蛋白质糖基化修饰解析与细胞改造

081703-生物化工

医药功能糖组学

2007-09--2013-06   西北大学   理学博士
2001-09--2005-06   西北农林科技大学   理学学士

博士研究生

理学博士

   

2017-01~2018-12,美国约翰霍普金斯大学, 博士后
2013-07~2022-11,江南大学, 副教授
2005-07~2007-08,国家微检测系统工程研究中心, 研究助理

   

（1） 陕西高等学校科学技术研究优秀成果奖, 一等奖, 省级, 2016

（ 1 ） 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法, 专利授权, 2021, 第 1 作者, 专利号: CN112285195A

（ 2 ） 一种牛奶外泌体的特征性标志物及鉴定牛奶外泌体的方法, 专利授权, 2019, 第 1 作者, 专利号: CN110530964A

（ 3 ） 一种快速分析生物样品中蛋白质及强极性长氨基酸序列糖肽的方法, 发明专利, 2019, 第 1 作者, 专利号: CN110441428A

（ 4 ） 一种亚细胞结构的特征性N-连接糖链及其应用, 发明专利, 2016, 第 1 作者, 专利号: CN105651853A

   

[1] Biology. 2023, 第 5 作者  通讯作者  
[2] Ganglong Yang, Chenyang Zuo, Yuxiang Lin, Xiaoman Zhou, Piaopiao Wen, Chairui Zhang, Han Xiao, Meichen Jiang, Morihisa Fujita, XiaoDong Gao, Fangmeng Fu. Comprehensive proteome, phosphoproteome and kinome characterization of luminal A breast cancer. FRONTIERS IN ONCOLOGY[J]. 2023, 第 1 作者13: https://doaj.org/article/2e2cb2ed767e40ebbd623f83b27c8bc1.
[3] Liu, YiShi, Wang, Yicheng, Zhou, Xiaoman, Zhang, Linpei, Yang, Ganglong, Gao, XiaoDong, Murakami, Yoshiko, Fujita, Morihisa, Kinoshita, Taroh. Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1. JOURNAL OF CELL BIOLOGY[J]. 2023, 第 5 作者222(5): http://dx.doi.org/10.1083/jcb.202208159.
[4] Yang, Yan, Yang, Ganglong, Li, ZiJie, Liu, YiShi, Gao, XiaoDong, Nakanishi, Hideki. Studies on the Proteinaceous Structure Present on the Surface of the Saccharomyces cerevisiae Spore Wall. JOURNAL OF FUNGI[J]. 2023, 第 2 作者9(4): http://dx.doi.org/10.3390/jof9040392.
[5] Journal of Agricultural and Food Chemistry. 2023, 第 10 作者  通讯作者  
[6] Liu, Guoyu, Yang, Yan, Yang, Ganglong, Duan, Shenglin, Yuan, Peng, Zhang, Shuang, Li, Feng, Gao, XiaoDong, Nakanishi, Hideki. Triosephosphate Isomerase and Its Product Glyceraldehyde-3-Phosphate Are Involved in the Regulatory Mechanism That Suppresses Exit from the Quiescent State in Yeast Cells. MICROBIOLOGY SPECTRUM[J]. 2022, 第 3 作者10(4): http://dx.doi.org/10.1128/spectrum.00897-22.
[7] Wang, Rong, Wen, Piaopiao, Yang, Ganglong, Feng, Yanyan, Mi, Yuanyuan, Wang, Xiaoying, Zhu, Shenglong, Chen, Yong Q. N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells. CELL DEATH & DISEASE[J]. 2022, 第 3 作者13(7): 
[8] Wang, Qiong, Wang, Tiexin, Wu, Wells W, Lin, ChangYi, Yang, Shuang, Yang, Ganglong, Jankowska, Ewa, Hu, Yifeng, Shen, RongFong, Betenbaugh, Michael J, Cipollo, John F. Comprehensive N- and O-Glycoproteomic Analysis of Multiple Chinese Hamster Ovary Host Cell Lines. JOURNAL OF PROTEOME RESEARCH[J]. 2022, 第 6 作者21(10): 2341-2355, http://dx.doi.org/10.1021/acs.jproteome.2c00207.
[9] Wen, Piaopiao, Chen, Jingru, Zuo, Chenyang, Gao, Xiaodong, Fujita, Morihisa, Yang, Ganglong. Proteome and Glycoproteome Analyses Reveal the Protein N-Linked Glycosylation Specificity of STT3A and STT3B. CELLS[J]. 2022, 第 6 作者  通讯作者  11(18): http://dx.doi.org/10.3390/cells11182775.
[10] 程颖, 孙承文, 秦艳, 时帅, 李岳阳, 樊启高, 杨刚龙, 高晓冬. 基于FFPE组织切片的膀胱癌N-连接糖链原位酶解及分析. 生物化学与生物物理进展[J]. 2022, 第 7 作者49(10): 2001-2014, http://www.pibb.ac.cn/pibbcn/article/abstract/20210393?st=article_issue.
[11] Huang, YiFan, Aoki, Kazuhiro, Akase, Sachiko, Ishihara, Mayumi, Liu, YiShi, Yang, Ganglong, Kizuka, Yasuhiko, Mizumoto, Shuji, Tiemeyer, Michael, Gao, XiaoDong, AokiKinoshita, Kiyoko F, Fujita, Morihisa. Global mapping of glycosylation pathways in human-derived cells. DEVELOPMENTAL CELL[J]. 2021, 第 6 作者56(8): 1195-+, http://dx.doi.org/10.1016/j.devcel.2021.02.023.
[12] SiSi Liu, YiShi Liu, XinYu Guo, Yoshiko Murakami, Ganglong Yang, XiaoDong Gao, Taroh Kinoshita, Morihisa Fujita. A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins. COMMUNICATIONS BIOLOGY[J]. 2021, 第 5 作者4(1): http://dx.doi.org/10.1038/s42003-021-02337-1.
[13] Yang, Ganglong, Wang, Qiong, Chen, Lijun, Betenbaugh, Michael J, Zhang, Hui. Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation. FRONTIERS IN CHEMISTRY[J]. 2021, 第 1 作者  通讯作者  9: http://dx.doi.org/10.3389/fchem.2021.755238.
[14] Bi, NianNian, Zhao, Song, Zhang, JianFeng, Cheng, Ying, Zuo, ChenYang, Yang, GangLong, Yang, Kun. Proteomics Investigations of Potential Protein Biomarkers in Sera of Rabbits Infected With Schistosoma japonicum. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2021, 第 6 作者  通讯作者  11: http://dx.doi.org/10.3389/fcimb.2021.784279.
[15] Yang, Ganglong, Hoti, Naseruddin, Chen, ShaoYung, Zhou, Yangying, Wang, Qiong, Betenbaugh, Michael, Zhang, Hui. One-Step Enrichment of Intact Glycopeptides From Glycoengineered Chinese Hamster Ovary Cells. FRONTIERS IN CHEMISTRY[J]. 2020, 第 1 作者8: https://doaj.org/article/ca98a11d481f44b696a8465def3cdc05.
[16] Chen, Wenyan, Wang, Rong, Li, Dan, Zuo, Chenyang, Wen, Piaopiao, Liu, Haili, Chen, Yongquan, Fujita, Morihisa, Wu, Zhimeng, Yang, Ganglong. Comprehensive Analysis of the Glycome and Glycoproteome of Bovine Milk-Derived Exosomes. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 第 10 作者  通讯作者  68(45): 12692-12701, https://www.webofscience.com/wos/woscc/full-record/WOS:000592487700018.
[17] Yang, Ganglong, Hu, Yingwei, Sun, Shisheng, Ouyang, Chuanzi, Yang, Weiming, Wang, Qiong, Betenbaugh, Michael, Zhang, Hui. Comprehensive Glycoproteomic Analysis of Chinese Hamster Ovary Cells. ANALYTICAL CHEMISTRY[J]. 2018, 第 1 作者90(24): 14294-14302, https://www.webofscience.com/wos/woscc/full-record/WOS:000454182800029.
[18] Yang, Ganglong, Lu, Wei, Yu, Di, Sun, Chengwen, Guo, Jia, Li, Zheng, Guan, Feng. Quantitative Analysis of Differential Proteome Expression in Epithelial-to-Mesenchymal Transition of Bladder Epithelial Cells Using SILAC Method. MOLECULES[J]. 2016, 第 1 作者21(1): https://doaj.org/article/ca61d2c63839409ca54e2c41b2a92a39.
[19] Yang, Ganglong, Huang, Luyu, Zhang, Jiaxu, Yu, Hanjie, Li, Zheng, Guan, Feng. Global Identification and Differential Distribution Analysis of Glycans in Subcellular Fractions of Bladder Cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2016, 第 1 作者12(7): 799-811, https://www.webofscience.com/wos/woscc/full-record/WOS:000376656400004.

   

（ 1 ） 生物免疫原的蛋白质组学解析和表达体系构建, 负责人, 境内委托项目, 2022-04--2026-03
（ 2 ） 基于单细胞多组学技术解析肺腺癌患者来源类器官和原始组织的空间蛋白质糖基化, 负责人, 研究所自主部署, 2023-09--2028-02
（ 3 ） 单细胞多组学技术开发与肿瘤微环境异质性解析, 负责人, 研究所自主部署, 2023-03--2026-12