基本信息
张宏民 男 博导 中国科学院高能物理研究所
电子邮件： zhanghongmin@ihep.ac.cn
通信地址： 广东省东莞市大朗镇中子源路1号
邮政编码： 523803
研究领域
1.中子生物成像方法方法学研究
2.基于硼中子俘获的肿瘤治疗（BNCT）
3.基于结构的药物设计和筛选
4.大分子机器组装机制
5.细胞内信号传导
招生信息
招收生物、药学、化学和物理方向硕士和博士研究生
招生专业
071010-生物化学与分子生物学
071011-生物物理学
0710Z2-计算生物学
071011-生物物理学
0710Z2-计算生物学
招生方向
中子成像技术研究，结构生物学方法学研究，肿瘤药物递送，生物大分子结构与功能
教育背景
1999-09--2004-07 中国科学技术大学 博士
1995-09--1999-06 中国科学技术大学 学士
1995-09--1999-06 中国科学技术大学 学士
工作经历
工作简历
2023-02~现在, 中国科学院高能物理研究所, 研究员
2013-11~2023-01,南方科技大学, 副教授/研究员
2008-11~2013-10,香港大学, 研究助理教授
2004-09~2008-11,哈佛医学院, 博士后
2013-11~2023-01,南方科技大学, 副教授/研究员
2008-11~2013-10,香港大学, 研究助理教授
2004-09~2008-11,哈佛医学院, 博士后
教授课程
普通生物学
专利与奖励
专利成果
（ 1 ） 铋(III)化合物及其方法, 发明专利, 2019, 第 5 作者, 专利号: CN110121349A
（ 2 ） Bismuth(III) compounds and methods thereof, 发明专利, 2019, 第 5 作者, 专利号: US10201518(B2)
（ 3 ） BISMUTH (III) COMPOUNDS AND METHODS THEREOF, 发明专利, 2018, 第 5 作者, 专利号: WO2018059263-A1
（ 2 ） Bismuth(III) compounds and methods thereof, 发明专利, 2019, 第 5 作者, 专利号: US10201518(B2)
（ 3 ） BISMUTH (III) COMPOUNDS AND METHODS THEREOF, 发明专利, 2018, 第 5 作者, 专利号: WO2018059263-A1
出版信息
发表论文
[1] Yujian Yang, Liu Cao, Ming Yan, Jun Zhou, Sidi Yang, Tiefeng Xu, Siyao Huang, Kun Li, Qifan Zhou, Guanguan Li, Yujun Zhu, Feng Cong, Hongmin Zhang, Deyin Guo, Yingjun Li, Xumu Zhang. Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2. ANTIVIRAL RESEARCH[J]. 2023, 第 13 作者 通讯作者 213: http://dx.doi.org/10.1016/j.antiviral.2023.105586.
[2] Xue, Wenjie, Wang, Yaling, Lian, Xu, Li, Xueyao, Pang, Jing, Kirchmair, Johannes, Wu, Kebin, Han, Zunsheng, You, Xuefu, Zhang, Hongmin, Xia, Jie, Wu, Song. Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY[J]. 2022, 第 10 作者37(1): 1620-1631, https://doaj.org/article/65d67e69c852493f8927843607a0ecb4.
[3] Zhu, Kaiyuan, Cai, Yang, Si, Xiaotong, Ye, Zuodong, Gao, Yuanzhu, Liu, Chuang, Wang, Rui, Ma, Zhibin, Zhu, Huazhang, Zhang, Liang, Li, Shengjin, Zhang, Hongmin, Yue, Jianbo. The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. CELL DEATH AND DIFFERENTIATION[J]. 2022, 第 12 作者 通讯作者 29(10): 2070-2088, http://dx.doi.org/10.1038/s41418-022-01000-4.
[4] Wang, Pengchao, Zhang, Guangming, Xu, Zeling, Chen, Zhe, Liu, Xiaohong, Wang, Chenyin, Zheng, Chaogu, Wang, Jiangyun, Zhang, Hongmin, Yan, Aixin. Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2022, 第 11 作者298(8): http://dx.doi.org/10.1016/j.jbc.2022.102258.
[5] Yun Nan Hou, Yang Cai, Wan Hua Li, Wei Ming He, Zhi Ying Zhao, Wen Jie Zhu, Qiang Wang, Xinyi Mai, Jun Liu, Hon Cheung Lee, Goran Stjepanovic, Hongmin Zhang, Yong Juan Zhao. A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. NATURE COMMUNICATIONS[J]. 2022, 第 12 作者 通讯作者 13: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780360/.
[6] Li, Wan Hua, Huang, Ke, Cai, Yang, Wang, Qian Wen, Zhu, Wen Jie, Hou, Yun Nan, Wang, Sujing, Cao, Sheng, Zhao, Zhi Ying, Xie, Xu Jie, Du, Yang, Lee, ChiSing, Lee, Hon Cheung, Zhang, Hongmin, Zhao, Yong Juan. Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate. ELIFE[J]. 2021, 第 14 作者 通讯作者 10: https://doaj.org/article/ad4f471898f24bb6b9401388eb12196c.
[7] Ma, Guixing, Wang, Sanshan, Wu, Kebin, Zhang, Weizhe, Ahmad, Ashfaq, Hao, Quan, Lei, Xiaoguang, Zhang, Hongmin. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2021, 第 8 作者 通讯作者 29: http://dx.doi.org/10.1016/j.bmc.2020.115902.
[8] Dawei Wang, Zuodong Ye, Wenjie Wei, Jingting Yu, Lihong Huang, Hongmin Zhang, Jianbo Yue, Mahak Sharma, Anna Akhmanova. Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors. ELIFE[J]. 2021, 第 6 作者10: http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202112118829148ZK.
[9] Yang, Fang, Pang, Bo, Lai, Kin Kui, Cheung, Nam Nam, Dai, Jun, Zhang, Weizhe, Zhang, Jinxia, Chan, KwokHung, Chen, Honglin, Sze, KongHung, Zhang, Hongmin, Hao, Quan, Yang, Dan, Yuen, KwokYung, Kao, Richard Y. Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle. JOURNAL OF VIROLOGY[J]. 2021, 第 11 作者95(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104107/.
[10] Ye, Zuodong, Wang, Dawei, Lu, Yingying, He, Yunjiao, Yu, Jingting, Wei, Wenjie, Chen, Chang, Wang, Rui, Zhang, Liang, Zhang, Liangren, Le, Minh T N, Cho, William C, Yang, Mengsu, Zhang, Hongmin, Yue, Jianbo. Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZ beta. ONCOGENE[J]. 2021, 第 14 作者40(10): 1775-1791, http://dx.doi.org/10.1038/s41388-021-01662-3.
[11] Zuodong Ye, Dawei Wang, Yingying Lu, Yunjiao He, Jingting Yu, Wenjie Wei, Chang Chen, Rui Wang, Liang Zhang, Liangren Zhang, Minh T N Le, William C Cho, Mengsu Yang, Hongmin Zhang, Jianbo Yue. Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ. ONCOGENE. 2021, 第 14 作者40(10): 1775-1791, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946642/.
[12] Xue, Wenjie, Li, Xueyao, Ma, Guixing, Zhang, Hongmin, Chen, Ya, Kirchmair, Johannes, Xia, Jie, Wu, Song. N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 第 4 作者188: http://dx.doi.org/10.1016/j.ejmech.2019.112022.
[13] Lu, Xin, Poon, Terence Chuen Wai, Zhang, Hongmin. Mass production of active recombinantChryseobacterium proteolyticumprotein glutaminase inEscherichia coliusing a sequential dual expression system and one-step purification. IUBMB LIFE[J]. 2020, 第 3 作者 通讯作者 72(11): 2391-2399, https://www.doi.org/10.1002/iub.2358.
[14] Xia, Jie, Feng, Bo, Wen, Gang, Xue, Wenjie, Ma, Guixing, Zhang, Hongmin, Wu, Song. Bacterial Lipoprotein Biosynthetic Pathway as a Potential Target for Structure-based Design of Antibacterial Agents. CURRENT MEDICINAL CHEMISTRY. 2020, 第 6 作者27(7): 1132-1150, https://www.webofscience.com/wos/woscc/full-record/WOS:000520070100007.
[15] Zhu, Kemeng, Chen, Huan, Jin, Jin, Wang, Ning, Maa, Guixing, Huang, Jiandong, Feng, Youjun, Xin, Jiuqing, Zhang, Hongmin, Liu, Henggui. Functional Identification and Structural Analysis of a New Lipoate Protein Ligase in Mycoplasma hyopneumoniae. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2020, 第 9 作者 通讯作者 10: https://doaj.org/article/fa913a4aa68d4d8e818d26a32b030289.
[16] Xia, Jie, Wang, Zhenyi, Huan, Yi, Xue, Wenjie, Wang, Xing, Wang, Yuxi, Liu, Zhenming, Hsieh, JuiHua, Zhang, Liangren, Wu, Song, Shen, Zhufang, Zhang, Hongmin, Wang, Xiang Simon. Pose Filter-Based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2020, 第 12 作者 通讯作者 60(3): 1202-1214, http://dx.doi.org/10.1021/acs.jcim.9b01030.
[17] Wang, Zhuo, Yan, Ming, Li, Jiaan, Long, Jiafu, Li, Yan, Zhang, Hongmin. Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH[J]. 2019, 第 6 作者 通讯作者 1866(4): 566-574, http://dx.doi.org/10.1016/j.bbamcr.2018.11.016.
[18] Lam, WaiHei, Sze, KongHung, Ke, Yihong, Tse, ManKit, Zhang, Hongmin, Woo, Patrick C Y, Lau, Susanna K P, Lau, Candy C Y, Xu, Simin, Lai, PokMan, Zhou, Ting, Antonyuk, Svetlana, V, Kao, Richard Y T, Yuen, KwokYung, Hao, Quan. Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts. INFECTION AND IMMUNITY[J]. 2019, 第 5 作者87(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000462160400009.
[19] Wang, Zhenyi, Cheng, Liansheng, Guo, Gongrui, Cheng, Baoyun, Hu, Siyi, Zhang, Hongmin, Zhu, Zhongliang, Niu, Liwen. Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2019, 第 6 作者 通讯作者 75(6): 554-563, http://dx.doi.org/10.1107/S2059798319006995.
[20] Wang, Runming, Lai, TszPui, Gao, Peng, Zhang, Hongmin, Ho, PakLeung, Woo, Patrick ChiuYat, Ma, Guixing, Kao, Richard YiTsun, Li, Hongyan, Sun, Hongzhe. Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors. NATURE COMMUNICATIONS[J]. 2018, 第 4 作者9: https://www.webofscience.com/wos/woscc/full-record/WOS:000423510600016.
[21] Wang, Zhuo, Li, Jiaan, Xiao, Wenang, Long, Jiafu, Zhang, Hongmin. The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis. LABORATORYINVESTIGATION[J]. 2018, 第 5 作者 通讯作者 98(12): 1600-1613, https://www.webofscience.com/wos/woscc/full-record/WOS:000451635100008.
[22] Runming Wang, TszPui Lai, Peng Gao, Hongmin Zhang, PakLeung Ho, Patrick ChiuYat Woo, Guixing Ma, Richard YiTsun Kao, Hongyan Li, Hongzhe Sun. Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors. NATURECOMMUNICATIONS[J]. 2018, 第 4 作者9(1): 1-12, https://doaj.org/article/f323b829fd714274aab5e5072828f56c.
[23] Chen, Zhizhen, Liu, Jie, Chu, Dafeng, Shan, Yaming, Ma, Guixing, Zhang, Hongmin, Zhang, Xiaohua Douglas, Wang, Pu, Chen, Qiang, Deng, Chuxia, Chen, Weizao, Dimitrov, Dimiter S, Zhao, Qi. A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2018, 第 6 作者14(7): 799-806, http://ir.siat.ac.cn:8080/handle/172644/14633.
[24] 张宏民. Identifying GAPDH as a Cyclic Adenosine Diphosphoribose (cADPR) Binding Protein by Pho-toaffinity Protein-Ligand Labeling Approach. J Am Chem Soc[J]. 2017, 第 1 作者
[25] Sze, KongHung, Lam, WaiHei, Zhang, Hongmin, Ke, Yihong, Tse, ManKit, Woo, Patrick C Y, Lau, Susanna K P, Lau, Candy C Y, Cai, Jianpiao, Tung, Edward T K, Lo, Raymond K C, Xu, Simin, Kao, Richard Y T, Hao, Quan, Yuen, KwokYung. Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response. CELL CHEMICAL BIOLOGY[J]. 2017, 第 3 作者24(2): 182-194, http://dx.doi.org/10.1016/j.chembiol.2016.12.014.
[26] Li, Ting, Qi, Shali, Unger, Mandy, Hou, Yun Nan, Deng, Qi Wen, Liu, Jun, Lam, Connie M C, Wang, Xian Wang, Xin, Du, Zhang, Peng, KochNolte, Friedrich, Hao, Quan, Zhang, Hongmin, Lee, Hon Cheung, Zhao, Yong Juan. Immuno-targeting the multifunctional CD38 using nanobody. SCIENTIFIC REPORTS[J]. 2016, 第 13 作者 通讯作者 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000376850300001.
[27] Ma, Guixing, Zhu, Yifan, Yu, Zhicheng, Ahmad, Ashfaq, Zhang, Hongmin. High resolution crystal structure of the catalytic domain of MCR-1. SCIENTIFIC REPORTS[J]. 2016, 第 11 作者6: http://dx.doi.org/10.1038/srep39540.
[28] Woo, Patrick C Y, Lau, Susanna K P, Lau, Candy C Y, Tung, Edward T K, Chong, Ken T K, Yang, Fengjuan, Zhang, Hongmin, Lo, Raymond K C, Cai, JianPao, AuYeung, Rex K H, Ng, WingFung, Tse, Herman, Wong, Samson S Y, Xu, Simin, Lam, Wai Hei, Tse, ManKit, Sze, Kong Hung, Kao, Richard Y, Reiner, Neil E, Hao, Quan, Yuen, KwokYung. Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei. PLOS NEGLECTED TROPICAL DISEASES[J]. 2016, 第 7 作者10(8): http://dx.doi.org/10.1371/journal.pntd.0004907.
[29] Hu, Menglong, Zhang, Hongmin, Liu, Qun, Hao, Quan. Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion. SCIENTIFIC REPORTS[J]. 2016, 第 2 作者6: https://www.webofscience.com/wos/woscc/full-record/WOS:000389676100001.
[30] Pang, Bo, Cheung, Nam Nam, Zhang, Weizhe, Dai, Jun, Kao, Richard Y, Zhang, Hongmin, Hao, Quan. Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites. SCIENTIFIC REPORTS[J]. 2016, 第 6 作者 通讯作者 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000379664900001.
[31] Wang, Minji, Lai, Tsz Pui, Wang, Li, Zhang, Hongmin, Yang, Nan, Sadler, Peter J, Sun, Hongzhe. "Anion clamp'' allows flexible protein to impose coordination geometry on metal ions. CHEMICAL COMMUNICATIONS[J]. 2015, 第 4 作者51(37): 7867-7870, https://www.webofscience.com/wos/woscc/full-record/WOS:000353639300022.
[32] Zhang, Weizhe, Zhang, Hongmin, Zhang, Tao, Fan, Haifu, Hao, Quan. Protein-complex structure completion using IPCAS (Iterative Protein Crystal structure Automatic Solution). ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2015, 第 2 作者71: 1487-1492, http://dx.doi.org/10.1107/S1399004715008597.
[33] Zhang Weizhe, Zhang Hongmin, Zhang Tao, Fan Haifu, Hao Quan. Protein-complex structure completion using IPCAS (Iterative Protein Crystal structure Automatic Solution). ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2015, 第 2 作者71(7): 1487-1492,
[34] Swarbrick, Joanna M, Graeff, Richard, Zhang, Hongmin, Thomas, Mark P, Hao, Quan, Potter, Barry V L. Cyclic Adenosine 5 '-Diphosphate Ribose Analogs without a "Southern" Ribose Inhibit ADP-ribosyl Cyclase-Hydrolase CD38. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 第 3 作者57(20): 8517-8529, https://www.webofscience.com/wos/woscc/full-record/WOS:000343740700023.
[35] Zhang Weizhe, Zhang Tao, Zhang Hongmin, Hao Quan. Crystallographic phasing with NMR models: an envelope approach. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2014, 第 3 作者70(7): 1977-1982, http://ir.iphy.ac.cn/handle/311004/58802.
[36] Zhang, Weizhe, Zhang, Tao, Zhang, Hongmin, Hao, Quan. Crystallographic phasing with NMR models: an envelope approach. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2014, 第 3 作者70: 1977-1982, https://www.webofscience.com/wos/woscc/full-record/WOS:000338917000018.
[37] 张宏民. Crystal Structures of Human CD38 in Complex with NAADP and ADPRP. Messenger[J]. 2013, 第 1 作者
[38] Ng, Andy KaLeung, Lam, Mandy KaHan, Zhang, Hongmin, Liu, Jinhuan, Au, Shannon WingNgor, Chan, Paul KaySheung, Wang, Jiahuai, Shaw, PangChui. Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein. JOURNAL OF VIROLOGY[J]. 2012, 第 3 作者86(12): 6758-6767, https://www.webofscience.com/wos/woscc/full-record/WOS:000304894100035.
[39] Zhou, Yeyun, Zhang, Hongmin, He, Bin, Du, Jintang, Lin, Hening, Cerione, Richard A, Hao, Quan. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5). JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 第 2 作者287(34): 28307-28314, http://dx.doi.org/10.1074/jbc.M112.384511.
[40] Yang, Nan, Zhang, Hongmin, Wang, Minji, Hao, Quan, Sun, Hongzhe. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. SCIENTIFIC REPORTS[J]. 2012, 第 2 作者2: https://www.webofscience.com/wos/woscc/full-record/WOS:000312489900002.
[41] 张礼和. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. BIOCHEMISTRY[J]. 2012, 51(1): 555-564,
[42] Zhang, HongMin, Graeff, Richard, Chen, Zhe, Zhang, LiangRen, Zhang, LiHe, Lee, HonCheung, Hao, Quan. Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal. JOURNAL OF MOLECULAR BIOLOGY[J]. 2011, 第 1 作者405(4): 1070-1078, http://dx.doi.org/10.1016/j.jmb.2010.11.044.
[43] Bo eZhou, Qiang eChen, Robert eMallis, Hongmin eZhang, Jinhuan eLiu, Ellis L Reinherz, Jiahuai eWang. A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: implications for pre-TCR dimerization. FRONTIERS IN IMMUNOLOGY[J]. 2011, 2: https://doaj.org/article/4354d2337db24cc49ee028a0e52837d0.
[44] Zhang, HongMin, Hao, Quan. Crystal structure of NDM-1 reveals a common beta-lactam hydrolysis mechanism. FASEB JOURNAL[J]. 2011, 第 1 作者 通讯作者 25(8): 2574-2582, https://www.webofscience.com/wos/woscc/full-record/WOS:000293337800008.
[45] Zhao, Yong Juan, Zhang, Hong Min, Lam, Connie Mo Ching, Hao, Quan, Lee, Hon Cheung. Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 第 2 作者286(25): 22170-22177, http://dx.doi.org/10.1074/jbc.M111.228379.
[46] Zhang, Hongmin, Astrof, Nathan S, Liu, JinHuan, Wang, JiaHuai, Shimaoka, Motomu. Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB JOURNAL[J]. 2009, 第 1 作者23(8): 2735-2740, https://www.webofscience.com/wos/woscc/full-record/WOS:000268836700041.
[47] Zhang, Hongmin, Liu, Jinhuan, Yang, Wei, Springer, Timothy, Shimaoka, Motomu, Wang, Jiahuai. Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2009, 第 1 作者106(43): 18345-18350, https://www.webofscience.com/wos/woscc/full-record/WOS:000271222500055.
[48] Zhang, Hongmin, Casasnovas, Jose M, Jin, Moonsoo, Liu, Jinhuan, Gahmberg, Carl G, Springer, Timothy A, Wang, Jiahuai. An unusual allosteric mobility of the C-terminal helix of a high-affinity alpha(L) integrin I domain variant bound to ICAM-5. MOLECULAR CELL[J]. 2008, 第 1 作者31(3): 432-437, http://dx.doi.org/10.1016/j.molcel.2008.06.022.
[49] Ng, Andy KaLeung, Zhang, Hongmin, Tan, Kemin, Li, Zongli, Liu, JinHuan, Chan, Paul KaySheung, Li, SuiMui, Chan, WoodYee, Au, Shannon WingNgor, Joachimiak, Andrzej, Walz, Thomas, Wang, JiaHuai, Shaw, PangChui. Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB JOURNAL[J]. 2008, 第 2 作者22(10): 3638-3647, https://www.webofscience.com/wos/woscc/full-record/WOS:000259642600025.
[50] Sun, JS, Zhang, QR, Zhang, TY, Zhu, ZL, Zhang, HM, Teng, MK, Niu, LW, Xu, WH. Developmental expression of FXPRLamide neuropeptides in peptidergic neurosecretory cells of diapause- and nondiapause-destined individuals of the cotton bollworm, Helicoverpa armigera. GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2005, 141(1): 48-57, http://dx.doi.org/10.1016/j.ygcen.2004.11.015.
[51] Zhang HM, Teng M, Niu LW, Wang YB, Wang YZ, Liu Q, Huang QQ, Hao Q, Dong YH, Liu P. Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2004, 60(5): 974-977, http://ir.ihep.ac.cn/handle/311005/238825.
[52] Zhang, HM, Yang, QY, Sun, MX, Teng, MK, Niu, LW. Hydrogen peroxide produced by two amino acid oxidases mediates antibacterial actions. JOURNAL OF MICROBIOLOGY[J]. 2004, 42(4): 336-339, https://www.webofscience.com/wos/woscc/full-record/WOS:000226509400011.
[53] Zhou Yeyun, Zhang Hongmin, He Bin, Du Jintang, Lin Hening, Cerione Richard A., Hao Quan. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5) *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 2 作者287(34): 28307-28314, http://dx.doi.org/10.1074/jbc.M112.384511.
[2] Xue, Wenjie, Wang, Yaling, Lian, Xu, Li, Xueyao, Pang, Jing, Kirchmair, Johannes, Wu, Kebin, Han, Zunsheng, You, Xuefu, Zhang, Hongmin, Xia, Jie, Wu, Song. Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY[J]. 2022, 第 10 作者37(1): 1620-1631, https://doaj.org/article/65d67e69c852493f8927843607a0ecb4.
[3] Zhu, Kaiyuan, Cai, Yang, Si, Xiaotong, Ye, Zuodong, Gao, Yuanzhu, Liu, Chuang, Wang, Rui, Ma, Zhibin, Zhu, Huazhang, Zhang, Liang, Li, Shengjin, Zhang, Hongmin, Yue, Jianbo. The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. CELL DEATH AND DIFFERENTIATION[J]. 2022, 第 12 作者 通讯作者 29(10): 2070-2088, http://dx.doi.org/10.1038/s41418-022-01000-4.
[4] Wang, Pengchao, Zhang, Guangming, Xu, Zeling, Chen, Zhe, Liu, Xiaohong, Wang, Chenyin, Zheng, Chaogu, Wang, Jiangyun, Zhang, Hongmin, Yan, Aixin. Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2022, 第 11 作者298(8): http://dx.doi.org/10.1016/j.jbc.2022.102258.
[5] Yun Nan Hou, Yang Cai, Wan Hua Li, Wei Ming He, Zhi Ying Zhao, Wen Jie Zhu, Qiang Wang, Xinyi Mai, Jun Liu, Hon Cheung Lee, Goran Stjepanovic, Hongmin Zhang, Yong Juan Zhao. A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. NATURE COMMUNICATIONS[J]. 2022, 第 12 作者 通讯作者 13: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780360/.
[6] Li, Wan Hua, Huang, Ke, Cai, Yang, Wang, Qian Wen, Zhu, Wen Jie, Hou, Yun Nan, Wang, Sujing, Cao, Sheng, Zhao, Zhi Ying, Xie, Xu Jie, Du, Yang, Lee, ChiSing, Lee, Hon Cheung, Zhang, Hongmin, Zhao, Yong Juan. Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate. ELIFE[J]. 2021, 第 14 作者 通讯作者 10: https://doaj.org/article/ad4f471898f24bb6b9401388eb12196c.
[7] Ma, Guixing, Wang, Sanshan, Wu, Kebin, Zhang, Weizhe, Ahmad, Ashfaq, Hao, Quan, Lei, Xiaoguang, Zhang, Hongmin. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2021, 第 8 作者 通讯作者 29: http://dx.doi.org/10.1016/j.bmc.2020.115902.
[8] Dawei Wang, Zuodong Ye, Wenjie Wei, Jingting Yu, Lihong Huang, Hongmin Zhang, Jianbo Yue, Mahak Sharma, Anna Akhmanova. Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors. ELIFE[J]. 2021, 第 6 作者10: http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202112118829148ZK.
[9] Yang, Fang, Pang, Bo, Lai, Kin Kui, Cheung, Nam Nam, Dai, Jun, Zhang, Weizhe, Zhang, Jinxia, Chan, KwokHung, Chen, Honglin, Sze, KongHung, Zhang, Hongmin, Hao, Quan, Yang, Dan, Yuen, KwokYung, Kao, Richard Y. Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle. JOURNAL OF VIROLOGY[J]. 2021, 第 11 作者95(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104107/.
[10] Ye, Zuodong, Wang, Dawei, Lu, Yingying, He, Yunjiao, Yu, Jingting, Wei, Wenjie, Chen, Chang, Wang, Rui, Zhang, Liang, Zhang, Liangren, Le, Minh T N, Cho, William C, Yang, Mengsu, Zhang, Hongmin, Yue, Jianbo. Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZ beta. ONCOGENE[J]. 2021, 第 14 作者40(10): 1775-1791, http://dx.doi.org/10.1038/s41388-021-01662-3.
[11] Zuodong Ye, Dawei Wang, Yingying Lu, Yunjiao He, Jingting Yu, Wenjie Wei, Chang Chen, Rui Wang, Liang Zhang, Liangren Zhang, Minh T N Le, William C Cho, Mengsu Yang, Hongmin Zhang, Jianbo Yue. Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ. ONCOGENE. 2021, 第 14 作者40(10): 1775-1791, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946642/.
[12] Xue, Wenjie, Li, Xueyao, Ma, Guixing, Zhang, Hongmin, Chen, Ya, Kirchmair, Johannes, Xia, Jie, Wu, Song. N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 第 4 作者188: http://dx.doi.org/10.1016/j.ejmech.2019.112022.
[13] Lu, Xin, Poon, Terence Chuen Wai, Zhang, Hongmin. Mass production of active recombinantChryseobacterium proteolyticumprotein glutaminase inEscherichia coliusing a sequential dual expression system and one-step purification. IUBMB LIFE[J]. 2020, 第 3 作者 通讯作者 72(11): 2391-2399, https://www.doi.org/10.1002/iub.2358.
[14] Xia, Jie, Feng, Bo, Wen, Gang, Xue, Wenjie, Ma, Guixing, Zhang, Hongmin, Wu, Song. Bacterial Lipoprotein Biosynthetic Pathway as a Potential Target for Structure-based Design of Antibacterial Agents. CURRENT MEDICINAL CHEMISTRY. 2020, 第 6 作者27(7): 1132-1150, https://www.webofscience.com/wos/woscc/full-record/WOS:000520070100007.
[15] Zhu, Kemeng, Chen, Huan, Jin, Jin, Wang, Ning, Maa, Guixing, Huang, Jiandong, Feng, Youjun, Xin, Jiuqing, Zhang, Hongmin, Liu, Henggui. Functional Identification and Structural Analysis of a New Lipoate Protein Ligase in Mycoplasma hyopneumoniae. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2020, 第 9 作者 通讯作者 10: https://doaj.org/article/fa913a4aa68d4d8e818d26a32b030289.
[16] Xia, Jie, Wang, Zhenyi, Huan, Yi, Xue, Wenjie, Wang, Xing, Wang, Yuxi, Liu, Zhenming, Hsieh, JuiHua, Zhang, Liangren, Wu, Song, Shen, Zhufang, Zhang, Hongmin, Wang, Xiang Simon. Pose Filter-Based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2020, 第 12 作者 通讯作者 60(3): 1202-1214, http://dx.doi.org/10.1021/acs.jcim.9b01030.
[17] Wang, Zhuo, Yan, Ming, Li, Jiaan, Long, Jiafu, Li, Yan, Zhang, Hongmin. Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH[J]. 2019, 第 6 作者 通讯作者 1866(4): 566-574, http://dx.doi.org/10.1016/j.bbamcr.2018.11.016.
[18] Lam, WaiHei, Sze, KongHung, Ke, Yihong, Tse, ManKit, Zhang, Hongmin, Woo, Patrick C Y, Lau, Susanna K P, Lau, Candy C Y, Xu, Simin, Lai, PokMan, Zhou, Ting, Antonyuk, Svetlana, V, Kao, Richard Y T, Yuen, KwokYung, Hao, Quan. Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts. INFECTION AND IMMUNITY[J]. 2019, 第 5 作者87(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000462160400009.
[19] Wang, Zhenyi, Cheng, Liansheng, Guo, Gongrui, Cheng, Baoyun, Hu, Siyi, Zhang, Hongmin, Zhu, Zhongliang, Niu, Liwen. Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2019, 第 6 作者 通讯作者 75(6): 554-563, http://dx.doi.org/10.1107/S2059798319006995.
[20] Wang, Runming, Lai, TszPui, Gao, Peng, Zhang, Hongmin, Ho, PakLeung, Woo, Patrick ChiuYat, Ma, Guixing, Kao, Richard YiTsun, Li, Hongyan, Sun, Hongzhe. Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors. NATURE COMMUNICATIONS[J]. 2018, 第 4 作者9: https://www.webofscience.com/wos/woscc/full-record/WOS:000423510600016.
[21] Wang, Zhuo, Li, Jiaan, Xiao, Wenang, Long, Jiafu, Zhang, Hongmin. The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis. LABORATORYINVESTIGATION[J]. 2018, 第 5 作者 通讯作者 98(12): 1600-1613, https://www.webofscience.com/wos/woscc/full-record/WOS:000451635100008.
[22] Runming Wang, TszPui Lai, Peng Gao, Hongmin Zhang, PakLeung Ho, Patrick ChiuYat Woo, Guixing Ma, Richard YiTsun Kao, Hongyan Li, Hongzhe Sun. Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors. NATURECOMMUNICATIONS[J]. 2018, 第 4 作者9(1): 1-12, https://doaj.org/article/f323b829fd714274aab5e5072828f56c.
[23] Chen, Zhizhen, Liu, Jie, Chu, Dafeng, Shan, Yaming, Ma, Guixing, Zhang, Hongmin, Zhang, Xiaohua Douglas, Wang, Pu, Chen, Qiang, Deng, Chuxia, Chen, Weizao, Dimitrov, Dimiter S, Zhao, Qi. A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2018, 第 6 作者14(7): 799-806, http://ir.siat.ac.cn:8080/handle/172644/14633.
[24] 张宏民. Identifying GAPDH as a Cyclic Adenosine Diphosphoribose (cADPR) Binding Protein by Pho-toaffinity Protein-Ligand Labeling Approach. J Am Chem Soc[J]. 2017, 第 1 作者
[25] Sze, KongHung, Lam, WaiHei, Zhang, Hongmin, Ke, Yihong, Tse, ManKit, Woo, Patrick C Y, Lau, Susanna K P, Lau, Candy C Y, Cai, Jianpiao, Tung, Edward T K, Lo, Raymond K C, Xu, Simin, Kao, Richard Y T, Hao, Quan, Yuen, KwokYung. Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response. CELL CHEMICAL BIOLOGY[J]. 2017, 第 3 作者24(2): 182-194, http://dx.doi.org/10.1016/j.chembiol.2016.12.014.
[26] Li, Ting, Qi, Shali, Unger, Mandy, Hou, Yun Nan, Deng, Qi Wen, Liu, Jun, Lam, Connie M C, Wang, Xian Wang, Xin, Du, Zhang, Peng, KochNolte, Friedrich, Hao, Quan, Zhang, Hongmin, Lee, Hon Cheung, Zhao, Yong Juan. Immuno-targeting the multifunctional CD38 using nanobody. SCIENTIFIC REPORTS[J]. 2016, 第 13 作者 通讯作者 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000376850300001.
[27] Ma, Guixing, Zhu, Yifan, Yu, Zhicheng, Ahmad, Ashfaq, Zhang, Hongmin. High resolution crystal structure of the catalytic domain of MCR-1. SCIENTIFIC REPORTS[J]. 2016, 第 11 作者6: http://dx.doi.org/10.1038/srep39540.
[28] Woo, Patrick C Y, Lau, Susanna K P, Lau, Candy C Y, Tung, Edward T K, Chong, Ken T K, Yang, Fengjuan, Zhang, Hongmin, Lo, Raymond K C, Cai, JianPao, AuYeung, Rex K H, Ng, WingFung, Tse, Herman, Wong, Samson S Y, Xu, Simin, Lam, Wai Hei, Tse, ManKit, Sze, Kong Hung, Kao, Richard Y, Reiner, Neil E, Hao, Quan, Yuen, KwokYung. Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei. PLOS NEGLECTED TROPICAL DISEASES[J]. 2016, 第 7 作者10(8): http://dx.doi.org/10.1371/journal.pntd.0004907.
[29] Hu, Menglong, Zhang, Hongmin, Liu, Qun, Hao, Quan. Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion. SCIENTIFIC REPORTS[J]. 2016, 第 2 作者6: https://www.webofscience.com/wos/woscc/full-record/WOS:000389676100001.
[30] Pang, Bo, Cheung, Nam Nam, Zhang, Weizhe, Dai, Jun, Kao, Richard Y, Zhang, Hongmin, Hao, Quan. Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites. SCIENTIFIC REPORTS[J]. 2016, 第 6 作者 通讯作者 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000379664900001.
[31] Wang, Minji, Lai, Tsz Pui, Wang, Li, Zhang, Hongmin, Yang, Nan, Sadler, Peter J, Sun, Hongzhe. "Anion clamp'' allows flexible protein to impose coordination geometry on metal ions. CHEMICAL COMMUNICATIONS[J]. 2015, 第 4 作者51(37): 7867-7870, https://www.webofscience.com/wos/woscc/full-record/WOS:000353639300022.
[32] Zhang, Weizhe, Zhang, Hongmin, Zhang, Tao, Fan, Haifu, Hao, Quan. Protein-complex structure completion using IPCAS (Iterative Protein Crystal structure Automatic Solution). ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2015, 第 2 作者71: 1487-1492, http://dx.doi.org/10.1107/S1399004715008597.
[33] Zhang Weizhe, Zhang Hongmin, Zhang Tao, Fan Haifu, Hao Quan. Protein-complex structure completion using IPCAS (Iterative Protein Crystal structure Automatic Solution). ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2015, 第 2 作者71(7): 1487-1492,
[34] Swarbrick, Joanna M, Graeff, Richard, Zhang, Hongmin, Thomas, Mark P, Hao, Quan, Potter, Barry V L. Cyclic Adenosine 5 '-Diphosphate Ribose Analogs without a "Southern" Ribose Inhibit ADP-ribosyl Cyclase-Hydrolase CD38. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 第 3 作者57(20): 8517-8529, https://www.webofscience.com/wos/woscc/full-record/WOS:000343740700023.
[35] Zhang Weizhe, Zhang Tao, Zhang Hongmin, Hao Quan. Crystallographic phasing with NMR models: an envelope approach. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2014, 第 3 作者70(7): 1977-1982, http://ir.iphy.ac.cn/handle/311004/58802.
[36] Zhang, Weizhe, Zhang, Tao, Zhang, Hongmin, Hao, Quan. Crystallographic phasing with NMR models: an envelope approach. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2014, 第 3 作者70: 1977-1982, https://www.webofscience.com/wos/woscc/full-record/WOS:000338917000018.
[37] 张宏民. Crystal Structures of Human CD38 in Complex with NAADP and ADPRP. Messenger[J]. 2013, 第 1 作者
[38] Ng, Andy KaLeung, Lam, Mandy KaHan, Zhang, Hongmin, Liu, Jinhuan, Au, Shannon WingNgor, Chan, Paul KaySheung, Wang, Jiahuai, Shaw, PangChui. Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein. JOURNAL OF VIROLOGY[J]. 2012, 第 3 作者86(12): 6758-6767, https://www.webofscience.com/wos/woscc/full-record/WOS:000304894100035.
[39] Zhou, Yeyun, Zhang, Hongmin, He, Bin, Du, Jintang, Lin, Hening, Cerione, Richard A, Hao, Quan. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5). JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 第 2 作者287(34): 28307-28314, http://dx.doi.org/10.1074/jbc.M112.384511.
[40] Yang, Nan, Zhang, Hongmin, Wang, Minji, Hao, Quan, Sun, Hongzhe. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. SCIENTIFIC REPORTS[J]. 2012, 第 2 作者2: https://www.webofscience.com/wos/woscc/full-record/WOS:000312489900002.
[41] 张礼和. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. BIOCHEMISTRY[J]. 2012, 51(1): 555-564,
[42] Zhang, HongMin, Graeff, Richard, Chen, Zhe, Zhang, LiangRen, Zhang, LiHe, Lee, HonCheung, Hao, Quan. Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal. JOURNAL OF MOLECULAR BIOLOGY[J]. 2011, 第 1 作者405(4): 1070-1078, http://dx.doi.org/10.1016/j.jmb.2010.11.044.
[43] Bo eZhou, Qiang eChen, Robert eMallis, Hongmin eZhang, Jinhuan eLiu, Ellis L Reinherz, Jiahuai eWang. A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: implications for pre-TCR dimerization. FRONTIERS IN IMMUNOLOGY[J]. 2011, 2: https://doaj.org/article/4354d2337db24cc49ee028a0e52837d0.
[44] Zhang, HongMin, Hao, Quan. Crystal structure of NDM-1 reveals a common beta-lactam hydrolysis mechanism. FASEB JOURNAL[J]. 2011, 第 1 作者 通讯作者 25(8): 2574-2582, https://www.webofscience.com/wos/woscc/full-record/WOS:000293337800008.
[45] Zhao, Yong Juan, Zhang, Hong Min, Lam, Connie Mo Ching, Hao, Quan, Lee, Hon Cheung. Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 第 2 作者286(25): 22170-22177, http://dx.doi.org/10.1074/jbc.M111.228379.
[46] Zhang, Hongmin, Astrof, Nathan S, Liu, JinHuan, Wang, JiaHuai, Shimaoka, Motomu. Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB JOURNAL[J]. 2009, 第 1 作者23(8): 2735-2740, https://www.webofscience.com/wos/woscc/full-record/WOS:000268836700041.
[47] Zhang, Hongmin, Liu, Jinhuan, Yang, Wei, Springer, Timothy, Shimaoka, Motomu, Wang, Jiahuai. Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2009, 第 1 作者106(43): 18345-18350, https://www.webofscience.com/wos/woscc/full-record/WOS:000271222500055.
[48] Zhang, Hongmin, Casasnovas, Jose M, Jin, Moonsoo, Liu, Jinhuan, Gahmberg, Carl G, Springer, Timothy A, Wang, Jiahuai. An unusual allosteric mobility of the C-terminal helix of a high-affinity alpha(L) integrin I domain variant bound to ICAM-5. MOLECULAR CELL[J]. 2008, 第 1 作者31(3): 432-437, http://dx.doi.org/10.1016/j.molcel.2008.06.022.
[49] Ng, Andy KaLeung, Zhang, Hongmin, Tan, Kemin, Li, Zongli, Liu, JinHuan, Chan, Paul KaySheung, Li, SuiMui, Chan, WoodYee, Au, Shannon WingNgor, Joachimiak, Andrzej, Walz, Thomas, Wang, JiaHuai, Shaw, PangChui. Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB JOURNAL[J]. 2008, 第 2 作者22(10): 3638-3647, https://www.webofscience.com/wos/woscc/full-record/WOS:000259642600025.
[50] Sun, JS, Zhang, QR, Zhang, TY, Zhu, ZL, Zhang, HM, Teng, MK, Niu, LW, Xu, WH. Developmental expression of FXPRLamide neuropeptides in peptidergic neurosecretory cells of diapause- and nondiapause-destined individuals of the cotton bollworm, Helicoverpa armigera. GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2005, 141(1): 48-57, http://dx.doi.org/10.1016/j.ygcen.2004.11.015.
[51] Zhang HM, Teng M, Niu LW, Wang YB, Wang YZ, Liu Q, Huang QQ, Hao Q, Dong YH, Liu P. Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2004, 60(5): 974-977, http://ir.ihep.ac.cn/handle/311005/238825.
[52] Zhang, HM, Yang, QY, Sun, MX, Teng, MK, Niu, LW. Hydrogen peroxide produced by two amino acid oxidases mediates antibacterial actions. JOURNAL OF MICROBIOLOGY[J]. 2004, 42(4): 336-339, https://www.webofscience.com/wos/woscc/full-record/WOS:000226509400011.
[53] Zhou Yeyun, Zhang Hongmin, He Bin, Du Jintang, Lin Hening, Cerione Richard A., Hao Quan. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5) *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 2 作者287(34): 28307-28314, http://dx.doi.org/10.1074/jbc.M112.384511.