基本信息
齐建勋  男  博导  中国科学院微生物研究所
电子邮件: jxqi@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码:

研究领域

采用结构生物学方法解析病原微生物侵入宿主的分子机制。基于病原与宿主的互作机制,进一步开展病原微生物防控研究,具体包括如下三个个方面:

1.基于病原优势表位设计纳米颗粒亚单位疫苗(nano-paiticle vaccine),来预防病原微生物的侵入;

2.基于已有抗原优势表位信息设计特异性抗体,来阻断病原微生物的侵入;

3.基于病原生命周期中关键酶设计小分子抑制剂,来阻断病原的生命周期,进而开发成高效阻断病原的抑制剂。

招生信息

每年招收一名硕士研究生和一名博士研究生。

招生专业
100103-病原生物学
071011-生物物理学
招生方向
病原微生物侵入宿主细胞的分子机制研究
基于优势表位的疫苗设计
抑制剂设计

教育背景

2004-09--2008-07   中国科学院物理研究所   研究生学历博士学位

工作经历

   
工作简历
2016-08~现在, 中国科学院微生物研究所, 研究员
2011-08~2016-06,中国科学院微生物研究所, 副研究员
2008-07~2011-08,中国科学院微生物研究所, 助理研究员
社会兼职
2022-07-01-今,中国生物化学与分子生物学学会蛋白质分会, 委员
2020-10-24-今,中国性病艾滋病防治协会, 委员

教授课程

结构生物学与医学研究
结构生物学在医学中的应用

专利与奖励

   
奖励信息
(1) Clarivate Highly Cited Researcher 2023, , 其他, 2023
(2) 全球前2%顶尖科学家榜单(World's Top 2% Scientists), , 其他, 2023
(3) Clarivate Highly Cited Researcher 2022, 其他, 2022
(4) Clarivate Highly Cited Researcher 2021, 其他, 2021
(5) 中华预防医学会科学技术奖, 一等奖, 部委级, 2017
(6) 北京市科学技术奖, 一等奖, 省级, 2011
专利成果
[1] 一种呼吸道合胞病毒抗原制备方法和应用. 2023-05-12.

[2] 一种呼吸道合胞病毒二价抗原制备方法和应用. 2023-10-12.

[3] 苏宝玲, 施一, 高福, 齐建勋, 赵学金, 王寒. 3-AP在制备抑制应病毒的药物中的应用. 202211439204.6, 2023-11-17.

[4] 高福, 王奇慧, 戴连攀, 杜沛, 齐建勋, 徐坤, 马雪慧. 新冠病毒三聚体嵌合疫苗及其用途. CN: CN115947872A, 2023-04-11.

[5] 高福, 王奇慧, 戴连攀, 杜沛, 齐建勋, 徐坤, 马雪慧. 新冠病毒三聚体嵌合疫苗及其用途. CN: CN115197331A, 2022-10-18.

[6] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种高效中和新型冠状病毒的人源抗体及其应用. CN: CN114395034A, 2022-04-26.

[7] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种新型冠状病毒稀有广谱表位的人源抗体及其应用. CN: CN114456264A, 2022-05-10.

[8] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种新型冠状病毒稀有广谱表位的人源抗体及其应用. CN: CN114456264A, 2022-05-10.

[9] 高福, 齐建勋, 傅立峰. 一种氮杂双环[3.1.0]己烷衍生物及其制备方法和用途. CN: CN115433256A, 2022-12-06.

[10] 高福, 齐建勋, 谭文杰, 傅立峰, 叶飞, 李学兵, 冯永. 博赛泼维在治疗或改善新型冠状病毒肺炎中的应用. CN: CN113143918A, 2021-07-23.

[11] 高福, 谭文杰, 齐建勋, 傅立峰, 叶飞, 李学兵, 冯永. GC376化合物的新用途. CN: CN113143917A, 2021-07-23.

[12] 严景华, 史瑞, 王奇慧, 齐建勋, 高福. 与新型冠状病毒的抗体有效结合的表位. CN: CN113527444A, 2021-10-22.

[13] 高福, 严景华, 李燕, 逯光文, 齐建勋. 一种中东呼吸综合征冠状病毒抗体及其制备方法. CN: CN103864924A, 2014-06-18.

出版信息

   
发表论文
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[2] Du, Shouwen, Peng, Ruchao, Xu, Wang, Qu, Xiaoyun, Wang, Yuhang, Wang, Jiamin, Li, Letian, Tian, Mingyao, Guan, Yudong, Wang, Jigang, Wang, Guoqing, Li, Hao, Deng, Lingcong, Shi, Xiaoshuang, Ma, Yidan, Liu, Fengting, Sun, Minhua, Wei, Zhengkai, Jin, Ningyi, Liu, Wei, Qi, Jianxun, Liu, Quan, Liao, Ming, Li, Chang. Cryo-EM structure of severe fever with thrombocytopenia syndrome virus. NATURE COMMUNICATIONS[J]. 2023, 第 21 作者  通讯作者  14(1): http://dx.doi.org/10.1038/s41467-023-41804-7.
[3] Zhao, Zhennan, Huang, Youhua, Liu, Congcong, Zhu, Dongjie, Gao, Shuaixin, Liu, Sheng, Peng, Ruchao, Zhang, Ya, Huang, Xiaohong, Qi, Jianxun, Wong, Catherine C L, Zhang, Xinzheng, Wang, Peiyi, Qin, Qiwei, Gao, George F. Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly. NATURE COMMUNICATIONS[J]. 2023, 第 10 作者  通讯作者  14(1): http://dx.doi.org/10.1038/s41467-023-37681-9.
[4] Wang, Qing, Meng, Fanhao, Xie, Yuting, Wang, Wei, Meng, Yumin, Li, Linjie, Liu, Tao, Qi, Jianxun, Ni, Xiaodan, Zheng, Sanduo, Huang, Jianhui, Huang, Niu. In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein. ACS CENTRAL SCIENCE. 2023, 第 8 作者http://dx.doi.org/10.1021/acscentsci.2c01190.
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[13] Sun, Qinglan, Shu, Chang, Shi, Wenyu, Luo, Yingfeng, Fan, Guomei, Nie, Jingyi, Bi, Yuhai, Wang, Qihui, Qi, Jianxun, Lu, Jian, Zhou, Yuanchun, Shen, Zhihong, Meng, Zhen, Zhang, Xinjiao, Yu, Zhengfei, Gao, Shenghan, Wu, Linhuan, Ma, Juncai, Hu, Songnian. VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomes. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 9 作者50(D1): D888-D897, http://dx.doi.org/10.1093/nar/gkab921.
[14] Li, Linghui, Chai, Yan, Peng, Weiyu, Li, Delin, Sun, Litao, Gao, George Fu, Qi, Jianxun, Xiao, Haixia, Liu, William Jun, von Itzstein, Mark, Gao, Feng. Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 第 7 作者119(42): http://dx.doi.org/10.1073/pnas.2210724119.
[15] Wang, Qingling, Yang, Qian, Liu, Congcong, Wang, Guoqing, Song, Hao, Shang, Guijun, Peng, Ruchao, Qu, Xiao, Liu, Sheng, Cui, Yingzi, Wang, Peiyi, Xu, Wenbo, Zhao, Xin, Qi, Jianxun, Yang, Mengsu, Gao, George F. Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 第 14 作者119(4): http://dx.doi.org/10.1073/pnas.2118590119.
[16] Linjie Li, Hanyi Liao, Yumin Meng, Weiwei Li, Pengcheng Han, Kefang Liu, Qing Wang, Dedong Li, Yanfang Zhang, Liang Wang, Zheng Fan, Yuqin Zhang, Qiyue Wang, Xin Zhao, Yeping Sun, Niu Huang, Jianxun Qi, George Fu Gao. Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1. CELL. 2022, 第 17 作者185(16): 2952-2960.e10, http://dx.doi.org/10.1016/j.cell.2022.06.023.
[17] Su, Chao, He, Juanhua, Han, Pengcheng, Bai, Bin, Li, Dedong, Cao, Jian, Tian, Mingxiong, Hu, Yu, Zheng, Anqi, Niu, Sheng, Chen, Qian, Rong, Xiaoyu, Zhang, Yanfang, Li, Weiwei, Qi, Jianxun, Zhao, Xin, Yang, Mengsu, Wang, Qihui, Gao, George Fu. Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants. JOURNAL OF VIROLOGY[J]. 2022, 第 15 作者96(17): http://dx.doi.org/10.1128/jvi.00814-22.
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[19] Huang, Min, Wu, Lili, Zheng, Anqi, Xie, Yufeng, He, Qingwen, Rong, Xiaoyu, Han, Pu, Du, Pei, Han, Pengcheng, Zhang, Zengyuan, Zhao, Runchu, Jia, Yunfei, Li, Linjie, Bai, Bin, Hu, Ziliang, Hu, Shixiong, Niu, Sheng, Hu, Yu, Liu, Honghui, Liu, Bo, Cui, Kaige, Li, Weiwei, Zhao, Xin, Liu, Kefang, Qi, Jianxun, Wang, Qihui, Gao, George Fu. Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3. IMMUNITY[J]. 2022, 第 25 作者  通讯作者  55(8): 1501-+, http://dx.doi.org/10.1016/j.immuni.2022.06.005.
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[21] Xu, Zepeng, Kang, Xinrui, Han, Pu, Du, Pei, Li, Linjie, Zheng, Anqi, Deng, Chuxia, Qi, Jianxun, Zhao, Xin, Wang, Qihui, Liu, Kefang, Gao, George Fu. Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses. NATURE COMMUNICATIONS[J]. 2022, 第 8 作者13(1): https://doaj.org/article/b2d7bd70a2634ce28943fb8ccea2bf04.
[22] Yuan, Bin, Peng, Qi, Cheng, Jinlong, Wang, Min, Zhong, Jin, Qi, Jianxun, Gao, George F, Shi, Yi. Structure of the Ebola virus polymerase complex. NATURE[J]. 2022, 第 6 作者610(7931): 394-+, http://dx.doi.org/10.1038/s41586-022-05271-2.
[23] Zhennan Zhao, Jingya Zhou, Mingxiong Tian, Min Huang, Sheng Liu, Yufeng Xie, Pu Han, Chongzhi Bai, Pengcheng Han, Anqi Zheng, Lutang Fu, Yuanzhu Gao, Qi Peng, Ying Li, Yan Chai, Zengyuan Zhang, Xin Zhao, Hao Song, Jianxun Qi, Qihui Wang, Peiyi Wang, George F Gao. Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. NATURE COMMUNICATIONS[J]. 2022, 第 19 作者  通讯作者  13(1): 1-12, https://doaj.org/article/90e8f270726e4bf38984d7f2e5f9e902.
[24] Chen, Yulu, Wang, Fei, Qi, Jianxun. Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nature Communications[J]. 2022, 第 3 作者  通讯作者  13(1): 7603, 
[25] 王奇慧, 齐建勋, 严景华, 高福. 平急一体化传染病防控平台在新冠肺炎疫情中的应用. 中国科学基金[J]. 2022, 第 2 作者36(4): 603-609, http://lib.cqvip.com/Qikan/Article/Detail?id=7108136608.
[26] Zhang, Di, Liu, Kefang, Lu, Dan, Wang, Pengyan, Zhang, Qingxu, Liu, Peipei, Zhao, Yingze, Chai, Yan, Lyu, Jianxin, Qi, Jianxun, Liu, William J. Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous beta 2-Microglobulin. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS[J]. 2021, 第 10 作者  通讯作者  http://dx.doi.org/10.3791/61462.
[27] Qi Peng, Ruchao Peng, Bin Yuan, Min Wang, Jingru Zhao, Lifeng Fu, Jianxun Qi, Yi Shi. Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir. 创新(英文)[J]. 2021, 第 7 作者2(1): 100080-172, http://lib.cqvip.com/Qikan/Article/Detail?id=7104965056.
[28] Niu, Sheng, Wang, Jia, Bai, Bin, Wu, Lili, Zheng, Anqi, Chen, Qian, Du, Pei, Han, Pengcheng, Zhang, Yanfang, Jia, Yunfei, Qiao, Chengpeng, Qi, Jianxun, Tian, Wenxia, Wang, HongWei, Wang, Qihui, Gao, George Fu. Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. EMBO JOURNAL[J]. 2021, 第 12 作者40(16): http://dx.doi.org/10.15252/embj.2021107786.
[29] Zhang, Zengyuan, Zhang, Yanfang, Liu, Kefang, Li, Yan, Lu, Qiong, Wang, Qingling, Zhang, Yuqin, Wang, Liang, Liao, Hanyi, Zheng, Anqi, Ma, Sufang, Fan, Zheng, Li, Huifang, Huang, Weijin, Bi, Yuhai, Zhao, Xin, Wang, Qihui, Gao, George F, Xiao, Haixia, Tong, Zhou, Qi, Jianxun, Sun, Yeping. The molecular basis for SARS-CoV-2 binding to dog ACE2. NATURE COMMUNICATIONS[J]. 2021, 第 21 作者  通讯作者  12(1): http://dx.doi.org/10.1038/s41467-021-24326-y.
[30] Xie, Yijia, Li, Xin, Chai, Yan, Song, Hao, Qi, Jianxun, Gao, George F. Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1. CELL REPORTS[J]. 2021, 第 5 作者  通讯作者  36(8): http://dx.doi.org/10.1016/j.celrep.2021.109600.
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[32] Zhao, Min, Fu, Lijun, Chai, Yan, Sun, Meng, Li, Yan, Wang, Shuo, Qi, Jianxun, Zeng, Bin, Kang, Le, Gao, George F, Tan, Shuguang. Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation. CELL REPORTS[J]. 2021, 第 7 作者36(12): http://dx.doi.org/10.1016/j.celrep.2021.109734.
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[187] 陈竹君, 逯光文, 齐建勋, 许翔, 张娜, 严景华, 王荣富. Ⅱ型单纯疱疹病毒糖蛋白D的晶体结构解析. 生物工程学报[J]. 2011, 第 3 作者27(10): 1499-1506, http://lib.cqvip.com/Qikan/Article/Detail?id=39746661.
[188] Shi, Yi, Qi, Jianxun, Iwamoto, Aikichi, Gao, George F. Plasticity of human CD8 alpha alpha binding to peptide-HLA-A*2402. MOLECULARIMMUNOLOGY[J]. 2011, 第 2 作者48(15-16): 2198-2202, https://www.webofscience.com/wos/woscc/full-record/WOS:000295395300054.
[189] Chen, Rong, Qi, Jianxun, Yao, Shugang, Pan, Xiaocheng, Gao, Feng, Xia, Chun. Expression, crystallization and preliminary crystallographic analysis of C-reactive protein from zebrafish. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 第 2 作者67: 1633-1636, http://dx.doi.org/10.1107/S1744309111037390.
[190] Chen Zhujun, Lu Guangwen, Qi Jianxun, Xiang Xu, Zhang Na, Yan Jinghua, Wang Rongfu. X-ray diffraction analysis of glycoprotein D from Herpes simplex virus type 2. CHINESE JOURNAL OF BIOTECHNOLOGY[J]. 2011, 第 3 作者27(10): 1499-1506, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4348133&detailType=1.
[191] Zhao, Yueju, Zhang, Yunhua, Cao, Yang, Qi, Jianxun, Mao, Liangwei, Xue, Yanfen, Gao, Feng, Peng, Hao, Wang, Xiaowei, Gao, George F, Ma, Yanhe. Structural Analysis of Alkaline beta-Mannanase from Alkaliphilic Bacillus sp N16-5: Implications for Adaptation to Alkaline Conditions. PLOS ONE[J]. 2011, 第 4 作者6(1): http://dx.doi.org/10.1371/journal.pone.0014608.
[192] Wang, Mingyang, Qi, Jianxun, Liu, Yue, Vavricka, Christopher J, Wu, Yan, Li, Qing, Gao, George F. Influenza A Virus N5 Neuraminidase Has an Extended 150-Cavity. JOURNAL OF VIROLOGY[J]. 2011, 第 2 作者85(16): 8431-8435, http://dx.doi.org/10.1128/JVI.00638-11.
[193] VAVRICKA Christopher John, LIU Yue, LI Qing, SHI Yi, WU Yan, SUN YePing, QI JianXun, GAO George Fu. Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase. 中国科学通报:英文版[J]. 2011, 第 7 作者56(17): 1747-1752, http://lib.cqvip.com/Qikan/Article/Detail?id=38025742.
[194] QiJianXunJiangFan. The balance of flexibility and rigidity in the active site residues of hen egg white lysozyme. Chinese Physics B[J]. 2011, 20(5): 58701-058701, https://cpb.iphy.ac.cn/EN/10.1088/1674-1056/20/5/058701.
[195] Lu, Guangwen, Qi, Jianxun, Chen, Zhujun, Xu, Xiang, Gao, Feng, Lin, Daizong, Qian, Wangke, Liu, Hong, Jiang, Hualiang, Yan, Jinghua, Gao, George F. Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. JOURNAL OF VIROLOGY[J]. 2011, 第 2 作者85(19): 10319-10331, http://www.irgrid.ac.cn/handle/1471x/757510.
[196] Zhang, Nianzhi, Qi, Jianxun, Feng, Sijia, Gao, Feng, Liu, Jun, Pan, Xiaocheng, Chen, Rong, Li, Qirun, Chen, Zhaosan, Li, Xiaoying, Xia, Chun, Gao, George F. Crystal Structure of Swine Major Histocompatibility Complex Class I SLA-1*0401 and Identification of 2009 Pandemic Swine-Origin Influenza A H1N1 Virus Cytotoxic T Lymphocyte Epitope Peptides. JOURNAL OF VIROLOGY[J]. 2011, 第 2 作者85(22): 11709-11724, http://dx.doi.org/10.1128/JVI.05040-11.
[197] Myongchol Ryu, Yong Chen, Jianxun Qi, Jun Liu, Zheng Fan, Gol Nam, Yi Shi, Hao Cheng, George F Gao. LILRA3 Binds Both Classical and Non-Classical HLA Class I Molecules but with Reduced Affinities Compared to LILRB1/LILRB2: Structural Evidence. PLOS ONE[J]. 2011, 第 3 作者6(4): https://doaj.org/article/771283f228424e01bb492484c8ea81d9.
[198] Fan, Zheng, Qi, Jianxun, Shi, Yawei, Liu, Yiwei. Crystallization and preliminary X-ray diffraction analysis of cyclic imide hydrolase (CIH) from Pseudomonas putida YZ-26. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 第 2 作者67: 521-523, https://www.webofscience.com/wos/woscc/full-record/WOS:000289738400026.
[199] 刘军, 齐建勋, 高福, 严景华, 高福. T细胞功能学与结构免疫学结合方法鉴定HLA-A2限制性的细胞毒性T淋巴细胞表位富集区. 科技导报[J]. 2011, 第 2 作者29(27): 19-26, http://lib.cqvip.com/Qikan/Article/Detail?id=39427917.
[200] Li, Xin, Liu, Jun, Qi, Jianxun, Gao, Feng, Li, Qirun, Li, Xiaoying, Zhang, Nianzhi, Xia, Chun, Gao, George F. Two Distinct Conformations of a Rinderpest Virus Epitope Presented by Bovine Major Histocompatibility Complex Class I N*01801: a Host Strategy To Present Featured Peptides. JOURNAL OF VIROLOGY[J]. 2011, 第 3 作者85(12): 6038-6048, http://dx.doi.org/10.1128/JVI.00030-11.
[201] Vavricka, Christopher John, Liu Yue, Li Qing, Shi Yi, Wu Yan, Sun YePing, Qi JianXun, Gao, George Fu. Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase. CHINESE SCIENCE BULLETIN[J]. 2011, 第 7 作者56(17): 1747-1752, http://lib.cqvip.com/Qikan/Article/Detail?id=38025742.
[202] Zheng, Beiwen, Zhang, Qiangmin, Gao, Jia, Han, Huiming, Li, Ming, Zhang, Jingren, Qi, Jianxun, Yan, Jinghua, Gao, George F. Insight into the Interaction of Metal Ions with TroA from Streptococcus suis. PLOS ONE[J]. 2011, 第 7 作者6(5): http://dx.doi.org/10.1371/journal.pone.0019510.
[203] Zhang, Shihong, Liu, Jun, Cheng, Hao, Tan, Shuguang, Qi, Jianxun, Yan, Jinghua, Gao, George F. Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes. MOLECULAR IMMUNOLOGY[J]. 2011, 第 5 作者49(1-2): 395-401, http://dx.doi.org/10.1016/j.molimm.2011.08.015.
[204] Pan, Xiaocheng, Qi, Jianxun, Zhang, Nianzhi, Li, Qirun, Yin, Chunsheng, Chen, Rong, Gao, Feng, Xia, Chun. Complex assembly, crystallization and preliminary X-ray crystallographic studies of the swine major histocompatibility complex molecule SLA-1*1502. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 第 2 作者67: 568-571, http://dx.doi.org/10.1107/S174430911100741X.
[205] 高福. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. NATURE COMMUNICATIONS[J]. 2011, 2: 577, http://www.corc.org.cn/handle/1471x/2200832.
[206] Yi, Yong, Gao, Feng, Mao, Xuhu, Xiao, Ming, Luo, Ping, Qi, Jianxun, Guo, Gang, Jing, Hua, Cui, Yan, Zou, Quanming. Crystallization and preliminary X-ray studies of native and mutant intimin from enterohaemorrhagic Escherichia coli. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 第 6 作者67: 41-43, https://www.webofscience.com/wos/woscc/full-record/WOS:000285928500008.
[207] Zhang, Nianzhi, Qi, Jianxun, Pan, Xiaocheng, Chen, ZhaoSan, Li, Xin, Gao, Feng, Xia, Chun. Crystallization and preliminary X-ray crystallographic studies of swine CD8 alpha. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 第 2 作者67: 888-891, http://dx.doi.org/10.1107/S1744309111020392.
[208] Wu, Yan, Gao, Feng, Liu, Jun, Qi, Jianxun, Gostick, Emma, Price, David A, Gao, George F. Structural Basis of Diverse Peptide Accommodation by the Rhesus Macaque MHC Class I Molecule Mamu-B*17: Insights into Immune Protection from Simian Immunodeficiency Virus. JOURNAL OF IMMUNOLOGY[J]. 2011, 第 4 作者187(12): 6382-6392, http://dx.doi.org/10.4049/jimmunol.1101726.
[209] 高福. Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition. PLOS PATHOGENS[J]. 2011, 7(10): e1002249, http://dx.doi.org/10.1371/journal.ppat.1002249.
[210] Xuan, Chunling, Shi, Yi, Qi, Jianxun, Zhang, Wei, Xiao, Haixia, Gao, George F. Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines. PROTEIN & CELL[J]. 2011, 第 3 作者2(12): 997-1005, http://124.16.173.210/handle/834782/1473.
[211] Liu, Jun, Dai, Lianpan, Qi, Jianxun, Gao, Feng, Feng, Youjun, Liu, Wenjun, Yan, Jinghua, Gao, George F. Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus. JOURNAL OF VIROLOGY[J]. 2011, 第 3 作者85(14): 7372-7383, http://dx.doi.org/10.1128/JVI.00350-11.
[212] 刘军, 齐建勋, 高峰, 严景华, 高福. T细胞功能学与结构免疫学结合方法鉴定HLA-A2限制性的细胞毒性T淋巴细胞表位富集区. 科技导报[J]. 2011, 第 2 作者29(27): 19-26, http://lib.cqvip.com/Qikan/Article/Detail?id=39427917.
[213] Zhang, Wei, Qi, Jianxun, Shi, Yi, Li, Qing, Gao, Feng, Sun, Yeping, Lu, Xishan, Lu, Qiong, Vavricka, Christopher J, Liu, Di, Yan, Jinghua, Gao, George F. Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. PROTEIN & CELL[J]. 2010, 第 2 作者1(5): 459-467, http://www.corc.org.cn/handle/1471x/2374127.
[214] Zhang, Jianhua, Chen, Yong, Gao, Feng, Chen, Weihong, Qi, Jianxun, Xia, Chun. Complex assembly, crystallization and preliminary X-ray crystallographic studies of duck MHC class I molecule. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2010, 第 5 作者66: 99-101, https://www.webofscience.com/wos/woscc/full-record/WOS:000273072500027.
[215] Gu, Jiang, Ji, Xiaowei, Qi, Jianxun, Ma, Ying, Mao, Xuhu, Zou, Quanming. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2010, 第 3 作者66: 929-931, https://www.webofscience.com/wos/woscc/full-record/WOS:000280708200016.
[216] Chen, Yong, Liu, Peipei, Gao, Feng, Cheng, Hao, Qi, Jianxun, Gao, George F. A dimeric structure of PD-L1: functional units or evolutionary relics?. PROTEIN & CELL[J]. 2010, 第 5 作者1(2): 153-160, http://www.corc.org.cn/handle/1471x/2406038.
[217] 齐建勋, 江凡. An improved loopless mounting method for cryocrystallography. 中国物理:英文版[J]. 2010, 第 1 作者212-221, http://lib.cqvip.com/Qikan/Article/Detail?id=32672862.
[218] 安敏, 高福, 齐建勋, 李锋, 刘杏忠. 灵芝免疫调节蛋白LZ-8的制备和晶体分析. 生物工程学报[J]. 2010, 第 3 作者1563-1568, http://lib.cqvip.com/Qikan/Article/Detail?id=35968927.
[219] Cheng, Xia, Lu, Guangwen, Qi, Jianxun, Cheng, Hao, Gao, Feng, Wang, Jundong, Yan, Jinghua. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2010, 第 3 作者66: 909-912, http://dx.doi.org/10.1107/S1744309110020518.
[220] QiJianXunJiangFan. An improved loopless mounting method for cryocrystallography. Chinese Physics B[J]. 2010, 19(1): 10601-010601, https://cpb.iphy.ac.cn/EN/10.1088/1674-1056/19/1/010601.
[221] 高福. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2010, 17(10): 1266-1268, http://dx.doi.org/10.1038/nsmb.1909.
[222] Liu, Jun, Wu, Peng, Gao, Feng, Qi, Jianxun, KawanaTachikawa, Ai, Xie, Jing, Vavricka, Christopher J, Iwamoto, Aikichi, Li, Taisheng, Gao, George F. Novel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lymphocyte Epitope Stabilized by Intrachain Hydrogen Bonds from Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein. JOURNAL OF VIROLOGY[J]. 2010, 第 4 作者84(22): 11849-11857, http://www.corc.org.cn/handle/1471x/2413817.
[223] Liu, Jun, Sun, Yeping, Qi, Jianxun, Chu, Fuliang, Wu, Hao, Gao, Feng, Li, Taisheng, Yan, Jinghua, Gao, George F. The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T-Lymphocyte Epitopes. JOURNAL OF INFECTIOUS DISEASES[J]. 2010, 第 3 作者202(8): 1171-1180, http://www.corc.org.cn/handle/1471x/2407379.
[224] Ju, Jiansong, Qi, Jianxun, Xu, Shujing, Ohnishi, Kouhei, Benedik, Michael J, Xue, Yanfen, Ma, Yanhe. Crystallization and preliminary X-ray study of alkaline alanine racemase from Bacillus pseudofirmus OF4. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2009, 第 2 作者65: 166-168, http://dx.doi.org/10.1107/S174430910900013X.
[225] Ju Jiansong, Qi Jianxun, Xu Shujing, Ohnishi Kouhei, Benedik Michael J, Xue Yanfen, Ma Yanhe. Crystallization and preliminary X-ray study of alkaline alanine racemase from Bacillus pseudofirmus OF4. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2009, 第 2 作者65(Pt 2): 166-168, http://ir.iphy.ac.cn/handle/311004/35438.
[226] Qian, Xiaomin, Qi, Jianxun, Chu, Fuliang, Liu, Jun, Li, Qing, Yan, Jinghua. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2009, 第 2 作者65: 615-617, https://www.webofscience.com/wos/woscc/full-record/WOS:000266452100019.
[227] Qian Xiaomin, Qi Jianxun, Chu Fuliang, Liu Jun, Li Qing, Yan Jinghua. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2009, 第 2 作者65(6): 615-617, http://ir.iphy.ac.cn/handle/311004/35437.
[228] 戴连攀, 周斌, 齐建勋, 马颖, 高福, 杨希才. 恒河猴MHC-I类分子Mamu-A^*02与猴免疫缺陷病毒抗原表位复合物的纯化和晶体学分析. 生物工程学报[J]. 2009, 第 3 作者1028-1034, http://lib.cqvip.com/Qikan/Article/Detail?id=31187163.
[229] Chen Weihong, Chu Fuliang, Peng Hao, Zhang Jianhua, Qi Jianxun, Jiang Fan, Xia Chun, Gao Feng. Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta(2)-microglobulin. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2008, 第 5 作者64: 200-202, http://ir.iphy.ac.cn/handle/311004/37838.
[230] Zhang Yueling, Gao Feng, Xue Yanfen, Zeng Yan, Peng Hao, Qi Jianxun, Ma Yanhe. Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldarius Tc-12-31. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2008, 第 6 作者64: 209-212, http://ir.iphy.ac.cn/handle/311004/35439.
[231] Zhang Jie, Gao Feng, Zhang Qianmin, Chen Qianying, Qi Jianxun, Yan Jinghua. Crystallization and crystallographic analysis of human NUDT16. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2008, 第 5 作者64(Pt 7): 639-640, http://www.irgrid.ac.cn/handle/1471x/757722.
[232] Zhang, Qiangmin, Gao, Feng, Qi, Jianxun, Cheng, Hao, Liu, Yiwei, Gao, George F. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Streptococcus suis serotype 2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2008, 第 3 作者64: 997-999, http://dx.doi.org/10.1107/S1744309108028340.
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[234] Chen, Weihong, Chu, Fuliang, Peng, Hao, Zhang, Jianhua, Qi, Jianxun, Jiang, Fan, Xia, Chun, Gao, Feng. Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta(2)-microglobulin. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2008, 第 5 作者64: 200-202, https://www.webofscience.com/wos/woscc/full-record/WOS:000253791100013.
[235] Zhang, Yueling, Gao, Feng, Xue, Yanfen, Zeng, Yan, Peng, Hao, Qi, Jianxun, Ma, Yanhe. Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldarius Tc-12-31. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2008, 第 6 作者64: 209-212, https://www.webofscience.com/wos/woscc/full-record/WOS:000253791100016.
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科研活动

   
科研项目
( 1 ) H7N9等新型流感病毒跨种传播机制研究, 负责人, 国家任务, 2014-01--2016-12
( 2 ) 寨卡病毒致病机制及其防控策略研究, 负责人, 国家任务, 2016-07--2017-06
( 3 ) 病原与宿主互作的重要蛋白结构解析, 负责人, 国家任务, 2016-07--2020-12
( 4 ) 基于配体-受体互作埃博拉病毒抑制剂的研究, 负责人, 国家任务, 2017-01--2020-12
( 5 ) 非洲猪瘟病毒主要蛋白结构与功能研究, 负责人, 国家任务, 2020-01--2022-12
( 6 ) 新型冠状病毒S蛋白识别受体分子机制研究, 负责人, 地方任务, 2020-02--2020-08
( 7 ) 病毒感染相关大分子信号识别的分子机制及阻断研究, 负责人, 中国科学院计划, 2020-01--2024-12
( 8 ) 肠具核梭杆菌和产毒性脆弱拟杆菌与宿主的关键蛋白 质机器结构、组成和功能及作用机制的解析, 参与, 国家任务, 2020-11--2025-10
( 9 ) 针对重要病原的免疫原设计, 负责人, 国家任务, 2021-11--2024-10
( 10 ) 冠状病毒广谱抑制剂的开发及其对长效免疫记忆的影响, 负责人, 国家任务, 2022-01--2025-12
参与会议
(1)Study on the entry mechanism of SARS-CoV-2 VOCs   第二届冠状病毒国际前沿研究与创新论坛   2023-09-12
(2)冠状病毒入侵机制及抑制剂的阻断研究   冠状病毒国际前沿研究与创新论坛   2021-11-01
(3)新冠病毒入侵分子机制及阻断的结构生物学研究   第八届(重庆)生命前言技术与医药高峰论坛   2020-11-06
(4)SARS-CoV-2:structural insights of virus entry and blocking by MABs and inhibitors   2020-07-16
(5)Structural biology of Zika virus   2018-09-02
(6)Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy   2017-07-16

指导学生

已指导学生

张艳芳  博士研究生  100103-病原生物学  

王晓敏  硕士研究生  077803-病原生物学  

张玉琴  硕士研究生  085238-生物工程  

现指导学生

陈雨露  博士研究生  100103-病原生物学  

丛龙飞  博士研究生  100103-病原生物学  

张曼玲  博士研究生  100103-病原生物学  

贾明珠  博士研究生  100103-病原生物学  

庞尔琪  硕士研究生  077803-病原生物学  

马超  博士研究生  100103-病原生物学  

廖焓伊  硕士研究生  077803-病原生物学  

张缯原  硕士研究生  077803-病原生物学  

孟玉敏  博士研究生  071010-生物化学与分子生物学  

李维维  硕士研究生  077803-病原生物学  

郭文静  硕士研究生  086000-生物与医药  

杨金月  硕士研究生  086000-生物与医药  

袁斌  博士研究生  100103-病原生物学  

燕浩飞  硕士研究生  077803-病原生物学  

郑婷婷  硕士研究生  077803-病原生物学  

张玉琴  博士研究生  100103-病原生物学  

杨金蕾  博士研究生  100103-病原生物学