1. 开发数字代谢体及其在伴随诊断、个性化营养/药物方面的应用；

2. 利用多组学数据研究衰老及衰老相关复杂疾病分子机理；

3. 甄别长寿人群内源性抗衰小分子及转化应用。

   

071007-遗传学

生物信息学，系统生物学，代谢网络，虚拟人体

2003-09--2009-07   中国科学院昆明动物研究所   博士
1999-09--2003-07   武汉轻工业大学   学士

研究生

博士学位

   

2026-02~现在, 中国科学院昆明动物研究所, 研究员
2015-07~2026-02,中国科学院昆明动物研究所, 副研究员
2014-07~2015-06,美国哈佛医学院麻省总医院, 访问学者
2009-07~2014-07,中国科学院昆明动物研究所, 助理研究员

   

（1） A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques, Nature Methods, 2025, 第 1 作者
（2） Transcriptomic evidence from peripheral blood reveals nonlinear gene expression trajectories of Aging in Female Rhesus Macaques, SCIENCE CHINA Life Sciences, 2025, 第 11 作者  通讯作者
（3） Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling, Life Medicine, 2025, 第 1 作者  通讯作者
（4） Specific differences and novel key regulatory genes of sex in influencing exceptional longevity phenotypes., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2024, 第 3 作者
（5） Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis, METABOLITES, 2023, 第 4 作者  通讯作者
（6） Screening of antibacterial compounds with novel structure from the FDA approved drugs using machine learning methods, AGING (ALBANY NY), 2022, 第 6 作者
（7） Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity, GENES, 2022, 第 6 作者
（8） System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity, Aging Cell, 2022, 第 1 作者
（9） Multiple time-series expression trajectories imply dynamic functional changes during cellular senescence, Computational and Structural Biotechnology Journal, 2022, 第 3 作者
（10） Mechanism of Thymus Rejuvenation in Elderly Macaques, REJUVENATION RESEARCH, 2022, 第 4 作者
（11） Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases, AGING-US, 2020, 第 2 作者
（12） Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma, PEERJ, 2020, 第 7 作者  通讯作者
（13） Identification of DNA N 6 -methyladenine sites by integration of sequence features, EPIGENETICS & CHROMATIN, 2020, 第 3 作者
（14） FastMM: an efficient toolbox for personalized constraint-based metabolic modeling, BMC BIOINFORMATICS, 2020, 第 1 作者
（15） Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA, PEERJ, 2019, 第 3 作者
（16） Low expression of aging-related NRXN3 is associated with Alzheimer disease A systematic review and meta-analysis, MEDICINE, 2018, 第 6 作者
（17） Subcellular stoichiogenomics reveal cell evolution and electrostatic interaction mechanisms in cytoskeleton, BMC GENOMICS, 2018, 第 5 作者
（18） A strategy to find novel candidate anti-Alzheimer's disease drugs by constructing interaction networks between drug targets and natural compounds in medical plants, PEERJ, 2018, 第 4 作者
（19） Identification of metabolism-associated genes and pathways involved in different stages of clear cell renal cell carcinoma, ONCOLOGY LETTERS, 2018, 第 9 作者  通讯作者
（20） A new method of identifying glioblastoma subtypes and creation of corresponding animal models, ONCOGENE, 2018, 第 2 作者
（21） Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets, ONCOTARGET, 2017, 第 5 作者
（22） The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds, SCIENTIFIC REPORTS, 2017, 第 6 作者  通讯作者
（23） Folate Deficiency and Gene Polymorphisms of MTHFR,MTR and MTRR Elevate the Hyperhomocysteinemia Risk, CLINICAL LABORATORY, 2017, 第 5 作者
（24） Different impairment of immune and inflammation functions in short and long-term after ischemic stroke, AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 第 4 作者
（25） Meta-Analysis of Parkinson's Disease and Alzheimer's Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes, JOURNAL OF ALZHEIMERS DISEASE, 2017, 第 7 作者  通讯作者
（26） Folate deficiency and gene polymorphisms of mthfr, mtr and mtrr elevate the hyperhomocysteinemia risk., CLINICAL LABORATORY, 2017, 第 5 作者
（27） Different impairment of immune and inflammation functions in short and long-term after ischemic stroke, AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 第 4 作者
（28） Pharmacophore-Map-Pick: A Method to Generate Pharmacophore Models for All Human GPCRs, MOLECULAR INFORMATICS, 2016, 第 2 作者
（29） Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts, PLOS ONE, 2016, 第 6 作者  通讯作者
（30） Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets, PEERJ, 2016, 第 9 作者  通讯作者
（31） Integrated analysis of alzheimer\'s disease and schizophrenia dataset revealed different expression pattern in learning and memory., JOURNAL OF ALZHEIMERS DISEASE, 2016, 第 5 作者  通讯作者
（32） In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database, SCIENTIFIC REPORTS, 2016, 第 9 作者  通讯作者
（33） ntegrated analysis of Alzheimer’s disease and schizophrenia dataset revealed different expression pattern in learning and memory, Journal of Alzheimer's Disease, 2016, 第 1 作者  通讯作者
（34） Corrigendum: In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database, SCIENTIFIC REPORTS, 2016, 第 9 作者
（35） Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin, PEERJ, 2016, 第 3 作者  通讯作者
（36） Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins, PLOS ONE, 2015, 第 4 作者
（37） Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2014, 第 4 作者
（38） Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer, BIOINFORMATICS, 2014, 第 1 作者
（39） CDRUG: a web server for predicting anticancer activity of chemical compounds, BIOINFORMATICS, 2012, 第 1 作者
（40） MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012, 第 2 作者
（41） Hearing aid for vertebrates via multiple episodic adaptive events on prestin genes, MOLECULAR BIOLOGY AND EVOLUTION, 2012, 第 2 作者
（42） CMASA: an accurate algorithm for detecting local protein structural similarity and its application to enzyme catalytic site annotation., BMC BIOINFORMATICS, 2010, 第 1 作者