大脑高级认知功能的神经环路基础及基于非人灵长类的脑疾病模型构建与功能解析

   

071006-神经生物学

感知觉加工，注意，工作记忆，情绪调节的神经基础
面向非人灵长类的先进神经调控技术
非人灵长类脑疾病模型构建及功能解析

2003-09--2010-01   中国科学院生物物理研究所   博士
1999-09--2003-06   南京大学物理系   学士

   

2017-10~现在, 中国科学院深圳先进技术研究院, 副研究员，研究员
2014-10~2017-09,中国科学院心理研究所, 副研究员
2010-09~2014-09,Brown University, Postdoctoral Research Associate

2025-04-02-今,中国实验动物学会灵长类实验动物专业委员会委员,
2024-01-01-2027-12-31,《Zoological Research》编委,
2022-02-01-今,《The Innovation》青年编委,

现代神经科学研究方法和技术
现代神经科学研究方法与技术
神经生理

   

（1） 中国生命科学十大进展, 国家级, 2023
（2） 中国神经科学重大进展, 国家级, 2023
（3） 鹏城优才（金卡）, 市地级, 2022
（4） 深圳市海外高层次人才, , 市地级, 2018
（5） 深圳市南山区领航人才, 市地级, 2018
（6） 中国科学院青年创新促进会, 部委级, 2017

（ 1 ） 一种基于集成学习的跨物种ECoG信号解码方法、系统、终端及存储介质, 发明专利, 2025, 第 3 作者, 专利号: CN202510446433.8

（ 2 ） 一种基于改进扩散模型的局部场电位信号生成方法及系统, 发明专利, 2025, 第 5 作者, 专利号: CN202510427310.X

（ 3 ） 一种置于玻璃隔断上的触控膜任务训练装置, 实用新型, 2024, 第 2 作者, 专利号: ZL202322885130.5

（ 4 ） 具有经修饰的腺相关病毒(AAV)衣壳多肽的重组AAV, 发明专利, 2024, 第 4 作者, 专利号: CN202410376890.X

（ 5 ） 一种置于玻璃隔断上的触控膜任务训练装置, 发明专利, 2023, 第 2 作者, 专利号: CN202311399518.2

（ 6 ） 基于脉冲神经网络的机械手控制方法、机械手及存储介质, 发明专利, 2023, 第 3 作者, 专利号: CN116833995A

（ 7 ） 一种植入式电极推进及保护装置, 实用新型, 2023, 第 2 作者, 专利号: CN219699943U

（ 8 ） 一种植入式电极推进及保护装置, 发明专利, 2023, 第 2 作者, 专利号: CN115944301A

（ 9 ） 一种记录装置, 实用新型, 2022, 第 4 作者, 专利号: CN114224358A

（ 10 ） 一种用于动物大脑定位的装置, 实用新型, 2021, 第 1 作者, 专利号: CN213606340U

（ 11 ） 一种基于任务驱动下的自动奖励装置, 发明专利, 2021, 第 5 作者, 专利号: CN112293277A

（ 12 ） 一种果糖非酶电化学传感器及其检测方法, 专利授权, 2019, 第 9 作者, 专利号: CN110220956A

   

(*corresponding author; #co-first author)

5篇代表性论著：

1. Yefei Chen#, Zexuan Hong#, Jingyi Wang, Kunlin Liu, Jing Liu, Jianbang Lin, Shijing Feng, Tianhui Zhang, Liang Shan, Taian Liu, Pinyue Guo, Yunping Lin, Tian Li, Qian Chen, Xiaodan Jiang, Anan Li, Xiang Li, Yuantao Li, Jonathan Wilde, Jin Bao*, Ji Dai*, and Zhonghua Lu*. “Circuit-Specific Gene Therapy Reverses Core Symptoms in a Primate Parkinson’s Disease Model”, Cell, 2023, 186 (24): 5394-5410.e18. Doi: 10.1016/j.cell.2023.10.004.

2. Zhiting Zhang#, Liang Shan#, Yuyin Wang#, Wenfang Li, Minqing Jiang, Feng Liang, Shijing Feng, Zhonghua Lu, Hong Wang*, Ji Dai*. “Primate Preoptic Neurons Drive Hypothermia and Cold Defense”. The Innovation, 2023, 4:100358. Doi: 10.1016/j.xinn.2022.100358.

3. Li Wang#, Bo Zhang#, Xiqian Lu, Ruidi Wang, Jian Ma, Yujie Chen, Yuan Zhou, Ji Dai*, Yi Jiang*. “Genetic and Neuronal Basis for Facial Emotion Perception in Humans and Macaques”, National Science Review, 2024 11(11), nwae381. Doi: 10.1093/nsr/nwae381.

4. Liang Shan#,*, Hui Huang#, Zhiting Zhang, Yuyin Wang, Fei Gu, Mingwei Lu, Wen Zhou, Yi Jiang*, Ji Dai*, “Mapping the Emergence of Visual Consciousness in the Human Brain via Brain-wide Intracranial Electrophysiology”, The Innovation, 2022, 3:100243. Doi: 10.1016/j.xinn.2022.100243.

5. Xinhe Liu, Zhiting Zhang, Lu Gan, Panke Yu, Ji Dai*. “Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates”, Advanced Science, 2025, 12(16):e2412963. Doi: 10.1002/advs.202412963.

其他Peer-reviewed publications:

6. Yongjun Xu, Zezhi Shao, Xin Liu, et al., “AI for Science: Progress, Challenges, and Perspectives”, The Innovation, 2026:1011530. Doi: 10.1016/j.xinn.2026.101530

7. Liang Shan#*, Yuyin Wang*, Rui Wu, Yan Huang*, Ji Dai*, “Subconscious information elicits distinct metacognition following active decision-making”, Biomedical Signal Processing and Control, 2026, 123:110660. Doi: 10.1016/j.bspc.2026.110660

8. Jiang M#, Li R#, Yang X#, Ren Z#, Yang Z#, et al., “Behavioral phenotypes and neuronal biomarkers in F1 mutant macaque model of SHANK3-associated autism spectrum disorders”, Neuron, 2026. Doi: 10.1016/j.neuron.2026.04.018.

9. K Chen, S Fang, H Li*, B Li, J Dai, “More papers, fewer breakthroughs: Can AI reshape scientific discovery?”, The Innovation, 2026:101316. Doi: 10.1016/j.xinn.2026.101316

10. Jiao Zhang, Xiaojian Li*, Ji Dai*, “Electrochemical detection of oxytocin: challenges and prospects”, Neuroscience Bulletin, 2026, 42(5):1194-1198. Doi: 10.1007/s12264-026-01618-1.

11. Wu, Z.#, Wang, Y.#, Chen, W.W.#, Sun H.#, Chen X.#, et al., “Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution”, Cell, 2025, 188(8): 2159-2174. Doi: 10.1016/j.cell.2025.02.007.

12. Yongqi Hu, Bingjie Zhang, Zhengwei Hu, Xuemei Liu, Xiaojian Li*, and Ji Dai*. The Application of an Ultra-Thin, High-Density μECoG Array in Dissecting Caffeine-Induced Cortical Dynamics in Mice. Sensors, 2025(25): 7552. https://doi.org/10.3390/s25247552.

13. Yueqi Wang, Xinhe Liu, Zhiting Zhang, Panke Yu, Ming Yin*, Ji Dai*. “Mapping neuronal dynamics in the Thalamus underlying consciousness transition in macaques”, The Innovation Life, 2025, 3:100152. Doi: 10.59717/j.xinn-life.2025.100152

14. Yueqi Wang, Xinhe Liu, Zhiting Zhang, Ming Yin, Ji Dai*. “Protocol for machine learning-based classification of neuronal cell types from spike waveforms”, STAR Protocols, 2025, 6(4):104169. https://doi.org/10.1016/j.xpro.2025.104169.

15. Ling Li, Zhiting Zhang, Xinhe Liu, Mengni Zhou, Shenglin Wen*, Ji Dai*. “TAK-653 Reverses Core Depressive Symptoms in Chronic Stress-Induced Monkey Model”, Biomedicines, 2025, 13(6):1389. Doi:10.3390/biomedicines13061389.

16. Siyuan Bu#, Qingyun Wang#, Gaojia Zhang, Zhiting Zhang, Ji Dai*, Zhijun Zhang*. “Inflammation molecular network alterations in a depressive-like primate model”, Journal of Affective Disorders, 2025, 379:410-420. Doi: 10.1016/j.jad.2025.03.021

17. Lu Gan, Zhilin Zhang, Zhiting Zhang, Jinglong Wu*, Ji Dai*, Shintaro Funahashi*. “What Task Feature Determines the Dominant Task in Dual-Task Conditions?”, eNeuro, 2025, 12(3):ENEURO.0542-24.2025. Doi: 10.1523/ENEURO.0542-24.2025

18. Xinhe Liu, Zhiting Zhang, Ji Dai*. “Evaluating Pupillometry as a Tool for Assessing Facial and Emotional Processing in Nonhuman Primates”, Applied Science, 2025, 15(6):3022. Doi:10.3390/app15063022

19. Ji Dai#, Huiyu Xu#, Tao Chen#, et al., “Artificial intelligence for medicine 2025: Navigating the endless frontier”, The Innovation Medicine, 2025, 3: 100120. Doi: 10.59717/j.xinn-med.2025.100120

20. Haijun Wang#, Ji Dai#, Yuanzheng Cui, Peijun Zhang, Fang Wang*, Buxing Han*, Erik Jeppesen. “Shaping the future of academic conferences”, The Innovation, 2025, 6:100738. Doi: 10.1016/j.xinn.2024.100738.

21. Ling Li, Shenglin Wen*, Ji Dai*. “The Current State and Future Outlook of PET Tracers for AMPA Receptors”, Neuroscience Bulletin, 2025, 41(3):531-535. Doi: 10.1007/s12264-024-01332-w.

22. Ming Luo*, Wenyu Yang, Long Bai, et al. “Artificial intelligence for life sciences: A comprehensive guide and future trends”, The Innovation Life, 2024, 2:100105. 10.59717/j.xinn-life.2024.100105

23. Zhiting Zhang, Ji Dai*. “Fully implantable wireless brain-computer interface for humans: Advancing toward the future”, The Innovation, 2024, 5:100595. 10.1016/j.xinn.2024.100595

24. Yefei Chen#, Jingyi Wang#, Jing Liu#, Jianbang Lin, Yunping Lin, Jinyao Nie, Qi Yue, Chunshan Deng, Xiaofei Qi, Yuantao Li, Ji Dai*, Zhonghua Lu*. “A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys”, Neuroscience Bulletin, 2024, 40(1):90-102. 10.1007/s12264-023-01091-0

25. Ji Dai*. “Pursue the nature of science: Advocate for a better research environment”, The Innovation, 2024, 5:100686. 10.1016/j.xinn.2024.100686

26. Tiantian Li#, Tao Huang#, Ning Xiao#, Ji Dai*. “Innovative medicine and health management: A special session of The Innovation Conference 2024”, The Innovation Medicine, 2024, 2:100088. 10.59717/j.xinn-med.2024.100088

27. Xiayi Feng, Ding Gao, Juan Zhou, Zhu Gui, Aoling Cai, Jie Wang, Ji Dai, Yipeng Jing, Junchao Qian, Zongqiang Cui, Lanxiang Li, Yue You, Luyi Tian, Xian-En Zhang, Dong Men. “Viral capsid-mediated efficient cell labeling of micron-sized magnetic particles for highly sensitive long-term in vivo tumor cells MRI tracking”. Chemical Engineering Journal, 2024, 498: 155830.

28. Li M#, Guan M#, Lin J#, Zhu K#, Zhu J, Guo M, Li Y, Chen Y, Chen Y, Zou Y, Wu D, Xu J, Yi W, Fan Y, Ma S, Chen Y, Xu J, Yang L, Dai J, Ye T*, Lu Z*, Chen Y*. “Early blood immune molecular alterations in cynomolgus monkeys with a PSEN1 mutation causing familial Alzheimer's disease”, Alzheimer's & Dementia, 2024, 20(8):5492-5510. doi: 10.1002/alz.14046.

29. Jiao J#, Xu D#, Kong Y#*, Cao Y#, Wang L, Hong Y, Li L, Gao C, Liu J, Zhang G, Zhou J, Dai J, Lu Z, Liu Y, Wang Y*, Zhang Z*. “circFKBP8(5S,6)-encoded protein as a novel endogenous regulator in major depressive disorder by inhibiting glucocorticoid receptor nucleus translocation”, Science Bulletin, 2024, 69(24):3826-3831. doi: 10.1016/j.scib.2024.06.021.

30. Gaojia Zhang#, Ling Li#, Yan Kong#,*, Dandan Xu, Yu Bao, Zhiting Zhang, Zhixiang Liao, Jiao Jiao, Dandan Fan, Xiaojing Long, Ji Dai, Chunming Xie, Zhiqiang Meng*, Zhijun Zhang*. “Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder”, Genes & Disease, 2024, 11(2):1009-1021.

31. Liang Shan#, Liu Yuan#, Bo Zhang#, Jian Ma, Xiao Xu, Fei Gu, Yi Jiang*, Ji Dai*. “Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions”, Neuroscience Bulletin, 2023, 39(12):1749−1761. 10.1007/s12264-023-01043-8 (Cover article)

32. Jingyi Wang#, Jianbang Lin#, Yefei Chen#, Jing Liu, Qiongping Zheng, Mao Deng, Ruiqi Wang, Yujing Zhang, Shijing Feng, Zhenyan Xu, Weiyi Ye, Yu Hu, Jiamei Duan, Yunping Lin, Ji Dai, Yu Chen, Yuantao Li, Tao Luo, Qian Chen*, and Zhonghua Lu*. “An Ultra-Compact Promoter Drives Widespread Neuronal Expression in Mouse and Monkey Brains”, Cell Reports, 2023, 42:113348.

33. Panke Yu#, Zhiting Zhang#, Yuyin Wang, Ji Dai*. “Protocol for MRI-guided virus injection in macaque deep brain regions”, STAR Protocols, 2023, 4:102768. 10.1016/j.xpro.2023.102768

34. Chunshan Deng, Xiaojian Li, Ji Dai*. “Challenges for translating implantable brain-computer interface to medical device”, The Innovation Medicine, 2023, 1:100040. 10.59717/j.xinn-med.2023.100040

35. Xinhe Liu, Lu Gan, Zhiting Zhang, Panke Yu, Ji Dai*. “Probing the Processing of Facial Expression via Time Perception and Eye Tracking in Monkeys”, Zoological Research, 2023, 44(5):882-893. 10.24272/j.issn.2095-8137.2023.003

36. Ji Dai*, Xin Cao, Yong Han, Tianbin Song, Yuming Guo, Jie Qiao. “The Innovation Medicine: An international journal of medical science”, The Innovation Medicine, 2023, 1:100001. 10.59717/j.xinn-med.2023.100001

37. Ji Dai*, “Launching from Earth”, The Innovation, 2023, 4:100430. 10.1016/j.xinn.2023.100430

38. Ying Zhang#*, Dheeraj Roy#*, Yi Zhu, Yefei Chen, Tomomi Aida, Yuanyuan Hou, Chenjie Shen, Nicholas Lea, Margaret Schroeder, Keith Skaggs, Heather Sullivan, Kyle Fischer, Edward Callaway, Ian Wickersham, Ji Dai, Xiao-Ming Li, Zhonghua Lu, Guoping Feng*. “Targeting thalamic circuits rescues motor and mood deficits in PD mice”, Nature, 2022, 607: 321-329.

39. Lu Gan, Jinglong Wu, Ji Dai*, Shintaro Funahashi*. “The Mechanism for Allocating Limited Working Memory Resources in Multitasking”, Neuroscience Bulletin, 2022, 38(7):829-833. 10.1007/s12264-022-00853-6

40. Jiani Chen, Liang Shan, Ji Dai*. “Distinct Recovery Process of Consciousness and Cognition after Anesthesia”, Neuroscience Bulletin, 2022, 38(1): 110-112. 10.1007/s12264-021-00786-6

41. Yongjun Xu, Qi Wang, Zhulin An, et al., “Artificial Intelligence: A Powerful Paradigm for Scientific Research”. The Innovation, 2021, 2:100179.

42. Ji Dai*. “Gaining a Better Understanding of Nonhuman Primate Research”, Science Bulletin, 2021, 66(15):1499-1501. 10.1016/j.scib.2021.02.021

43. Yuxuan Yao, Ji Dai*. “Naturally Occurring Parkinson’s Disease Raises the Need for Nonhuman Primate in Neurodegenerative Diseases Research”, Neuroscience Bulletin, 2021, 37(8):1267-1269. 10.1007/s12264-021-00786-6

44. Tremblay S, Acker L, Afraz A, et al., “An Open Resource for Non-human Primate Optogenetics”. Neuron. 2020, 108(6):1075-1090.e6.

45. Chunshan Deng, Hong Yuan, Ji Dai*. “Behavioral Manipulation by Optogenetics in the Nonhuman Primate”, The Neuroscientist, 2018, 24(5): 526-539.

46. Ji Dai, Yi Wang. “Contrast coding in the primary visual cortex depends on temporal contexts”, European Journal of Neuroscience. 2018, 47(8): 947-58.

47. Bo Zhang, Ji Dai*, Tao Zhang. “NeoAnalysis: A Python-Based Toolbox for Quick Electrophysiological Data Processing and Analysis”. Biomedical Engineering Online. 2017, 16:129.

48. Ji Dai*, Tao Zhang. “The progress of optogenetic studies in nonhuman primates”, Progress in Biochemistry and Biophysics, 2016, 43(4): 354-360.

49. Ji Dai, Ilker Ozden, Daniel I. Brooks, Fabien Wagner, Travis May, Naubahar Agha, Benjamin Brush, David Borton, Arto V. Nurmikko, David L. Sheinberg “Modified toolbox for optogenetics in the nonhuman primate”, Neurophotonics, 2015, 2(3), 031202.

50. Ji Dai, Daniel I. Brooks, David L. Sheinberg. “Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates”. Current Biology, 2014 Jan 6;24(1):63-9.

51. Ji Dai and Yi Wang. “Representation of Surface Luminance and Contrast in Primary Visual Cortex”, Cerebral Cortex. 2012, 22(4):776-87.

已指导学生

袁宏  硕士研究生  040201-基础心理学  

陈鑫  硕士研究生  085211-计算机技术  

李文艺  硕士研究生  085404-计算机技术  

王钰茵  硕士研究生  086000-生物与医药  

袁柳  硕士研究生  086000-生物与医药  

俞潘可  硕士研究生  086000-生物与医药  

邱文灿  硕士研究生  085409-生物医学工程  

现指导学生

朱孝苍  博士研究生  071006-神经生物学  

胡永琪  硕士研究生  086000-生物与医药  

马海燕  硕士研究生  085409-生物医学工程  

卢钰媛  硕士研究生  086000-生物与医药