梁璟  女  博导  中国科学院心理研究所
电子邮件: liangj@psych.ac.cn
通信地址: 北京朝阳区林萃路16号心理所
邮政编码: 100101

研究方向

认知功能相关的神经环路研究

认知功能的行为分析
利用啮齿类实验动物进行认知功能的行为研究。
认知功能的神经环路定位研究
利用转基因动物、电生理及影像学手段,研究认知功能障碍相关疾患的神经环路机制。

招生信息

招收博士研究生和硕士研究生。

招生专业
040220-医学心理学
招生方向
认知功能障碍的神经机制研究

教育背景

2002-09--2007-06   北京大学   博士
1997-09--2002-06   山西医科大学   学士
学历
研究生学历

学位
博士学位

工作经历

获得博士学位后,一直从事科研工作。

工作简历
2011-11~2013-11,美国斯坦福大学, 访问副教授
2011-04~现在, 中国科学院心理研究所, 副研究员
2007-07~2011-03,中国科学院心理研究所, 助理研究员

教授课程

   
功能神经解剖

为中国科学院大学任课老师,承担研究生的功能神经解剖学教学工作。

专利与奖励

   
奖励信息
(1) 中华医学科技奖, 三等奖, 国家级, 2013
(2) 北京大学科技创新奖, 一等奖, 研究所(学校), 2006
(3) 北京大学光华奖, 一等奖, 研究所(学校), 2004
(4) 北京大学神经科学研究所优秀奖, 一等奖, 专项, 2004

出版信息

   
发表论文
[1] 代中华, 徐星, 陈卫奇, 聂莉娜, 刘颖, 隋南, 梁璟. The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder. Current Addiction Reports[J]. 2022, [2] 尚文, 代中华, 张建军, 沈芳, 隋南, 梁璟. Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks. Dev Psychobiol[J]. 2022, [3] Mirmohammadali Mirramezani Alizamini, 陈星, 聂莉娜, 代中华, 刘颖, Abbas Haghparast, 张建军, 沈芳, 隋南, 梁璟. Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making. Progress in Neuro-Psychopharmacology & Biological Psychiatry[J]. 2022, [4] Mirmohammadali Mirramezani Alizamini, Li, Yonghui, Jian-Jun Zhang, 梁璟, Abbas Haghparast. Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse. World J Biol Psychiatry .[J]. 2022, [5] 刘颖, 刘超, 林青华, 张建军, 杜文洁, 梁璟, 隋南. 下丘脑黑皮质素及中脑多巴胺系统对奖赏行为的调控. 生物化学与生物物理进展[J]. 2021, 48(5): 541-549, https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2021&filename=SHSW202105007&uniplatform=NZKPT&v=_NF7n-lYJs-1uBLCAOYg2HXCV1pC_ZkYGAJlNYSdPkK0ju2WMUPokgk7x_HP1Bbb.
[6] Liu Ying, Liu Chao, Lin QingHua, Zhang JianJun, Du WenJie, Liang Jing, Sui Nan. Hypothalamic Melanocortin and Mesencephalic Dopamine Systems Regulate Reward-related Behaviors in Food Intake and Drug Use. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 48(5): 541-549, http://dx.doi.org/10.16476/j.pibb.2020.0281.
[7] Duan, Ying, Meng, Yiming, Du, Wenjie, Li, Ming, Zhang, Jianjun, Liang, Jing, Li, Yonghui, Sui, Nan, Shen, Fang. Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2. ADDICTION BIOLOGY[J]. 2021, 26(6): http://dx.doi.org/10.1111/adb.13053.
[8] Jiang, FengZe, Zheng, Wei, Wu, Chao, Li, Yonghui, Shen, Fang, Liang, Jing, Li, Ming, Zhang, JianJun, Sui, Nan. Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats. ADDICTION BIOLOGY[J]. 2020, 11-, [9] Zhang, JianJun, Jiang, FengZe, Zheng, Wei, Duan, Ying, Jin, ShuBo, Shen, Fang, Liang, Jing, Li, Ming, Sui, Nan. DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats. ADDICTION BIOLOGY[J]. 2020, 25(2): 12-, [10] Deng, Xiaofei, Gu, Lijia, Sui, Nan, Guo, Jianyou, Liang, Jing. Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(33): 16583-16592, http://dx.doi.org/10.1073/pnas.1819133116.
[11] Wang, Xingyue, Qiao, Yanhua, Dai, Zhonghua, Sui, Nan, Shen, Fang, Zhang, Jianjun, Liang, Jing. Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner. Brain Struct Funct[J]. 2019, 224(1): 419-434, http://dx.doi.org/10.1007/s00429-018-1780-4.
[12] Piao, Chengji, Liu, Tiane, Ma, Lian, Ding, Xuekun, Wang, Xingyue, Chen, Xing, Duan, Ying, Sui, Nan, Liang, Jing. Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats. PSYCHOPHARMACOLOGY[J]. 2017, 234(19): 2941-2953, http://dx.doi.org/10.1007/s00213-017-4689-3.
[13] Piao, Chengji, Deng, Xiaofei, Wang, Xingyue, Yuan, Yiran, Liu, Zhengkui, Liang, Jing. Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility. BEHAVIOURAL BRAIN RESEARCH[J]. 2017, 317: 16-26, http://dx.doi.org/10.1016/j.bbr.2016.09.017.
[14] Qiao Yanhua, Wang Xingyue, Ma Lian, Li Shengguang, Liang Jing. Functional inactivation of dorsal medial striatum alters behavioral flexibility and recognition process in mice. Physiology & Behavior[J]. 2017, 179: 467-477, http://dx.doi.org/10.1016/j.physbeh.2017.07.026.
[15] Tian, Yonglu, Yang, Chaojuan, Shang, Shujiang, Cai, Yijun, Deng, Xiaofei, Zhang, Jian, Shao, Feng, Zhu, Desheng, Liu, Yunbo, Chen, Guiquan, Liang, Jing, Sun, Qiang, Qiu, Zilong, Zhang, Chen. Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2017, 10: http://dx.doi.org/10.3389/fnmol.2017.00269.
[16] Liang, Jing, Xu, Wei, Hsu, Yutien, Yee, X Ada, Chen, Lu, Suedhof, C Thomas. Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. MOLECULAR PSYCHIATRY[J]. 2015, 20(7): 850-859, http://dx.doi.org/10.1038/mp.2015.31.
[17] Xing, Xiaoli, Wang, Hongbo, Zhang, Lili, Bai, Yunjing, Liang, Jing, Liu, Zhengkui, Zheng, Xigeng. Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague-Dawley rats. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR[J]. 2015, 133: 43-50, http://dx.doi.org/10.1016/j.pbb.2015.03.013.
[18] Ding, Xuekun, Qiao, Yanhua, Piao, Chengji, Zheng, Xigeng, Liu, Zhengkui, Liang, Jing. N-methyl-D-aspartate receptor-mediated glutamate transmission in nucleus accumbens plays a more important role than that in dorsal striatum in cognitive flexibility. FRONTIERS IN BEHAVIORAL NEUROSCIENCE[J]. 2014, 8: http://dx.doi.org/10.3389/fnbeh.2014.00304.
[19] Ding, Xuekun, Liang, Jing, Zheng, Xigeng, Bai, Yunjing, Liu, Zhengkui, Li, Yingying, Xing, Xiaoli. Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2013, 702(1-3): 294-301, http://dx.doi.org/10.1016/j.ejphar.2013.01.051.
[20] 梁璟. Dynamic changes of tyrosine hydroxylase and dopamine concentration in the VTA-NAc projection during the morphine-CPP expression in rats. Neurochemical Research. 2012, [21] Liang, Jing, Ma, Sisi, Li, Yijing, Ping, Xingjie, Hu, Ling, Cui, Cailian. Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats. NEUROCHEMICAL RESEARCH[J]. 2012, 37(7): 1482-1489, http://www.irgrid.ac.cn/handle/1471x/951953.
[22] Bai, Yunjing, Peng, Yonghua, Liang, Jing, Zheng, Xigeng. Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2012, 689(1-3): 118-124, http://dx.doi.org/10.1016/j.ejphar.2012.05.011.
[23] 梁璟. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens.. Neuropharmacology. 2011, [24] 梁璟. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects.. Chin Sci Bull.. 2011, [25] Liang, Jing, Chen, JiHuan, Chen, XiaoHong, Peng, YongHua, Zheng, Xigeng. Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment. BEHAVIOURAL BRAIN RESEARCH[J]. 2011, 216(1): 321-331, http://dx.doi.org/10.1016/j.bbr.2010.08.012.
[26] Liang, Jing, Zheng, Xigeng, Chen, Jihuan, Li, Yingying, Xing, Xiaoli, Bai, Yunjing, Li, Yingcong. Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization. EUROPEAN NEUROPSYCHOPHARMACOLOGY[J]. 2011, 21(11): 825-834, http://dx.doi.org/10.1016/j.euroneuro.2010.12.006.
[27] Li, Youhong, Zheng, Xigeng, Liang, Jing, Peng, Yuonghua. Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression. BEHAVIOURAL PROCESSES[J]. 2010, 83(3): 331-339, http://dx.doi.org/10.1016/j.beproc.2010.01.020.
[28] 梁璟. Effect of prolonged traumatic context exposure on conditioned fear response.. Chin J Behav Med and Brain Sci.. 2009, [29] 梁璟. Electroacupuncture of 2 Hz has a Rewarding Effect: Evidence from a Conditioned Place Preference Study in Rats.. Evid Based Complement Alternat Med.. 2008, [30] 梁璟. The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats.. Peptides. 2007, [31] Chen, JH, Liang, J, Wang, GB, Han, JS, Cui, CL. Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats. EXPERIMENTAL NEUROLOGY[J]. 2005, 194(2): 550-556, http://dx.doi.org/10.1016/j.expneurol.2005.04.001.

科研活动

   
科研项目
( 1 ) 纹状体神经元树突嵴结构及功能重塑在成瘾性用药导致的认知弹性损伤中的作用, 主持, 国家级, 2013-01--2016-12
( 2 ) 精神活性物质成瘾记忆的形成和消除, 参与, 国家级, 2015-01--2019-08
( 3 ) 自闭症症状相关的“皮层-基底神经节-丘脑-皮层”环路功能失常, 主持, 国家级, 2016-01--2019-12
( 4 ) 内侧前额叶皮层-伏隔核神经环路对于认知灵活性的调控作用, 主持, 省级, 2016-01--2018-12

指导学生

已指导学生

丁学坤  02  51792  

朴成姬  02  51792  

乔艳华  02  51792  

现指导学生

马莲  02  19046  

王星玥  02  19046