
刘飞 男 中国科学院水生生物研究所
电子邮件: liufei2018@ihb.ac.cn
通信地址: 湖北省武汉市武昌区东湖南路7号中科院水生所2号楼913
邮政编码:430072
研究方向
以经济鱼类黄鳝和模式生物斑马鱼为主要研究对象,专注于探索鱼类组织器官发育和生长生殖调控等生命过程的深层机制,解决鱼类人工繁殖和遗传育种中的重要问题。
主要研究方向包括:
剪接因子和可变剪接事件在鱼类生殖系统发育中功能与调控机制
黄鳝性逆转的分子机制
黄鳝基因编辑育种
鱼类感光系统发育与进化
光周期与昼夜和季节性节律调控
光遗传学控制鱼类基因表达
招生信息
学科组介绍:
鱼类RNA生物学学科组隶属于中国科学院水生生物研究所水产种质创制与未来渔业发展研究中心、中国科学院“水产品种创制与高效养殖重点实验室”(原“淡水生态与生物技术国家重点实验室”)。
学科组现有研究员 1名(罗大极研究员,国家优青),副研究员 1名(本人),高级工程师1名,博士后 1名。
学科组为研究生提供丰厚的科研补贴和良好的实验环境。实验室宽敞明亮,占地面积200多平方,实验设施齐全,满足常规分子生物学、细胞生物学、生物化学、组织病理学、基因编辑、组学分析等实验需求。
招生人数:
博士 1~2名(罗老师),硕士 1~3名(罗老师和本人)
实验室地址:
湖北省武汉市武昌区东湖南路7号,中科院水生所2号楼908(学生办公室)、909(老师办公室)、910(老师办公室)、911(电泳室)、912(分子和生化实验室)、913(细胞房), 1号楼 117(鱼房)、118(显微操作室) 。
联系方式:
Email: liufei2018@ihb.ac.cn
我们是一个年轻的、富有激情的团队,欢迎热爱探索、立志从事科学研究的同学加入。如果感兴趣,任何时候都可以联系,了解更多学科组概况和招生信息。
招生专业
071002-动物学
招生方向
鱼类遗传育种
光周期与生物节律
教育背景
2009-09--2010-06 华中科技大学 硕士(硕博连读)
2005-09--2009-06 华中科技大学 本科,理学学士
学历
博士研究生
学位
遗传学博士
工作经历
2014-12~2021-05,华中科技大学, 博士后
2021-05~至今,中国科学院水生生物研究所, 副研究员
出版信息
截止2024年,以第一作者(含共同)或通讯作者(含共同)发表SCI论文17篇,包括Nucleic Acids Research、PLOS Genetics、Cell Death & Disease、Water Biology and Security、iScience、Journal of Biological Chemistry、Human Molecular Genetics等国际知名期刊。
发表论文
[2] Kui Sun, Yunqiao Han, Jingzhen Li, Shanshan Yu, Yuwen Huang, Yangjun Zhang, Jamas Reilly, Jiayi Tu, Pan Gao, Danna Jia, Xiang Chen, Hualei Hu, Mengmeng Ren, Pei Li, Jiong Luo, Xiang Ren, Xianqin Zhang, Xinhua Shu, Fei Liu, Mugen Liu, Zhaohui Tang. The splicing factor DHX38 enables retinal development through safeguarding genome integrity. ISCIENCE[J]. 2023, 26(11): 108103, http://dx.doi.org/10.1016/j.isci.2023.108103.
[3] WATER BIOLOGY AND SECURITY. 2023, 第 1 作者
[4] ISCIENCE. 2023, 第 19 作者 通讯作者
[5] Gao, Pan, Jia, Danna, Li, Pei, Huang, Yuwen, Hualei, Hu, Sun, Kui, Lv, Yuexia, Chen, Xiang, Han, Yunqiao, Zhang, Zuxiao, Ren, Xiang, Wang, Qing, Liu, Fei, Tang, Zhaohui, Liu, Mugen. Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARalpha Pathway. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE[J]. 2022, 63(5): 32, https://iovs.arvojournals.org/article.aspx?articleid=2778864.
[6] Xing Lin, Fei Liu, Kaifeng Meng, Hairong Liu, Yuanli Zhao, Yuanyuan Chen, Wei Hu, Daji Luo. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. LIFE[J]. 2022, 12(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501657/.
[7] Liu, Fei, Qin, Yayun, Huang, Yuwen, Gao, Pan, Li, Jingzhen, Yu, Shanshan, Jia, Danna, Chen, Xiang, Lv, Yuexia, Tu, Jiayi, Sun, Kui, Han, Yunqiao, Reilly, James, Shu, Xinhua, Lu, Qunwei, Tang, Zhaohui, Xu, Chengqi, Luo, Daji, Liu, Mugen. Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLOS GENETICS[J]. 2022, 18(3): https://doaj.org/article/5ec87f08a1f5433195e0b9eaee7ac910.
[8] Danna Jia, Pan Gao, Yuexia Lv, Yuwen Huang, James Reilly, Kui Sun, Yunqiao Han, Hualei Hu, Xiang Chen, Zuxiao Zhang, Pei Li, Jiong Luo, Xinhua Shu, Zhaohui Tang, Fei Liu, Mugen Liu, Xiang Ren. Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish. CELL DEATH & DISEASE[J]. 2022, 13(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672332/.
[9] INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022, 第 13 作者
[10] PLOS GENETICS. 2022, 第 1 作者
[11] LIFE. 2022, 第 2 作者 通讯作者
[12] CELL DEATH & DISEASE. 2022, 第 15 作者 通讯作者
[13] NUCLEIC ACIDS RESEARCH. 2021, 第 2 作者
[14] Li, Jingzhen, Liu, Fei, Lv, Yuexia, Sun, Kui, Zhao, Yuntong, Reilly, Jamas, Zhang, Yangjun, Tu, Jiayi, Yu, Shanshan, Liu, Xiliang, Qin, Yayun, Huang, Yuwen, Gao, Pan, Jia, Danna, Chen, Xiang, Han, Yunqiao, Shu, Xinhua, Luo, Daji, Tang, Zhaohui, Liu, Mugen. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(4): 2027-2043, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913766/.
[15] MOLECULAR VISION. 2020, 第 9 作者 通讯作者
[16] Qin, Yayun, Gao, Pang, Yu, Shanshan, Li, Jingzhen, Huang, Yuwen, Jia, Danna, Tang, Zhaohui, Li, Pengcheng, Liu, Fei, Liu, Mugen. A large deletion spanning PITX2 and PANCR in a Chinese family with Axenfeld-Rieger syndrome. MOLECULAR VISION[J]. 2020, 26: 670-678, https://www.webofscience.com/wos/woscc/full-record/WOS:000575379500001.
[17] Qu, Zhen, Yimer, Tinsae Assefa, Xie, Shanglun, Wong, Fulton, Yu, Shanshan, Liu, Xiliang, Han, Shanshan, Ma, Juanjuan, Lu, Zhaojing, Hu, Xuebin, Qin, Yayun, Huang, Yuwen, Lv, Yuexia, Li, Jingzhen, Tang, Zhaohui, Liu, Fei, Liu, Mugen. Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2019, 1865(10): 2694-2705, http://dx.doi.org/10.1016/j.bbadis.2019.07.009.
[18] Liu, Fei, Qin, Yayun, Yu, Shanshan, Soares, Dinesh C, Yang, Lifang, Weng, Jun, Li, Chang, Gao, Meng, Lu, Zhaojing, Hu, Xuebin, Liu, Xiliang, Jiang, Tao, Liu, Jing Yu, Shu, Xinhua, Tang, Zhaohui, Liu, Mugen. Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(15): 6225-6239, http://dx.doi.org/10.1074/jbc.M116.760314.
[19] Qin, Y, Liu, F, Yu, S, Yang, L, Gao, M, Tang, Z, Guo, A Y, Zhang, M, Li, P, Liu, M. Identification of a novel NRL mutation in a Chinese family with retinitis pigmentosa by whole-exome sequencing. EYE. 2017, 31(5): 815-817, https://www.webofscience.com/wos/woscc/full-record/WOS:000401036900026.
[20] Wang, Jiuxiang, Liu, Ying, Liu, Fei, Huang, Changzheng, Han, Shanshan, Lv, Yuexia, Liu, ChunJie, Zhang, Su, Qin, Yayun, Ling, Lei, Gao, Meng, Yu, Shanshan, Li, Chang, Huang, Mi, Liao, Shengjie, Hu, Xuebin, Lu, Zhaojing, Liu, Xiliang, Jiang, Tao, Tang, Zhaohui, Zhang, Huiping, Guo, AnYuan, Liu, Mugen. Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000373580100001.
[21] Liu, Fei, Chen, Jiaxiang, Yu, Shanshan, Raghupathy, Rakesh Kotapati, Liu, Xiliang, Qin, Yayun, Li, Chang, Huang, Mi, Liao, Shengjie, Wang, Jiuxiang, Zou, Jian, Shu, Xinhua, Tang, Zhaohui, Liu, Mugen. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. HUMAN MOLECULAR GENETICS[J]. 2015, 24(16): 4648-4659, http://dx.doi.org/10.1093/hmg/ddv197.
[22] Chen, Jiaxiang, Liu, Fei, Li, Hui, Archacld, Stephen, Gao, Meng, Liu, Ying, Liao, Shengjie, Huang, Mi, Wang, Jiuxiang, Yu, Shanshan, Li, Chang, Tang, Zhaohui, Liu, Mugen. pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation. CELLULAR SIGNALLING[J]. 2015, 27(11): 2314-2323, http://dx.doi.org/10.1016/j.cellsig.2015.08.011.
[23] Liu, Fei, Huang, Yinghao, Liu, Luying, Liang, Bo, Qu, Zhen, Huang, Gang, Li, Chang, Tian, Ronghua, Jiang, Zhuhui, Liu, Fucan, Yu, Xiaoyan, Huang, Yingjie, Liu, Jingyu, Tang, Zhaohui. Identification of a novel NOG mutation in a Chinese family with proximal symphalangism. CLINICA CHIMICA ACTA[J]. 2014, 429: 129-133, http://dx.doi.org/10.1016/j.cca.2013.12.004.
[24] Liu, Fei, Li, Pengcheng, Liu, Ying, Li, Weirong, Wong, Fulton, Du, Rong, Wang, Lei, Li, Chang, Jiang, Fagang, Tang, Zhaohui, Liu, Mugen. Novel compound heterozygous mutations in MYO7A in a Chinese family with Usher syndrome type 1. MOLECULAR VISION[J]. 2013, 19: 695-701, https://www.webofscience.com/wos/woscc/full-record/WOS:000316417500006.
[25] Wang, Qiufen, Liu, Fei, Xing, Yue, Wei, Xianjin, Li, Hui, Zhang, Shirong, Liu, Jingyu, Wang, Qing, Tang, Zhaohui, Liu, Mugen. Mutation c.359_363de1GTATTinsATAC in the COL4A5 Causes alport syndrome in a Chinese family. GENE[J]. 2013, 512(2): 482-485, https://www.webofscience.com/wos/woscc/full-record/WOS:000313768900048.
科研活动
本人主持并完成了国家自然科学基金青年项目和中国博士后科学基金面上项目各一项。作为项目骨干参与了科技创新2030—重大项目“抗病抗逆鱼新品种设计与培育”、中国科学院先导专项“大宗水产动物重大病毒病害的高效防控机理与技术”、湖北省重点研发计划“黄鳝性别控制关键因子发掘与精准育种技术研究”、“黄鳝优良种质创制关键技术研究”、湖北洪山实验室重大项目“黄鳝精准育种分子模块挖掘与研究”等科研项目。
在研项目
( 2 ) 大宗水产动物重大病毒病害的高效防控机理与技术, 参与, 中国科学院计划, 2023-11--2028-12
( 3 ) 抗病抗逆鱼新品种设计与培育-草鱼抗出血病基因编辑育种新材料创制, 负责人, 国家任务, 2023-09--2025-12
( 4 ) 湖北洪山实验室重大项目-黄鳝精准育种分子模块挖掘与研究, 参与, 地方任务, 2022-08--2025-08
( 5 ) 湖北省重点研发计划-黄鳝性别控制关键因子发掘与精准育种技术研究, 参与, 地方任务, 2022-05--2024-12
参与会议
(2)剪接因子Prpf31与视网膜祖细胞的分化和维持 第二届武汉RNA学术研讨会 2021-05-08