基本信息
王飞  男  博导  中国科学院成都生物研究所
电子邮件: wangfei@cib.ac.cn
通信地址: 成都市人民南路四段9号中科院成都生物所植化楼407
邮政编码: 610047

研究领域

采用化学生物学的原理与方法,发现调控干扰素激活的JAK/STAT信号通路,雌激素的生物合成和代谢,RNAi信号通路和蛋白质泛素降解信号通路的天然产物化学小分子,研究其构效关系,以活性小分子为探针研究其作用机制,以期发现新的信号调控机制以及具有诊疗作用的药物前体;

  探索新型蛋白质标记体系,实时动态的研究细胞膜受体在天然配体和化学小分子作用下的变化,以发现细胞膜受体的新的作用机制; 

  以骨质疏松为模型,研究中药治疗骨质疏松的物质基础和作用机制。 

招生信息

   
招生专业
100701-药物化学
100706-药理学
招生方向
干扰素、雌激素生物合成和microRNA途径的化学生物学研究
干扰素、雌激素生物合成和microRNA途径的化学生物学研究

教育背景

2000-09--2005-09   中国科学院遗传与发育生物学研究所   博士(硕博连读)
1996-09--2000-07   河南师范大学   学士

工作经历

   
工作简历
2014-01~现在, 中国科学院成都生物研究所, 研究员
2008-03~2013-12,中国科学院成都生物研究所, 副研究员
2005-10~2008-02,University of California San Francisco, 博士后
社会兼职
2018-02-22-2022-02-22,中国人民政治协商会议成都市第十五届委员会, 常务委员
2016-01-01-今,成都市九三学社高新区委员会第二支社, 主委
2013-01-01-2014-12-31,中国科学院青年创新促进会成都分会, 会长
2011-06-01-2014-06-01,中国科学院青年创新促进会, 理事

教授课程

化学生物学

专利与奖励

   
奖励信息
(1) 中国科学院院长特别奖, 特等奖, 院级, 2004
(2) 中国科学院地奥奖一等奖, 一等奖, 院级, 2004
(3) 中科院遗传发育所“研究生优秀论, 一等奖, 研究所(学校), 2004
专利成果
[1] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫福蒂, 付乃洁, 黎玥佳. 一种抗肿瘤的联合用药物. CN: CN109453164B, 2021-08-06.

[2] 焦威, 向玲, 邵华武, 王飞, 张中辉. 一类千金子二萜衍生物及其应用. CN: CN113200950A, 2021-08-03.

[3] 肖伟烈, 王飞, 李一明, 周宗元, 曹碧云, 李晓莉, 张芮菡, 张兴杰. 含氮联芳环类化合物、制备方法和应用. CN: CN113087693A, 2021-07-09.

[4] 王飞, 阿皮恰德苏克萨穆然, 张国林, 康佳娜旺克阿将, 林源, 沈晓飞. 二芳基庚烷类化合物. CN: CN106831383B, 2021-03-30.

[5] 肖伟烈, 王飞, 普德兵, 杜宝文, 张芮菡, 史楠, 高俊博, 张兴杰. 一类异海松烷型二萜衍生物,其药物组合物及其用途. CN: CN108530281B, 2021-02-02.

[6] 王飞, 阿皮恰德苏克萨穆然, 张国林, 提帕万初普阿焦布, 林源, 沈晓飞. 二芳基庚烷类化合物的用途. CN: CN106806361B, 2020-03-06.

[7] 王飞, 阿彼察·苏萨朗, 张国林",null,"卢晓霞. 姜黄素衍生物的用途. CN: CN110327315A, 2019-10-15.

[8] 张国林, 王飞, 卢晓霞, 闻永举, 周宗元. 一种苄胺酰类衍生物及其在制备抗炎药物中的用途. CN: CN109879772A, 2019-06-14.

[9] 王飞, 卢晓霞, 张国林, 王涛, 彭婷. 一种miRNA生物合成抑制剂. CN: CN109810071A, 2019-05-28.

[10] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫夫蒂, 付乃洁. 一种IDO1抑制剂及其应用. CN: CN109485615A, 2019-03-19.

[11] 肖伟烈, 王飞, 张兴杰, 杜宝文, 张芮菡. 甲氧基-7-木犀草素及其制备方法和用途. 中国: CN108383821A, 2018-08-10.

[12] 王飞, 张国林, 王淳, 彭勇, 蒲文臣, 邓腾, 强喆, 李娇. SHP2抑制剂在制备抗肿瘤的药物中的用途. 中国: CN108113984A, 2018-06-05.

[13] 王飞, 张国林, 奥汝丸.汪嘎纳. 6‑羟基‑3‑O‑甲基山奈酚6‑O‑吡喃葡萄糖苷的新用途. 中国: CN107714711A, 2018-02-23.

[14] 王飞, 张国林, 何玉娇, 张华. 一种苯基恶唑类化合物在制备治疗癌症的药中的应用. 中国: CN104306373A, 2015-01-28.

[15] 王飞, 张国林, 何玉娇, 张华. 苯基恶唑类化合物及在制备治疗癌症的药中的应用. 中国: CN104230836A, 2014-12-24.

[16] 张国林, 王飞, 淳泽, 林源. 菲及二氢菲类化合物及其应用. 中国: CN103408612A, 2013-11-27.

[17] 王飞, 章从恩, 陈前锋, 张国林. 一种特女贞苷的制备方法. 中国: CN102372754A, 2012-03-14.

[18] 王飞, 邰正福, 杨莉娟, 张国林. 一种抗病毒的组合药物. 中国: CN102343083A, 2012-02-08.

出版信息

   
发表论文
[1] Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang. Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65: 460-484, [2] Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang, Yaoyao Zhang, Guolin Zhang, Fei Wang, Gang Zhao, Junling Guo. Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy. THERANOSTICS[J]. 2022, 12: 2028-2040, [3] Dong-yi Cao, Zhong-hui Zhang, Run-ze Li, Xiao-ke Shi, Rui-ying Xi, Guo-lin Zhang, Fu Li, Fei Wang. A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation. Immunology Letters[J]. 2022, 244: 28-39, [4] Nai-jie Fu, Rui-ying Xi, Xiao-ke Shi, Run-ze Li, Zhong-hui Zhang, Ling-yu Li, Guo-lin Zhang, Fei Wang. Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways. Toxicology and Applied Pharmacology[J]. 2022, 441: 115988-, [5] Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorganic & Medicinal Chemistry[J]. 2022, 66: 116811-, [6] Zhang, Xuejian, Luo, Guoyong, Cao, Yu, Mishig, Dumaa, Lodonjav, Munkhgerel, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang. (+/-)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa. BIOORGANIC CHEMISTRY[J]. 2021, 116: http://dx.doi.org/10.1016/j.bioorg.2021.105364.
[7] Xiao-Yu Hou, Yu Cao, Bing-Lan Wu, Bin Chen, Fu Li, Fei Wang, Ming-Kui Wang, Lun Wang. New 2-isobutylmalates from the tubers of Bletilla striata and their potential anti-pulmonary fibrosis activities. Phytochemistry Letters[J]. 2021, 46: 95-99, [8] Peng, Ting, Wonganan, Orawan, Zhang, Zhonghui, Yu, Jialing, Xi, Ruiying, Cao, Yu, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei. A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating beta-TrCP E3 Ubiquitin Ligase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(7): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000638678600001.
[9] Zhou, Zongyuan, Li, Yiming, Ma, Xiaofang, Cao, Biyun, Peng, Ting, Sheng, Yuwen, Peng, Huipan, Li, Runze, Cao, Yu, Xi, Ruiying, Li, Fu, Wang, Mengru, Sun, Handong, Zhang, Guolin, Zhang, Hongbin, Hu, Kaifeng, Xiao, Weilie, Wang, Fei. Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(11): 7404-7421, [10] 席芮颖, 付乃洁, 李润择, 张国林, 王飞. 氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡. 应用与环境生物学报[J]. 2021, 28: 365-371, https://t.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKHTPvOGrUOOqX1coEOzL8AFqhlmu-o6sXjzYJdv148CfTKvdryZMFAk5AWFaMJpGIVQ9Jw4CizvT.
[11] Laura, Gertrude Foudjo Melacheu, Njoya, Emmanuel Mfotie, Jouda, JeanBosco, Kweka, Brussine Nadege Wakeu, Mbazoa, Celine Djama, Wang, Fei, Seguin, Elisabeth, Wandji, Jean. A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf. NATURAL PRODUCT RESEARCH[J]. 2021, 35(10): 1590-1595, http://dx.doi.org/10.1080/14786419.2019.1628749.
[12] Xu, Jian, Li, Runze, Xu, Nian, Liu, Xiaohua, Wang, Fei, Feng, Xiaoming. Enantioselective 4+2 Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids. ORGANIC LETTERS[J]. 2021, 23(5): 1856-1861, http://dx.doi.org/10.1021/acs.orglett.1c00260.
[13] Wisanwattana, Wisanee, Wongkrajang, Kanjana, Cao, Dongyi, Shi, Xiaoke, Zhang, Zhonghui, Zhou, Zongyuan, Li, Fu, Mei, Qinggang, Wang, Chun, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei. Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway. FRONTIERS IN ENDOCRINOLOGY[J]. 2021, 12: https://doaj.org/article/5be6f442dd374776b11afcae1eb91b69.
[14] Zhang, Zhonghui, Du, Guoyuan, Gong, Guidong, Sheng, Yuwen, Lu, Xiangyu, Cai, Wentao, Wang, Fei, Zhao, Gang. A novel ferrocene-palladium metal complex: synthesis, single crystal structure, in vitro cytotoxicity study and molecular docking. JOURNAL OF MOLECULAR STRUCTURE[J]. 2021, 1232: http://dx.doi.org/10.1016/j.molstruc.2021.130021.
[15] Lian, Xufan, Zhang, Xiuli, Wang, Fei, Wang, Xiaoning, Xue, Zheyong, Qi, Xiaoquan. Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway ofMelia toosendan. PHYSIOLOGIA PLANTARUM[J]. 2020, 170(4): 528-536, https://www.webofscience.com/wos/woscc/full-record/WOS:000565153300001.
[16] Wang, Dongmei, Yang, Yun, Shi, Xiaoke, Yang, Kaitai, Yin, Kaipu, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Viburnumfocesides A - D, 1-O-isovaleroylated iridoid 11-O-alloside derivatives from Viburnum foetidum var. ceanothoides. FITOTERAPIA[J]. 2020, 143: http://dx.doi.org/10.1016/j.fitote.2020.104601.
[17] Xiong, Wei, Wang, Xiaohong, Shen, Xianyan, Hu, Cuifang, Wang, Xin, Wang, Fei, Zhang, Guolin, Wang, Chun. Synthesis of Flavonols via Pyrrolidine Catalysis: Origins of the Selectivity for Flavonol versus Aurone. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(20): 13160-13176, https://www.webofscience.com/wos/woscc/full-record/WOS:000582579900028.
[18] Zhang, PuZhao, Zhang, YaMei, Lin, Yuan, Wang, Fei, Zhang, GuoLin. Three new diterpenes from Dysoxylum lukii and their NO production inhibitory activity. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2020, 22(6): 531-536, https://www.webofscience.com/wos/woscc/full-record/WOS:000469740600001.
[19] Du, BaoWen, Zhang, XingJie, Shi, Nan, Peng, Ting, Gao, JunBo, Azimova, Bahtigul, Zhang, Ruihan, Pu, DeBing, Wang, Chun, Abduvaliev, Anvar, Rakhmanov, Alisher, Zhang, GuoLin, Xiao, WeiLie, Wang, Fei. Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2020, 879: http://dx.doi.org/10.1016/j.ejphar.2020.173154.
[20] Fei Wang. Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp.CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways. Planta Medica. 2020, [21] Zhang, Xuejian, Peng, Ting, Shi, Xiaoke, Fang, Dongmei, Tang, Lin, Chen, Fang, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa. PHYTOCHEMISTRY[J]. 2020, 180: http://dx.doi.org/10.1016/j.phytochem.2020.112534.
[22] Liu Deming, Yang Dong, Zhou Chunyan, Wu Jiasi, Zhang Guolin, Wang Ping, Wang Fei, Meng Xianli. Aloe-emodin induces hepatotoxicity by the inhibition of multidrug resistance protein 2. PHYTOMEDICINE[J]. 2020, 68: http://dx.doi.org/10.1016/j.phymed.2019.153148.
[23] Ebokaiwe, Azubuike Peter, Njoya, Emmanuel Mfotie, Sheng, Yuwen, Zhang, Zhonghui, Li, Sheng, Zhou, Zongyuan, Qiang, Zhe, Peng, Ting, Hussein, Ahmed A, Zhang, Guolin, Lu, Xiaoxia, Li, Lin, Wang, Fei. Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2020, 404: http://dx.doi.org/10.1016/j.taap.2020.115203.
[24] Zhang, Puzhao, Lin, Yuan, Wang, Fei, Fang, Dongmei, Zhang, Guolin. Diterpenes from Dysoxylum lukii Merr. PHYTOCHEMISTRY LETTERS[J]. 2019, 29: 53-56, http://dx.doi.org/10.1016/j.phytol.2018.09.012.
[25] Huang, Xin, Zhao, Yongyun, Pu, Qinlin, Liu, Getong, Peng, Yan, Wang, Fei, Chen, Gangyi, Sun, Meiling, Du, Feng, Dong, Juan, Cui, Xin, Tang, Zhuo, Mo, Xianming. Intracellular selection of trans-cleaving hammerhead ribozymes. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(5): 2514-2522, [26] Zhao, Xingwang, Xie, Hengyi, Zhao, Meng, Ahsan, Asma, Li, Xinxin, Wang, Fei, Yi, Junyang, Yang, Zhiyong, Wu, Chuan, Raman, Indu, Li, QuanZhen, Kim, Tae Jin, Liu, Wanli. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. SCIENCE ADVANCES[J]. 2019, 5(7): [27] Li, Rui, Liu, Fang, Yang, Xiao, Chen, Lianqi, Wang, Fei, Zhang, Guolin, Zhang, Qian, Zhang, Liang, He, Yuxin, Li, Yufeng, Lai, Peng, Chen, Xianggui, Ye, Min, Xiao, Hongtao, Xiao, Hang. Analysis of bisabolocurcumin ether (a terpene-conjugated curcuminoid) and three curcuminoids in Curcuma species from different regions by UPLC-ESI MS/MS and their in vitro anti-inflammatory activities. JOURNAL OF FUNCTIONAL FOODS[J]. 2019, 52: 186-195, http://dx.doi.org/10.1016/j.jff.2018.11.008.
[28] Wu, Jiasi, Luo, Yu, Jiang, Qing, Li, Sheng, Huang, Wenge, Xiang, Li, Liu, Deming, Hu, Yingfan, Wang, Ping, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, Meng, Xianli. Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1. PHARMACOLOGICAL RESEARCH[J]. 2019, 147: 104348-, http://dx.doi.org/10.1016/j.phrs.2019.104348.
[29] 史楠, 史小可, Jovliqizi, Azimova, Bahtigul, Abduvaliev, Anvar, Rakhmanov, Alisher, 王飞. Eryxin通过抑制芳香化酶表达调控雌激素生物合成. 应用与环境生物学报[J]. 2019, 25(5): 1205-1210, http://lib.cqvip.com/Qikan/Article/Detail?id=7100213343.
[30] Fei Wang. wo new indole alkaloids from Tabernaemontana contorta Stapf. Phytochemistry Letters. 2019, [31] Yang, Lingling, Chen, Yang, He, Junlin, Njoya, Emmanuel Mfotie, Chen, Jianjun, Liu, Siyan, Xie, Congqiang, Huang, Wenze, Wang, Fei, Wang, Zhouyu, Li, Yuzhi, Qian, Shan. 4,6-Substituted-1 H-Indazoles as potent IDO1/TDO dual inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2019, 27(6): 1087-1098, http://dx.doi.org/10.1016/j.bmc.2019.02.014.
[32] Melacheu, Gertrude Laura Foudjo, Njoya, Emmanuel Mfotie, Jouda, JeanBosco, Kweka, Brussine Nadege Wakeu, Mbazoa, Celine Djama, Wang, Fei, Wandji, Jean. Two new indole alkaloids from Tabernaemontana contorta Stapf. PHYTOCHEMISTRY LETTERS[J]. 2019, 30: 116-119, http://dx.doi.org/10.1016/j.phytol.2019.01.028.
[33] 李晟, 李焱鑫, Emmanuel, Mfotie, Njoya, 蒋黎, 李霖, 王飞. 瑞香素及噁唑类小分子抑制吲哚胺-2,3-双加氧酶1(IDO1)的研究. 天然产物研究与开发[J]. 2018, 30(12): 2128-2132,2096, http://lib.cqvip.com/Qikan/Article/Detail?id=7001044758.
[34] Pu, DeBing, Du, BaoWen, Chen, Wen, Gao, JunBo, Hu, Kun, Shi, Nan, Li, YiMing, Zhang, XingJie, Zhang, RuiHan, Li, XiaoNian, Zhang, HongBin, Wang, Fei, Xiao, WeiLie. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva. ORGANIC LETTERS[J]. 2018, 20(19): 6314-6317, https://www.webofscience.com/wos/woscc/full-record/WOS:000447118200072.
[35] Han, Xiaojuan, Chen, Honghan, Zhou, Jiao, Tai, Haoran, Gong, Hui, Wang, Xiaobo, Huang, Ning, Qin, Jianqiong, Fang, Tingting, Wang, Fei, Xiao, Hengyi. The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2018, 233(5): 3945-3954, https://www.webofscience.com/wos/woscc/full-record/WOS:000424644700021.
[36] JeanBosco Jouda, Emmanuel Mfotie Njoya, Cline Djama Mbazoa, ZongYuan Zhou, Alain Meli Lannang, Jean Wandji, Yoshihito Shiono, Fei Wang. Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways. Bioorganic Chemistry. 2018, 80: 216-222, http://dx.doi.org/10.1016/j.bioorg.2018.06.021.
[37] Qiang, Zhe, Zhou, Zongyuan, Peng, Ting, Jiang, Puzi, Shi, Nan, Njoya, Emmanuel Mfotie, Azimova, Bahtigul, Liu, Wanli, Chen, Weihua, Zhang, Guolin, Wang, Fei. Inhibition of TPL2 by interferon- suppresses bladder cancer through activation of PDE4D. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH[J]. 2018, 37(1): http://ir.imde.ac.cn/handle/131551/24538.
[38] Wang, Junyi, Lin, Feng, Wan, Zhengpeng, Sun, Xiaolin, Lu, Yun, Huang, Jianyong, Wang, Fei, Zeng, Yingyue, Chen, YingHua, Shi, Yan, Zheng, Wenjie, Li, Zhanguo, Xiong, Chunyang, Liu, Wanli. Profiling the origin, dynamics, and function of traction force in B cell activation. SCIENCE SIGNALING[J]. 2018, 11(542): https://www.webofscience.com/wos/woscc/full-record/WOS:000440925500001.
[39] Wan, Zhengpeng, Xu, Chenguang, Chen, Xiangjun, Xie, Hengyi, Li, Zongyu, Wang, Jing, Ji, Xingyu, Chen, Haodong, Ji, Qinghua, Shaheen, Samina, Xu, Yang, Wang, Fei, Tang, Zhuo, Zheng, JiShen, Chen, Wei, Lou, Jizhong, Liu, Wanli. PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation. JOURNAL OF CELL BIOLOGY[J]. 2018, 217(7): 2565-2582, https://www.webofscience.com/wos/woscc/full-record/WOS:000438081900028.
[40] Ebokaiwe, Azubuike P, Ijomone, Omamuyovwi M, Osawe, Sharon O, Chukwu, Chukwuma J, Ejike, Chukwunonso E C C, Zhang, Guolin, Wang, Fei. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. REDOX REPORT[J]. 2018, 23(1): 194-205, http://ir.imde.ac.cn/handle/131551/24561.
[41] Gong, Guidong, Cao, Yuan, Wang, Fei, Zhao, Gang. Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells. ORGANOMETALLICS[J]. 2018, 37(7): 1103-1113, https://www.webofscience.com/wos/woscc/full-record/WOS:000429886300003.
[42] Gong, Guidong, Cao, Yuan, Qian, Hongyun, Zhou, Yangyang, Zhao, Haihang, Li, Ling, Wang, Fei, Zhao, Gang. Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system. CHEMICAL COMMUNICATIONS[J]. 2018, 54(60): https://www.webofscience.com/wos/woscc/full-record/WOS:000439702200002.
[43] Fu Li, BaoWen Du, DanFeng Lu, WenXuan Wu, Kanjana Wongkrajang, Lun Wang, WenChen Pu, ChangLu Liu, HanWei Liu, MingKui Wang, Fei Wang. Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/cdbf79c242b5456e9d71bb62e04b9411.
[44] Orawan Wonganan, Yu-jiao He, Xiao-fei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology. 2017, 336: 31-39, http://dx.doi.org/10.1016/j.taap.2017.10.004.
[45] Wonganan, Orawan, He, Yujiao, Shen, Xiaofei, Wongkrajang, Kanjana, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2017, 336: 31-39, https://www.webofscience.com/wos/woscc/full-record/WOS:000416880000004.
[46] Fei Wang. Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Oncotarget. 2017, [47] Shaheen, Samina, Wan, Zhengpeng, Li, Zongyu, Chau, Alicia, Li, Xinxin, Zhang, Shaosen, Liu, Yang, Yi, Junyang, Zeng, Yingyue, Wang, Jing, Chen, Xiangjun, Xu, Liling, Chen, Wei, Wang, Fei, Lu, Yun, Zheng, Wenjie, Shi, Yan, Sun, Xiaolin, Li, Zhanguo, Xiong, Chunyang, Liu, Wanli. Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKC beta and focal adhesion kinase. ELIFE[J]. 2017, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000406612300001.
[48] Sheng Li, Lijuan Yang, Ping Wang, Yujiao He, Junmei Huang, Hanwei Liu, Xiaofei Shen, Fei Wang. Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation. Food & Nutrition Research[J]. 2016, 60: 1-12, https://doaj.org/article/bd73899fe81f49e386ad5d46963c156d.
[49] Wu, Jiasi, Zhang, Hai, Hu, Boyang, Yang, Lijuan, Wang, Ping, Wang, Fei, Meng, Xianli. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2016, 780: 106-114, http://dx.doi.org/10.1016/j.ejphar.2016.03.037.
[50] Pu, Wenchen, Yuan, Yun, Lu, Danfeng, Wang, Xin, Liu, Hanwei, Wang, Chun, Wang, Fei, Zhang, Guolin. 2-Phenylbenzobfurans: Synthesis and promoting activity on estrogen biosynthesis. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 26(22): 5497-5500, http://dx.doi.org/10.1016/j.bmcl.2016.10.013.
[51] Chen, Lianqi, Shen, Xiaofei, Hu, Boyang, Lin, Yuan, Igbe, Ighodaro, Zhang, Chenggang, Zhang, Guolin, Yuan, Xiaohong, Wang, Fei. Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 26(10): 2521-2525, http://dx.doi.org/10.1016/j.bmcl.2016.03.088.
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[57] Sornkaew, Nilubon, Lin, Yuan, Wang, Fei, Zhang, Guolin, Chokchaisiri, Ratchanaporn, Zhang, Ailian, Wongkrajang, Kanjana, Suebsakwong, Parichat, Piyachaturawat, Pawinee, Suksamrarn, Apichart. Diarylheptanoids of Curcuma comosa with Inhibitory Effects on Nitric Oxide Production in Macrophage RAW 264.7 Cells. NATURAL PRODUCT COMMUNICATIONS[J]. 2015, 10(1): 89-93, http://210.75.237.14/handle/351003/27608.
[58] Wan, Zhengpeng, Chen, Xiangjun, Chen, Haodong, Ji, Qinghua, Chen, Yingjia, Wang, Jing, Cao, Yiyun, Wang, Fei, Lou, Jizhong, Tang, Zhuo, Liu, Wanli. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. ELIFE[J]. 2015, 4: http://210.75.237.14/handle/351003/27571.
[59] Guo, Jiajia, Yuan, Yun, Lu, Danfeng, Du, Baowen, Xiong, Liang, Shi, Jiangong, Yang, Lijuan, Liu, Wanli, Yuan, Xiaohong, Zhang, Guolin, Wang, Fei. Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3 beta,5 alpha,8 alpha-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19). TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2014, 279(1): 23-32, http://210.75.237.14/handle/351003/26671.
[60] Jiajia Guo, Yun Yuan, Danfeng Lu, Baowen Du, Liang Xiong, Jiangong Shi, Lijuan Yang, Wanli Liu, Xiaohong Yuan, Guolin Zhang, Fei Wang. Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19). Toxicology and Applied Pharmacology. 2014, 279(1): 23-32, http://dx.doi.org/10.1016/j.taap.2014.05.008.
[61] Lin, Yuan, Wang, Fei, Zhang, GuoLin. Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2014, 16(7): 800-812, http://210.75.237.14/handle/351003/26703.
[62] Hu, Boyang, Zhang, Hai, Meng, Xianli, Wang, Fei, Wang, Ping. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2014, 153(3): 846-853, http://210.75.237.14/handle/351003/26683.
[63] Yang, Chunyan, Li, Fu, Du, Baowen, Chen, Bin, Wang, Fei, Wang, Mingkui. Isolation and Characterization of New Phenolic Compounds with Estrogen Biosynthesis-Inhibiting and Antioxidation Activities from Broussonetia papyrifera Leaves. PLOS ONE[J]. 2014, 9(4): http://210.75.237.14/handle/351003/26688.
[64] 袁韵, 林之蔚, 郭加加, 王飞, 袁小红. 细胞膜结合的雌激素受体的特异性标记. 应用与环境生物学报[J]. 2014, 20(2): 227-232, http://www.irgrid.ac.cn/handle/1471x/1028564.
[65] Tai, Zhengfu, Lin, Yuan, He, Yujiao, Huang, Junmei, Guo, Jiajia, Yang, Lijuan, Zhang, Guolin, Wang, Fei. Luteolin sensitizes the antiproliferative effect of interferon alpha/beta by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. CELLULAR SIGNALLING[J]. 2014, 26(3): 619-628, http://210.75.237.14/handle/351003/26695.
[66] Zhengfu Tai, Yuan Lin, Yujiao He, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang, Fei Wang. Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. Cellular Signalling. 2014, 26(3): 619-628, http://dx.doi.org/10.1016/j.cellsig.2013.11.039.
[67] Chen, Qianfeng, Yang, Lijuan, Zhang, Guolin, Wang, Fei. Bioactivity-guided Isolation of Antiosteoporotic Compounds from Ligustrum lucidum. PHYTOTHERAPY RESEARCH[J]. 2013, 27(7): 973-979, http://www.irgrid.ac.cn/handle/1471x/900548.
[68] Yang, Lijuan, Lu, Danfeng, Guo, Jiajia, Meng, Xianli, Zhang, Guolin, Wang, Fei. Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19). JOURNAL OF ETHNOPHARMACOLOGY[J]. 2013, 145(3): 715-721, http://www.irgrid.ac.cn/handle/1471x/900498.
[69] Zhang, Puzhao, Wang, Fei, Yang, Lijuan, Zhang, Guolin. Pregnane alkaloids from Sarcococca hookeriana var. digyna. FITOTERAPIA[J]. 2013, 89: 143-148, http://www.irgrid.ac.cn/handle/1471x/900537.
[70] Fei Wang. Trichinenlides A-T, Mexcicanolide-Type Limonoids from Trichilia sinensis. Journal of Natural Products. 2013, [71] Xu, JinBiao, Lin, Yuan, Dong, ShiHui, Wang, Fei, Yue, JianMin. Trichinenlides A-T, Mexicanolide-Type Limonoids from Trichilia sinensis. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 76(10): 1872-1880, http://www.irgrid.ac.cn/handle/1471x/900533.
[72] Liu, HanWei, Yu, XiuZhu, Padula, Daniele, Pescitelli, Gennaro, Lin, ZhiWei, Wang, Fei, Ding, Kai, Lei, Ming, Gao, JinMing. Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 59: 265-273, http://dx.doi.org/10.1016/j.ejmech.2012.11.003.
[73] Lin, Yuan, Wang, Fei, Yang, Lijuan, Chun, Ze, Bao, Jinku, Zhang, Guolin. Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum. PHYTOCHEMISTRY[J]. 2013, 95(2013): 242-251, http://dx.doi.org/10.1016/j.phytochem.2013.08.008.
[74] 丹枫, Azimova Bahtigul Jovliqizi, 张国林, 王飞. 采用磁微粒分离酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型. 天然产物研究与开发[J]. 2013, 25(1): 27-30, http://210.75.237.14/handle/351003/24044.
[75] 郭加加, 黄君梅, 王飞. 冰乙酸水解法提高女贞子提取物中红景天苷含量. 应用与环境生物学报[J]. 2013, 19(4): 723-726, http://210.75.237.14/handle/351003/24058.
[76] Hua, Lei, Li, Ya, Wang, Fei, Lu, Danfeng, Gao, Kun. Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd. FITOTERAPIA[J]. 2012, 83(6): 1036-1041, http://www.irgrid.ac.cn/handle/1471x/656376.
[77] Guo-Lin Zhang. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological Pharmaceutical Bulletin. 2012, [78] Lu, Danfeng, Yang, Lijuan, Wang, Fei, Zhang, Guolin. Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2012, 60(34): 8411-8418, http://www.irgrid.ac.cn/handle/1471x/656377.
[79] 林之蔚, 邰正福, 万忠民, 王飞, 雷泞菲. 荧光光谱法研究木栓酮与牛血清白蛋白的相互作用. 应用与环境生物学报. 2012, 18(2): 287-291, http://lib.cqvip.com/Qikan/Article/Detail?id=41871147.
[80] Lu, Danfeng, Yang, Lijuan, Li, Qilin, Gao, Xiaoping, Wang, Fei, Zhang, Guolin. Egonol gentiobioside and egonol gentiotrioside from Styrax perkinsiae promote the biosynthesis of estrogen by aromatase. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2012, 691(1-3): 275-282, http://dx.doi.org/10.1016/j.ejphar.2012.07.005.
[81] Fei Wang. Aqueous extract of Fructus Ligustri Lucidi regulates the proliferation and differentiation of UMR-106. Nat Prod Res Dev. 2011, [82] Pu, Wenchen, Wang, Fei, Wang, Chun. Bioactivities and Synthetic Methods of 2-Arylbenzobfurans. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 31(2): 155-165, http://www.irgrid.ac.cn/handle/1471x/517902.
[83] 王星, 吕广颖, 杨利娟, 王飞, 王淳. 7-羟基异黄酮及其衍生物的合成与选择性雌激素受体结合的构效关系研究. 有机化学[J]. 2011, 31(8): 1245-1251, http://lib.cqvip.com/Qikan/Article/Detail?id=39062125.
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科研活动

   
科研项目
( 1 ) 女贞子抗高原反应的研究, 主持, 部委级, 2013-01--2015-12
( 2 ) 蛋白激酶A介导的磷酸化调控芳香化酶降解机制的化学生物学研究, 主持, 国家级, 2014-01--2017-12
( 3 ) 基于共轭聚合物纳米粒子的蛋白质-蛋白质相互作用药物筛选新方法的研究及其应用, 主持, 部委级, 2014-01--2016-12
( 4 ) 青年研究员人才支持项目, 主持, 市地级, 2013-01--2017-12
( 5 ) 四川省杰出青年学术技术带头人计划, 主持, 省级, 2014-01--2016-12
( 6 ) α7尼古丁乙酰胆碱受体激动剂治疗类风湿性关节炎的研究, 主持, 省级, 2016-03--2019-06
( 7 ) 治疗老年性疾病的天然产物药物发现研究, 参与, 国家级, 2015-10--2018-09
( 8 ) 苯基噁唑类化合物通过TRBP调控microRNA生物合成抑制肝癌转移的化学生物学研究, 主持, 国家级, 2017-01--2020-12
( 9 ) 二苯庚烷类化合物作为α7尼古丁乙酰胆碱受体激动剂治疗心律失常的研究, 主持, 部委级, 2016-09--2018-09
( 10 ) 基于天然产物的老年性疾病候选药物研究, 参与, 国家级, 2019-01--2021-12
( 11 ) 黄烷酮类小分子靶向蛋白酪氨酸磷酸酶SHP2调控RAS信号通路抑制肺癌的化学生物学研究, 主持, 国家级, 2020-01--2023-12

指导学生

已指导学生

郭加加  硕士研究生  077901-药物化学  

邓腾  硕士研究生  078001-药物化学  

李晟  硕士研究生  085238-生物工程  

彭辉盼  硕士研究生  105500-药学  

盛钰雯  硕士研究生  085238-生物工程  

史楠  硕士研究生  077804-病理学与病理生理学  

现指导学生

史小可  硕士研究生  100104-病理学与病理生理学  

周宗元  博士研究生  100706-药理学  

李润择  硕士研究生  077804-病理学与病理生理学  

曹东怡  博士研究生  100701-药物化学  

靳钰洁  硕士研究生  078006-药理学  

盛钰雯  博士研究生  100706-药理学