基本信息
杜宇  男  硕导  中国科学院福建物质结构研究所
电子邮件: duyu@fjirsm.ac.cn
通信地址: 上街镇高新区中科院海西研究院
邮政编码:

研究领域

天然产物与药物的不对称全合成,有机小分子或金属有机配合物催化的不对称合成方法学,生物活性高分子的合成与应用

招生信息

   
招生专业
070303-有机化学
招生方向
有机合成化学
金属有机
生物高分子材料

教育背景

2004-09--2011-06   厦门大学   理学博士学位
2000-09--2004-07   厦门大学   学士学位

工作经历

2011年毕业于厦门大学化学化工学院,取得有机化学专业理学博士学位,之后前往新加坡南洋理工大学,在有机化学方向和生物活性高分子材料领域进行了6年的博士后研究,2018年初回国,进入中国科学院福建物质结构研究所工作。近年来围绕有机合成化学,先后进行了天然产物和药物的不对称全合成、氮杂环卡宾催化的自由基反应,抑菌活性α-β-多肽的合成、表征与应用,中心手性金属催化的不对称反应等研究课题。


工作简历
2018-06~现在, 中国科学院福建物质结构研究所, 副研究员
2011-07~2017-12,新加坡南洋理工大学, Senior Research Fellow

专利与奖励

   
专利成果
[1] 杜宇, 黄永亮, 苏伟平. 一种TML型触发器分子及其制备方法和应用. 202210415496.3, 2022-04-20.

出版信息

   
发表论文
[1] Yongliang Huang, Yu Du, Weiping Su. Convenient and flexible syntheses of gem-dimethyl carboxylic triggers via mono-selective β-C(sp3)–H arylation of pivalic acid with ortho-substituted aryl iodides. Org. Chem. Front.[J]. 2022, 9: 3293-3300, [2] Jian Yang, Siliang Ming, Gang Yao, Haifeng Yu, Yu Du, Jun Gong. Construction of chiral chroman skeletons via catalytic asymmetric [4 + 2] cyclization of ortho-hydroxyphenyl-substituted para-quinone methides catalyzed by a chiral-at-metal rhodium complex. Org. Chem. Front.[J]. 2022, 9: 2759-2765, [3] Hui Shen, Yu Du, Jian Kan, Weiping Su. Synthesis of 3-substituted 2-oxindoles from secondary α-bromo-propionanilides via palladium-catalyzed intramolecular cyclization. Org. Biomol. Chem.[J]. 2022, 20: 3589-3597, [4] Siliang Ming, Saira Qurban, Yu Du, Weiping Su. Asymmetric Synthesis of Multi-Substituted Tetrahydrofurans via Palladium/Rhodium Synergistic Catalyzed [3+2] Decarboxylative Cycloaddition of Vinylethylene Carbonates. Chem. Eur. J.[J]. 2021, 27: 12742-12746, [5] 杜宇, 黄永亮, 高越, 沈慧, 苏伟平, 洪茂椿. 手性配体在钯催化不对称碳氢键活化反应中的应用. 中国科学:化学[J]. 2021, 51(2): 123-143, http://lib.cqvip.com/Qikan/Article/Detail?id=7104253875.
[6] Wan, Qian, Chen, Liang, Li, Shiwu, Kang, Qiang, Yuan, Yaofeng, Du, Yu. Enantioselective Synthesis of Multisubstituted Spirocyclopentane Oxindoles Enabled by Pd/Chiral Rh(III) Complex Synergistic Catalysis. ORGANIC LETTERS[J]. 2020, 22(24): 9539-9544, https://www.webofscience.com/wos/woscc/full-record/WOS:000607016900026.
[7] Hu, Liangjian, Lin, Shaoxia, Li, Shiwu, Kang, Qiang, Du, Yu. Chiral-at-Metal Rhodium(III) Complex Catalyzed Enantioselective Vinylogous Michael Addition of alpha,alpha-Dicyanoolefins with alpha,beta-Unsaturated 2-Acyl Imidazoles. CHEMCATCHEM[J]. 2020, 12(1): 118-121, https://www.webofscience.com/wos/woscc/full-record/WOS:000498419200001.
[8] Chen, Liang, Hu, Liangjian, Du, Yu, Su, Weiping, Kang, Qiang. Asymmetric Photoinduced Giese Radical Addition Enabled by a Single Chiral-at-Metal Rhodium Complex. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 40(11): 3944-3952, http://dx.doi.org/10.6023/cjoc202004041.
[9] Wan, Qian, Li, Shiwu, Kang, Qiang, Yuan, Yaofeng, Du, Yu. Chiral-at-Metal Rh(III) Complex Catalyzed Cascade Reduction-Michael Addition Reaction. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 84(23): 15201-15211, https://www.webofscience.com/wos/woscc/full-record/WOS:000502170600019.
[10] Li, ShiWu, Du, Yu, Kang, Qiang. A chiral-at-metal asymmetric catalyzed vinylogous Michael addition of ortho-methyl aromatic nitro compounds for isoxazole derivative synthesis. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(15): 2775-2779, https://www.webofscience.com/wos/woscc/full-record/WOS:000476771100028.
[11] Qurban, Saira, Du, Yu, Gong, Jun, Lin, ShaoXia, Kang, Qiang. Enantioselective synthesis of tetrahydroisoquinoline derivatives via chiral-at-metal rhodium complex catalyzed 3+2 cycloaddition. CHEMICAL COMMUNICATIONS[J]. 2019, 55(2): 249-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000453911200021.
[12] Zhang, Haoran, Li, Shiwu, Kang, Qiang, Du, Yu. Chiral-at-metal rhodium(iii) complex catalyzed enantioselective synthesis of C2-substituted benzofuran derivatives. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(21): 3683-3687, [13] Kaixi Zhang, Yu Du, Zhangyong Si, Yang Liu, Michelle E Turvey, Cheerlavancha Raju, Damien Keogh, Lin Ruan, Subramanion L Jothy, Sheethal Reghu, Kalisvar Marimuthu, Partha Pratim De, Oon Tek Ng, Jos R Mediavilla, Barry N Kreiswirth, Yonggui Robin Chi, Jinghua Ren, Kam C Tam, XueWei Liu, Hongwei Duan, Yabin Zhu, Yuguang Mu, Paula T Hammond, Guillermo C Bazan, Kevin Pethe, Mary B ChanPark. Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters. NATURE COMMUNICATIONS[J]. 2019, 10(1): https://doaj.org/article/833f1cd964474e91b7b1b5f1074c3c0a.
[14] Qurban, Saira, Gong, Jun, Du, Yu, Kang, Qiang. Rhodium(iii)/amine synergistically catalyzed enantioselective Michael addition of cyclic ketones with ,-unsaturated 2-acyl imidazoles. ORGANIC CHEMISTRY FRONTIERS[J]. 2018, 5(19): 2870-2874, https://www.webofscience.com/wos/woscc/full-record/WOS:000447950500017.
[15] Pu, Yuji, Du, Yu, Khin, Mya Mya, Ravikumar, Vikashini, Rice, Scott A, Duan, Hongwei, ChanPark, Mary B. Using Diphenylphosphoryl Azide (DPPA) for the Facile Synthesis of Biodegradable Antiseptic Random Copolypeptides. MACROMOLECULAR RAPID COMMUNICATIONS[J]. 2017, 38(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000398605700005.
[16] Yuexia Zhang, Yu Du, Zhijian Huang, Jianfeng Xu, Xingxing Wu, Yuhuang Wang, Ming Wang, Song Yang, Richard D. Webster, Yonggui Robin Chi. N‑Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β‑Hydroxylation of Enals. J. Am. Chem. Soc.[J]. 2015, 137: 2416-2419, [17] Yu Du, Yuhuang Wang, Xin Li, Yaling Shao, Guohui Li, Richard D. Webster, Yonggui Robin Chi. N‑Heterocyclic Carbene Organocatalytic Reductive β,β-Coupling Reactions of Nitroalkenes via Radical Intermediates. Org. Lett.[J]. 2014, 16: 5678-5681, 

科研活动

   
科研项目
( 1 ) 氮杂环卡宾与中心手性金属配合物共催化的单电子转移自由基反应研究, 主持, 国家级, 2019-01--2022-12