General
Du Yang Institute of Automation, Chinese Academy of Sciences
Email: yang.du@ia.ac.cn
Telephone: 010-62611658-907
Address: No. 95 Zhongguancun East Road,Intelligent Building, Room 907
Postcode: 100190

Research Areas

(1) Medical Image Analysis and Artificial Intelligence

(2) Multimodality  Molecular Imaging and Biomedical Application

Education

(1) PhD, The University of Hong Kong, 2005.9-2009.9
(2) Master Degree, Dalian Medical University, 2002.9-2005.7
(3) Bacholer Degree, Dalian Medical University, 1997.9-2002.7

Publications

   
Papers

(1) ImmunoAIzer: A Deep learning-based computational frame-work to characterize cell distribution and gene mutation in tumor microenvironment, Cancers, 2021, Correspondence author
(2) Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging, Nano Lett, 2021, 3rd author
(3) A Novel Adaptive Parameter Search Elastic Net Method for Fluorescent Molecular Tomography, IEEE Trans Med Imaging, 2021, Correspondence author
(4) A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that Inhibits Metastasis and Recurrence Combined with Immunotherapy, ACS Nano, 2020, Correspondence author
(5) Upfront metronomic chemotherapy synergizes with immunotherapy to optimize chemoimmunotherapy in squamous cell lung carcinoma, J Immunother Cancer, 2020, 2nd author
(6) Combination immunotherapy with cytotoxic T lymphocyte-associated antigen-4 and programmed death protein-1 inhibitors prevents postoperative breast tumor recurrence and metastasis, Mol Cancer Ther, 2020, Correspondence author
(7) Reconstruction for Fluorescence Molecular Tomography via Adaptive Group Orthogonal Matching Pursuit, IEEE Trans Biomed Eng, 2020, Correspondence author
(8) Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer, Exp Mol Med, 2019, Correspondence author
(9) Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer, Biomaterials, 2019, 2nd author
(10) Antitumorigenic and antiangiogenic efficacy of apatinib in liver cancer evaluated by multimodality molecular imaging, Exp Mol Med, 2019, Correspondence author
(11) Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis, ACS Nano, 2019, Correspondence author
(12) Noninvasive Imaging in Cancer Immunotherapy: The Way to Precision Medicine, Cancer Lett, 2019, 1st author
(13) Development of Novel Selective Histone Deacetylase 6 Inhibitor for in vivo Breast Tumor Therapy and Targeted Imaging, Journal of Materials Chemistry B, 2019, 2nd author
(14) Preclinical comparison of regorafenib and sorafenib efficacy for hepatocellular carcinoma using multimodality molecular imaging, Cancer Letters, 2019, 2nd author
(15) Optimization of Magnetic Theranostic Agent for in vivo MPI/MRI-guided Magnetic Hyperthermia Therapy, Nano Letters, 2019, 1st author
(16) Liposomal Nanohybrid Cerasomes Targeted to PD-L1 Enable Dual-Modality Imaging and Improve Antitumor Treatments, Cancer Letters, 2018, 1st author
(17) Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier, Nanoscale, 2018, 2nd author
(18) The fluorescence molecular imaging and tomography of matrix metalloproteinase-activatable near infrared fluorescence probe and image-guided orthotopic glioma resection, Mol Imaging Biol, 2018, 2nd author
(19) Radiomics analysis allows for precise prediction of epilepsy in patients with low-grade gliomas, NeuroImage:Clinical, 2018, 4th author
(20) Prediction of the anti-glioma therapeutic effects of temozolomide through the in vivo molecular imaging of the MMP expression, Biomedical Optics Express, 2018, 2nd author
(21) PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model, BMC Cancer, 2018, 2nd author
(22) EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer, Nanoscale, 2018, 2nd author
(23) Development of a Novel Ferrocenyl Histone Deacetylase Inhibitor for Triple-Negative Breast Cancer Therapy, Organometallics, 2018, 2nd author
(24) A novel estrogen receptor α-targeted near-infrared fluorescent probe for in vivo detection of breast tumor, Molecular Pharmaceutics, 2018, 2nd author
(25) Advances in Molecular Imaging of Immunotherapeutic Targets in Breast Cancer: Current and Future Prospect, European Radiology, 2018, 1st author
(26) Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin, Nanomedicine-Nanotechnology Biology and Medicine, 2018, 1st author
(27) Sparse reconstruction of fluorescence molecular tomography using variable splitting and alternating direction scheme, Mol Imaging Biol, 2017, 2nd author
(28) Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model, International Journal of Nanomedicine, 2017,1st author
(29) Nuclear and fluorescent labeled PD-1-Liposome-DOX-64Cu/IRDye800CW allows improved breast tumor targeted imaging and therapy, Mol Pharmacuetics, 2017, 1st author
(30) Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography, SPIE Medical Imaging, 2017, 3rd author
(31) Theranostic Gold Nanorod‒DNA Origami Hybrids for Enhanced in vivo Optoacoustic Imaging and Photothermal Therapy, Advanced Materials, 2016, 1st author
(32) Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles, Nanoscale, 2016, 2nd author
(33) Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer, Journal of Biomedical Nanotechnology, 2016, 2nd author
(34) Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma, Advanced Materials, 2016, 3rd author
(35) Activation of Mesenchymal Stem Cells by Macrophages Promotes Tumor Progression through Immune Suppressive Effects, Oncotarget, 2016, 4th author
(36) Self-assembled Gold DNA Nanoparticles for Cancer Theranostics, Small, 2015, Correspondence author
(37) Increased precision of orthotopic and metastatic breast cancer surgery guided by matrix metalloproteinase-activatable near-infrared fluorescence probes, Scentific Reports, 2015, Correspondence author
(38) GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment, International Journal of Nanomedicine, 2015, 1st author
(39) Zoledronic Acid Prevents the Tumor-promoting effects of Mesenchymal Stem, Oncotarget, 2015, 1st author
(40) Monitoring Tumor Targeting and Treatment Effects of IRDye 800CW and GX1-conjugated Poly Lactic Acid Nanoparticles Encapsulating Endostar on Glioma by Optical Molecular Imaging, Molecular imaging, 2015, 1st author
(41) Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation, Endocrinology, 2015, 2nd author
(42) DNA origami as an in vivo drug delivery vehicle for cancer therapy, ACS Nano, 2014, Correspondence author
(43) The PEG Coated TiO2 Nanocarriers with Enhanced Chemotherapeutic Effects of Doxorubicin in vivo: Evidence from Orthotopic Breast Tumor Bearing Mouse Model, Journal of Materials Chemistry B, 2014, 1st author
(44) Comprehensive evaluation of the anti-angiogenic and anti-neoplastic effects of Endostar on liver cancer through optical molecular imaging, PLoS One, 2014, 1st author
(45) Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology, Theranostics, 2014, 2nd author
(46) Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation, Endocrinology, 2014, 2nd author
(47) Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method, Journal of Biomedical Optics, 2014, 2nd author
(48) (18)F-fluorodeoxyglucose uptake and tumor hypoxia: revisit (18)f-fluorodeoxyglucose in oncology application, Translational Oncology, 2014, 2nd author
(49) Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization, Cell Metabolism, 2014, 4th author
(50) Macrophage VLDL receptor promotes PAFAH secretion in mothers milk and suppresses systemic inflammation in nursing neonates, Nature Communications, 2012, 1st author
(51) Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity, Genes and development, 2012, 1st author
(52) A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that Inhibits Metastasis and Recurrence Combined with Immunotherapy, ACS Nano, 2009, Correspondence author

Conferences

(1) Chang Bian, Yu Wang, Yu An, Hanfan Wang, Yang Du*, Jie Tian*.  A computational Prediction Method Based on Modified U-Net for Cell Distribution in Tumor Microenvironment.  SPIE Medical Imaging, Oral presentation, 2021, USA, San Diego. 

(2) Ling Xinkong, Yu An, Yang Du*, Jie Tian*.  The improved reconstruction of fluorescence molecular tomography via regularized doubly orthogonal matching pursuit method. SPIE Medical Imaging, Oral presentation, 2020, USA, Houston. 

(3) Yang Du, Jie Tian*. A DNA Origami assembled with QD655 and gold nanorod working as a novel nanoprobe for fluorescence and optoacoustic dual modality imaging in 4T1 mammary tumor model. World Molecular Imaging Congress (WMIC), Oral presentation, 2017.9, USA, Philadelphia.

(4) Yang Du, The appliation of molecular imaging on oncology drug development. Korea Society of Molecular Imaging, Oral presentation, 2017.8, Karea, Seoul.

(5) Qian Liang, Jinzuo Ye, Yang Du*, Chongwei Chi, Jie Tian*. Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography. SPIE Medical Imaging. Oral presentation, 2017.2, USA, florida.

(6) Yang Du*, Qian Zhang, Jie Tian*. AS1411 aptamer guided QD655 labeled DNA Origami working as a novel nanoprobe for fluorescence molecular imaging in breast tumor mouse model. World Molecular Imaging Congress (WMIC), Oral presentation, 2015.9, USA, Hawaii

(7) Yang Du, Nicolas Beziere, Qian Zhang, Dong Peng, Ntziachristos Vasilis, Jie Tian*. The gold nanorods decorated with DNA Origami working as a novel photoacoustic imaging probe in 4T1 breast tumor model; World Molecular Imaging Congress (WMIC), Oral presentation, 2014.9, Korea
(8) Yang Du. Application of Molecular Imaging Technology in Tumor Study, Japanese Society of Molecular Imaging, Oral presentation, 2013.5, Japan
(9) Yang Du, GX1-conjugated IRDye 800CW: a new optical molecular imaging agent for anti-colorectal cancer in vivo. CMR Meeting, Oral presentation, 2013.11. China Beijing
(10) Qian Zhang, Yaqian Li, Xin Yang, Xingde Li, Yang Du*, Jie Tian*. GX1-conjugated Endostar nanoparticle: a new drug delivery system for anti-colorectal cancer in vivo. World Molecular Imaging Congress (WMIC), 2013.9, USA Savannah
(11) Qian Zhang, Yang Du*, Hente Ke, Jie Tian*. Molecular imaging in photothermal therapy evaluation. WMIC, 2013.9 USA Savanna

Students

已指导学生

梁倩  硕士研究生  085211-计算机技术  

孔令鑫  硕士研究生  081104-模式识别与智能系统  

边畅  硕士研究生  081104-模式识别与智能系统  

王宇  硕士研究生  081104-模式识别与智能系统  

现指导学生

主辉  硕士研究生  085400-电子信息  

彭正耀  硕士研究生  081104-模式识别与智能系统