General

Feng Xie, Professor, National-level Young Talent. He received his Ph.D. in Microbiology from the University of Science and Technology of China. He subsequently conducted postdoctoral research at the Institute of Microbiology, Chinese Academy of Sciences (IM, CAS), and at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany. In 2025, he joined the Institute of Synthetic Biology at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. His research has been published in leading international journals, including Science, Cell Chemical Biology, and Cell Reports Physical Science.

Research Areas

Focusing on the development of novel enabling technologies in synthetic biology, the elucidation, construction, and modification of biosynthetic pathways for active natural products, and the design and construction of live microorganisms with therapeutic potential.

Education

2008-07--2015-06   University of Science and Technology of China   Ph. D.

2004-09--2008-06   Anhui University   B.Sc.

Experience

2025-11~present, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Professor

2019-11~2025-12, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), PostDoc

2017-11~2019-10, Institute of Microbiology, Chinese Academy of Sciences/HIPS, PostDoc

2015-07~2019-11, Institute of Microbiology, Chinese Academy of Sciences, PostDoc

Publications

（1） Streptavidins Coordinate Biotin Sequestration and Self-Resistance Within a Biotin-Pathway Antibiotic Network, Advanced Science, 2026, Co-first author

（2） Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria, SCIENCE, 2024, First author

（3） Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase, CELL REPORTS PHYSICAL SCIENCE, 2023, First author

（4） Stereoselective Syntheses of Deuterated Pipecolic Acids as Tools to Investigate the Stereoselectivity of the Hydroxylase GetF, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2022, Co-first author

（5） Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis, CELL CHEMICAL BIOLOGY, 2020, First author

（6） Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro4.4non-8-ene, CHEMBIOCHEM, 2019, Co-first author

（7） Anti-MRSA and anti-TB metabolites from marine-derived verrucosispora sp MS100047, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, Co-first author

（8） A new salicylate synthase AmS is identified for siderophores biosynthesis in Amycolatopsis methanolica 239(T), APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, First author