Development of new synthetic methodologies.

Total synthesis of complex natural products and their SAR and action mode studies.

Discovery of small modulators for target proteins and special biological processes. 

Selected publications

1.     Accelerating effect induced by the structure of a-amino acid in the copper-catalyzed couplings of aryl halides with a-amino acids. Synthesis of benzolactam-V8. Dawei Ma, Yongda Zhang, Jiangchao Yao, Shihui Wu and Fenggang Tao, J. Am. Chem. Soc. 1998, 120, 12459.

2.     Total synthesis of microsclerodermin E, Jidong Zhu and Dawei Ma, Angew. Chem. Int. Ed. 2003, 42, 5348.

3.     Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles, Hui Zhang, Qian Cai and Dawei Ma, J. Org. Chem. 2005, 70, 5164.

4.     Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperature, Xiaoan Xie, Yu Chen and Dawei Ma, J. Am. Chem. Soc. 2006, 128, 16050.

5.     Enantioselective addition of activated terminal alkynes to 1-acylpyridinium salts catalyzed by Cu-bis(oxazoline) complexes, Zhankui Sun, Shouyun Yu, Zuoding Ding and Dawei Ma, J. Am. Chem. Soc. 2007, 129, 9300.

6.     Total synthesis and structure of papuamide B, a potent anti-HIV marine cyclodepsipeptide, Weiqing Xie, Derong Ding, Weiwei Zi, Guangyu Li and Dawei Ma, Angew. Chem. Int. Ed. 2008, 47, 2844.

7.     Copper/amino acid catalyzed cross-couplings of aryl and vinyl halides with nucleophiles, Dawei Ma and Cai Qian, Acc. Chem. Res. 2008, 41, 1450.

8.     Total synthesis of piperazimycin A, a cytotoxic cyclic hexadepsipeptide, Wenhua Li, Jiangang Gan and Dawei Ma, Angew. Chem. Int. Ed. 2009, 48, 8891.

9.     Asymmetric, protecting-group-free total synthesis of (-)-englerin A, Qianghui Zhou, Xiaofei Chen and Dawei Ma, Angew. Chem. Int. Ed. 2010, 49, 3513.

10.  A convergent route to galbulimima alkaloid (-)-GB 13 and (+)-GB 16, Weiwei Zi, Shouyun Yu and Dawei Ma, Angew. Chem. Int. Ed. 2010, 49, 5887.

11.  Total synthesis and absolute stereochemical assignment of (-)-communesin F, Ziwei Zuo, Weiqing Xie and Dawei Ma, J. Am. Chem. Soc. 2010, 132, 13226.

12.  Total synthesis of akuammiline alkaloid (-)-vincorine via intramolecular oxidative coupling, Weiwei Zi, Weiqing Xie and Dawei Ma, J. Am. Chem. Soc. 2012, 134, 9126.

13.  Potentially biomimetic total synthesis and relative stereochemical assignment of (±)-gracilamine, Songchuan Tian, Weiwei Zi and Dawei Ma, Angew. Chem. Int. Ed. 2012, 51, 10141

14.  Total synthesis of (±)-spiroquinazoline, (-)-alantryphenone, (+)-laptin A and (-)-quinadoline B, Mingyao Wu and Dawei Ma, Angew. Chem. Int. Ed. 2013, 52, 9759.

15.  Organocatalytic and scalable synthesis of anti-flu drugs zanamivir, laninamivir and CS-8958, Junshan Tian, Jiankang Zhong, Yunsheng Li and Dawei Ma, Angew. Chem. Int. Ed. 2014, 53, 13885. 

16.  Total synthesis of leucosceptroids A and B, Sheng Guo, Jie Liu and Dawei Ma, Angew. Chem. Int. Ed. 2015, 54, 1298.

17.  Intramolecular dearomative oxidative coupling of indoles: A unified strategy for the total synthesis of indoline alkaloid, Weiwei Zi, Zhiwei Zuo and Dawei Ma, Acc. Chem. Res. 2015, 48, 702.

18.  CuI/oxalic diamides catalyzed coupling reaction of (hetero)aryl chlorides and amines, Wei Zhou, Mengyang Fan, Junli Yin, Yongwen Jiang and Dawei Ma, J. Am. Chem. Soc. 2015, 137, 11942.

19.  Assembly of primary (hetero)arylamines via CuI/oxalic diamide-catalyzed coupling of aryl chlorides and ammonia, Mengyang Fan, Wei Zhou, Yongwen Jiang and Dawei Ma, Org. Lett. 2015, 17, 5934.

20.  Diaryl ether formation through CuI/oxalic diamide catalyzed coupling of (hetero)aryl chlorides and phenols, Mengyang Fan, Wei Zhou, Yongwen Jiang and Dawei Ma, Angew. Chem. Int. Ed. 2016, 55, 6211.

已指导学生

杨家德  01  19132  

孙海鹰  01  19132  

夏成峰  01  19132  

邹斌  01  19132  

田红旗  01  19132  

朱继东  01  19132  

唐国志  01  19132  

王以  01  19132  

俞寿云  01  19132  

蒲晓涛  01  19132  

朱伟  01  19132  

余尚海  01  19132  

龙凯  01  19132  

魏景军  01  19132  

曹冶宇  01  19132  

吴清泉  01  19132  

蔡倩  01  19132  

孙威  01  19132  

刘烽  01  19132  

谢卫青  01  19132  

潘鹤龄  01  19132  

何刚  01  19132  

甘建刚  01  19132  

李盈  01  19132  

孙占奎  01  19132  

王晶  01  19132  

谭立  01  19132  

周强辉  01  19132  

李文华  01  19132  

朱少林  01  19132  

马安琪  01  19132  

资伟伟  01  19132  

田松川  01  19132  

左智伟  01  19132  

孙学锋  01  19132  

田峻山  01  19132  

吴明遥  01  19132  

钟建康  02  63220  

魏毅  01  19132  

胡安华  01  19132  

李运生  02  63220  

周庆海  01  19132  

滕明星  01  19132  

孟令醒  01  19132  

伍海波  02  19132  

郭盛  01  19132  

樊梦阳  01  19132  

现指导学生

殷俊力  02  19132  

汪俊洁  02  19132  

刘杰  02  19132  

高洁  02  67935  

倪冬顺  01  19132  

张萌  01  19132  

赵祥波  01  19132  

李武  02  19132  

胡琦飞  02  19132  

陈莹  02  19132  

夏尚华  01  67935  

甘露  01  67935  

高杨  01  19132  

王平鸾  01  19132  

陈志翔  01  19132  

刘政  01  67935  

何卫明  01  67935