细胞分子生物学、化学生物学、生物信息学及组学等多学科交叉为研究基础，在疾病发生发展过程中，探索生物分子的功能解析和分子机制，以及开展基于化学生物学的生物大小分子相互结合靶点研究。

Ø代谢稳态和癌症代谢的功能解析与分子机制研究 
Ø基于生物分子相互作用的化学生物学研究 
Ø基于人工智能、机器学习及生物信息学的生物分子功能研究

对代谢稳态、癌症代谢、化学生物学、生物信息学相关科学研究感兴趣的同学，

欢迎加入我们团队一起探索科学的奥秘！

细胞分子生物学，肿瘤生物学，癌症代谢，化学生物学

06/2015-present   Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
02/2014-05/2015   Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

   

   

（1） KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC, Cell Death Dis, 2024, 通讯作者
（2） Integrated proteogenomic and metabolomic characterization of papillary thyroid cancer with different recurrence risks, Nature Communications, 2024, 通讯作者
（3） Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate, CELL RESEARCH, 2023, 
（4） Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancers, CELL DEATH & DISEASE, 2023, 
（5） Lysine-372-dependent SUMOylation inhibits the enzymatic activity of glutamine synthases, FASEB JOURNAL, 2023, 
（6） Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts, Gut, 2023, 通讯作者
（7） The roles of E3 ubiquitin ligases in cancer progression and targeted therapy, CLINICAL AND TRANSLATIONAL MEDICINE, 2023, 
（8） Dichloroacetic acid and rapamycin synergistically inhibit tumor progression, Dichloroacetic acid and rapamycin synergistically inhibit tumor progression, JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B, 2023, 
（9） Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes, NATURE CELL BIOLOGY, 2023, 
（10） Low-dose metformin targets the lysosomal AMPK pathway through PEN2, NATURE, 2022, 
（11） UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis, JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B, 2022, 
（12） Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma (vol 4, pg 1022, 2022), NATURE METABOLISM, 2022, 
（13） USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma, Nature Communications, 2022, 通讯作者
（14） Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex, Cell Death Dis, 2022, 通讯作者
（15） AQP3-mediated H2O2 uptake inhibits LUAD autophagy by inactivating PTEN, CANCER SCIENCE, 2021, 
（16） Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress, NATURE METABOLISM, 2021, 
（17） Creatine promotes cancer metastasis through activation of Smad2/3, CELL METABOLISM, 2021, 
（18） Aldolase is a sensor for both low and high glucose,linking to AMPK and mTORC1, Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1, CELL RESEARCH, 2021, 
（19） 基于超高效液相色谱-飞行时间质谱法测定LAMTOR1在肝脏炎症恶性转化中调控的代谢物, Identification of LAMTOR1-regulated metabolites using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry in malignant transformation of liver inflammation, 色谱, 2021, 
（20） HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer, MOLECULAR ONCOLOGY, 2021, 
（21） The double-edged roles of ROS in cancer prevention and therapy, THERANOSTICS, 2021, 
（22） Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network, ADVANCED SCIENCE, 2021, 
（23） YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma, YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma, CANCER COMMUNICATIONS, 2021, 
（24） Rational Design of Crystallization-Induced-Emission Probes To Detect Amorphous Protein Aggregation in Live Cells, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 
（25） Semi-Quantitatively Designing Two-Photon High-Performance Fluorescent Probes for Glutathione S-Transferases, Semi-Quantitatively Designing Two-Photon High-Performance Fluorescent Probes for Glutathione S-Transferases, RESEARCH, 2020, 
（26） Preparation and antitumor activity of selenium-modified glucomannan oligosaccharides, JOURNAL OF FUNCTIONAL FOODS, 2020, 
（27） Cholesterol as a functional metabolite cooperates with metadherin in cancer cells, Cholesterol as a functional metabolite cooperates with metadherin in cancer cells, CHINESE CHEMICAL LETTERS, 2020, 
（28） Semi-Quantitatively Designing Two-Photon High-Sensitive Fluorescent Probes for Glutathione S-Transferases with Negligible Background Noise, RESEARCH, 2020, 通讯作者
（29） F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects, THERANOSTICS, 2020, 
（30） Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute‐On‐Chronic Liver Failure, ADVANCED SCIENCE, 2020, 
（31） A fluorophore's electron-deficiency does matter in designing high-performance near-infrared fluorescent probes, CHEMICAL SCIENCE, 2020, 
（32） An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases, ONCOGENE, 2020, 
（33） PTEN-deficient cells prefer glutamine for metabolic synthesis, PTEN-deficient cells prefer glutamine for metabolic synthesis, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2020, 
（34） A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases, THERANOSTICS, 2020, 
（35） HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma, BMC MEDICAL GENOMICS, 2020, 
（36） Comprehensive profiling by non-targeted stable isotope tracing capillary electrophoresis-mass spectrometry: a new tool complementing metabolomic analyses of polar metabolites, CHEMISTRY-A EUROPEAN JOURNAL, 2019, 
（37） 细胞蛋白质组学和代谢组学整合策略表征散斑型BTB/POZ蛋白质突变调控的关键代谢通路, Identification of speckle type BTB/POZ protein mutation regulated key metabolic pathways by cell based proteomics and metabolomics, 色谱, 2019, 
（38） Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products, RSC ADVANCES, 2019, 
（39） Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPK alpha, METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 
（40） Capillary Electrophoresis-Mass Spectrometry Based Metabolomics Analysis of Metabolic Reprogramming Induced by Phosphatase and Tensin Homolog, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2019, 
（41） A Multidimensional Characterization of E3Ubiquitin Ligase and Substrate Interaction Network, ISCIENCE, 2019, 
（42） Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα, METABOLISM, 2019, 第 17 作者
（43） Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation, JOURNAL OF PROTEOME RESEARCH, 2019, 
（44） Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress, CELL RESEARCH, 2019, 
（45） Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK, CELL METABOLISM, 2019, 
（46） Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma, ONCOLOGY REPORTS, 2019, 
（47） Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress, Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress, 细胞研究:英文版, 2019, 第 15 作者
（48） Biochemical reactions in metabolite-protein interaction, Biochemical reactions in metabolite-protein interaction, 中国化学快报：英文版, 2018, 第 7 作者
（49） Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling, BIOMEDICINE & PHARMACOTHERAPY, 2018, 通讯作者
（50） Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer, INTERNATIONAL JOURNAL OF CANCER, 2018, 
（51） Saikosaponin d from radix bupleuri suppresses triple-negative breast cancer cell growth by targeting beta-catenin signaling, BIOMEDICINE & PHARMACOTHERAPY, 2018, 
（52） USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma, CANCER LETTERS, 2018, 
（53） Long non-coding RNA MALAT1 suppresses breast cancer metastasis, NATURE GENETICS, 2018, 
（54） LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling, MOLECULAR CELL, 2018, 
（55） SAR Studies of N -2-(1 H -Tetrazol-5-yl)phenylbenzamide Derivatives as PotentG Protein-Coupled Receptor-35 Agonists, ACS MEDICINAL CHEMISTRY LETTERS, 2018, 
（56） Biochemical reactions in metabolite-protein interaction, CHINESE CHEMICAL LETTERS, 2018, 
（57） 肝素结合细胞因子影响乳腺癌细胞的增殖、侵袭和上皮细胞间质化的功能研究, Effects of Midkine on cell proliferation ,invasion and epithelium mesenchymal transition of breast cancer cells, 河北医药, 2017, 
（58） Identification of metabolic pathways related to SPOP mutations in prostate cancer, Oncotarget, 2017, 通讯作者
（59） Induction of CYP1A1 increases gefitinib-induced oxidative stress and apoptosis in A549 cells, TOXICOLOGY IN VITRO, 2017, 
（60） Mass spectrometry-based metabolomics for precision medicine, 2017, 
（61） Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK, NATURE, 2017, 
（62） Identification of SPOP related metabolic pathways in prostate cancer, ONCOTARGET, 2017, 
（63） High-throughput metabolic profiling based on small amount of hepatic cells, ELECTROPHORESIS, 2017, 
（64） Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer, SCIENTIFIC REPORTS, 2016, 
（65） α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling, Nat Cell Biol, 2014, 第 1 作者
（66） FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway, CANCER RESEARCH, 2014,