Luminescent Materials, Physics and  Devices

We have a solid theoretical foundation and rich work experience in the fields of elemental excitation in condensed matter, luminescence dynamics in condensed matter, photoelectron materials and devices, interactions between light and biomolecules in biological systems, and Förster resonance energy transfer. It has research characteristics and advantages in rare earth luminescent materials, physics, biophotonics, and other research directions.

Desired backgrounds include: 

• Rare Earth (lanthanide) doped luminescent materials and physics

• Biophotonics: NIR-II fluorescence imaging/phototherapy/Biosensing,

• Surface modification of nanoparticles

• Dynamic regulation of luminescence: Ferroelectric/Magneto-Optical Modulation

• Simulation of Luminescence Process: Monte Carlo and other methods

   

[1] D. Gan, X. Xie, F. Long, H. Chen, Q. Li, Z. Sui, W. Wang, D. Li, Y. Chang*, Yb3+ Energy Relay in Stratified Lanthanide Nanoparticles Enables Multidimensional NIR-II Lifetime Imaging, Advanced Materials (2026) 2519832.

[2] F. Long, D. Gan, H. Chen, Q. Li, W. Wang, Z. Sui, Y. Zhang, D. Li, Y. Chang*, Dye-Sensitized Cascaded Energy Transfer Amplification of 1525 nm Luminescence in High-Doped Nanoparticles, Light: Science & Applications (2026)

[3] Y. Chang*, H. Chen, X. Xie, Y. Wan, Q. Li, F. Wu, R. Yang, W. Wang, X. Kong, Bright Tm³⁺-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging, Nature Communications 14(1) (2023) 1079.

[4] D. Gan, Y. Cao, F. Long, Q. Li, H. Chen*, W. Wang, X. Li, B. Li, D. Li, Y. Chang*, Spatially Partitioned Doping in Upconversion Nanoparticles for Efficient FRET-Based ClO- Detection and Inflammation Grading Imaging, Laser & Photonics Reviews (2025)

[5] Synergistic Comprehensive Activation Methods for Dual-Modality PDT and Hypoxia-Triggered Chemotherapy Guided by NIR-II Imaging beyond 1700 nm in Deep Tumors, Small, 2025, 2500553

[6] W. Wang, J. Yang, B. Ma, H. Zhu, Y. Yi, X. Li, Q. Li*, H. Chen, B. Li, X. Kong, Y. Chang*, Ytterbium as the Energy Regulator to Enhance the NIR-IIb Luminescence of Er-Rich Sub-20 nm Nanocrystals for Ratiometric Fluorescence Imaging, Laser & Photonics Reviews (2024), 2400786.

[7] Q. Li, Y. Huang, H. Zhu, Y. Zhu, Y. Yi, X. Li, H. Chen, B. Li, D. Li, Y. Chang*, NIR-I Activated Orthogonal NIR-IIb/c Emissions in a Lanthanide-Doped Nanoparticle for Fluorescence Imaging and Information Encryption, Advanced Science (2024), 11, 2408097

[8] S. Liu, Y. Pei, Y. Sun, Z. Wang, H. Chen, D. Zhu, M. R. Bryce, B. Tang, Y. Chang,“Three birds with one stone” nanoplatform: Efficient near‐infrared‐triggered type‑I AIE photosensitizer for mitochondria-targeted photodynamic therapy against hypoxic tumors, Aggregate,(2024) e547

[9] Q.Q. Li, X.Y. Xie, H. Wu, H.R. Chen, W. Wang, X.G. Kong, Y. Chang*, Superenhancement Photon Upconversion Nanoparticles for Photoactivated Nanocryometer, Nano Letters 23(8) (2023) 3444-3450.

[10] X. Xie, Q. Li, H. Chen, W. Wang, F. Wu, L. Tu, Y. Zhang, X. Kong, Y. Chang*, Manipulating the Injected Energy Flux via Host-Sensitized Nanostructure for Improving Multiphoton Upconversion Luminescence of Tm³⁺, Nano Letters 22(13) (2022) 5339-5347.

[11] F.X. Wu, H.R. Chen, Q.Q. Li, R.Q. Liu, Y.K. Suo, B. Li, X.G. Kong, Z. Cheng, H.G. Liu*, Y. Chang*, Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity, Chemical Engineering Journal 468 (2023).

[12] X. Dai, Y. Liu, F. Meng, Q. Li, F. Wu, J. Yuan, H. Chen, H. Lv, Y. Zhou*, Y. Chang*, Amplification of oxidative damage using near-infrared II-mediated photothermal/thermocatalytic effects for periodontitis treatment, Acta biomaterialia 171 (2023) 519-531.

[13] F. Wu, H. Chen, R. Liu, Y. Suo, Q. Li, Y. Zhang, H. Liu, Z. Cheng*, Y. Chang*, Modulation of the Tumor Immune Microenvironment by Bi₂Te₃-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy, Advanced healthcare materials 11(19) (2022) e2200809.

[14] H. Chen, F. Wu, X. Xie, W. Wang, Q. Li, L. Tu, B. Li, X. Kong, Y. Chang*, Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy, ACS Nano 15(12) (2021) 20643-20655.

[15] Y. Feng, H. Chen, Y. Wu, I. Que, F. Tamburini, F. Baldazzi, Y. Chang*, H. Zhang*, Optical imaging and pH-awakening therapy of deep tissue cancer based on specific upconversion nanophotosensitizers, Biomaterials 230 (2020) 119637.

[16] Y. Feng, Y. Wu, J. Zuo, L. Tu, I. Que, Y. Chang*, L.J. Cruz, A. Chan, H. Zhang*, Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy, Biomaterials 201 (2019) 33-41.

[17] J. Zuo, L. Tu, Q. Li, Y. Feng, I. Que, Y. Zhang, X. Liu, B. Xue, L.J. Cruz, Y. Chang*, H. Zhang*, X. Kong*, Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided "Off-On" Therapy, ACS Nano 12(4) (2018) 3217-3225.

[18] X. Liu, Z. Fan, L. Zhang, Z. Jin, D. Yan, Y. Zhang, X. Li, L. Tu, B. Xue, Y. Chang*, H. Zhang*, X. Kong*, Bcl-2 inhibitor uploaded upconversion nanophotosensitizers to overcome the photodynamic therapy resistance of cancer through adjuvant intervention strategy, Biomaterials 144 (2017) 73-83.