Health informatics, medical signal analysis, and intelligent instrumentation encompass the following areas:

1. Physiological information detection: focusing on wearable and non-intrusive measurement techniques.
2. Physiological information analysis: employing signal processing, machine learning, artificial intelligence, data mining, and other technologies to extract key features, screen, provide early warnings, and diagnose and predict diseases.
3. Physical stimulation intervention: developing neural rehabilitation technologies and equipment utilizing electrical, magnetic, acoustic, and other multimodal physical stimulations.

Master’s students, postdoctoral fellows, visiting master’s/doctoral students

Majors required: 

Biomedical Engineering, Electronic Information, Pattern Recognition and Intelligent Systems, Signal and Information Processing, Computer Science, Software Engineering, Medicine, and other majors related to the aforementioned subjects.

Research interest: 

Biomedical engineering Recruitment Field: Wearable and non-intrusive measurement Intelligent analysis of physiological signals Multi-modal physical stimulation intervention

2015-09--2019-09 PhD, Pattern Recognition and Intelligent Systems, University of Chinese Academy of Sciences, China 

2002-09--2009-05, Bachelor and Master of Biomedical Engineering, Central South University, China

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2021/10~ present, Associate Professor, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), China

2019/09~2021/10, Postdoctoral, Department of Electronic and Electrical Engineering, Southern University of Science and Technology, China

2009/05~2015/08, Research Assistant~Assistant Research Fellow, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), China

Modern signal processing

   

1.  Wan-Hua Lin^#, Dingchang Zheng, Guanglin Li*, Fei Chen*, “Age-related changes in blood volume pulse wave at fingers and ears,” IEEE. J. Biomed. Health. Inform., vol. 28, no. 9, pp. 5070–5080, Sep. 2024

2. Wan-Hua Lin^#, Dingchang Zheng, Guanglin Li, Hui Zhou, Fei Chen*. Investigation on pulse wave forward peak detection and its applications in cardiovascular health. IEEE Transactions on Biomedical Engineering, vol. 69(2): 700-709, Feb.2022

3. Ning Ji, Yuanheng Li, Jingjing Wei, Fei Chen, Lisheng Xu, Guanglin Li and Wan-Hua Lin*. Autonomic modulation by low–intensity focused ultrasound stimulation of the vagus nerve. Journal of Neural Engineering, vol. 19(6): 700-709, Dec., 2022

4. Ning Ji#, Wan-Hua Lin^#, Fei Chen, Lisheng Xu, Jianping Huang, Guanglin Li*, “Blood pressure modulation with low intensity focused ultrasound stimulation to the vagus nerve: A pilot animal study,” Frontiers in Neuroscience, vol.14, no.586424, Nov 12, 2020

5. Y.-T. Zhang^#*, Y.-L. Zheng⁺, W. Lin⁺, H. Zhang⁺, and X.-L. Zhou, “Challenges and opportunities in cardiovascular health informatics,” IEEE Transactions on Biomedical Engineering, vol. 60, no. 3, pp. 633-642, Feb 1, 2013

6. Wan-Hua Lin^#, FeiChen^#, YanjuanGeng, NingJi, PengFang, GuanglinLi*. “Towards accurate estimation of cuffless and continuous blood pressure using multi-order derivative and multivariate photoplethysmogram features,” Biomedical Signal Processing and Control, vol. 63, no. 2021, pp. 102198, Jan, 2021.

7. Wan-Hua Lin^#, Xiangxin Li, Yuanheng Li, Guanglin Li, and Fei Chen*, “Investigating the physiological mechanisms of the photoplethysmogram features for blood pressure estimation,” Physiol. Meas., vol. 41, pp. 044003, May 1, 2020 (Best paper award, 1/171) .

8. Wan-Hua Lin^#, Oluwarotimi Williams Samuel, Guanglin Li*, “Reply to Comment on 'New photoplethysmogram indicators for improving cuffless and continuous blood pressure estimation accuracy,” Physiol. Meas., vol. 39, no. 9, pp. 098002, Sep 27, 2018

9. Wan-Hua Lin^#, Hui Wang, Oluwarotimi Williams Samuel, Gengxing Liu, Zhen Huang, Guanglin Li*, “New photoplethysmogram indicators for improving cuffless and continuous blood pressure estimation accuracy,” Physiol. Meas., vol. 39, no. 2, pp. 025005, Feb 26, 2018 (Top-cited award, 1%).

10. Wan-Hua Lin^#, Heye Zhang, and Yuan-Ting Zhang*, “Investigation on Cardiovascular Risk Prediction Using Physiological Parameters,” Comput Math Method M, vol. 2013, no. 16, pp. 272691, Sep 23, 2013

11. Lin Xu^#, Hui Zhao^#, Jian Qiu^#, Wei Zhu, Hongqiang Lei, Zekun Cai, Wan-Hua Lin*, Wenhua Huang*, Heye Zhang, and Yuan-Ting Zhang, “The Different Effects of BMI and WC on Organ Damage in Patients from a Cardiac Rehabilitation Program after Acute Coronary Syndrome,” Biomed Res Int, vol. 2015 no. pp. 942695, Feb 16, 2015

12. Wei Guo^#, Xin Liu^#, Zhifan Gao^#, Sandeep Pirbhulal, Wenhua Huang, Wan-Hua Lin*, Heye Zhang, Ning Tan, and Yuan-Ting Zhang, “Quantification of three-dimensional computed tomography angiography for evaluating coronary luminal stenosis using digital subtraction angiography as the standard of reference,” Biomed Eng Online, vol. 14, no. 50, pp. 1-11, May 30, 2015

13. Lin Xu#, Hongqiang Lei^#, Jian Qiu^#, Jun Ma, Hui Zhao, Yu Deng, Wan-Hua Lin*, and Wenhua Huang, “Correlation between beat-to-beat blood pressure variability and arterial stiffness in healthy adults in the cold pressor test,” Australas Phys Eng Sci Med, vol.39, no.4, pp. 977-985, Oct 9, 2015

14. Shan Liang, Hongye Guan, Guangyou Yang, Wanhua Lin, Zhihe Long, Tianyan Zhong, Rui Lin, Lili Xing, Yan Zhang, Guanglin Li, Meihua Chen*, Xinyu Xue*, Yang Zhan*. “A self-powered biocompatible brain probe for remote blood pressure regulation,” Nano Energy 115, 2023: 108764

15. H. Wu^#, W. Lin, F. Chen*, D. Zheng, “Effect of temporal misalignment on understanding mandarin sentences in simulated combined electric-and-acoustic stimulation,” Journal of the Acoustical Society of America, vol.148, no.6, pp. EL433-EL439, Dec, 2020

16.  Peng Fang, Yuhui Peng, Wanhua Lin, Yingying Wang, Shuting Wang, Xiaoqing Zhang, Kai Wu, Guanglin Li. “Wrist pulse recording with a wearable piezoresistor-piezoelectret compound sensing system and its applications in health monitoring,” IEEE Sensors Journal, vol. 21, no. 18, Sep., 5, 2021

17. Rong-Chao Peng^#, Wen-Rong Yan, Ning-Ling Zhang, Wan-Hua Lin, Xiao-Lin Zhou*, and Yuan-Ting Zhang, “Investigation of Five Algorithms for Selection of the Optimal Region of Interest in Smartphone Photoplethysmography,” Journal of Sensors, vol. 2016, pp. 6830152, Nov.18, 2015

18. Rong-Chao Peng^#, Wen-Rong Yan, Ning-Ling Zhang, Wan-Hua Lin, Xiao-Lin Zhou*, and Yuan-Ting Zhang, “Cuffless and Continuous Blood Pressure Estimation from the Heart Sound Signals,” Sensors, vol. 15, no. 9, pp. 23653-23666, Sep 17, 2015

19. Rong-Chao Peng^#, Wen-Rong Yan, Xiao-Lin Zhou *, Ning-Ling Zhang, Wan-Hua Lin, and Yuan-Ting Zhang, “Time-frequency analysis of heart rate variability during the cold pressor test using a time-varying autoregressive model,” Physiol. Meas., vol. 36, no. 3, pp. 441-452, Mar, 2015

20. Chunyue Li^#, Huahua Xiong^#, Wanqing Wu^#, Xionghong Tian, Yongjian Wang, Dan Wu, Wan-Hua Lin, Fen Miao, Heye Zhang*, Wenhua Huang, and Yuan-Ting Zhang, “The relationship between heart-carotid pulse transit time and carotid intima-media thickness in hypertensive patients,” J Hum Hypertens, vol. 2015, no.11, pp. 1-6, Mar 12, 2014

21. Rong-Chao Peng ^#, Xiao-Lin Zhou *, Wan-Hua Lin, and Yuan-Ting Zhang, “Extraction of heart rate variability from smartphone photoplethysmograms,” Comput Math Method M, vol. 2015, pp. 516826, Dec 12, 2014

22. Minhua Lu^#, Dan Wu^#, Wan-Hua Lin, Weifang Li, Heye Zhang*, and Wenhua Huang, “A stochastic filtering approach to recover strain images from quasi-static ultrasound elastography,” Biomed Eng Online, vol. 13, no. 15, pp. 1-17, Feb 12, 2014

23. Huahua Xiong^#, Dan Wu^#, Xionghong Tian, Wan-Hua Lin, Chunyue Li, Heye Zhang*, Yunpeng Cai, and Yuan-Ting Zhang, “The Relationship between the 24 h Blood Pressure Variability and Carotid Intima-Media Thickness: A Compared Study,” Comput Math Method M, vol. 2014, pp. 303159, Feb 11, 2014

24. Carmen C. Y. Poon^#, Qing Liu, Hui Gao, Wan-Hua Lin, Yuan-Ting Zhang*, “Wearable Intelligent Systems for E-Health,” Journal of Computing Science and Engineering, vol. 5, no. 3, pp. 246-256, Sep 1, 2011.

1. Jingjing Wei^#, Ning Ji^#, Lin Wang, Xinyu Wu, Guanglin Li*, Wan-Hua Lin*. Comparison of Blood Pressure Modulation by Low-Intensity Focused Ultrasound Stimulation of Carotid Sinus, Nodose Ganglion, and Vagus Nerve. 46th Annual International Conference of the IEEE-EMBS (EMBC 2024): Orlando, USA

2. Ning Ji, Yuanheng Li, Jingjing Wei, Lei Huang, Wan-Hua Lin*, and Guanglin Li*.” The Changes of Cardiovascular Neurotransmitter Levels under Low-Intensity Focused Ultrasound Stimulation of the Vagus Nerve,” 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2023), Sydney, Australia, 24-27 Jul. 2023

3. Wan-Hua Lin^#, Ning Ji, Lin Wang, and Guanglin Li*. “A Characteristic Filtering Method for Pulse Wave Signal Quality Assessment,” 41th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2019), Berlin, Germany, 22-27 Jul. 2019

4. Wan-Hua Lin^#, Hui Wang, Oluwarotimi Williams Samuel, and Guanglin Li*, “Using a new PPG indicator to increase the accuracy of PTT-based continuous cuffless blood pressure estimation,” 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2017), Jeju Island, Korea, 11-15 Jul. 2017, pp.738-741

5. Wan-Hua Lin^#, Oluwarotimi Williams Samuel, Qing Liu, Yuan-Ting Zhang, and Guanglin Li*, “Comparison of the Correlation of Different Pulse Transit Time Parameters to Blood Pressure,” The International Conference on Health Informatics (IFMBE-ICHI2015), Haikou, China, 8-10 Oct. 2015, pp.169-173

6. Wan-Hua Lin^#, Dan Wu, Chunyue Li, Heye Zhang, and Yuan-Ting Zhang*, "Comparison of Heart Rate Variability from PPG with That from ECG," The International Conference on Health Informatics (IFMBE-ICHI2013), Vilamoura, Portugal, 7-9 Nov. 2013, pp. 213-215

7. Wan-Hua Lin^#, M. Y. M. Wong, Li-Na Pu, and Yuan-Ting Zhang*, “Comparison of Median Filter and Discrete Dyadic Wavelet Transform for ECG Noise Cancellation,” 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010), Buenos Aires, Argentina, 31 Aug.-4 Sep. 2010, pp.2395-2398

8. Ning Ji, Wan-Hua Lin, Yuanheng Li, Fei Chen, Lisheng Xu, and Guanglin Li, “A pilot study of thermal effect of low-intensity focused ultrasound on blood pressure modulation,” 43th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2021), Guadalajara, Mexico, 31 October-4 November, 2021, pp. 5690–5693

9. Ning Ji, Wan-Hua Lin, Wenyan Liu, Jianping Huang, Yuanheng Li, Oluwarotimi Williams Samuel, Lisheng Xu, and Guanglin Li. Central aortic pressure waveform estimation using genetic-algorithm-based multichannel blind system identification. 2019 Intelligent Rehabilitation and Human-machine Engineering Conference (IRHE), Qinhuangdao, China, 18-21 Nov. 2019, pp.1-4

10. Dan Wu^#, Huahua Xiong, Xiaohong Tian, Wan-Hua Lin, Chunyue Li, Heye Zhang*, and Yuan-Ting Zhang*. "The Relationship between the 24-h Blood Pressure Variability and Carotid Intima-Media Thickness: A Preliminary Study," The International Conference on Health Informatics (ICHI2013), Vilamoura, Portugal, 7-9 Nov. 2013, pp. 210-212

11. Ze Zhao^#, Wan-Hua Lin, Ping Yang, Yuan-Ting Zhang*, “Spectral and Coherence Analysis of the Variabilities of Heart Rate, Stroke Volume, and Systolic Blood Pressure in Exercise Stress Tests," Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2012), Hong Kong, China, 5-7 Jan. 2012, pp.771-774

Xiangni Lin, Master student

Jingxin Shi, Master student

Chunjie Yuan, Master student

(1) IOP Publishing "China High Cited Paper Award", 2021 

(2) Shenzhen High-level Professional Talent Reserve level talent, 2021 

(3) Martin Black Prize for Best Paper published in the jornal Physiological Measurement in 2020