Protein Structure and Function

Cryo-EM

Drug Research and Development

Ion Channel

2013-08--2017-07 Ph.D., Chinese University of Hong Kong

2009-09--2012-06 Master Degree, Fudan University 

2005-09--2009-06 Bachelor Degree, Guizhou University 

2023-05~present, Associate Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

2020-01~2023-04, Assistant Professor, Southern University of Science and Technology

2018-05~2018-07, Visiting scholar, Stanford University

2012-07~2013-07, Research Assistant, Shanghai Institute of Applied Physics, Chinese Academy of Sciences

• Tao Ma^#, Lei Wang^#, Anping Chai^#, Chao Liu, Wenqiang Cui, Shuguang, Yuan, Liang Sun, Xiaokang Zhang, Zhenzhen Zhang, Jianping Lu, Yuanzhu Gao, Peiyi Wang, Zhifang Li, Yujie Liang, Horst Vogel^*, Yu Tian Wang^*, Daping Wang^*, Kaige Yan^*, Huawei Zhang^*. Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. Nature Communications, 2023, 14: 3424 (IF 17.69, JCR Q1)
• Hang Zhang, Shiyu Wang, Zhenzhen Zhang, Mengzhuo Hou, Chunyu Du, Zhenye Zhao, Horst Vogel, Zhifang Li, Kaige Yan, Xiaokang Zhang, Jianping Lu, Yujie Liang, Shuguang Yuan*, Daping Wang*, Huawei Zhang*. Cryo-EM structure of human heptameric pannexin 2 channel. Nature Communications 2023, 14:1118 (IF 17.69, JCR Q1)
• Kongfu Zhu, Chuang Yuan, Yongming Du, Kailei Sun, Xiaokang Zhang, Horst Vogel, Xudong Jia, Yuanzhu Gao, Qinfen Zhang, Daping Wang*, Huawei Zhang*. Applications and prospects of cryo-EM in drug discovery. Military Medical Research 2023, 10:10 (IF 34.91, JCR Q1)
• Hanhan Guo, Jianghong Huang, Yujie Liang, Daping Wang*, Huawei Zhang*. Focusing on Hypoxia-Inducible Factor Pathway: Role, Regulation and Therapy for Osteoarthritis. European Journal of Medical Research. 2022 Dec 12;27(1):288. Doi: 10.1186/s40001-022-00926-2  (IF 2.17, JCR Q2)
• Zhenzhen Zhang^#, Mengzhuo Hou^#, Huaxing Ou, Daping Wang, Zhifang Li*, Huawei Zhang* and Jianping Lu*. Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders. Front. Endocrinol. doi: 10.3389/fendo.2022.1067529（IF 6.05，JCR Q1）
• Kongfu Zhu^#, Chao Liu^#, Yuanzhu Gao, Jianping Lu, Daping Wang*, Huawei Zhang* (2022) Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2. Front. Pharmacol. 2022, 13:907437. Doi: 10.3389/fphar.2022.907437 (IF 5.81, JCR Q1)
• Ping Lu^#, Huawei Zhang^#, Yuanzhu Gao^#, Xudong Jia, Zhe Liu, Daping Wang, Shannon Wing Ngor Au*, Qinfen Zhang* Cryo-electron tomography reveals the roles of FliY in Helicobacter pylori flagellar motor assembly. mSphere 2022,7(1):e0094421. Doi: 10.1128/msphere.00944-21(# co-first author). (IF 4.39, JCR Q1)
• Kaiming Zhang^#, Huawei Zhang^#, Shanshan Li^#, Grigore D Pintilie, Tung-Chung Mou, Yuanzhu Gao, Qinfen Zhang, Henry van den Bedem, Michael F Schmid, Shannon Wing Ngor Au, Wah Chiu. Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution. Proc Natl Acad Sci U S A 2019,116 (14) 6800-6805. Doi: 10.1073/pnas.1821959116. (# co-first author). (IF 12.78, JCR Q1)
• Huawei Zhang, Kwok Ho Lam, Wendy Wai Ling Lam, Sandra Yuen Yuen Wong, Vera Sau Fong Chan, Shannon Wing Ngor Au. A putative spermidine synthase interacts with flagellar switch protein FliM and regulates motility in Helicobacter pylori. Mol Microbiol. 2017, 106 (5): 690-703. Doi: 10.1111/mmi.13829. (IF 3.80, JCR Q1)
• Huawei Zhang, and Shannon Wing Ngor Au. Helicobacter pylori does not use spermidine synthase to produce spermidine. Biochem Biophys Res Commun 2017, 490 (3): 861-867. (IF 3.57, JCR Q2)
• Huawei Zhang, Ximin Zeng, Qi Qi, Kailei Sun, Chongjun Ma, Xiaojian Hu, and Jun Lin. The in vitro interaction of CmeA with CmeC. Sci. Bull. 2014, 59 (25): 3114-3119. (IF 20.57, JCR Q1)

My current interest is to investigate the structure and function of disease-related membrane protein targets such as ion channels and gap junctions. I’m also interested in the screening and development of small molecule, peptide and antibody therapeutics to modulate the function of those protein targets.