大脑高级认知功能的神经环路基础及基于非人灵长类的脑疾病模型构建与功能解析

   

071006-神经生物学

感知觉加工，注意，工作记忆，情绪调节的神经基础
面向非人灵长类的先进神经调控技术
非人灵长类脑疾病模型构建及功能解析

2003-09--2010-01   中国科学院生物物理研究所   博士
1999-09--2003-06   南京大学物理系   学士

   

2017-10~现在, 中国科学院深圳先进技术研究院, 副研究员（PI）
2014-10~2017-09,中国科学院心理研究所, 副研究员
2010-09~2014-09,Brown University, Postdoctoral Research Associate

2024-01-01-2027-12-31,《Zoological Research》编委,

现代神经科学研究方法和技术
现代神经科学研究方法与技术
神经生理

   

（1） 中国生命科学十大进展, 国家级, 2023
（2） 中国神经科学重大进展, 国家级, 2023
（3） 深圳市海外高层次人才, , 市地级, 2018
（4） 深圳市南山区领航人才, 市地级, 2018
（5） 中国科学院青年创新促进会, 部委级, 2017

（ 1 ） 一种植入式电极推进及保护装置, 发明专利, 2023, 第 2 作者, 专利号: CN115944301A

（ 2 ） 一种记录装置, 实用新型, 2022, 第 4 作者, 专利号: CN114224358A

（ 3 ） 一种用于动物大脑定位的装置, 实用新型, 2021, 第 1 作者, 专利号: CN213606340U

（ 4 ） 一种基于任务驱动下的自动奖励装置, 发明专利, 2021, 第 5 作者, 专利号: CN112293277A

（ 5 ） 一种果糖非酶电化学传感器及其检测方法, 专利授权, 2019, 第 9 作者, 专利号: CN110220956A

   

1.        Yefei Chen^#, Jingyi Wang^#, Jing Liu^#, Jianbang Lin, Yunping Lin, Jinyao Nie, Qi Yue, Chunshan Deng, Xiaofei Qi, Yuantao Li, Ji Dai^*, Zhonghua Lu^*. “A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys”, Neuroscience Bulletin, 2024, 40(1):90-102.

2.        Zhiting Zhang, Ji Dai*. “Fully implantable wireless brain-computer interface for humans: Advancing toward the future”, The Innovation, 2024, 5:100595.

3.        Gaojia Zhang^#, Ling Li^#, Yan Kong^#,*, Dandan Xu, Yu Bao, Zhiting Zhang, Zhixiang Liao, Jiao Jiao, Dandan Fan, Xiaojing Long, Ji Dai, Chunming Xie, Zhiqiang Meng^*, Zhijun Zhang^*. “Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder”, Genes & Disease, 2024, 11(2):1009-1021.

4.        Yefei Chen^#, Zexuan Hong^#, Jingyi Wang, Kunlin Liu, Jing Liu, Jianbang Lin, Shijing Feng, Tianhui Zhang, Liang Shan, Taian Liu, Pinyue Guo, Yunping Lin, Tian Li, Qian Chen, Xiaodan Jiang, Anan Li, Xiang Li, Yuantao Li, Jonathan Wilde, Jin Bao^*, Ji Dai^*, and Zhonghua Lu^*. “Circuit-Specific Gene Therapy Reverses Core Symptoms in a Primate Parkinson’s Disease Model”, Cell, 2023, 186 (24): 5394-5410.e18.

5.        Jingyi Wang^#, Jianbang Lin^#, Yefei Chen^#, Jing Liu, Qiongping Zheng, Mao Deng, Ruiqi Wang, Yujing Zhang, Shijing Feng, Zhenyan Xu, Weiyi Ye, Yu Hu, Jiamei Duan, Yunping Lin, Ji Dai, Yu Chen, Yuantao Li, Tao Luo, Qian Chen^*, and Zhonghua Lu*. “An Ultra-Compact Promoter Drives Widespread Neuronal Expression in Mouse and Monkey Brains”, Cell Reports, 2023, 42:113348.

6.        Panke Yu^#, Zhiting Zhang^#, Yuyin Wang, Ji Dai*. “Protocol for MRI-guided virus injection in macaque deep brain regions”, STAR Protocols, 2023, 4:102768.

7.        Chunshan Deng, Xiaojian Li, Ji Dai*. “Challenges for translating implantable brain-computer interface to medical device”, The Innovation Medicine, 2023, 1:100040.

8.        Xinhe Liu, Lu Gan, Zhiting Zhang, Panke Yu, Ji Dai^*. “Probing the Processing of Facial Expression via Time Perception and Eye Tracking in Monkeys”, Zoological Research, 2023, 44(5):882-893.

9.        Ji Dai^*, Xin Cao, Yong Han, Tianbin Song, Yuming Guo, Jie Qiao. “The Innovation Medicine: An international journal of medical science”, The Innovation Medicine, 2023, 1:100001.

10.    Ji Dai^*, “Launching from Earth”, The Innovation, 2023, 4:100430.

11.    Liang Shan^#, Liu Yuan^#, Bo Zhang^#, Jian Ma, Xiao Xu, Fei Gu, Yi Jiang^*, Ji Dai^*. “Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions”, Neuroscience Bulletin, 2023, 39(12):1749−1761.(Cover article)

12.    Zhiting Zhang^#, Liang Shan^#, Yuyin Wang^#, Wenfang Li, Minqing Jiang, Feng Liang, Shijing Feng, Zhonghua Lu, Hong Wang^*, Ji Dai^*. “Primate Preoptic Neurons Drive Hypothermia and Cold Defense”. The Innovation, 2023, 4:100358. 

13.    Liang Shan^#,*, Hui Huang^#, Zhiting Zhang, Yuyin Wang, Fei Gu, Mingwei Lu, Wen Zhou, Yi Jiang^*, Ji Dai^*, “Mapping the Emergence of Visual Consciousness in the Human Brain via Brain-wide Intracranial Electrophysiology”, The Innovation, 2022, 3:100243. 

14.    Ying Zhang^#*, Dheeraj Roy^#*, Yi Zhu, Yefei Chen, Tomomi Aida, Yuanyuan Hou, Chenjie Shen, Nicholas Lea, Margaret Schroeder, Keith Skaggs, Heather Sullivan, Kyle Fischer, Edward Callaway, Ian Wickersham, Ji Dai, Xiao-Ming Li, Zhonghua Lu, Guoping Feng^*. “Targeting thalamic circuits rescues motor and mood deficits in PD mice”, Nature, 2022, 607: 321-329.

15.    Lu Gan, Jinglong Wu, Ji Dai^*, Shintaro Funahashi^*. “The Mechanism for Allocating Limited Working Memory Resources in Multitasking”, Neuroscience Bulletin, 2022, 38(7):829-833.

16.    Jiani Chen, Liang Shan, Ji Dai^*. “Distinct Recovery Process of Consciousness and Cognition after Anesthesia”, Neuroscience Bulletin, 2022, 38(1): 110-112.

17.    Yongjun Xu, Qi Wang, Zhulin An, et al., “Artificial Intelligence: A Powerful Paradigm for Scientific Research”. The Innovation, 2021, 2:100179.

18.    Ji Dai^*. “Gaining a Better Understanding of Nonhuman Primate Research”, Science Bulletin, 2021, 66(15):1499-1501.

19.    Yuxuan Yao, Ji Dai^*. “Naturally Occurring Parkinson’s Disease Raises the Need for Nonhuman Primate in Neurodegenerative Diseases Research”, Neuroscience Bulletin, 2021, 37(8):1267-1269.

20.    Tremblay S, Acker L, Afraz A, et al., “An Open Resource for Non-human Primate Optogenetics”. Neuron. 2020, 108(6):1075-1090.e6.

21.    Chunshan Deng, Hong Yuan, Ji Dai^*. “Behavioral Manipulation by Optogenetics in the Nonhuman Primate”, The Neuroscientist, 2018, 24(5): 526-539.

22.    Ji Dai, Yi Wang. “Contrast coding in the primary visual cortex depends on temporal contexts”, European Journal of Neuroscience. 2018, 47(8): 947-58.

23.    Bo Zhang, Ji Dai^*, Tao Zhang. “NeoAnalysis: A Python-Based Toolbox for Quick Electrophysiological Data Processing and Analysis”. Biomedical Engineering Online. 2017, 16:129.

24.    Ji Dai^*, Tao Zhang. “The progress of optogenetic studies in nonhuman primates”, Progress in Biochemistry and Biophysics, 2016, 43(4): 354-360.

25.    Ji Dai, Ilker Ozden, Daniel I. Brooks, Fabien Wagner, Travis May, Naubahar Agha, Benjamin Brush, David Borton, Arto V. Nurmikko, David L. Sheinberg “Modified toolbox for optogenetics in the nonhuman primate”, Neurophotonics, 2015, 2(3), 031202.

26.    Ji Dai, Daniel I. Brooks, David L. Sheinberg. “Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates”. Current Biology, 2014 Jan 6;24(1):63-9.

27.    Ji Dai and Yi Wang. “Representation of Surface Luminance and Contrast in Primary Visual Cortex”, Cerebral Cortex. 2012, 22(4):776-87.

 

（ 1 ） 猕猴下丘脑亚区介导的体温调控新策略研究, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 面孔情绪在猕猴杏仁核的神经表征, 负责人, 地方任务, 2022-01--2024-12
（ 3 ） 深圳市灵长类转化医学工程研究中心组建项目, 负责人, 地方任务, 2021-10--2024-09
（ 4 ） 前额叶在多任务整合中的神经环路机制, 参与, 国家任务, 2021-01--2024-12
（ 5 ） 面向太空环境的体温调控机理的研究, 参与, 地方任务, 2020-10--2023-09
（ 6 ） 灵长类亚细胞分辨率高速三维显微成像系统, 参与, 地方任务, 2019-10--2022-09
（ 7 ） 基于逆向病毒的光遗传技术在猕猴注意机制研究中的作用, 参与, 地方任务, 2019-10--2022-09
（ 8 ） 基于高通量植入式微电极阵列的脑活动信息获取技术, 参与, 国家任务, 2019-08--2021-07
（ 9 ） 面向非人灵长类的新式研究技术和方法, 负责人, 研究所自主部署, 2018-11--2020-11
（ 10 ） 神经信号检测和调控新技术, 参与, 中国科学院计划, 2018-01--2022-12
（ 11 ） 利用光遗传技术研究猕猴额-顶通路在注意调控中的作用, 负责人, 国家任务, 2017-01--2019-12
（ 12 ） 中国科学院青年创新促进会会员经费, 负责人, 中国科学院计划, 2017-01--2020-12
（ 13 ） 侧内顶叶至上丘神经通路对注意缺失症的调节作用, 负责人, 中国科学院计划, 2015-10--2017-10
（ 14 ） 转基因灵长类动物模型脑疾病研究平台, 参与, 地方任务, 2015-09--2020-12

已指导学生

袁宏  硕士研究生  040201-基础心理学  

陈鑫  硕士研究生  085211-计算机技术  

李文艺  硕士研究生  085404-计算机技术  

王钰茵  硕士研究生  086000-生物与医药  

袁柳  硕士研究生  086000-生物与医药  

现指导学生

俞潘可  硕士研究生  086000-生物与医药  

吴圣栋  硕士研究生  085404-计算机技术