基本信息
耿长安  男  博导  中国科学院昆明植物研究所
电子邮件: gengchangan@mail.kib.ac.cn
通信地址: 昆明市黑龙潭蓝黑路132号
邮政编码: 650201

研究领域

1、基于多靶点的降血糖活性成分发现、药效评价和新药研发

借鉴中医药对糖尿病(消渴)的认识,选择临床有效中药及亲缘药用植物,以课题组建立的降血糖多靶点筛选体系(PTP1B、TCPTP、α-葡萄糖苷酶、Gpa、GK等),开展活性和液质导向的新颖活性分子的发现、结构优化、作用机制和成药性研究,为天然来源的新型降血糖先导分子的发现和创新药物研发提供依据。

2、传统药用植物的综合开发利用研究

利用LCMS和体外多靶点筛选体系,对传统中药不同基源、不同部位开展系统比较分析,揭示其物质基础和活性成分差异,为中药资源的综合开发利用提供参考。


招生信息

招生意向:天然药物化学、合成药物化学、分析化学及相关专业


招生专业
100701-药物化学
070303-有机化学
100800-中药学

教育背景

2008-09--2011-06   中国科学院昆明植物研究所   理学博士学位
2005-09--2008-06   中国科学院昆明植物研究所   理学硕士学位
2001-09--2005-06   中国海洋大学药学院   医学学士学位

工作经历

   
工作简历
2021-04~现在, 中国科学院昆明植物研究所, 博士生导师
2020-11~现在, 中国科学院昆明植物研究所, 研究员
2017-04~现在, 中国科学院昆明植物研究所, 硕士生导师
2016-10~2017-09,英国华威大学, 访问学者
2014-01~2020-11,中国科学院昆明植物研究所, 副研究员
2011-09~2013-12,中国科学院昆明植物研究所, 助理研究员

专利与奖励

   
专利成果
[1] 陈纪军, 苏丽花, 马云保, 耿长安, 李天泽, 黄晓燕, 胡敬, 张雪梅. 暗绿蒿素A-P及其药物组合物与其制备方法和应用. CN: CN113185562A, 2021-07-30.
[2] 陈纪军, 高振, 黄晓燕, 耿长安, 李天泽, 马云保, 胡敬, 张雪梅. 茵陈蒿中香豆酸及其药物组合物与其制备方法和应用. CN: CN113173905A, 2021-07-27.
[3] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种2,6-环氧二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110903270B, 2021-07-09.
[4] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种2,6-环氧二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110903270B, 2021-07-09.
[5] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔酸类化合物及其药物组合物和其用途. CN: CN108530292B, 2021-04-09.
[6] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔酸类化合物及其药物组合物和其用途. CN: CN108530292B, 2021-04-09.
[7] 耿长安, 何小凤, 陈纪军, 张雪梅, 胡敬, 李天泽, 黄晓燕, 马云保. 草豆蔻中二芳基庚烷-查尔酮聚合物及其药物组合物与应用. CN: CN112592328A, 2021-04-02.
[8] 陈纪军, 耿长安, 马云保, 黄晓燕, 张雪梅, 杨静. 8S-癸-9-烯-4,6-二炔-1,8-二醇及其药物组合物和应用. CN: CN108821947B, 2021-03-30.
[9] 陈纪军, 耿长安, 马云保, 黄晓燕, 张雪梅, 杨静. 8S-癸-9-烯-4,6-二炔-1,8-二醇及其药物组合物和应用. CN: CN108821947B, 2021-03-30.
[10] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 李天泽, 高振, 马云保, 张雪梅. 异序乌桕素A-H及其药物组合物和其应用. CN: CN108440292B, 2021-02-12.
[11] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 李天泽, 高振, 马云保, 张雪梅. 异序乌桕素A-H及其药物组合物和其应用. CN: CN108440292B, 2021-02-12.
[12] 陈纪军, 苏丽花, 耿长安, 张心湉, 马云保, 黄晓燕, 李天泽, 胡敬, 张雪梅. 暗绿蒿内酯A-R及其药物组合物和应用. CN: CN112225746A, 2021-01-15.
[13] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 高振, 李天泽, 马云保, 张雪梅. 异序乌桕素I和J及其药物组合物和其应用. CN: CN108314620B, 2021-01-01.
[14] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 高振, 李天泽, 马云保, 张雪梅. 异序乌桕素I和J及其药物组合物和其应用. CN: CN108314620B, 2021-01-01.
[15] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110964027B, 2020-12-18.
[16] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110964027B, 2020-12-18.
[17] 陈纪军, 苏丽花, 耿长安, 马云保, 黄晓燕, 张心湉, 李天泽, 张雪梅. 暗绿蒿醇A-B及其药物组合物和其制备方法与应用. CN: CN112062738A, 2020-12-11.
[18] 耿长安, 何小凤, 陈纪军, 胡敬, 李天泽, 黄晓燕, 马云保, 张雪梅. 黄烷醇-脂肪醇杂合体及其药物组合物与其制备方法和应用. CN: CN111978330A, 2020-11-24.
[19] 耿长安, 陈纪军, 张建钢, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 钩藤酰胺A及其药物组合物和应用. CN: CN107827940B, 2020-10-09.
[20] 耿长安, 陈纪军, 张建钢, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 钩藤酰胺A及其药物组合物和应用. CN: CN107827940B, 2020-10-09.
[21] 陈纪军, 唐爽, 耿长安, 张心湉, 马云保, 黄晓燕, 李天泽, 张雪梅. 多花蒿烯内酯A-S和多花蒿素A-G及其药物组合物和应用. CN: CN111704594A, 2020-09-25.
[22] 耿长安, 何小凤, 陈纪军, 胡敬, 李天泽, 黄晓燕, 马云保, 张雪梅. 黄烷醇-薄荷烷杂合体及其药物组合物与其制备方法和应用. CN: CN111704622A, 2020-09-25.
[23] 陈纪军, 杨通华, 耿长安, 马云保, 颜得秀, 黄晓燕, 张雪梅. 厚朴酚糖苷在制备治疗中枢神经系统疾病药物中的应用. CN: CN108143741B, 2020-09-18.
[24] 陈纪军, 杨通华, 耿长安, 马云保, 颜得秀, 黄晓燕, 张雪梅. 厚朴酚糖苷在制备治疗中枢神经系统疾病药物中的应用. CN: CN108143741B, 2020-09-18.
[25] 陈纪军, 申程, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. 野艾蒿中倍半萜及其药物组合物与其制备方法和应用. CN: CN111635380A, 2020-09-08.
[26] 陈纪军, 尹秀娟, 马云保, 黄晓燕, 耿长安, 张雪梅. 以芦竹碱衍生物为活性成分的药物组合物及其应用. CN: CN107174586B, 2020-08-11.
[27] 陈纪军, 尹秀娟, 马云保, 黄晓燕, 耿长安, 张雪梅. 以芦竹碱衍生物为活性成分的药物组合物及其应用. CN: CN107174586B, 2020-08-11.
[28] 耿长安, 高振, 陈纪军, 张雪梅, 马云保, 黄晓燕, 李天泽, 胡敬. 香豆酸类化合物的应用、药物组合物及其应用. CN: CN110917184A, 2020-03-27.
[29] 耿长安, 高振, 陈纪军, 张雪梅, 马云保, 黄晓燕, 李天泽, 胡敬. 香豆酸类化合物的应用、药物组合物及其应用. CN: CN110917184A, 2020-03-27.
[30] 陈纪军, 耿长安, 陈思月, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 双酚F在制备治疗中枢神经系统疾病的药物中的应用. CN: CN109820840A, 2019-05-31.
[31] 陈纪军, 耿长安, 陈思月, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 双酚F在制备治疗中枢神经系统疾病的药物中的应用. CN: CN109820840A, 2019-05-31.
[32] 陈纪军, 陈思月, 耿长安, 马云保, 黄晓燕, 张雪梅. 多聚苄衍生物及其药物组合物与其制备方法和其应用. CN: CN109809971A, 2019-05-28.
[33] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. Paeonilactiflorol及其药物组合物与其制备方法和应用. CN: CN109810084A, 2019-05-28.
[34] 陈纪军, 陈思月, 耿长安, 马云保, 黄晓燕, 张雪梅. 多聚苄衍生物及其药物组合物与其制备方法和其应用. CN: CN109809971A, 2019-05-28.
[35] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. Paeonilactiflorol及其药物组合物与其制备方法和应用. CN: CN109810084A, 2019-05-28.
[36] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. 芍药籽中寡聚芪类化合物在制药中的应用. CN: CN109700796A, 2019-05-03.
[37] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. 芍药籽中寡聚芪类化合物在制药中的应用. CN: CN109700796A, 2019-05-03.
[38] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 张雪梅, 马云保. 芍药籽提取物在制药中的应用. CN: CN109692209A, 2019-04-30.
[39] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 张雪梅, 马云保. 芍药籽提取物在制药中的应用. CN: CN109692209A, 2019-04-30.
[40] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔醇类化合物及其药物组合物和其用途. 中国: CN108569953A, 2018-09-25.
[41] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔醇类化合物及其药物组合物和其用途. 中国: CN108569953A, 2018-09-25.
[42] 陈纪军, 耿长安, 梁文娟, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. Paeonivayin在制备治疗中枢神经系统疾病的药物中的应用. 中国: CN107898799A, 2018-04-13.
[43] 陈纪军, 耿长安, 梁文娟, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. Paeonivayin在制备治疗中枢神经系统疾病的药物中的应用. 中国: CN107898799A, 2018-04-13.
[44] 陈纪军, 杨通华, 李天泽, 耿长安, 张雪梅. (20S,24R)‑20,24‑环氧达玛烷‑3β,12β,25‑三醇及其应用. 中国: CN107778340A, 2018-03-09.
[45] 陈纪军, 杨通华, 李天泽, 耿长安, 张雪梅. (20S,24R)‑20,24‑环氧达玛烷‑3β,12β,25‑三醇及其应用. 中国: CN107778340A, 2018-03-09.
[46] 陈纪军, 耿长安, 黄晓燕, 马云保, 赵勇, 张雪梅. 烯炔糖苷酯类化合物及其药物组合物和应用. 中国: CN105111252B, 2017-12-22.
[47] 陈纪军, 耿长安, 黄晓燕, 马云保, 赵勇, 张雪梅. 烯炔糖苷酯类化合物及其药物组合物和应用. 中国: CN105111252B, 2017-12-22.
[48] 陈纪军, 耿长安, 马云保, 赵勇, 黄晓燕, 张雪梅. 4‑6‑乙基‑4‑(1H)‑吡啶酮‑2‑基‑3R‑O‑β‑D‑吡喃葡萄糖基丁酸及其药物组合物和应用. 中国: CN105111259B, 2017-10-20.
[49] 陈纪军, 耿长安, 马云保, 赵勇, 黄晓燕, 张雪梅. 4‑6‑乙基‑4‑(1H)‑吡啶酮‑2‑基‑3R‑O‑β‑D‑吡喃葡萄糖基丁酸及其药物组合物和应用. 中国: CN105111259B, 2017-10-20.
[50] 陈纪军, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. (±)UncarilinsA和B及其药物组合物和应用. 中国: CN107056790A, 2017-08-18.
[51] 陈纪军, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. (±)UncarilinsA和B及其药物组合物和应用. 中国: CN107056790A, 2017-08-18.
[52] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种杏鲍菇饮料及其制作方法. 中国: CN106937715A, 2017-07-11.
[53] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种山楂饮料及其制作方法. 中国: CN106937716A, 2017-07-11.
[54] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种洋葱饮料及其制备方法. 中国: CN106937720A, 2017-07-11.
[55] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种紫薯饮料及其制备方法. 中国: CN106937717A, 2017-07-11.
[56] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种杏鲍菇饮料及其制作方法. 中国: CN106937715A, 2017-07-11.
[57] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种山楂饮料及其制作方法. 中国: CN106937716A, 2017-07-11.
[58] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种洋葱饮料及其制备方法. 中国: CN106937720A, 2017-07-11.
[59] 沈勇, 张丽, 李晓波, 张雪梅, 耿长安. 一种紫薯饮料及其制备方法. 中国: CN106937717A, 2017-07-11.
[60] 陈纪军, 尹秀娟, 耿长安, 马云保, 黄晓燕, 张雪梅. 芦竹碱衍生物及其药物组合物和其在制药中的应用. 中国: CN106905300A, 2017-06-30.
[61] 陈纪军, 尹秀娟, 耿长安, 马云保, 黄晓燕, 张雪梅. 芦竹碱衍生物及其药物组合物和其在制药中的应用. 中国: CN106905300A, 2017-06-30.
[62] 陈纪军, 尹秀娟, 耿长安, 张雪梅. 托品酮衍生物及其药物组合物和其制备方法与应用. 中国: CN105924436A, 2016-09-07.
[63] 陈纪军, 尹秀娟, 耿长安, 张雪梅. 托品酮衍生物及其药物组合物和其制备方法与应用. 中国: CN105924436A, 2016-09-07.
[64] 陈纪军, 杨通华, 黄晓燕, 马云保, 张雪梅, 沈勇, 耿长安, 卢承杰. Graveobioside A在制备抗高尿酸血症和抗痛风的药物或保健食品中的应用. 中国: CN105560262A, 2016-05-11.
[65] 陈纪军, 杨通华, 黄晓燕, 马云保, 张雪梅, 沈勇, 耿长安, 卢承杰. Graveobioside A在制备抗高尿酸血症和抗痛风的药物或保健食品中的应用. 中国: CN105560262A, 2016-05-11.
[66] 陈纪军, 杨通华, 黄晓燕, 马云保, 张雪梅, 沈勇, 耿长安, 卢承杰. 芹菜籽提取物在制备抗高尿酸血症和抗痛风的药物或保健食品中的应用. 中国: CN105535048A, 2016-05-04.
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[68] 陈纪军, 孙长利, 耿长安, 黄晓燕, 马云保, 张雪梅. 柴胡总皂苷及其单体皂苷在制药中的应用. 中国: CN105055471A, 2015-11-18.
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出版信息

   
发表论文
[1] Su, LiHua, Li, TianZe, Ma, YunBao, Geng, ChangAn, Huang, XiaoYan, Zhang, Xin, Gao, Zhen, Chen, JiJun. Artematrovirenolides A-D and Artematrolides S-Z, Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens. CHINESE JOURNAL OF CHEMISTRY[J]. 2022, 40(1): 104-114, [2] Su, LiHua, Li, TianZe, Geng, ChangAn, Ma, YunBao, Huang, XiaoYan, Wang, JinPing, Zhang, XueMei, Chen, JiJun. Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 8(6): 1249-1256, http://dx.doi.org/10.1039/d0qo01615b.
[3] XiaoFeng He, JiJun Chen, TianZe Li, Jing Hu, XueMei Zhang, ChangAn Geng. Diarylheptanoid-chalcone hybrids with PTP1B and α-glucosidase dual inhibition from Alpinia katsumadai. Bioorganic Chemistry. 2021, 108: http://dx.doi.org/10.1016/j.bioorg.2021.104683.
[4] Huang, Qian, Chen, JiJun, Pan, Yang, He, XiaoFeng, Wang, Yuan, Zhang, XueMei, Geng, ChangAn. Chemical profiling and antidiabetic potency of Paeonia delavayi: Comparison between different parts and constituents. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2021, 198: http://dx.doi.org/10.1016/j.jpba.2021.113998.
[5] He, XiaoFeng, Chen, JiJun, Huang, XiaoYan, Hu, Jing, Zhang, XuKe, Guo, YuanQiang, Zhang, XueMei, Geng, ChangAn. The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors. INDUSTRIAL CROPS AND PRODUCTS[J]. 2021, 160: http://dx.doi.org/10.1016/j.indcrop.2020.112908.
[6] XiaoFeng He, JiJun Chen, TianZe Li, Jing Hu, XuKe Zhang, YuanQiang Guo, XueMei Zhang, ChangAn Geng. Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as α-glucosidase inhibitors from Amomum tsao-ko. Chinese Chemical Letters. 2021, 32(3): 1202-1205, http://dx.doi.org/10.1016/j.cclet.2020.08.050.
[7] He, XiaoFeng, Chen, JiJun, Li, TianZe, Hu, Jing, Zhang, XueMei, Geng, ChangAn. Diarylheptanoid-chalcone hybrids with PTP1B and alpha-glucosidase dual inhibition from Alpinia katsumadai. BIOORGANIC CHEMISTRY[J]. 2021, 108: http://dx.doi.org/10.1016/j.bioorg.2021.104683.
[8] XiaoFeng He, JiJun Chen, XiaoYan Huang, Jing Hu, XuKe Zhang, YuanQiang Guo, XueMei Zhang, ChangAn Geng. The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and α-glucosidase dual inhibitors. Industrial Crops & Products. 2021, 160: http://dx.doi.org/10.1016/j.indcrop.2020.112908.
[9] He, XiaoFeng, Zhang, XuKe, Geng, ChangAn, Hu, Jing, Zhang, XueMei, Guo, YuanQiang, Chen, JiJun. Tsaokopyranols A-M, 2,6-epoxydiarylheptanoids from Amomum tsao-ko and their alpha-glucosidase inhibitory activity. BIOORGANIC CHEMISTRY[J]. 2020, 96: https://www.webofscience.com/wos/woscc/full-record/WOS:000516796900075.
[10] He, XiaoFeng, Wang, HuiMei, Geng, ChangAn, Hu, Jing, Zhang, XueMei, Guo, YuanQiang, Chen, JiJun. Amomutsaokols A-K, diarylheptanoids from Amomum tsao-ko and their alpha-glucosidase inhibitory activity. PHYTOCHEMISTRY[J]. 2020, 177: https://www.webofscience.com/wos/woscc/full-record/WOS:000558604600002.
[11] Su, LiHua, Geng, ChangAn, Ze, Li Tian, Huang, XiaoYan, Ma, YunBao, Zhang, XueMei, Wu, Gang, Yang, ZhuLiang, Chen, JiJun. Spiroseoflosterol, a Rearranged Ergostane-Steroid from the Fruiting Bodies of Butyriboletus roseoflavus. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(5): 1706-1710, http://ir.kib.ac.cn/handle/151853/72084, http://www.irgrid.ac.cn/handle/1471x/6927924, http://ir.kib.ac.cn/handle/151853/72085, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537539300042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[12] He, XiaoFeng, Chen, JiJun, Li, TianZe, Zhang, XuKe, Guo, YuanQiang, Zhang, XueMei, Hu, Jing, Geng, ChangAn. Nineteen New Flavanol-Fatty Alcohol Hybrids with alpha-Glucosidase and PTP1B Dual Inhibition: One Unusual Type of Antidiabetic Constituent from Amomum tsao-ko. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 68(41): 11434-11448, https://www.webofscience.com/wos/woscc/full-record/WOS:000615975700011.
[13] Deng, ZhenTao, Chen, JiJun, Geng, ChangAn. ent-Labdane and ent-kaurane diterpenoids from Chelonopsis odontochila with alpha-glucosidase inhibitory activity. BIOORGANIC CHEMISTRY[J]. 2020, 95: https://www.webofscience.com/wos/woscc/full-record/WOS:000512762900077.
[14] Paul, Swastika, Zhang, Xuemei, Yang, Yongping, Geng, Changan. Chemical Constituents from Turnip and Their Effects on alpha-Glucosidase. PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY[J]. 2020, 89(1): 131-136, https://www.webofscience.com/wos/woscc/full-record/WOS:000519775600013.
[15] Su, LiHua, Geng, ChangAn, Li, TianZe, Ma, YunBao, Huang, XiaoYan, Zhang, XueMei, Chen, JiJun. Artatrovirenols A and B: Two Cagelike Sesquiterpenoids from Artemisia atrovirens. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(21): 13466-13471, https://www.webofscience.com/wos/woscc/full-record/WOS:000589941700007.
[16] Yang, XiaoTong, Geng, ChangAn, Li, TianZe, Deng, ZhenTao, Chen, JiJun. Synthesis and biological evaluation of chepraecoxin A derivatives as alpha-glucosidase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2020, 30(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000519194300021.
[17] JianGang Zhang, XiaoYan Huang, YunBao Ma, JiJun Chen, ChangAn Geng. UFLC-PDA-MS/MS Profiling of Seven Uncaria Species Integrated with Melatonin/5-Hydroxytryptamine Receptors Agonistic Assay. Natural Products and Bioprospecting[J]. 2020, 10(1): 23-36, https://doaj.org/article/14947be1f9634d05b60ee46a3ec5a769.
[18] Swastika Paul, 13, Xuemei Zhang, Yongping Yang, Changan Geng. Chemical Constituents from Turnip and Their Effects on α-Glucosidase. Phyton. 2020, 89(1): [19] Pan, Yang, Gao, Zhen, Huang, XiaoYan, Chen, JiJun, Geng, ChangAn. Chemical and biological comparison of different parts of Paeonia suffruticosa (Mudan) based on LCMS-IT-TOF and multi-evaluation in vitro. INDUSTRIAL CROPS AND PRODUCTS[J]. 2020, 144: http://dx.doi.org/10.1016/j.indcrop.2019.112028.
[20] Tang, Shuang, Zhang, XinTian, Ma, YunBao, Huang, XiaoYan, Geng, ChangAn, Li, TianZe, Zhang, XueMei, Shen, Cheng, Su, LiHua, Gao, Zhen, Chen, JiJun. Artemyrianolides A-S, Cytotoxic Sesquiterpenoids from Artemisia myriantha. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(9): 2618-2630, https://www.webofscience.com/wos/woscc/full-record/WOS:000575848000009.
[21] Shen, Cheng, Huang, XiaoYan, Geng, ChangAn, Li, TianZe, Wang, JinPing, Tang, Shuang, Su, LiHua, Gao, Zhen, Zhang, XueMei, Chen, JiJun. Cytotoxic sesquiterpenoids against hepatic stellate cell line LX2 from Artemisia lavandulaefolia. BIOORGANIC CHEMISTRY[J]. 2020, 103: http://dx.doi.org/10.1016/j.bioorg.2020.104107.
[22] Deng, ZhenTao, Geng, ChangAn, Yang, TongHua, Xiang, ChunLei, Chen, JiJun. Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox. FITOTERAPIA[J]. 2019, 132: 60-67, http://ir.kib.ac.cn/handle/151853/64397.
[23] Chen, SiYue, Geng, ChangAn, Ma, YunBao, Huang, XiaoYan, Yang, XiaoTong, Su, LiHua, He, XiaoFeng, Li, TianZe, Deng, ZhenTao, Gao, Zhen, Zhang, XueMei, Chen, JiJun. Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2019, 27(15): 3299-3306, http://dx.doi.org/10.1016/j.bmc.2019.06.008.
[24] Yang, TongHua, Yan, DeXiu, Huang, XiaoYan, Hou, Bo, Ma, YunBao, Peng, Hua, Zhang, XueMei, Chen, JiJun, Geng, ChangAn. Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis. PHYTOCHEMISTRY[J]. 2019, 164: 228-235, http://dx.doi.org/10.1016/j.phytochem.2019.05.019.
[25] Geng, ChangAn, Yang, TongHua, Huang, XiaoYan, Ma, YunBao, Zhang, XueMei, Chen, JiJun. Antidepressant potential of Uncaria rhynchophylla and its active flavanol, catechin, targeting melatonin receptors. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2019, 232: 39-46, http://ir.kib.ac.cn/handle/151853/66863.
[26] ChenChen Zhang, ChangAn Geng, JiJun Chen. A Fragmentation Study on Four Oligostilbenes by Electrospray Tandem Mass Spectrometry. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2019, 9(4): 279-286, http://dx.doi.org/10.1007/s13659-019-0212-3.
[27] ChangAn Geng, MengHong Yan, XueMei Zhang, JiJun Chen. Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay. Natural Products and Bioprospecting[J]. 2019, 9(2): 139-144, https://doaj.org/article/a7863950b6da4653bd00c651ce1cbdf7.
[28] Geng Changan. Phytochemical and Biological Progress of Cynanchum paniculatum. Medicine Research. 2019, [29] Tang, Haoran, Ke, Yang, Ren, Zongfang, Lei, Xuefen, Xiao, Shufeng, Bao, Tianhao, Shi, Zhitian, Zou, Renchao, Wu, Tiangen, Zhou, Jian, Geng, ChangAn, Wang, Lin, Chen, Jijun. Bioinformatics analysis of differentially expressed genes in hepatocellular carcinoma cells exposed to Swertiamarin. JOURNAL OF CANCER[J]. 2019, 10(26): 6526-6534, http://dx.doi.org/10.7150/jca.33666.
[30] Paul, Swastika, Geng, ChangAn, Yang, TongHua, Yang, YongPing, Chen, JiJun. Comparative study of the glucosinolate profiles in turnip from four agroclimatic zones of china and neighboring countries. JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION[J]. 2019, 13(4): 2798-2811, [31] Paul, Swastika, Geng, ChangAn, Yang, TongHua, Yang, YongPing, Chen, JiJun. Phytochemical and Health-Beneficial Progress of Turnip (Brassica rapa). JOURNAL OF FOOD SCIENCEnull. 2019, 84(1): 19-30, https://www.webofscience.com/wos/woscc/full-record/WOS:000455527800004.
[32] Zhang, ChenChen, Geng, ChangAn, Huang, XiaoYan, Zhang, XueMei, Chen, JiJun. Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2019, 67(24): 6765-6772, https://www.webofscience.com/wos/woscc/full-record/WOS:000472679000010.
[33] Yang, TongHua, Ma, YunBao, Geng, ChangAn, Yan, DeXiu, Huang, XiaoYan, Li, TianZe, Zhang, XueMei, Chen, JiJun. Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 156: 381-393, http://dx.doi.org/10.1016/j.ejmech.2018.07.027.
[34] Xinglong Chen, Zhentao Deng, Xiaoyan Huang, Changan Geng, Jijun Chen. Liquid chromatography–mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola. International Journal of Mass Spectrometry. 2018, 430: 1-7, http://dx.doi.org/10.1016/j.ijms.2018.03.009.
[35] Chen, Xinglong, Zhang, Xiugiong, Geng, Changan, Li, Tianze, Chen, Jijun. New C-16-noriridals and formyl-monocycloiridals from the rhizomes of Iris pseudoacorus. FITOTERAPIA[J]. 2018, 124: 160-166, http://dx.doi.org/10.1016/j.fitote.2017.11.005.
[36] 张建钢, 陈纪军, 耿长安. 《中国药典》收载的钩藤基原植物吲哚生物碱研究进展. 中国中药杂志. 2018, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=62&recid=&FileName=ZGZY201904009&DbName=CJFDLAST2019&DbCode=CJFQ&yx=A&pr=&URLID=11.2272.R.20181121.1124.012&bsm=QK0101;.
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[38] ChangAn Geng, TongHua Yang, XiaoYan Huang, Jing Yang, YunBao Ma, TianZe Li, XueMei Zhang, JiJun Chen. Anti-hepatitis B virus effects of the traditional Chinese herb Artemisia capillaris and its active enynes. Journal of Ethnopharmacology. 2018, 224: 283-289, http://dx.doi.org/10.1016/j.jep.2018.06.005.
[39] Wang, Yi, Geng, Changan, Yuan, Xiaolong, Hua, Mei, Tian, Fenghua, Li, Changtian. Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens. PLOS ONE[J]. 2018, 13(7): http://ir.kib.ac.cn/handle/151853/64708.
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[41] ChangAn Geng, JiJun Chen. The Progress of Anti-HBV Constituents from Medicinal Plants in China. Natural Products and Bioprospecting[J]. 2018, 8(4): 227-244, http://ir.kib.ac.cn/handle/151853/64800.
[42] Tian, Fenghua, Wang, Yi, Geng, Changan, Yuan, Xiaolong, Hua, Mei, Li, Changtian. Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens. MYCOKEYS[J]. 2018, 83-105, http://www.irgrid.ac.cn/handle/1471x/1781710.
[43] Yan, DeXiu, Geng, ChangAn, Yang, TongHua, Huang, XiaoYan, Li, TianZe, Gao, Zhen, Ma, YunBao, Peng, Hua, Zhang, XueMei, Chen, JiJun. LC-MS guided isolation of diterpenoids from Sapium insigne with alpha-glucosidase inhibitory activities. FITOTERAPIA[J]. 2018, 128: 57-65, http://ir.kib.ac.cn/handle/151853/63340.
[44] Zhang, JianGang, Huang, XiaoYan, Ma, YunBao, Zhang, XueMei, Chen, JiJun, Geng, ChangAn. Dereplication-guided isolation of a new indole alkaloid triglycoside from the hooks of Uncaria rhynchophylla by LC with ion trap time-of-flight MS. JOURNAL OF SEPARATION SCIENCE[J]. 2018, 41(7): 1532-1538, https://www.webofscience.com/wos/woscc/full-record/WOS:000429715600003.
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[46] ChangAn Geng, TongHua Yang, XiaoYan Huang, Jing Yang, YunBao Ma, TianZe Li, XueMei Zhang, JiJun Chen. Anti-hepatitis B virus effects of the traditional Chinese herb Artemisia capillaris and its active enynes. Journal of Ethnopharmacology[J]. 2018, 283–289-, http://ir.kib.ac.cn/handle/151853/64615.
[47] Chen, Xinglong, Zhang, Xiuqiong, Ma, Yunbao, Deng, Zhentao, Geng, Changan, Chen, Jijun. Iridal-type triterpenoids with anti-HBV activity from Iris confusa. FITOTERAPIA[J]. 2018, 129: 126-132, http://dx.doi.org/10.1016/j.fitote.2018.06.005.
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[117] 蒋富强, 张雪梅, 马云保, 耿长安, 江志勇, 陈纪军. 毛萼獐牙菜化学成分的研究. 中国中药杂志. 2011, 36(16): 2215-2218, http://lib.cqvip.com/Qikan/Article/Detail?id=39003119.
[118] 王洪玲, 陈浩, 耿长安, 张雪梅, 马云保, 江志勇, 陈纪军. 椭圆叶花锚的化学成分研究. 中国中药杂志[J]. 2011, 36(11): 1454-1457, http://lib.cqvip.com/Qikan/Article/Detail?id=38096256.
[119] Liu, JiFeng, Jiang, ZhiYong, Geng, ChangAn, Zhang, Quan, Shi, Yao, Ma, YunBao, Zhang, XueMei, Chen, JiJun. Two New Lignans and Anti-HBV Constituents from Illicium henryi. CHEMISTRY & BIODIVERSITY[J]. 2011, 8(4): 692-698, http://www.irgrid.ac.cn/handle/1471x/392903.
[120] Geng, ChangAn, Zhang, XueMei, Ma, YunBao, Luo, Jie, Chen, JiJun. Swerilactones L-O, Secoiridoids with C-12 and C-13 Skeletons from Swertia mileensis. JOURNAL OF NATURAL PRODUCTS[J]. 2011, 74(8): 1822-1825, http://dx.doi.org/10.1021/np200256b.
[121] Geng, ChangAn, Wang, LiJun, Zhang, XueMei, Ma, YunBao, Huang, XiaoYan, Luo, Jie, Guo, RuiHua, Zhou, Jun, Shen, Yong, Zuo, AiXue, Jiang, ZhiYong, Chen, JiJun. Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 17(14): 3893-3903, http://dx.doi.org/10.1002/chem.201003180.
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科研活动

   
科研项目
( 1 ) 天然活性分子Paeoveitol的全合成及结构优化, 主持, 省级, 2017-06--2020-05
( 2 ) 基于褪黑素受体的传统中药钩藤中镇静催眠活性物质的发现及构效关系研究, 主持, 国家级, 2016-01--2019-12
( 3 ) 基于神经递质受体的活性成分发现和构效关系研究, 主持, 部委级, 2016-01--2018-12
( 4 ) 赤芍和牡丹皮中褪黑素受体天然/类天然激动剂的发现及抗抑郁药效评价, 主持, 国家级, 2018-01--2021-12
( 5 ) 褪黑素受体激动剂的发现及其药效评价, 主持, 部委级, 2018-01--2020-12
( 6 ) 基于褪黑素受体的降血糖活性物质的发现及药效评价, 主持, 省级, 2019-10--2022-09
( 7 ) 基于多靶点的天然降血糖活性物质的发现和药效评价, 主持, 省级, 2019-01--2023-12
参与会议
(1)作用于褪黑素受体的具有抗抑郁作用新型小分子的发现   中国化学会第十二届全国天然有机化学学术会议   2018-07-28
(2)传统中药活性成分研究   2017 年郑州大学青者国际论坛   2017-12-15
(3)Effect of celery seeds on gout treatment   IUNS 21th ICN国际营养联合会第21届国际营养大会   2017-10-15
(4)传统中药抗HBV活性研究   中国科学院青年创新促进会2015年学术年会暨会员代表大会   2015-11-11
(5)Application of Phytochemistry on exploring the traditional medicines   传统民族药开发与保护国际培训班   2015-10-25
(6)传统中药青叶胆的抗HBV活性成分研究   第一届中医药青年学者沙龙   2013-03-31

指导学生

已指导学生

潘秧  硕士研究生  105500-药学  

黄骞  硕士研究生  105500-药学  

现指导学生

丁敏  硕士研究生  078001-药物化学