1、基于多靶点的降血糖活性成分发现、药效评价和新药研发

借鉴中医药对糖尿病（消渴）的认识，选择临床有效中药及亲缘药用植物，以课题组建立的降血糖多靶点筛选体系（PTP1B、TCPTP、α-葡萄糖苷酶、Gpa、GK等），开展活性和液质导向的新颖活性分子的发现、结构优化、作用机制和成药性研究，为天然来源的新型降血糖先导分子的发现和创新药物研发提供依据。

2、传统药用植物的综合开发利用研究

利用LCMS和体外多靶点筛选体系，对传统中药不同基源、不同部位开展系统比较分析，揭示其物质基础和活性成分差异，为中药资源的综合开发利用提供参考。

招生意向：天然药物化学、合成药物化学、分析化学及相关专业

100701-药物化学
070303-有机化学
100800-中药学

2008-09--2011-06   中国科学院昆明植物研究所   理学博士学位
2005-09--2008-06   中国科学院昆明植物研究所   理学硕士学位
2001-09--2005-06   中国海洋大学药学院   医学学士学位

   

2021-04~现在, 中国科学院昆明植物研究所, 博士生导师
2020-11~现在, 中国科学院昆明植物研究所, 研究员
2017-04~现在, 中国科学院昆明植物研究所, 硕士生导师
2016-10~2017-09,英国华威大学, 访问学者
2014-01~2020-11,中国科学院昆明植物研究所, 副研究员
2011-09~2013-12,中国科学院昆明植物研究所, 助理研究员

   

[1] 耿长安, 何小凤, 陈纪军, 胡敬, 李天泽, 黄晓燕, 马云保, 张雪梅. 黄烷醇-脂肪醇杂合体及其药物组合物与其制备方法和应用. CN: CN111978330B, 2023-08-22.
[2] 陈纪军, 何小凤, 李天泽, 耿长安, 马云保, 张雪梅, 黄晓燕, 胡敬. 黄花蒿醇A-C及其药物组合物和其制备方法与应用. CN: CN116621800A, 2023-08-22.
[3] 陈纪军, 苏丽花, 李天泽, 马文静, 马云保, 耿长安, 董伟, 何小凤, 张雪梅. 魁蒿烯内酯A-F及其药物组合物和其制备方法与应用. CN: CN116589474A, 2023-08-15.
[4] 陈纪军, 苏丽花, 李天泽, 耿长安, 马云保, 黄晓燕, 胡敬, 张雪梅. 暗绿蒿烯内酯A-L及其药物组合物和其应用. CN: CN113527324B, 2023-08-11.
[5] 耿长安, 陈纪军, 王恬, 吴圣丽, 张雪梅, 马云保, 黄晓燕, 胡敬, 李天泽. 一类二芳基庚烷及其制备方法和应用. CN: CN116574079A, 2023-08-11.
[6] 陈纪军, 何小凤, 李天泽, 耿长安, 马云保, 张雪梅, 黄晓燕, 胡敬. 南牡蒿内酯A-D及其药物组合物和其应用. CN: CN115490660B, 2023-08-11.
[7] 陈纪军, 董伟, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. 中甸艾中倍半萜二聚体及其药物组合物与其制备方法和应用. CN: CN115010720B, 2023-08-11.
[8] 陈纪军, 李天泽, 马云保, 耿长安, 张雪梅. 愈创木烷倍半萜多聚体与其药物及其制备方法和应用. CN: CN113788840B, 2023-08-11.
[9] 耿长安, 陈纪军, 丁敏, 李天泽, 张雪梅, 黄晓燕, 马云保, 胡敬. 砂仁素A～D及其药物组合物与其制备方法和应用. CN: CN114560842B, 2023-08-04.
[10] 耿长安, 陈纪军, 何小凤, 李天泽, 张雪梅, 黄晓燕, 马云保, 胡敬. 二芳基庚烷二聚体及其药物组合物与其制备方法和应用. CN: CN113929698B, 2023-08-04.
[11] 陈纪军, 董伟, 李天泽, 马云保, 马文静, 李凤娇, 王永翠, 何小凤, 耿长安, 张雪梅. 中甸艾内酯B1-B17及其药物组合物和其制备方法与应用. CN: CN116478185A, 2023-07-25.
[12] 耿长安, 陈纪军, 崔粲, 吴圣丽, 张雪梅, 李天泽, 马云保, 黄晓燕, 胡敬. 一类倍半萜类化合物及其制备方法和应用. CN: CN116444355A, 2023-07-18.
[13] 陈纪军, 李天泽, 杨晓烔, 马云保, 黄晓燕, 耿长安, 张雪梅, 胡敬. 多花蒿内酯H衍生物及其药物组合物和其制备方法与应用. CN116082284A, 2023-05-09.
[14] 陈纪军, 商冲, 李天泽, 耿长安, 张雪梅, 黄晓燕. 蒙古蒿内酯A-F及其药物组合物和其制备方法与应用. CN115894418A, 2023-04-04.
[15] 马云保, 陈纪军, 王远, 李天泽, 耿长安, 张雪梅, 黄晓燕, 胡敬. 白叶蒿内酯A-L及其药物组合物和其制备方法与应用. CN115785041A, 2023-03-14.
[16] 陈纪军, 高振, 李天泽, 马云保, 耿长安, 黄晓燕, 胡敬, 张雪梅. 牛尾蒿倍半萜内酯A-N及其药物组合物和其制备方法与应用. CN115745933A, 2023-03-07.
[17] 陈纪军, 何小凤, 李天泽, 耿长安, 马云保, 张雪梅, 黄晓燕, 胡敬. 南牡蒿内酯A-D及其药物组合物和其应用. CN115490660A, 2022-12-20.
[18] 陈纪军, 董伟, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. 中甸艾中倍半萜二聚体及其药物组合物与其制备方法和应用. CN115010720A, 2022-09-06.
[19] 陈纪军, 李天泽, 马云保, 耿长安, 黄晓燕, 胡敬, 张雪梅. 一种愈创木烷倍半萜二聚体及其衍生物和其在制药中的应用. CN115010719A, 2022-09-06.
[20] 陈纪军, 何小凤, 李天泽, 耿长安, 马云保, 张雪梅, 黄晓燕, 胡敬. 南牡蒿素及其药物组合物和其制备方法与应用. CN114957190A, 2022-08-20.
[21] 马云保, 张鑫, 陈纪军, 李天泽, 耿长安. 多花蒿内酯A-J及其药物组合物与其制备方法和应用. CN114874170A, 2022-08-09.
[22] 陈纪军, 李天泽, 孙金金, 王金平, 马云保, 黄晓燕, 耿长安, 胡敬, 张雪梅. Ludartin衍生物和其药物组合物及其制备方法和应用. CN114539195A, 2022-05-27.
[23] 陈纪军, 高振, 李天泽, 马云保, 马文静, 耿长安, 何小凤, 黄晓燕, 胡敬, 张雪梅. 牛尾蒿内酯A-T及其药物组合物和其制备方法与应用. CN114524825A, 2022-05-24.
[24] 耿长安, 陈纪军, 丁敏, 李天泽, 张雪梅, 黄晓燕, 马云保, 胡敬. 砂仁素A～D及其药物组合物与其制备方法和应用. CN114560842A, 2022-05-11.
[25] 耿长安, 陈纪军, 何小凤, 李天泽, 张雪梅, 黄晓燕, 马云保, 胡敬. 二芳基庚烷二聚体及其药物组合物与其制备方法和应用. CN: CN113929698A, 2022-01-14.
[26] 陈纪军, 李天泽, 马云保, 耿长安, 张雪梅. 愈创木烷倍半萜多聚体与其药物及其制备方法和应用. CN: CN113788840A, 2021-12-14.
[27] 陈纪军, 杨晓烔, 李天泽, 耿长安. 20S,24R-环氧-达玛烷-3β,12β,25-三醇衍生物与其药物组合物. CN: CN113730419A, 2021-12-03.
[28] 陈纪军, 李天泽, 耿长安, 张雪梅. 愈创木烷倍半萜二聚体的制备方法. CN: CN113735875A, 2021-12-03.
[29] 耿长安, 陈纪军, 何小凤, 胡敬, 李天泽, 张雪梅, 黄晓燕, 马云保. 一类新颖二芳基庚烷-黄烷酮杂合体及其药物组合物和应用. CN: CN113582981A, 2021-11-02.
[30] 陈纪军, 苏丽花, 李天泽, 耿长安, 马云保, 黄晓燕, 胡敬, 张雪梅. 暗绿蒿烯内酯A-L及其药物组合物和其应用. CN: CN113527324A, 2021-10-22.
[31] 陈纪军, 苏丽花, 马云保, 耿长安, 李天泽, 黄晓燕, 胡敬, 张雪梅. 暗绿蒿素A-P及其药物组合物与其制备方法和应用. CN: CN113185562A, 2021-07-30.
[32] 陈纪军, 高振, 黄晓燕, 耿长安, 李天泽, 马云保, 胡敬, 张雪梅. 茵陈蒿中香豆酸及其药物组合物与其制备方法和应用. CN: CN113173905A, 2021-07-27.
[33] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种2,6-环氧二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110903270B, 2021-07-09.
[34] 陈纪军, 王金平, 李天泽, 黄晓燕, 耿长安, 马云保, 张雪梅, 胡敬. 珊塔玛内酯衍生物及其药物组合物和其制备方法与应用. CN: CN112939910A, 2021-06-11.
[35] 耿长安, 何小凤, 陈纪军, 张雪梅, 胡敬, 李天泽, 黄晓燕, 马云保. 草豆蔻中二芳基庚烷-查尔酮聚合物及其药物组合物与应用. CN: CN112592328A, 2021-04-02.
[36] 陈纪军, 苏丽花, 耿长安, 张心湉, 马云保, 黄晓燕, 李天泽, 胡敬, 张雪梅. 暗绿蒿内酯A-R及其药物组合物和应用. CN: CN112225746A, 2021-01-15.
[37] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110964027B, 2020-12-18.
[38] 陈纪军, 苏丽花, 耿长安, 马云保, 黄晓燕, 张心湉, 李天泽, 张雪梅. 暗绿蒿醇A-B及其药物组合物和其制备方法与应用. CN: CN112062738A, 2020-12-11.
[39] 耿长安, 何小凤, 陈纪军, 胡敬, 李天泽, 黄晓燕, 马云保, 张雪梅. 黄烷醇-脂肪醇杂合体及其药物组合物与其制备方法和应用. CN: CN111978330A, 2020-11-24.
[40] 陈纪军, 唐爽, 耿长安, 张心湉, 马云保, 黄晓燕, 李天泽, 张雪梅. 多花蒿烯内酯A-S和多花蒿素A-G及其药物组合物和应用. CN: CN111704594A, 2020-09-25.
[41] 耿长安, 何小凤, 陈纪军, 胡敬, 李天泽, 黄晓燕, 马云保, 张雪梅. 黄烷醇-薄荷烷杂合体及其药物组合物与其制备方法和应用. CN: CN111704622A, 2020-09-25.
[42] 陈纪军, 申程, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. 野艾蒿中倍半萜及其药物组合物与其制备方法和应用. CN: CN111635380A, 2020-09-08.
[43] 陈纪军, 李天泽, 张雪梅, 耿长安. 苔黑酚葡萄糖苷的制备方法. CN: CN111233951A, 2020-06-05.
[44] 耿长安, 陈纪军, 杨晓烔, 李天泽, 黄晓燕, 胡敬. 先花铃子香素A衍生物与其药物组合物及其制备方法和应用. CN: CN111233702A, 2020-06-05.
[45] 耿长安, 高振, 陈纪军, 张雪梅, 马云保, 黄晓燕, 李天泽, 胡敬. 香豆酸类化合物的应用、药物组合物及其应用. CN: CN110917184A, 2020-03-27.
[46] 陈纪军, 耿长安, 陈思月, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 双酚F在制备治疗中枢神经系统疾病的药物中的应用. CN: CN109820840A, 2019-05-31.
[47] 陈纪军, 陈思月, 耿长安, 马云保, 黄晓燕, 张雪梅. 多聚苄衍生物及其药物组合物与其制备方法和其应用. CN: CN109809971A, 2019-05-28.
[48] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. Paeonilactiflorol及其药物组合物与其制备方法和应用. CN: CN109810084A, 2019-05-28.
[49] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. 芍药籽中寡聚芪类化合物在制药中的应用. CN: CN109700796A, 2019-05-03.
[50] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 张雪梅, 马云保. 芍药籽提取物在制药中的应用. CN: CN109692209A, 2019-04-30.
[51] 耿长安, 陈纪军, 闫孟红, 马云保, 黄晓燕, 张雪梅. 构树中黄酮类成分在制备抗口腔菌疾病的药物中的应用. CN: CN109172640A, 2019-01-11.
[52] 耿长安, 陈纪军, 闫孟红, 马云保, 黄晓燕, 张雪梅. 构树醇化合物及其组合物与其用途. CN: CN109180660A, 2019-01-11.
[53] 耿长安, 陈纪军, 闫孟红, 马云保, 黄晓燕, 张雪梅. 构树提取物在制备抗口腔疾病的产品中的应用. CN: CN108904594A, 2018-11-30.
[54] 陈纪军, 耿长安, 马云保, 黄晓燕, 张雪梅, 杨静. 8S-癸-9-烯-4,6-二炔-1,8-二醇及其药物组合物和应用. CN: CN108821947A, 2018-11-16.
[55] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔醇类化合物及其药物组合物和其用途. CN: CN108569953A, 2018-09-25.
[56] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔酸类化合物及其药物组合物和其用途. CN: CN108530292A, 2018-09-14.
[57] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 李天泽, 高振, 马云保, 张雪梅. 异序乌桕素A-H及其药物组合物和其应用. CN: CN108440292A, 2018-08-24.
[58] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 高振, 李天泽, 马云保, 张雪梅. 异序乌桕素I和J及其药物组合物和其应用. CN: CN108314620A, 2018-07-24.
[59] 陈纪军, 杨通华, 耿长安, 马云保, 颜得秀, 黄晓燕, 张雪梅. 厚朴酚糖苷在制备治疗中枢神经系统疾病药物中的应用. CN: CN108143741A, 2018-06-12.
[60] 陈纪军, 耿长安, 梁文娟, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. Paeonivayin在制备治疗中枢神经系统疾病的药物中的应用. CN: CN107898799A, 2018-04-13.
[61] 耿长安, 陈纪军, 张建钢, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 钩藤酰胺A及其药物组合物和应用. CN: CN107827940A, 2018-03-23.
[62] 陈纪军, 杨通华, 李天泽, 耿长安, 张雪梅. (20S,24R)‑20,24‑环氧达玛烷‑3β,12β,25‑三醇及其应用. CN: CN107778340A, 2018-03-09.
[63] 陈纪军, 尹秀娟, 马云保, 黄晓燕, 耿长安, 张雪梅. 以芦竹碱衍生物为活性成分的药物组合物及其应用. CN: CN107174586A, 2017-09-19.
[64] 陈纪军, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. (±)UncarilinsA和B及其药物组合物和应用. CN: CN107056790A, 2017-08-18.
[65] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种杏鲍菇饮料及其制作方法. CN: CN106937715A, 2017-07-11.
[66] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种山楂饮料及其制作方法. CN: CN106937716A, 2017-07-11.
[67] 沈勇, 张丽. 一种紫薯饮料及其制备方法. CN: CN106937717A, 2017-07-11.
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[105] Wang, LiJun, Chen, Hao, Ma, YunBao, Huang, XiaoYan, Geng, ChangAn, Zhang, XueMei, Chen, JiJun. Design, Synthesis and Biological Evaluation of Caudatin Analogs as Potent Hepatitis B Virus Inhibitors. MEDICINAL CHEMISTRY[J]. 2015, 第 5 作者11(2): 165-179, http://www.irgrid.ac.cn/handle/1471x/959076.
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[107] Zhao, Yong, Geng, ChangAn, Chen, Hao, Ma, YunBao, Huang, XiaoYan, Cao, TuanWu, He, Kang, Wang, Hao, Zhang, XueMei, Chen, JiJun. Isolation, synthesis and anti-hepatitis B virus evaluation of p-hydroxyacetophenone derivatives from Artemisia capillaris. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2015, 第 2 作者25(7): 1509-1514, http://dx.doi.org/10.1016/j.bmcl.2015.02.024.
[108] Chen, XingLong, Geng, ChangAn, Chen, JiJun. A Fragmentation Study of Six C-21 Steroidal Aglycones by Electrospray Ionization Ion-Trap Time-of-Flight Tandem Mass Spectrometry. NATURAL PRODUCT COMMUNICATIONS[J]. 2015, 第 2 作者10(12): 2053-2058, http://ir.kib.ac.cn/handle/151853/25431.
[109] Geng, ChangAn, Huang, XiaoYan, Ma, YunBao, Zhang, XueMei, Chen, JiJun. Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2015, 第 1 作者25(7): 1568-1571, http://dx.doi.org/10.1016/j.bmcl.2015.02.009.
[110] Guo, Ao, He, Dongming, Xu, HongBo, Geng, ChangAn, Zhao, Jian. Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents. SCIENTIFIC REPORTS[J]. 2015, 第 4 作者5: http://www.irgrid.ac.cn/handle/1471x/1028947.
[111] Geng, ChangAn, Chen, XingLong, Zhou, NingJia, Chen, Hao, Ma, YunBao, Huang, XiaoYan, Zhang, XueMei, Chen, JiJun. LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii. ORGANIC LETTERS[J]. 2014, 第 1 作者16(2): 370-373, http://www.irgrid.ac.cn/handle/1471x/832464.
[112] Chen, Hao, Ma, YunBao, Huang, XiaoYan, Geng, ChangAn, Zhao, Yong, Wang, LiJun, Guo, RuiHua, Liang, WenJuan, Zhang, XueMei, Chen, JiJun. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2014, 第 4 作者24(10): 2353-2359, http://dx.doi.org/10.1016/j.bmcl.2014.03.060.
[113] 荣光庆, 耿长安, 马云保, 黄晓燕, 王洪玲, 赵勇, 张雪梅, 陈纪军. 合欢花乙酸乙酯部位化学成分研究. 中国中药杂志[J]. 2014, 第 2 作者39(10): 1845-1851, https://d.wanfangdata.com.cn/periodical/zgzyzz201410018.
[114] Hao Chen, LiJun Wang, YunBao Ma, XiaoYan Huang, ChangAn Geng, XueMei Zhang, JiJun Chen. Panaxadiol and Panaxatriol Derivatives as Anti-Hepatitis B Virus Inhibitors. 应用天然产物(英文)[J]. 2014, 第 5 作者4(3): 163-74, http://lib.cqvip.com/Qikan/Article/Detail?id=7105123814.
[115] Zhao, Yong, Geng, ChangAn, Ma, YunBao, Huang, XiaoYan, Chen, Hao, Cao, TuanWu, He, Kang, Wang, Hao, Zhang, XueMei, Chen, JiJun. UFLC/MS-IT-TOF guided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2014, 第 2 作者156(10): 147-154, http://www.irgrid.ac.cn/handle/1471x/929628.
[116] Yang, CaiYan, Geng, ChangAn, Huang, XiaoYan, Wang, Hao, Xu, HongBo, Liang, WenJuan, Ma, YunBao, Zhang, XueMei, Zhou, Jun, Chen, JiJun. Noreudesmane sesquiterpenoids from the leaves of Nicotiana tabacum. FITOTERAPIA[J]. 2014, 第 2 作者96: 81-87, http://www.irgrid.ac.cn/handle/1471x/877334.
[117] Liang, WenJuan, Geng, ChangAn, Zhang, XueMei, Chen, Hao, Yang, CaiYan, Rong, GuangQing, Zhao, Yong, Xu, HongBo, Wang, Hao, Zhou, NingJia, Ma, YunBao, Huang, XiaoYan, Chen, JiJun. (+/-)-Paeoveitol, a Pair of New Norditerpene Enantiomers from Paeonia veitchii. ORGANIC LETTERS[J]. 2014, 第 2 作者16(2): 424-427, http://dx.doi.org/10.1021/ol403315d.
[118] Yang, CaiYan, Geng, ChangAn, Ma, YunBao, Huang, XiaoYan, Zhang, XueMei, Zhou, Jun, Chen, JiJun. Two new sesquiterpenoid glycosides from Nicotiana tabacum. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2014, 第 2 作者16(6): 611-616, http://www.irgrid.ac.cn/handle/1471x/877335.
[119] Zhao, Yong, Geng, ChangAn, Sun, ChangLi, Ma, YunBao, Huang, XiaoYan, Cao, TuanWu, He, Kang, Wang, Hao, Zhang, XueMei, Chen, JiJun. Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris. FITOTERAPIA[J]. 2014, 第 2 作者95: 187-193, http://www.irgrid.ac.cn/handle/1471x/849582.
[120] Geng, ChangAn, Chen, Hao, Chen, XingLong, Zhang, XueMei, Lei, LiGong, Chen, JiJun. Rapid characterization of chemical constituents in Saniculiphyllum guangxiense by ultra fast liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY[J]. 2014, 第 1 作者361: 9-22, http://dx.doi.org/10.1016/j.ijms.2014.01.021.
[121] Cao, TuanWu, Geng, ChangAn, Jiang, FuQiang, Ma, YunBao, He, Kang, Zhou, NingJia, Zhang, XueMei, Zhou, Jun, Chen, JiJun. Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity. FITOTERAPIA[J]. 2013, 第 2 作者89: 175-182, https://www.webofscience.com/wos/woscc/full-record/WOS:000323856500019.
[122] 李耀利, 尚明英, 耿长安, 张雪梅, 陈纪军, 蔡少青. 云南产青叶胆及其习用品药材中5种成分的HPLC含量测定. 中国中药杂志[J]. 2013, 第 3 作者38(9): 1394-1400, http://www.irgrid.ac.cn/handle/1471x/830630.
[123] Wang, HongLing, Cao, TuanWu, Jiang, FuQiang, Geng, ChangAn, Zhang, XueMei, Huang, XiaoYan, Wang, LiJun, KangHe, Sing Wd, HaoChen, Liang, WenJuan, Rong, GuangQing, Chen, JiJun. Swerpunilactones A and B, the first example of xanthone and secoiridoid heterodimers from Swertia punicea, S. hispidicalyx, and S. yunnanensis. TETRAHEDRON LETTERS[J]. 2013, 第 4 作者54(21): 2710-2712, http://dx.doi.org/10.1016/j.tetlet.2013.03.057.
[124] Geng, ChangAn, Liu, XiKui. Five new indole alkaloids from the leaves of Rauvolfia yunnanensis. FITOTERAPIA[J]. 2013, 第 1 作者89: 42-47, http://www.irgrid.ac.cn/handle/1471x/730365.
[125] Geng, ChangAn, Ma, YunBao, Chen, JiJun. Bishyoscyamine, one unusual dimeric tropane alkaloid from Anisodus acutangulus. CHINESE CHEMICAL LETTERS[J]. 2013, 第 1 作者24(3): 236-238, http://dx.doi.org/10.1016/j.cclet.2013.01.042.
[126] 陈慧鑫, 耿长安, 曹团武, 张雪梅, 马云保, 黄晓燕, 陈纪军. 辣椒黄酮苷A的化学结构. 中国中药杂志[J]. 2013, 第 2 作者38(12): 1934-1937, http://www.irgrid.ac.cn/handle/1471x/830629.
[127] Wang, HongLing, Geng, ChangAn, Ma, YunBao, Zhang, XueMei, Chen, JiJun. Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma. FITOTERAPIA[J]. 2013, 第 2 作者89: 183-187, http://www.irgrid.ac.cn/handle/1471x/730367.
[128] Guo, RuiHua, Geng, ChangAn, Huang, XiaoYan, Ma, YunBao, Zhang, Quan, Wang, LiJun, Zhang, XueMei, Zhang, RongPing, Chen, JiJun. Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2013, 第 2 作者23(5): 1201-1205, http://dx.doi.org/10.1016/j.bmcl.2013.01.024.
[129] Geng, ChangAn, Wang, LiJun, Guo, RuiHua, Chen, JiJun. Small-Molecule Inhibitors for the Treatment of Hepatitis B Virus Documented in Patents. MINI-REVIEWS IN MEDICINAL CHEMISTRY[J]. 2013, 第 1 作者13(5): 749-776, http://www.irgrid.ac.cn/handle/1471x/648872.
[130] ChangAn GENG, XueMei ZHANG, YunBao MA, XiaoYan HUANG, JiJun CHEN. Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis. 应用天然产物(英文)[J]. 2013, 第 1 作者3(5): 243-249, http://lib.cqvip.com/Qikan/Article/Detail?id=7105122791.
[131] Cao, TuanWu, Geng, ChangAn, Ma, YunBao, He, Kang, Wang, HongLing, Zhou, NingJia, Zhang, XueMei, Tao, YanDuo, Chen, JiJun. Xanthones with Anti-Hepatitis B Virus Activity from Swertia mussotii. PLANTA MEDICA[J]. 2013, 第 2 作者79(8): 697-700, http://dx.doi.org/10.1055/s-0032-1328399.
[132] Geng, ChangAn, Huang, XiaoYan, Lei, LiGong, Zhang, XueMei, Chen, JiJun. Chemical Constituents of Saniculiphyllum guangxiense. CHEMISTRY & BIODIVERSITY[J]. 2012, 第 1 作者  通讯作者  9(8): 1508-1516, https://www.doi.org/10.1002/cbdv.201100270.
[133] 耿家玲, 耿长安, 陈纪军. 西南獐牙菜化学成分的研究. 天然产物研究与开发[J]. 2012, 第 2 作者24(1): 42-46, http://lib.cqvip.com/Qikan/Article/Detail?id=40591094.
[134] Geng, ChangAn, Ma, YunBao, Zhang, XueMei, Yao, ShuYing, Xue, DuoQing, Zhang, RongPing, Chen, JiJun. Mulberrofuran G and Isomulberrofuran G from Morus alba L.: Anti-hepatitis B Virus Activity and Mass Spectrometric Fragmentation. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2012, 第 1 作者60(33): 8197-8202, http://www.irgrid.ac.cn/handle/1471x/522625.
[135] He, Kang, Ma, YunBao, Cao, TuanWu, Wang, HongLing, Jiang, FuQiang, Geng, ChangAn, Zhang, XueMei, Chen, JiJun. Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia. PLANTA MEDICA[J]. 2012, 第 6 作者78(8): 814-820, http://www.irgrid.ac.cn/handle/1471x/832369.
[136] Wang, LiJun, Geng, ChangAn, Ma, YunBao, Huang, XiaoYan, Luo, Jie, Chen, Hao, Zhang, XueMei, Chen, JiJun. Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2012, 第 2 作者22(10): 3473-3479, http://dx.doi.org/10.1016/j.bmcl.2012.03.081.
[137] Wang, LiJun, Geng, ChangAn, Ma, YunBao, Luo, Jie, Huang, XiaoYan, Chen, Hao, Zhou, NingJia, Zhang, XueMei, Chen, JiJun. Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2012, 第 2 作者54: 352-365, http://dx.doi.org/10.1016/j.ejmech.2012.05.012.
[138] Guo, RuiHua, Zhang, Quan, Ma, YunBao, Luo, Jie, Geng, ChangAn, Wang, LiJun, Zhang, XueMei, Zhou, Jun, Jiang, ZhiYong, Chen, JiJun. Structure-activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2011, 第 5 作者46(1): 307-319, http://dx.doi.org/10.1016/j.ejmech.2010.11.019.
[139] 蒋富强, 张雪梅, 马云保, 耿长安, 江志勇, 陈纪军. 毛萼獐牙菜化学成分的研究. 中国中药杂志[J]. 2011, 第 4 作者36(16): 2215-2218, http://lib.cqvip.com/Qikan/Article/Detail?id=39003119.
[140] 王洪玲, 陈浩, 耿长安, 张雪梅, 马云保, 江志勇, 陈纪军. 椭圆叶花锚的化学成分研究. 中国中药杂志[J]. 2011, 第 3 作者36(11): 1454-1457, http://lib.cqvip.com/Qikan/Article/Detail?id=38096256.
[141] Liu, JiFeng, Jiang, ZhiYong, Geng, ChangAn, Zhang, Quan, Shi, Yao, Ma, YunBao, Zhang, XueMei, Chen, JiJun. Two New Lignans and Anti-HBV Constituents from Illicium henryi. CHEMISTRY & BIODIVERSITY[J]. 2011, 第 3 作者8(4): 692-698, http://www.irgrid.ac.cn/handle/1471x/392903.
[142] Geng, ChangAn, Zhang, XueMei, Ma, YunBao, Luo, Jie, Chen, JiJun. Swerilactones L-O, Secoiridoids with C-12 and C-13 Skeletons from Swertia mileensis. JOURNAL OF NATURAL PRODUCTS[J]. 2011, 第 1 作者74(8): 1822-1825, http://dx.doi.org/10.1021/np200256b.
[143] Geng, ChangAn, Wang, LiJun, Zhang, XueMei, Ma, YunBao, Huang, XiaoYan, Luo, Jie, Guo, RuiHua, Zhou, Jun, Shen, Yong, Zuo, AiXue, Jiang, ZhiYong, Chen, JiJun. Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 第 1 作者17(14): 3893-3903, http://dx.doi.org/10.1002/chem.201003180.
[144] Guo, RuiHua, Zhang, Quan, Ma, YunBao, Huang, XiaoYan, Luo, Jie, Wang, LiJun, Geng, ChangAn, Zhang, XueMei, Zhou, Jun, Jiang, ZhiYong, Chen, JiJun. Synthesis and biological assay of 4-aryl-6-chloro-quinoline derivatives as novel non-nucleoside anti-HBV agents. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2011, 第 7 作者19(4): 1400-1408, http://dx.doi.org/10.1016/j.bmc.2011.01.006.
[145] Geng, ChangAn, Zhang, XueMei, Ma, YunBao, Jiang, ZhiYong, Liu, JiFeng, Zhou, Jun, Chen, JiJun. Three new secoiridoid glycoside dimers from Swertia mileensis. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2010, 第 1 作者12(6): 542-548, https://www.webofscience.com/wos/woscc/full-record/WOS:000278787000019.
[146] 王洪玲, 耿长安, 张雪梅, 马云保, 江志勇, 陈纪军. 大籽獐牙菜化学成分的研究. 中国中药杂志[J]. 2010, 第 2 作者3161-3164, http://lib.cqvip.com/Qikan/Article/Detail?id=36046009.
[147] Geng, ChangAn, Zhang, XueMei, Ma, YunBao, Jiang, ZhiYong, Luo, Jie, Zhou, Jun, Wang, HongLing, Chen, JiJun. Swerilactones E-G, three unusual lactones from Swertia mileensis. TETRAHEDRON LETTERS[J]. 2010, 第 1 作者51(18): 2483-2485, http://dx.doi.org/10.1016/j.tetlet.2010.02.156.
[148] 耿长安, 姚淑英, 薛多清, 左爱学, 张雪梅, 江志勇, 马云保, 陈纪军. 桑白皮中1个新的异戊二烯基取代黄酮. 中国中药杂志[J]. 2010, 第 1 作者1560-1565, http://lib.cqvip.com/Qikan/Article/Detail?id=34316516.
[149] Geng ChangAn, Liu XiKui. Indole Alkaloids from the Leaves of Rauvolfia yunnanensis. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE[J]. 2010, 第 1 作者31(4): 731-735, http://www.irgrid.ac.cn/handle/1471x/392776.
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（ 1 ） 天然活性分子Paeoveitol的全合成及结构优化, 主持, 省级, 2017-06--2020-05
（ 2 ） 基于褪黑素受体的传统中药钩藤中镇静催眠活性物质的发现及构效关系研究, 主持, 国家级, 2016-01--2019-12
（ 3 ） 基于神经递质受体的活性成分发现和构效关系研究, 主持, 部委级, 2016-01--2018-12
（ 4 ） 赤芍和牡丹皮中褪黑素受体天然/类天然激动剂的发现及抗抑郁药效评价, 主持, 国家级, 2018-01--2021-12
（ 5 ） 褪黑素受体激动剂的发现及其药效评价, 主持, 部委级, 2018-01--2020-12
（ 6 ） 基于褪黑素受体的降血糖活性物质的发现及药效评价, 主持, 省级, 2019-10--2022-09
（ 7 ） 基于多靶点的天然降血糖活性物质的发现和药效评价, 主持, 省级, 2019-01--2023-12

（1）作用于褪黑素受体的具有抗抑郁作用新型小分子的发现   中国化学会第十二届全国天然有机化学学术会议   2018-07-28
（2）传统中药活性成分研究   2017 年郑州大学青者国际论坛   2017-12-15
（3）Effect of celery seeds on gout treatment   IUNS 21th ICN国际营养联合会第21届国际营养大会   2017-10-15
（4）传统中药抗HBV活性研究   中国科学院青年创新促进会2015年学术年会暨会员代表大会   2015-11-11
（5）Application of Phytochemistry on exploring the traditional medicines   传统民族药开发与保护国际培训班   2015-10-25
（6）传统中药青叶胆的抗HBV活性成分研究   第一届中医药青年学者沙龙   2013-03-31

已指导学生

潘秧  硕士研究生  105500-药学  

黄骞  硕士研究生  105500-药学  

现指导学生

丁敏  硕士研究生  078001-药物化学