（一）基础研究
　　1、炎症小体活化及调控的分子机理
　　NLRP3炎症小体能被种类众多而相关性不大的刺激物激活，包括铝盐、硅颗粒、流感病毒、ATP等，这提示其上游有众多的调控分子。我们将通过多种技术手段寻找调控炎症小体活化的新分子，并对这些分子的作用机理进行深入研究。
　　2、炎症小体在自身免疫性疾病中的作用机理
　　已有研究发现NLRP3炎症小体跟系统性红斑狼疮和结肠炎等疾病的发生有关。本实验室将深入研究NLRP3在这两种疾病中发挥作用的分子和细胞机制，以及天然免疫系统影响获得性免疫反应的机理。
　　3、炎症小体在抗感染中的作用机理
　　作为天然免疫系统的重要组成部分，炎症小体在对抗病原微生物感染过程中发挥重要作用。已有研究发现NLRP3炎症小体在抗流感病毒、腺病毒、白色念珠菌等病原体感染中作用非常关键。我们结合本所病原微生物研究的优势，探索NLRP3在抗重要病原微生物感染过程中的功能及相关机制。

（二）应用研究
　　1、炎症小体的药理调控
　　NLRP3炎症小体参与众多的生理病理过程，因此寻找合适的药物调控炎症小体具有重要的治疗价值。我们将探索多种药物对NLRP3的调控作用，并通过适当的改造以开发对炎症小体的干预策略。
　　2、基于NLR信号的疫苗佐剂开发

071005-微生物学
085238-生物工程

天然免疫学
炎症

2001-08--2005-05   德国慕尼黑技术大学   博士
1997-09--2000-07   山东师范大学，中科院上海细胞生物学研究所（联合培养）   硕士
1993-09--1997-07   山东师范大学   学士

1.2010/5-至今，中国科学院上海巴斯德研究所，天然免疫研究组，研究员
2.2005/5-2010/4，美国国家卫生研究院，过敏与传染病研究所，博士后
3.2000/9-2001/7，德国汉堡马普学会，结构与分子生物学实验室，访问学者​

2010-05~现在, 中国科学院上海巴斯德研究所, 研究员
2005-05~2009-12,美国国立卫生研究院, 博士后

2013-04-08-今,上海市细胞生物学学会理事,
2011-09-01-今,上海市微生物学会会员,
2010-09-01-今,中国免疫学会会员,
2010-09-01-今,中国细胞生物学学会会员,

高级免疫学与病毒学系列讲座

（1） 赛诺菲-安万特-中科院上海生命科学研究院优秀青年人才奖, , 其他, 2011
（2） 国家优秀自费留学生奖学金, , 国家级, 2004

[1] 孟广勋, 李娟. 一种抗病毒蛋白酶CPAVM1及其应用. 202211468718.4, 2022-11-23.
[2] 孟广勋, 牛俊领. 假长双歧杆菌及其应用. 202110763051.X, 2021-07-07.
[3] 孟广勋, 喻实. 基于S 蛋白R815 位点的冠状病毒干预的方法和产品. 202110220208.4, 2020-09-05.
[4] 孟广勋, 姚福家, 李政. 抑制多种病毒感染的药物及其联用. CN108938637A, 2018-12-07.
[5] 孟广勋, 王洪斌. 铁离子在抑制RNA病毒中的应用. CN: CN108014129A, 2018-05-11.
[6] 孟广勋, 王洪斌. 柠檬酸根离子和铁离子在抑制RNA病毒中的应用. CN106581052A, 2017-04-26.

   

[1] Shi Yu, Bingjie Zhou, Juan Li, Mengdan Chen, Rong Deng, Gary Wong, Dimitri Lavillette, 孟广勋. SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation. Proceedings of the National Academy of Sciences of the United States of America[J]. 2022, 119(1): [2] Lu, Ailing, Wu, Shuxian, Niu, Junling, Cui, Mengmeng, Chen, Mengdan, Clapp, William L, Barnes, Betsy J, Meng, Guangxun. Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY[J]. 2021, 73(8): 1467-1477, http://dx.doi.org/10.1002/art.41677.
[3] Meng Guangxun. Citrobacter freundii activates the NLRP3 inflammasome via T6SS. The Journal of Infectious Diseases. 2020, [4] Li, Wenjing, Shi, Lei, Zhuang, Zhenpeng, Wu, Han, Lian, Meng, Chen, Yihui, Li, Lei, Ge, Weikai, Jin, Qin, Zhang, Quanjun, Zhao, Yu, Liu, Zhaoming, Ouyang, Zhen, Ye, Yinghua, Li, Yingying, Wang, Hai, Liao, Yuan, Quan, Longquan, Xiao, Lei, Lai, Liangxue, Meng, Guangxun, Wang, Kepin. Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses. JOURNAL OF IMMUNOLOGY[J]. 2020, 205(9): 2532-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000581921400019.
[5] Yihui Chen, Hongbin Wang, Junchen Shen, Rong Deng, Xiaomin Yao, Qiuhong Guo, Ailing Lu, Bing Sun, Yan Zhang, Guangxun Meng. Gasdermin D Drives the Non-exosomal Secretion of An Insulin Signal Antagonist Galectin-3. 2019, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=2&recid=&FileName=IGMD201906001057&DbName=IPFDLAST2020&DbCode=IPFD&yx=&pr=&URLID=&bsm=.
[6] Li, Zheng, Yao, Fujia, Xue, Guang, Xu, Yongfen, Niu, Junling, Cui, Mengmeng, Wang, Hongbin, Wu, Shuxian, Lu, Ailing, Zhong, Jin, Meng, Guangxun. Antiviral effects of simeprevir on multiple viruses. ANTIVIRAL RESEARCH[J]. 2019, 172: http://dx.doi.org/10.1016/j.antiviral.2019.104607.
[7] Junling Niu, Shuxian Wu, Mingkuan Chen, Ke Xu, Qiuhong Guo, Ailing Lu, Liping Zhao, Bing Sun, Guangxun Meng. Hyperactivation of the NLRP3 inflammasome protects mice against influenza A virus infection via IL-1β mediated neutrophil recruitment. Cytokine. 2019, 120: 115-124, http://dx.doi.org/10.1016/j.cyto.2019.04.019.
[8] Li, Zhi, Lu, Gen, Meng, Guangxun. Pathogenic Fungal Infection in the Lung. FRONTIERS IN IMMUNOLOGY[J]. 2019, 10: https://doaj.org/article/a59a6048da9c4f4189d72c7416847d0d.
[9] Wang, Hongbin, Li, Zheng, Niu, Junling, Xu, Yongfen, Ma, Li, Lu, Ailing, Wang, Xun, Qian, Zhikang, Huang, Zhong, Jin, Xia, Leng, Qibin, Wang, Jianhua, Zhong, Jin, Sun, Bing, Meng, Guangxun. Antiviral effects of ferric ammonium citrate. CELL DISCOVERY[J]. 2018, 4(1): https://doaj.org/article/0551ffba54c549f68bf2f35954839be5.
[10] Meng Guangxun. nterleukin-18 protects mice from Enterovirus 71 infection. Cytokine. 2017, [11] Rongrong Ren, Shuxian Wu, Jialin Cai, Yuqin Yang, Xiaonan Ren, Yanling Feng, Lixiang Chen, Boyin Qin, Chunhua Xu, Hua Yang, Zhigang Song, Di Tian, Yunwen Hu, Xiaohui Zhou, Guangxun Meng. The H7N9 influenza A virus infection results in lethal inflammation in the mammalian host via the NLRP3-caspase-1 inflammasome. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/e130a582158a4b9793309e0045886d09.
[12] Lu, Ailing, Li, Hua, Niu, Junling, Wu, Shuxian, Xue, Guang, Yao, Xiaomin, Guo, Qiuhong, Wan, Nianhong, Abliz, Paride, Yang, Guiwen, An, Liguo, Meng, Guangxun. Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus. JOURNAL OF IMMUNOLOGY[J]. 2017, 198(3): 1119-1129, https://www.webofscience.com/wos/woscc/full-record/WOS:000392412700016.
[13] Xing, Yue, Yao, Xiaomin, Li, Hua, Xue, Guang, Guo, Qiuhong, Yang, Guiwen, An, Liguo, Zhang, Yan, Meng, Guangxun. Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome. JOURNAL OF IMMUNOLOGY[J]. 2017, 199(5): 1561-1566, https://www.webofscience.com/wos/woscc/full-record/WOS:000408005200005.
[14] Meng Guangxun. Microbiota Remodeled by Hyperactive NLRP3 Mutation Neutralizes Inflammation in the Gut. Nature Communications. 2017, [15] Kong, Xiang, Lu, AiLing, Yao, XinMing, Hua, Qiang, Li, XiaoYong, Qin, Li, Zhang, HongMei, Meng, GuangXun, Su, Qing. Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY[J]. 2017, 2017: https://doaj.org/article/3445d752b60b41e59fe410097ead5400.
[16] Meng Guangxun. Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS. Inflammasome. 2016, [17] Javed Numan, Xue Guang, Lu Ailing, Xing Yue, Iwakura Yoichiro, Xiao Hui, Lecoeur Herv, Spth Gerald F, Meng Guangxun. Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. Cytokine[J]. 2016, [18] Wang, Hongbin, Lei, Xiaobo, Xiao, Xia, Yang, Chunfu, Lu, Wenli, Huang, Zhong, Leng, Qibin, Jin, Qi, He, Bin, Meng, Guangxun, Wang, Jianwei. Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome. CELL REPORTS[J]. 2015, 12(1): 42-48, http://dx.doi.org/10.1016/j.celrep.2015.05.047.
[19] 牛俊领, 陈明宽, 吴淑娴, 孟广勋, 徐存拴, 卢爱灵. NLRP3炎症小体在流感病毒感染中的作用. 中国细胞生物学学报[J]. 2015, 37(4): 547-552, [20] Chen, Mingkuan, Xing, Yue, Lu, Ailing, Fang, Wei, Sun, Bing, Chen, Changbin, Liao, Wanqing, Meng, Guangxun. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes. JOURNAL OF IMMUNOLOGY[J]. 2015, 195(10): 4962-4972, https://www.webofscience.com/wos/woscc/full-record/WOS:000364822800046.
[21] Liqiong eSong, Yuanming eHuang, Meng eZhao, Zhihao eWang, Hui eSun, Shujing eWang, Biao eKan, Guangxun eMeng, Weili eLiang, Zhihong eRen. A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages. Frontiers in Microbiology[J]. 2015, 6: https://doaj.org/article/ebaf39da2be64787a580abad56b0f92b.
[22] 孟广勋, 郭彩琴, 陈明宽. 天然免疫系统与新生隐球菌感染. 中国真菌学杂志[J]. 2015, 10(4): 193-196, http://lib.cqvip.com/Qikan/Article/Detail?id=665816243.
[23] Meng Guangxun. Effect of Enterohemorrhagic Escherichia coli O157:H7-Specific Enterohemolysin on Interleukin-1β Production Differs between Human and Mouse Macrophages due to the Different Sensitivity of NLRP3 Activation. Immunology. 2015, [24] Caiqin Guo, Mingkuan Chen, Zhenzong Fa, Ailing Lu, Wei Fang, Bing Sun, Changbin Chen, Wanqing Liao, Guangxun Meng. Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome. Microbes and Infection. 2014, 845-854, http://dx.doi.org/10.1016/j.micinf.2014.08.013.
[25] Chen, Wei, Xu, Yongfen, Li, Hua, Tao, Wanyin, Xiang, Yu, Huang, Bing, Niu, Junqi, Zhong, Jin, Meng, Guangxun. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells. PLOS ONE[J]. 2014, 9(1): https://doaj.org/article/4d263f5c99854e5999c11cfdcc85f5b0.
[26] Watanabe, T, Asano, N, Meng, G, Yamashita, K, Arai, Y, Sakurai, T, Kudo, M, Fuss, I J, Kitani, A, Shimosegawa, T, Chiba, T, Strober, W. NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6. MUCOSAL IMMUNOLOGY[J]. 2014, 7(6): 1312-1325, https://www.webofscience.com/wos/woscc/full-record/WOS:000344091700004.
[27] Mao, Liming, Zhang, Liping, Li, Hua, Chen, Wei, Wang, Hongbin, Wu, Shuxian, Guo, Caiqin, Lu, Ailing, Yang, Guiwen, An, Liguo, Abliz, Paride, Meng, Guangxun. Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome. INFECTION AND IMMUNITY[J]. 2014, 82(2): 882-892, https://www.webofscience.com/wos/woscc/full-record/WOS:000330357100039.
[28] Meng Guangxun. Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome.. INFECT IMMUN.. 2013, [29] Meng Guangxun. Alarmin HNP-1 promotes pyroptosis and IL-1b release through different roles of NLRP3 inflammasome. Innate Immunity. 2013, [30] Mao, Kairui, Chen, Shuzhen, Chen, Mingkuan, Ma, Yonglei, Wang, Yan, Huang, Bo, He, Zhengyu, Zeng, Yan, Hu, Yu, Sun, Shuhui, Li, Jing, Wu, Xiaodong, Wang, Xiangrui, Strober, Warren, Chen, Chang, Meng, Guangxun, Sun, Bing. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. CELL RESEARCH[J]. 2013, 23(2): 201-212, http://www.irgrid.ac.cn/handle/1471x/756526.
[31] Meng Guangxun. Pannexin-1 infl uences peritoneal cavity cell. Protein Cell. 2013, [32] Lei, Guowei, Chen, Mingkuan, Li, Hua, Niu, JunLing, Wu, Shuxian, Mao, Liming, Lu, Ailing, Wang, Hongbin, Chen, Wei, Xu, Bin, Leng, Qibin, Xu, Cunshuan, Yang, Guiwen, An, Liguo, Zhu, LiPing, Meng, Guangxun. Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome. CELL RESEARCH. 2013, 23(7): 965-968, https://www.webofscience.com/wos/woscc/full-record/WOS:000321113700014.
[33] Li, Hua, Wu, Shuxian, Mao, Liming, Lei, Guowei, Zhang, Liping, Lu, Ailing, An, Liguo, Yang, Guiwen, Abliz, Paride, Meng, Guangxun. Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome. PROTEIN & CELL[J]. 2013, 4(7): 529-538, https://www.webofscience.com/wos/woscc/full-record/WOS:000322393900007.
[34] Meng Guangxun. The NLRP3 Infl ammasome activation in human. Protein Cell. 2013, [35] Meng Guangxun. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells.. PLOS ONE. 2013, [36] Xu, Yongfen, Li, Hua, Chen, Wei, Yao, Xiaomin, Xing, Yue, Wang, Xun, Zhong, Jin, Meng, Guangxun. Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells. PLOS ONE[J]. 2013, 8(11): https://doaj.org/article/ef11198478194558ad78a4bd5d884fe0.
[37] Yuumi Nakamura, Luigi Franchi, Naotomo Kambe, Guangxun Meng, Warren Strober, Gabriel Nez. Critical Role for Mast Cells in Interleukin-1β-Driven Skin Inflammation Associated with an Activating Nlrp3 Mutation. Immunity. 2012, 37(1): 85-95, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411177/.
[38] 雷国伟, 毛立明, 李华, 安利国, 杨桂文, 孟广勋. 炎症小体在对抗微生物感染中的作用. 中国细胞生物学学报[J]. 2011, 33(12): 1301-1315, http://lib.cqvip.com/Qikan/Article/Detail?id=40304878.
[39] Chen, Mingkuan, Wang, Hongbin, Chen, Wei, Meng, Guangxun. Regulation of adaptive immunity by the NLRP3 inflammasome. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2011, 11(5): 549-554, http://dx.doi.org/10.1016/j.intimp.2010.11.025.
[40] Meng, Guangxun, Strober, Warren. New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations. EUROPEAN JOURNAL OF IMMUNOLOGY[J]. 2010, 40(3): 649-653, https://www.webofscience.com/wos/woscc/full-record/WOS:000275935600015.
[41] Shuzhen Chen, Xiaodong Wu, Shuhui Sun, Guangxun Meng, Zhiyun Tao, Chen Yang, Yu Hu, Kairui Mao, Bing Sun, Yan Zeng. Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production. American Association of Immunologists. 2010, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902021667125ZK.
[42] Meng, Guangxun, Zhang, Fuping, Fuss, Ivan, Kitani, Atsushi, Strober, Warren. A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses. IMMUNITY[J]. 2009, 30(6): 860-874, http://dx.doi.org/10.1016/j.immuni.2009.04.012.
[43] Zhang, Fuping, Meng, Guangxun, Strober, Warren. Interactions among the transcription factors Runx1, ROR gamma t and Foxp3 regulate the differentiation of interleukin 17-producing T cells. NATURE IMMUNOLOGY[J]. 2008, 9(11): 1297-1306, https://www.webofscience.com/wos/woscc/full-record/WOS:000260248600017.
[44] Meng Guangxun. Cellular recognition of Tri-myristoylated peptide or enterobacterial LPS via both TLR2 and TLR4.. J Biol Chem. 2007, [45] Meng, GX, Grabiec, A, Rutz, M, Jochen, MB, Luppa, PB, Wagner, H, Bauer, S, Kirschning, CJ. Murine TLR2 expression analysis and systemic antagonism by usage of specific monoclonal antibodies. IMMUNOLOGY LETTERS[J]. 2005, 98(2): 200-207, http://dx.doi.org/10.1016/j.imlet.2004.11.015.
[46] Grabiec, A, Meng, GX, Fichte, S, Bessler, W, Wagner, H, Kirschning, CJ. Human but not murine Toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2004, 279(46): 48004-48012, https://www.webofscience.com/wos/woscc/full-record/WOS:000224957000072.
[47] Meng, GX, Rutz, M, Schiemann, M, Metzger, J, Grabiec, A, Schwandner, R, Luppa, PB, Ebel, F, Busch, DH, Bauer, S, Wagner, H, Kirschning, CJ. Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. JOURNAL OF CLINICAL INVESTIGATION[J]. 2004, 113(10): 1473-1481, https://www.webofscience.com/wos/woscc/full-record/WOS:000221531200015.
[48] Meng, GX, Grabiec, A, Vallon, M, Ebe, B, Hampel, S, Bessler, W, Wagner, H, Kirschning, CJ. Cellular recognition of Tri-/Di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2003, 278(41): 39822-39829, http://dx.doi.org/10.1074/jbc.M304766200.

   

（ 1 ） 诱导多能干细胞治疗NLRP3相关自发炎症的研究, 主持, 国家级, 2012-01--2015-12
（ 2 ） 难治性丙肝转归预警预测的研究, 主持, 国家级, 2012-01--2015-12
（ 3 ） NLRP3炎症小体识别新生隐球菌生物膜的机理与功能研究, 主持, 国家级, 2014-01--2017-12
（ 4 ） 狼疮靶器官受损相关炎症通路活化的细胞及分子调节机制研究, 参与, 国家级, 2014-04--2019-04
（ 5 ） 优化NLRP3突变小鼠并研究其抗流感功能及机制, 参与, 国家级, 2014-01--2016-12
（ 6 ） 白细胞介素在胃肠癌发生发展中的协作机制, 参与, 国家级, 2015-01--2017-12
（ 7 ） HCV感染与宿主天然免疫系统相互识别与调节的机理研究, 参与, 国家级, 2015-01--2019-08
（ 8 ） NLRP3炎症小体对肠道病毒71型识别与应答的分子和细胞机, 主持, 国家级, 2016-01--2019-12
（ 9 ） NLRP3炎症小体与利什曼原虫的相互调控研究, 主持, 部委级, 2016-01--2018-12
（ 10 ） Role of pattern recognition receptors, inflammasome, and microbial capsule in host response to skin and scalp microbiome, 主持, 院级, 2016-07--2018-01

（1）EV71病毒与NLRP3炎症小体的相互调控研究   法国巴斯德所国际网络科技论坛   王洪斌   2015-10-14
（2）Nlrp3-R258W Mutation Protects Mice from Animal Models of Colitis and Colorectal Cancer”   第十七届国际粘膜免疫学大会   姚小敏   2015-07-14
（3）NLRP3-R258W MUTATION PROTECTS MICE FROM EXPERIMENTAL COLITIS AND COLORECTAL CANCER”   第六届FIMSA免疫学大会   姚小敏   2015-06-30
（4）Function of the inflammasome in the host defense against Cryptococcus neoformans infection   Guangxun Meng   2014-05-15
（5）An Essential Role for the NLRP3 Inflammasome in Host Defense against Cryptococcus neoformans infection   2012 上海国际医学真菌学高峰论坛   孟广勋   2012-11-15
（6）Blau Syndrome-Associated NOD2 Mutation Results in Loss of Regulatory Function   Guangxun MENG   2011-11-18
（7）IL-17 dominant Inflammation from Mice with Nlrp3 Mutation in Experimental Uveitis   中国免疫学会第六次全国会员代表大会第七届学术会议   Guangxun Meng   2010-10-22
（8）Interleukine-17 dominant inflammation in Experimental Uveitis from Mice with Nlrp3 Mutation   Guangxun Meng, Phyllis B. Silver, Rachel R. Caspi, and Warren Strober   2010-07-17

已指导学生

陈明宽  01  19178  

王洪斌  01  19178  

陈伟  01  19178  

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