基本信息
叶国注  男  硕导  中国科学院城市环境研究所
电子邮件: gzye@iue.ac.cn
通信地址: 福建省厦门市集美大道1799号
邮政编码: 361021

研究领域

环境微生态健康

疾病环境健康效应

环境功能代谢组学




招生信息

   
招生专业
083001-环境科学
招生方向
环境功能代谢组学
疾病环境健康效应
环境微生态健康

教育背景

2010-09--2015-01   中国科学院大连化学物理研究所   博士
2006-09--2009-07   中国农业科学院茶叶研究所   硕士
2002-09--2006-06   四川农业大学   学士

工作经历

   
工作简历
2021-12~现在, 中国科学院城市环境研究所, 副研究员
2015-04~2021-12,中国科学院城市环境研究所, 助理研究员
社会兼职
2023-02-24-今,Metabolites客座编辑, Guest Editor
2022-06-23-今,Frontiers in Chemistry客座副编辑, Guest Associate Editor
2021-08-16-今,Frontiers in Endocrinology编委, Review Editor

专利与奖励

   
专利成果
[1] 叶国注, 黄乾生, 苏玉斌, 潘智宇, 郑宇泓. 一种组合物及应用和抑制或消杀金黄色葡萄球菌的方法. 114732019A, 2022-07-12.
[2] 叶国注, 黄乾生, 苏玉斌. 评价细菌氨基糖苷类抗生素耐药效应的试剂盒及其应用. 114019055A, 2022-02-08.
[3] 叶国注, 黄乾生, 张旭. 用于评价肝脏微塑料毒性的试剂盒及其应用和检测. CN: 112461952A, 2021-03-09.
[4] 叶国注, 黄乾生, 高菡, 张旭. 评价白藜芦醇干预肺上皮细胞多环芳烃毒性效应的试剂或试剂盒及其应用和检测. CN: 112375802A, 2021-02-19.
[5] 叶国注, 董四君, 林怡, 朱慧敏. 用于评价肠道脂质积累及其干预试剂或试剂盒及应用和检测. CN: 107632084B, 2020-03-17.
[6] 叶国注, 董四君, 朱慧敏, 林怡, 黄乾生, 池毓烺. 一种评价溴代阻燃剂生物毒性及其遗传效应的方法. CN: 107796934B, 2020-03-10.
[7] 许国旺, 叶国注, 尹沛源, 路鑫, 赵燕妮. 一种有效获取血清小分子代谢物信息的方法. CN: 104458983A, 2015-03-25.

出版信息

   
发表论文
(1) Altered metabolome and microbiome associated with compromised intestinal barrier induced hepatic lipid metabolic disorder in mice after subacute and subchronic ozone exposure, Environment International, 2024, 第 8 作者
(2) EV-COMM: A database of interspecies and intercellular interactions mediated by extracellular vesicles, Journal of Extracellular Vesicles, 2024, 第 6 作者
(3) Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogramming, Frontiers in Pharmacology, 2023, 通讯作者
(4) Gut microbiota related response of Oryzias melastigma to combined exposure of polystyrene microplastics and tetracycline, SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 第 5 作者
(5) L-glutamine sensitizes Gram-positive-resistant bacteria to gentamicin killing, MICROBIOLOGY SPECTRUM, 2023, 第 8 作者
(6) Impact of Airborne Pathogen-Derived Extracellular Vesicles on Macrophages Revealed by Raman Spectroscopy and Multiomics, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2023, 第 6 作者
(7) Integrated metabolomic and transcriptomic analysis identifies benzoapyrene-induced characteristic metabolic reprogramming during accumulation of lipids and reactive oxygen species in macrophages, SCIENCE OF THE TOTAL ENVIRONMENT, 2022, 通讯作者
(8) Plasma lipidomics identifies unique lipid signatures and potential biomarkers for patients with aortic dissection, FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 第 2 作者
(9) Polystyrene microplastics induce metabolic disturbances in marine medaka (Oryzias melastigmas) liver, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 第 1 作者
(10) Polystyrene microplastics induce microbial dysbiosis and dysfunction in surrounding seawater, ENVIRONMENT INTERNATIONAL, 2021, 第 1 作者
(11) Aryl hydrocarbon receptor mediates benzoapyrene-induced metabolic reprogramming in human lung epithelial BEAS-2B cells, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 通讯作者
(12) Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka (Oryzias melastigma), ENVIRONMENT INTERNATIONAL, 2021, 第 7 作者
(13) Metabolomics insights into oleate-induced disorders of phospholipid metabolism in macrophages, The Journal of Nutrition, 2021, 通讯作者
(14) Comprehensive metabolomics insights into benzo a pyrene-induced metabolic reprogramming related to H460 cell invasion and migration, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 通讯作者
(15) Comprehensive metabolomics insights into benzoapyrene-induced metabolic reprogramming related to H460 cell invasion and migration, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 通讯作者
(16) Benzo[a]pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling, JOURNAL OF APPLIED TOXICOLOGY, 2020, 通讯作者
(17) Metabolomic characterization of metabolic disturbances in the extracellular microenvironment of oleate-treated macrophages using gas chromatography-mass spectrometry, ANALYTICAL LETTERS, 2020, 通讯作者
(18) Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 第 1 作者
(19) Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 第 5 作者
(20) PPARalpha and PPARgamma activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression, CELL DEATH AND DISEASE, 2019, 第 1 作者
(21) Peroxisome proliferator-activated receptor A/G reprogrammes metabolism associated with lipid accumulation in macrophages, METABOLOMICS, 2019, 通讯作者
(22) MicroRNA-26a-CD36 signaling pathway: Pivotal role in lipid accumulation in hepatocytes induced by PM2.5 liposoluble extracts, ENVIRONMENTAL POLLUTION, 2019, 第 2 作者
(23) Comprehensive metabolic responses of HepG2 cells to fine particulate matter exposure: Insights from an untargeted metabolomics, SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 第 1 作者
(24) Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice, TOXICOLOGY, 2019, 第 6 作者
(25) Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer, INTERNATIONAL JOURNAL OF CANCER, 2018, 第 2 作者
(26) PCBs–high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice, ENVIRONMENTAL POLLUTION, 2018, 第 5 作者
(27) MiR-26a functions as a tumor suppressor in ambient particulate matter-bound metal-triggered lung cancer cell metastasis by targeting LIN28B-IL6-STAT3 axis, ARCHIVES OF TOXICOLOGY, 2018, 其他(合作组作者)
(28) Environmental risk assessment of selected organic chemicals based on TOC test and QSAR estimation models, Environmental risk assessment of selected organic chemicals based on TOC test and QSAR estimation models, 环境科学学报:英文版, 2018, 第 5 作者
(29) Environmental risk assessment of selected organic chemicals based on TOC test and QSAR estimation models, JOURNAL OF ENVIRONMENTAL SCIENCES, 2018, 第 5 作者
(30) New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure, ENVIRONMENTAL POLLUTION, 2018, 第 8 作者
(31) Metabolomics Reveals Protection of Resveratrol in Diet-Induced Metabolic Risk Factors in Abdominal Muscle, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 第 2 作者
(32) Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells, JOURNAL OF ENVIRONMENTAL SCIENCES, 2018, 第 4 作者
(33) Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses, SCIENCE OF THE TOTAL ENVIRONMENT, 2017, 第 7 作者
(34) Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2017, 第 9 作者
(35) Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol A and tetrachlorobisphenol A, SCIENTIFIC REPORTS, 2016, 第 1 作者
(36) Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer, SCIENTIFIC REPORTS, 2016, 第 8 作者
(37) Integration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarker involved in prostate cancer, MOLECULAR & CELLULAR PROTEOMICS, 2016, 第 8 作者
(38) Blood volatile compounds as biomarkers for colorectal cancer, CANCER BIOLOGY & THERAPY, 2014, 第 14 作者
(39) 基于气相色谱-质谱联用与液相色谱-质谱联用的非靶向代谢组学用于3类茶叶中化学成分分析, Non-targeted metabolomics study for the analysis of chemical compositions in three types of tea by using gas chromatography mass spectromet and hqmd chromatography.mass spectrometry, 色谱, 2014, 第 3 作者
(40) Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics, JOURNAL OF PROTEOME RESEARCH, 2014, 第 1 作者
(41) Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics, CANCER RESEARCH, 2013, 第 4 作者
(42) Chemical properties investigation of commercial cigarettes by a "pseudo" targeted method using GC-MS-selected ions monitoring, JOURNAL OF SEPARATION SCIENCE, 2013, 第 4 作者
(43) Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry, JOURNAL OF PROTEOME RESEARCH, 2012, 第 1 作者
(44) A novel approach to transforming a non-targeted metabolic profiling method to a pseudo-targeted method using the retention time locking gas chromatography/mass spectrometry-selected ions monitoring, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 4 作者
(45) Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines, JOURNAL OF SEPARATION SCIENCE, 2011, 第 3 作者

科研活动

   
科研项目
( 1 ) 同位素标记脂质组学和蛋白组学研究油酸促进大肠杆菌耐受庆大霉素的分子机制, 负责人, 地方任务, 2022-07--2025-06
( 2 ) 磷脂代谢重编程介导大肠杆菌耐受庆大霉素的分子机制, 负责人, 地方任务, 2023-08--2026-08
参与会议
(1)代谢组与微生物组揭示微塑料暴露对水生态系统的紊乱效应   第十一届全国环境化学大会   叶国注   2022-07-28
(2)油酸经由PPARA/G调控的Fatp1表达诱发巨噬细胞脂肪酸和甘油三酯蓄积   第十届全国环境化学大会   2019-08-17
(3)代谢组学揭示双酚A卤代物的发育、神经和遗传毒性:以海水青鳉鱼卵为例   中国环境科学学会环境医学与健康分会 2015年会   2015-11-01
(4)基于气质联用技术的拟靶标代谢组学方法及其应用   第十九届全国色谱学术报告会及仪器展览会   2013-04-02