoshan, Liu, Jing, Hu, Ying, Chen, Lei, Jiang, Tingting, Sun, Lei, Sun, Ye, Besenbacher, Flemming, Chen, Chunying, Yu, Miao. Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION[J]. 2018, 第 3 作者35(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000441893400010.
[21] Xiao, Yating, Liu, Jing, Guo, Mengyu, Zhou, Huige, Jin, Jun, Liu, Jiaming, Liu, Ying, Zhang, Zhanjun, Chen, Chunying. Synergistic combination chemotherapy using carrier-free celastrol and doxorubicin nanocrystals for overcoming drug resistance. NANOSCALE[J]. 2018, 第 2 作者10(26): 12639-12649, http://dx.doi.org/10.1039/c8nr02700e.
[22] Yu, Xin, Zhao, Zhenhuan, Ren, Na, Liu, Jing, Sun, Dehui, Ding, Longhua, Liu, Hong. Top or Bottom, Assembling Modules Determine the Photocatalytic Property of the Sheetlike Nanostructured Hybrid Photocatalyst Composed with Sn3O4 and rGO (GQD). ACS SUSTAINABLE CHEMISTRY & ENGINEERING[J]. 2018, 第 4 作者  通讯作者  6(9): 11775-11782, http://dx.doi.org/10.1021/acssuschemeng.8b02030.
[23] Zhao Yuliang. Molecular mechanism of Gd@C82(OH)22 increasing collagen expression: Implication for encaging tumor. Biomaterials. 2018, 
[24] Guo, Mengyu, Zhou, Guoqiang, Liu, Zhu, Liu, Jing, Tang, Jinglong, Xiao, Yating, Xu, Wenshi, Liu, Ying, Chen, Chunying. Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes. SCIENCE BULLETIN[J]. 2018, 第 4 作者63(2): 92-100, http://www.corc.org.cn/handle/1471x/2178061.
[25] Xu, Wenshi, Guo, Mengyu, Liu, Jing, Xiao, Yating, Zhou, Guoqiang, Liu, Ying, Chen, Chunying. Poly(lactic-co-glycolic acid)/Polycaprolactone Nanofibrous Membranes for High-Efficient Capture of Nano- and Microsized Particulate Matter. JOURNALOFBIOMEDICALNANOTECHNOLOGY[J]. 2018, 第 3 作者14(1): 179-189, http://www.corc.org.cn/handle/1471x/2177969.
[26] Jin, Jun, Guo, Menyu, Liu, Jiaming, Liu, Jing, Zhou, Huige, Li, Jiayang, Wang, Liming, Liu, Huibiao, Li, Yuliang, Zhao, Yuliang, Chen, Chunying. Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 第 4 作者10(10): 8436-8442, 
[27] Zhang, Xiao, Guo, Zhao, Liu, Jing, Tian, Gan, Chen, Kui, Yu, Shicang, Gu, Zhanjun. Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells. SCIENCE BULLETIN[J]. 2017, 第 3 作者62(14): 985-996, http://www.corc.org.cn/handle/1471x/2177014.
[28] 赵宇亮. Poly (Vinylpyrollidone)‐and Selenocysteine‐Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues. ADVANCED MATERIALS[J]. 2017, 29(34): http://www.corc.org.cn/handle/1471x/2177025.
[29] Tang, Jinglong, Zhou, Huige, Liu, Jiaming, Liu, Jing, Li, Wanqi, Wang, Yuqing, Hu, Fan, Huo, Qing, Li, Jiayang, Liu, Ying, Chen, Chunying. Dual-Mode Imaging-Guided Synergistic Chemo- and Magnetohyperthermia Therapy in a Versatile Nanoplatform To Eliminate Cancer Stem Cells. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 第 4 作者9(28): 23497-23507, http://dx.doi.org/10.1021/acsami.7b06393.
[30] Liu, Jing, Chen, Qi, Sun, YaNan, Xu, MengYing, Liu, Wei, Han, BaoHang. Gold nanoparticles encapsulated in hierarchical porous polycarbazole: preparation and application in catalytic reduction. RSC ADVANCES[J]. 2016, 第 1 作者6(54): 48543-48549, http://dx.doi.org/10.1039/c6ra04515d.
[31] Liu, Jing, Wang, Pengyang, Zhang, Xiao, Wang, Liming, Wang, Dongliang, Gu, Zhanjun, Tang, Jinglong, Guo, Mengyu, Cao, Mingjing, Zhou, Huige, Liu, Ying, Chen, Chunying. Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo. ACS NANO[J]. 2016, 第 1 作者10(4): 4587-4598, 
[32] 赵宇亮. Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor. NANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2016, 12(2): 486-487, http://dx.doi.org/10.1016/j.nano.2015.12.116.
[33] Liu, Jing, Zheng, Xiaopeng, Yan, Liang, Zhou, Liangjun, Tian, Gan, Yin, Wenyan, Wang, Liming, Liu, Ying, Hu, Zhongbo, Gu, Zhanjun, Chen, Chunying, Zhao, Yuliang. Bismuth Sulfide Nanorods as a Precision Nanomedicine for in Vivo Multimodal Imaging-Guided Photothermal Therapy of Tumor. ACS NANO[J]. 2015, 第 1 作者9(1): 696-707, http://dx.doi.org/10.1021/nn506137n.

   

（ 1 ） 基于铁死亡增强的三阴性乳腺癌治疗性疫苗的设计与应用研究, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 构效调控QS-21基纳米颗粒新佐剂的构建与免疫保护增效研究, 负责人, 地方任务, 2021-12--2024-12
（ 3 ） 纳米材料的免疫学效应与疾病治疗, 负责人, 中国科学院计划, 2021-03--2024-03
（ 4 ） 非氧依赖的氧化铁基纳米复合材料在肿瘤光动力治疗中的作用及机制研究, 负责人, 国家任务, 2020-01--2022-12
（ 5 ） 中国科协青年人才托举工程项目, 负责人, 其他国际合作项目, 2018-12--2021-12

现指导学生

戴一帜  博士研究生  0703J1-纳米科学与技术  

黄月  硕士研究生  070304-物理化学  

王卓  硕士研究生  0703J1-纳米科学与技术  

王明戈  硕士研究生  0710J1-纳米科学与技术