采用化学生物学的原理与方法，发现调控干扰素激活的JAK/STAT信号通路，雌激素的生物合成和代谢，RNAi信号通路和蛋白质泛素降解信号通路的天然产物化学小分子，研究其构效关系，以活性小分子为探针研究其作用机制，以期发现新的信号调控机制以及具有诊疗作用的药物前体；

　　探索新型蛋白质标记体系，实时动态的研究细胞膜受体在天然配体和化学小分子作用下的变化，以发现细胞膜受体的新的作用机制； 

　　以骨质疏松为模型，研究中药治疗骨质疏松的物质基础和作用机制。 

   

100701-药物化学
100706-药理学

干扰素、雌激素生物合成和microRNA途径的化学生物学研究
干扰素、雌激素生物合成和microRNA途径的化学生物学研究

2000-09--2005-09   中国科学院遗传与发育生物学研究所   博士（硕博连读）
1996-09--2000-07   河南师范大学   学士

   

2014-01~现在, 中国科学院成都生物研究所, 研究员
2008-03~2013-12,中国科学院成都生物研究所, 副研究员
2005-10~2008-02,University of California San Francisco, 博士后

2018-02-22-2022-02-22,中国人民政治协商会议成都市第十五届委员会, 常务委员
2016-01-01-今,成都市九三学社高新区委员会第二支社, 主委
2013-01-01-2014-12-31,中国科学院青年创新促进会成都分会, 会长
2011-06-01-2014-06-01,中国科学院青年创新促进会, 理事

化学生物学

   

（1） 中国科学院院长特别奖, 特等奖, 院级, 2004
（2） 中国科学院地奥奖一等奖, 一等奖, 院级, 2004
（3） 中科院遗传发育所“研究生优秀论, 一等奖, 研究所（学校）, 2004

[1] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫福蒂, 付乃洁, 黎玥佳. 一种抗肿瘤的联合用药物. CN: CN109453164B, 2021-08-06.

[2] 焦威, 向玲, 邵华武, 王飞, 张中辉. 一类千金子二萜衍生物及其应用. CN: CN113200950A, 2021-08-03.

[3] 肖伟烈, 王飞, 李一明, 周宗元, 曹碧云, 李晓莉, 张芮菡, 张兴杰. 含氮联芳环类化合物、制备方法和应用. CN: CN113087693A, 2021-07-09.

[4] 王飞, 阿皮恰德苏克萨穆然, 张国林, 康佳娜旺克阿将, 林源, 沈晓飞. 二芳基庚烷类化合物. CN: CN106831383B, 2021-03-30.

[5] 肖伟烈, 王飞, 普德兵, 杜宝文, 张芮菡, 史楠, 高俊博, 张兴杰. 一类异海松烷型二萜衍生物，其药物组合物及其用途. CN: CN108530281B, 2021-02-02.

[6] 王飞, 阿皮恰德苏克萨穆然, 张国林, 提帕万初普阿焦布, 林源, 沈晓飞. 二芳基庚烷类化合物的用途. CN: CN106806361B, 2020-03-06.

[7] 王飞, 阿彼察·苏萨朗, 张国林",null,"卢晓霞. 姜黄素衍生物的用途. CN: CN110327315A, 2019-10-15.

[8] 张国林, 王飞, 卢晓霞, 闻永举, 周宗元. 一种苄胺酰类衍生物及其在制备抗炎药物中的用途. CN: CN109879772A, 2019-06-14.

[9] 王飞, 卢晓霞, 张国林, 王涛, 彭婷. 一种miRNA生物合成抑制剂. CN: CN109810071A, 2019-05-28.

[10] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫夫蒂, 付乃洁. 一种IDO1抑制剂及其应用. CN: CN109485615A, 2019-03-19.

[11] 肖伟烈, 王飞, 张兴杰, 杜宝文, 张芮菡. 甲氧基-7-木犀草素及其制备方法和用途. 中国: CN108383821A, 2018-08-10.

[12] 王飞, 张国林, 王淳, 彭勇, 蒲文臣, 邓腾, 强喆, 李娇. SHP2抑制剂在制备抗肿瘤的药物中的用途. 中国: CN108113984A, 2018-06-05.

[13] 王飞, 张国林, 奥汝丸.汪嘎纳. 6‑羟基‑3‑O‑甲基山奈酚6‑O‑吡喃葡萄糖苷的新用途. 中国: CN107714711A, 2018-02-23.

[14] 王飞, 张国林, 何玉娇, 张华. 一种苯基恶唑类化合物在制备治疗癌症的药中的应用. 中国: CN104306373A, 2015-01-28.

[15] 王飞, 张国林, 何玉娇, 张华. 苯基恶唑类化合物及在制备治疗癌症的药中的应用. 中国: CN104230836A, 2014-12-24.

[16] 张国林, 王飞, 淳泽, 林源. 菲及二氢菲类化合物及其应用. 中国: CN103408612A, 2013-11-27.

[17] 王飞, 章从恩, 陈前锋, 张国林. 一种特女贞苷的制备方法. 中国: CN102372754A, 2012-03-14.

[18] 王飞, 邰正福, 杨莉娟, 张国林. 一种抗病毒的组合药物. 中国: CN102343083A, 2012-02-08.

   

[1] Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang. Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65: 460-484, [2] Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang, Yaoyao Zhang, Guolin Zhang, Fei Wang, Gang Zhao, Junling Guo. Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy. THERANOSTICS[J]. 2022, 12: 2028-2040, [3] Dong-yi Cao, Zhong-hui Zhang, Run-ze Li, Xiao-ke Shi, Rui-ying Xi, Guo-lin Zhang, Fu Li, Fei Wang. A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation. Immunology Letters[J]. 2022, 244: 28-39, [4] Nai-jie Fu, Rui-ying Xi, Xiao-ke Shi, Run-ze Li, Zhong-hui Zhang, Ling-yu Li, Guo-lin Zhang, Fei Wang. Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways. Toxicology and Applied Pharmacology[J]. 2022, 441: 115988-, [5] Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorganic & Medicinal Chemistry[J]. 2022, 66: 116811-, [6] Zhang, Xuejian, Luo, Guoyong, Cao, Yu, Mishig, Dumaa, Lodonjav, Munkhgerel, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang. (+/-)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa. BIOORGANIC CHEMISTRY[J]. 2021, 116: http://dx.doi.org/10.1016/j.bioorg.2021.105364.
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[18] Zhang, PuZhao, Zhang, YaMei, Lin, Yuan, Wang, Fei, Zhang, GuoLin. Three new diterpenes from Dysoxylum lukii and their NO production inhibitory activity. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2020, 22(6): 531-536, https://www.webofscience.com/wos/woscc/full-record/WOS:000469740600001.
[19] Du, BaoWen, Zhang, XingJie, Shi, Nan, Peng, Ting, Gao, JunBo, Azimova, Bahtigul, Zhang, Ruihan, Pu, DeBing, Wang, Chun, Abduvaliev, Anvar, Rakhmanov, Alisher, Zhang, GuoLin, Xiao, WeiLie, Wang, Fei. Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2020, 879: http://dx.doi.org/10.1016/j.ejphar.2020.173154.
[20] Fei Wang. Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp.CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways. Planta Medica. 2020, [21] Zhang, Xuejian, Peng, Ting, Shi, Xiaoke, Fang, Dongmei, Tang, Lin, Chen, Fang, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa. PHYTOCHEMISTRY[J]. 2020, 180: http://dx.doi.org/10.1016/j.phytochem.2020.112534.
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[29] 史楠, 史小可, Jovliqizi, Azimova, Bahtigul, Abduvaliev, Anvar, Rakhmanov, Alisher, 王飞. Eryxin通过抑制芳香化酶表达调控雌激素生物合成. 应用与环境生物学报[J]. 2019, 25(5): 1205-1210, http://lib.cqvip.com/Qikan/Article/Detail?id=7100213343.
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[33] 李晟, 李焱鑫, Emmanuel, Mfotie, Njoya, 蒋黎, 李霖, 王飞. 瑞香素及噁唑类小分子抑制吲哚胺-2，3-双加氧酶1（IDO1）的研究. 天然产物研究与开发[J]. 2018, 30(12): 2128-2132,2096, http://lib.cqvip.com/Qikan/Article/Detail?id=7001044758.
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[40] Ebokaiwe, Azubuike P, Ijomone, Omamuyovwi M, Osawe, Sharon O, Chukwu, Chukwuma J, Ejike, Chukwunonso E C C, Zhang, Guolin, Wang, Fei. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. REDOX REPORT[J]. 2018, 23(1): 194-205, http://ir.imde.ac.cn/handle/131551/24561.
[41] Gong, Guidong, Cao, Yuan, Wang, Fei, Zhao, Gang. Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells. ORGANOMETALLICS[J]. 2018, 37(7): 1103-1113, https://www.webofscience.com/wos/woscc/full-record/WOS:000429886300003.
[42] Gong, Guidong, Cao, Yuan, Qian, Hongyun, Zhou, Yangyang, Zhao, Haihang, Li, Ling, Wang, Fei, Zhao, Gang. Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system. CHEMICAL COMMUNICATIONS[J]. 2018, 54(60): https://www.webofscience.com/wos/woscc/full-record/WOS:000439702200002.
[43] Fu Li, BaoWen Du, DanFeng Lu, WenXuan Wu, Kanjana Wongkrajang, Lun Wang, WenChen Pu, ChangLu Liu, HanWei Liu, MingKui Wang, Fei Wang. Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/cdbf79c242b5456e9d71bb62e04b9411.
[44] Orawan Wonganan, Yu-jiao He, Xiao-fei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology. 2017, 336: 31-39, http://dx.doi.org/10.1016/j.taap.2017.10.004.
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[70] Fei Wang. Trichinenlides A-T, Mexcicanolide-Type Limonoids from Trichilia sinensis. Journal of Natural Products. 2013, [71] Xu, JinBiao, Lin, Yuan, Dong, ShiHui, Wang, Fei, Yue, JianMin. Trichinenlides A-T, Mexicanolide-Type Limonoids from Trichilia sinensis. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 76(10): 1872-1880, http://www.irgrid.ac.cn/handle/1471x/900533.
[72] Liu, HanWei, Yu, XiuZhu, Padula, Daniele, Pescitelli, Gennaro, Lin, ZhiWei, Wang, Fei, Ding, Kai, Lei, Ming, Gao, JinMing. Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 59: 265-273, http://dx.doi.org/10.1016/j.ejmech.2012.11.003.
[73] Lin, Yuan, Wang, Fei, Yang, Lijuan, Chun, Ze, Bao, Jinku, Zhang, Guolin. Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum. PHYTOCHEMISTRY[J]. 2013, 95(2013): 242-251, http://dx.doi.org/10.1016/j.phytochem.2013.08.008.
[74] 丹枫, Azimova Bahtigul Jovliqizi, 张国林, 王飞. 采用磁微粒分离酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型. 天然产物研究与开发[J]. 2013, 25(1): 27-30, http://210.75.237.14/handle/351003/24044.
[75] 郭加加, 黄君梅, 王飞. 冰乙酸水解法提高女贞子提取物中红景天苷含量. 应用与环境生物学报[J]. 2013, 19(4): 723-726, http://210.75.237.14/handle/351003/24058.
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[77] Guo-Lin Zhang. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological Pharmaceutical Bulletin. 2012, [78] Lu, Danfeng, Yang, Lijuan, Wang, Fei, Zhang, Guolin. Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2012, 60(34): 8411-8418, http://www.irgrid.ac.cn/handle/1471x/656377.
[79] 林之蔚, 邰正福, 万忠民, 王飞, 雷泞菲. 荧光光谱法研究木栓酮与牛血清白蛋白的相互作用. 应用与环境生物学报. 2012, 18(2): 287-291, http://lib.cqvip.com/Qikan/Article/Detail?id=41871147.
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（ 1 ） 女贞子抗高原反应的研究, 主持, 部委级, 2013-01--2015-12
（ 2 ） 蛋白激酶A介导的磷酸化调控芳香化酶降解机制的化学生物学研究, 主持, 国家级, 2014-01--2017-12
（ 3 ） 基于共轭聚合物纳米粒子的蛋白质-蛋白质相互作用药物筛选新方法的研究及其应用, 主持, 部委级, 2014-01--2016-12
（ 4 ） 青年研究员人才支持项目, 主持, 市地级, 2013-01--2017-12
（ 5 ） 四川省杰出青年学术技术带头人计划, 主持, 省级, 2014-01--2016-12
（ 6 ） α7尼古丁乙酰胆碱受体激动剂治疗类风湿性关节炎的研究, 主持, 省级, 2016-03--2019-06
（ 7 ） 治疗老年性疾病的天然产物药物发现研究, 参与, 国家级, 2015-10--2018-09
（ 8 ） 苯基噁唑类化合物通过TRBP调控microRNA生物合成抑制肝癌转移的化学生物学研究, 主持, 国家级, 2017-01--2020-12
（ 9 ） 二苯庚烷类化合物作为α7尼古丁乙酰胆碱受体激动剂治疗心律失常的研究, 主持, 部委级, 2016-09--2018-09
（ 10 ） 基于天然产物的老年性疾病候选药物研究, 参与, 国家级, 2019-01--2021-12
（ 11 ） 黄烷酮类小分子靶向蛋白酪氨酸磷酸酶SHP2调控RAS信号通路抑制肺癌的化学生物学研究, 主持, 国家级, 2020-01--2023-12

已指导学生

郭加加  硕士研究生  077901-药物化学  

邓腾  硕士研究生  078001-药物化学  

李晟  硕士研究生  085238-生物工程  

彭辉盼  硕士研究生  105500-药学  

盛钰雯  硕士研究生  085238-生物工程  

史楠  硕士研究生  077804-病理学与病理生理学  

现指导学生

史小可  硕士研究生  100104-病理学与病理生理学  

周宗元  博士研究生  100706-药理学  

李润择  硕士研究生  077804-病理学与病理生理学  

曹东怡  博士研究生  100701-药物化学  

靳钰洁  硕士研究生  078006-药理学  

盛钰雯  博士研究生  100706-药理学