基本信息

王飞 男 博导 中国科学院成都生物研究所
电子邮件: wangfei@cib.ac.cn
通信地址: 成都市人民南路四段9号中科院成都生物所植化楼407
邮政编码: 610047
电子邮件: wangfei@cib.ac.cn
通信地址: 成都市人民南路四段9号中科院成都生物所植化楼407
邮政编码: 610047
研究领域
采用化学生物学的原理与方法,发现调控干扰素激活的JAK/STAT信号通路,雌激素的生物合成和代谢,RNAi信号通路和蛋白质泛素降解信号通路的天然产物化学小分子,研究其构效关系,以活性小分子为探针研究其作用机制,以期发现新的信号调控机制以及具有诊疗作用的药物前体;
探索新型蛋白质标记体系,实时动态的研究细胞膜受体在天然配体和化学小分子作用下的变化,以发现细胞膜受体的新的作用机制;
以骨质疏松为模型,研究中药治疗骨质疏松的物质基础和作用机制。
招生信息
招生专业
100701-药物化学100706-药理学
招生方向
干扰素、雌激素生物合成和microRNA途径的化学生物学研究干扰素、雌激素生物合成和microRNA途径的化学生物学研究
教育背景
2000-09--2005-09 中国科学院遗传与发育生物学研究所 博士(硕博连读)1996-09--2000-07 河南师范大学 学士
工作经历
工作简历
2014-01~现在, 中国科学院成都生物研究所, 研究员2008-03~2013-12,中国科学院成都生物研究所, 副研究员2005-10~2008-02,University of California San Francisco, 博士后
社会兼职
2018-02-22-2022-02-22,中国人民政治协商会议成都市第十五届委员会, 常务委员
2016-01-01-今,成都市九三学社高新区委员会第二支社, 主委
2013-01-01-2014-12-31,中国科学院青年创新促进会成都分会, 会长
2011-06-01-2014-06-01,中国科学院青年创新促进会, 理事
2016-01-01-今,成都市九三学社高新区委员会第二支社, 主委
2013-01-01-2014-12-31,中国科学院青年创新促进会成都分会, 会长
2011-06-01-2014-06-01,中国科学院青年创新促进会, 理事
教授课程
化学生物学
专利与奖励
奖励信息
(1) 中国科学院院长特别奖, 特等奖, 院级, 2004(2) 中国科学院地奥奖一等奖, 一等奖, 院级, 2004(3) 中科院遗传发育所“研究生优秀论, 一等奖, 研究所(学校), 2004
专利成果
[1] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫福蒂, 付乃洁, 黎玥佳. 一种抗肿瘤的联合用药物. CN: CN109453164B, 2021-08-06.[2] 焦威, 向玲, 邵华武, 王飞, 张中辉. 一类千金子二萜衍生物及其应用. CN: CN113200950A, 2021-08-03.[3] 肖伟烈, 王飞, 李一明, 周宗元, 曹碧云, 李晓莉, 张芮菡, 张兴杰. 含氮联芳环类化合物、制备方法和应用. CN: CN113087693A, 2021-07-09.[4] 王飞, 阿皮恰德苏克萨穆然, 张国林, 康佳娜旺克阿将, 林源, 沈晓飞. 二芳基庚烷类化合物. CN: CN106831383B, 2021-03-30.[5] 肖伟烈, 王飞, 普德兵, 杜宝文, 张芮菡, 史楠, 高俊博, 张兴杰. 一类异海松烷型二萜衍生物,其药物组合物及其用途. CN: CN108530281B, 2021-02-02.[6] 王飞, 阿皮恰德苏克萨穆然, 张国林, 提帕万初普阿焦布, 林源, 沈晓飞. 二芳基庚烷类化合物的用途. CN: CN106806361B, 2020-03-06.[7] 王飞, 阿彼察·苏萨朗, 张国林",null,"卢晓霞. 姜黄素衍生物的用途. CN: CN110327315A, 2019-10-15.[8] 张国林, 王飞, 卢晓霞, 闻永举, 周宗元. 一种苄胺酰类衍生物及其在制备抗炎药物中的用途. CN: CN109879772A, 2019-06-14.[9] 王飞, 卢晓霞, 张国林, 王涛, 彭婷. 一种miRNA生物合成抑制剂. CN: CN109810071A, 2019-05-28.[10] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫夫蒂, 付乃洁. 一种IDO1抑制剂及其应用. CN: CN109485615A, 2019-03-19.[11] 肖伟烈, 王飞, 张兴杰, 杜宝文, 张芮菡. 甲氧基-7-木犀草素及其制备方法和用途. 中国: CN108383821A, 2018-08-10.[12] 王飞, 张国林, 王淳, 彭勇, 蒲文臣, 邓腾, 强喆, 李娇. SHP2抑制剂在制备抗肿瘤的药物中的用途. 中国: CN108113984A, 2018-06-05.[13] 王飞, 张国林, 奥汝丸.汪嘎纳. 6‑羟基‑3‑O‑甲基山奈酚6‑O‑吡喃葡萄糖苷的新用途. 中国: CN107714711A, 2018-02-23.[14] 王飞, 张国林, 何玉娇, 张华. 一种苯基恶唑类化合物在制备治疗癌症的药中的应用. 中国: CN104306373A, 2015-01-28.[15] 王飞, 张国林, 何玉娇, 张华. 苯基恶唑类化合物及在制备治疗癌症的药中的应用. 中国: CN104230836A, 2014-12-24.[16] 张国林, 王飞, 淳泽, 林源. 菲及二氢菲类化合物及其应用. 中国: CN103408612A, 2013-11-27.[17] 王飞, 章从恩, 陈前锋, 张国林. 一种特女贞苷的制备方法. 中国: CN102372754A, 2012-03-14.[18] 王飞, 邰正福, 杨莉娟, 张国林. 一种抗病毒的组合药物. 中国: CN102343083A, 2012-02-08.
出版信息
发表论文
[1] Felicetti, Tommaso, Di Iacovo, Nicola, Della Fazia, Maria Agnese, Piobbico, Danilo, Pieroni, Stefania, Pacetti, Martina, Yu, Jialing, Sun, Yilun, Massari, Serena, Barreca, Maria Letizia, Sabatini, Stefano, Tabarrini, Oriana, Cecchetti, Violetta, Wang, Fei, Pommier, Yves, Morlando, Mariangela, Servillo, Giuseppe, Manfroni, Giuseppe. New anti-ovarian cancer quinolone derivatives acting by modulating microRNA processing machinery. RSC MEDICINAL CHEMISTRY[J]. 2025, 第 14 作者16(1): 98-124, http://dx.doi.org/10.1039/d4md00649f.[2] Sheng, Yuwen, Lin, Yuan, Qiang, Zhe, Shen, Xiaofei, He, Yujiao, Li, Lingyu, Li, Sheng, Zhang, Guolin, Wang, Fei. Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2025, 第 9 作者 通讯作者 301(2): http://dx.doi.org/10.1016/j.jbc.2025.108195.[3] He, Xin, Fu, Yihua, Xi, Ruiying, Zhang, Cefei, Lan, Kexin, Su, Zhishan, Wang, Fei, Feng, Xiaoming, Liu, Xiaohua. Asymmetric Carbene Insertion into Se-S Bonds by Synergistic Rh(II)/Guanidine Catalysis Involving Chalcogen-Bond Assistance. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2025, 第 7 作者64(5): http://dx.doi.org/10.1002/anie.202417636.[4] Ruihan Zhang, Zhao Wu, Hairong Wang, Minghui Ji, Tianze Shen, Linhan Yang, Yiming Li, Jialing Yu, Yinqiao Huang, Lingyu Li, Zihan Xu, Yuwen Sheng, Xiaoli Li, Fei Wang, Weilie Xiao. Structural optimization and pharmacological evaluation of diphenyl amine esters as anti-hepatocellular carcinoma agents by targeting TAR RNA-Binding Protein 2. European Journal of Medicinal Chemistry[J]. 2025, 第 14 作者 通讯作者 null(null): 117676, https://www.sciencedirect.com/science/article/pii/S0223523425004416.[5] Cao, Yu, Wen, Yongju, Zhou, Zongyuan, Xi, Ruiying, Shuai, Wen, Zhang, Jichao, Suksamrarn, Apichart, Zhang, Guolin, Lu, Xiaoxia, Wang, Fei. Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2025, 第 10 作者 通讯作者 284(null): http://dx.doi.org/10.1016/j.ejmech.2024.117229.[6] Naijie Fu, Yuwen Sheng, Zhe Fan, Zhao Wu, Lingyu Li, Ruiying Xi, Xiaoke Shi, Guolin Zhang, Fei Wang. Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS ‐mutant Nonsmall Cell Lung Cancer. ADVANCED SCIENCE[J]. 2025, 第 9 作者 通讯作者 12(15): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005787/.[7] Wang, Yu, Zhang, Shaocun, Kang, Na, Dong, Lihui, Ni, Haochen, Liu, Sichen, Chong, Siankang, Ji, Zhenglin, Wan, Zhengpeng, Chen, Xiangjun, Wang, Fei, Lu, Yun, Hou, Baidong, Tong, Pei, Qi, Hai, Xu, Meng Michelle, Liu, Wanli. Progressive polyadenylation and m6A modification of Ighg1 mRNA maintain IgG1 antibody homeostasis in antibody-secreting cells. IMMUNITY[J]. 2024, 第 11 作者57(11): http://dx.doi.org/10.1016/j.immuni.2024.10.004.[8] Cao, Dongyi, Xi, Ruiying, Li, Hongye, Zhang, Zhonghui, Shi, Xiaoke, Li, Shanshan, Jin, Yujie, Liu, Wanli, Zhang, Guolin, Liu, Xiaohua, Dong, Shunxi, Feng, Xiaoming, Wang, Fei. Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2024, 第 13 作者 通讯作者 67(17): 15873-15891, http://dx.doi.org/10.1021/acs.jmedchem.4c01558.[9] Hou, Liuzhen, Yang, Longqing, Yang, Gaofei, Luo, Zhe, Xiao, Wanlong, Yang, Linhan, Wang, Fei, Gong, LiuZhu, Liu, Xiaohua, Cao, Weidi, Feng, Xiaoming. Catalytic Asymmetric Dearomative 2+2 Photocycloaddition/Ring-Expansion Sequence of Indoles with Diversified Alkenes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2024, 第 7 作者146(33): 23457-23466, http://dx.doi.org/10.1021/jacs.4c06780.[10] Zeng, Zi, Yang, Longqing, Xiao, Zhijie, Chen, Long, Zhong, Ziwei, Wang, Fei, Liu, Xiaohua, Dong, Shunxi, Feng, Xiaoming. A Remarkable Influence of La(III)/N,N′-Dioxide Structure on Asymmetric Formal Substitution of 3-Bromo-3-substituted Oxindoles with TMSCN. ACS CATALYSIS[J]. 2024, 第 6 作者14(5): 2908-2916, http://dx.doi.org/10.1021/acscatal.3c06130.[11] Shi, Xiaoke, Peng, Ting, Azimova, Bahtigul, Li, Xiaoli, Li, Shanshan, Cao, Dongyi, Fu, Naijie, Zhang, Guolin, Xiao, Weilie, Wang, Fei. Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2024, 第 10 作者 通讯作者 331(null): http://dx.doi.org/10.1016/j.jep.2024.118279.[12] Luo, Qiliang, Mao, Tao, Luo, Yao, Zhang, Yuxin, Wang, Fei, Dong, Shunxi, Feng, Xiaoming. Enantioselective Synthesis of Spirocyclopentane-1,3′-oxindole Scaffolds with Five Consecutive Stereocenters. ORGANIC LETTERS[J]. 2024, 第 5 作者26(30): 6402-6406, http://dx.doi.org/10.1021/acs.orglett.4c02173.[13] Li, Hongye, Zhou, Yuqiao, Tan, Zheng, Wang, Xiangyu, Zhang, Yuxin, Wang, Fei, Feng, Xiaoming, Liu, Xiaohua. Enantioselective sulfonylation to construct 3-sulfonylated oxindoles. CHEMICAL COMMUNICATIONS[J]. 2024, 第 6 作者60(32): 4354-4357, http://dx.doi.org/10.1039/d4cc00802b.[14] Zhu, Chenhao, Zhou, Yuqiao, Zhang, Jing, Li, Jianfeng, Zhang, Yuxin, Wang, Fei, Feng, Xiaoming, Dong, Shunxi. Rare-Earth Metal-Catalyzed Asymmetric Addition/ Hydroamidination of Nitriles and Allylamines for the Concise Synthesis of Chiral Imidazolines. CCS CHEMISTRY. 2024, 第 6 作者http://dx.doi.org/10.31635/ccschem.024.202403937.[15] Cuifeng Li, Meng Zhao, Xiaohang Liu, Yuxin Li, Bihua Xu, Lina Zhou, Xiaolin Sun, Wenbo Sun, Na Kang, Zhenglin Ji, Tong Li, Haoran An, Fei Wang, Chuan Wu, JingYing Ye, JingRen Zhang, Qingwen Wang, Xiaodong Zhao, Zhanguo Li, Wanli Liu. Ion channel TRPV2 is critical in enhancing B cell activation and function. THE JOURNAL OF EXPERIMENTAL MEDICINE. 2024, 第 13 作者221(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10866685/.[16] Shi, Hailong, Yu, Jialing, Li, Lingyu, Ji, Minghui, Li, Runze, Peng, Ting, Cheng, Yao, Wang, Tao, Yang, Linhan, Wu, Zhao, Zhang, Guolin, Wang, Fei, Lu, Xiaoxia. Design, Synthesis, and Antitumor Activity Evaluation of 2-Phenylthiazole-5-Carboxylic Acid Derivatives Targeting Transactivation Response RNA-Binding Protein 2. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2024, 第 12 作者 通讯作者 68(1): 421-447, http://dx.doi.org/10.1021/acs.jmedchem.4c02041.[17] Sheng, Yuwen, Qiao, Chong, Zhang, Zhonghui, Shi, Xiaoke, Yang, Linhan, Xi, Ruiying, Yu, Jialing, Liu, Wanli, Zhang, Guolin, Wang, Fei. Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism. ADVANCED SCIENCE[J]. 2024, 第 10 作者 通讯作者 12(3): http://dx.doi.org/10.1002/advs.202409310.[18] Ji, Minghui, Li, Lingyu, Yu, Jialing, Wu, Zhao, Sheng, Yuwen, Wang, Fei. New insights into the function and therapeutic potential of RNA-binding protein TRBP in viral infection, chronic metabolic diseases, brain disorders and cancer. LIFE SCIENCES[J]. 2024, 第 6 作者 通讯作者 358: http://dx.doi.org/10.1016/j.lfs.2024.123159.[19] Xi, Ruiying, Cao, Yu, Fu, Naijie, Sheng, Yuwen, Yu, Jialing, Li, Lingyu, Zhang, Guolin, Wang, Fei. Allosteric inhibition of the tyrosine phosphatase SHP2 enhances the anti-tumor immunity of interferon α through induction of caspase-1-mediated pyroptosis in renal cancer. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2024, 第 8 作者 通讯作者 143(null): http://dx.doi.org/10.1016/j.intimp.2024.113498.[20] Journal of Ethnopharmacology. 2024, 通讯作者 [21] Journal of Organic Chemistry. 2023, 第 4 作者[22] Liao, Yangyang, Zhang, Xinjie, Cao, Dongyi, Wang, Fei, Chen, Hulan, Li, Rui. Separation and identification of terpene-conjugated curcuminoids based on liquid chromatography-tandem mass spectrometry and their in vitro anti-inflammatory activities. JOURNAL OF SEPARATION SCIENCE[J]. 2023, 第 4 作者46(10): https://www.doi.org/10.1002/jssc.202200789.[23] Shi, Hailong, Yang, Jinlian, Qiao, Zeen, Li, Lingyu, Liu, Gang, Dai, Qi, Xu, Li, Jiao, Wei, Zhang, Guolin, Wang, Fei, Lu, Xiaoxia, Ma, Xiaofeng. Design, synthesis and structure-activity relationship studies on erianin analogues as pyruvate carboxylase inhibitors in hepatocellular carcinoma cells. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2023, 第 10 作者21(34): 7005-7017, http://dx.doi.org/10.1039/d3ob01114c.[24] Organic & Biomolecular Chemistry. 2023, 第 10 作者[25] Phytochemistry. 2023, 第 6 作者[26] Angew Chem Int Ed Engl. 2023, 第 6 作者[27] Organic Chemistry Frontiers. 2023, 第 5 作者[28] Organic Letters. 2023, 第 5 作者[29] Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang. Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 20 作者 通讯作者 65: 460-484, [30] Zhang, Xuejian, Cao, Yu, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa. PHYTOCHEMISTRY[J]. 2022, 第 5 作者203: http://dx.doi.org/10.1016/j.phytochem.2022.113378.[31] Peng, Ting, He, Yujiao, Wang, Tao, Yu, Jialing, Ma, Xiaofang, Zhou, Zongyuan, Sheng, Yuwen, Li, Lingyu, Peng, Huipan, Li, Sheng, Zou, Jiawei, Yuan, Yi, Zhao, Yongyun, Shi, Hailong, Li, Fu, Liu, Wanli, Hu, Kaifeng, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP- Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 20 作者 通讯作者 null(null): http://dx.doi.org/10.1021/acs.jmedchem.2c00189.[32] 李润择, 曹东怡, 张中辉, 李晟, 吴嘉思, 王飞. 半胱氨酸天冬氨酸蛋白水解酶caspase-1抑制剂体外筛选模型的构建及应用. 应用与环境生物学报[J]. 2022, 第 6 作者28(3): 631-637, http://lib.cqvip.com/Qikan/Article/Detail?id=7107667466.[33] Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang, Yaoyao Zhang, Guolin Zhang, Fei Wang, Gang Zhao, Junling Guo. Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy. THERANOSTICS[J]. 2022, 第 8 作者 通讯作者 12: 2028-2040, [34] Dong-yi Cao, Zhong-hui Zhang, Run-ze Li, Xiao-ke Shi, Rui-ying Xi, Guo-lin Zhang, Fu Li, Fei Wang. A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation. Immunology Letters[J]. 2022, 第 8 作者 通讯作者 244: 28-39, [35] Wu, Jiasi, Lan, Yuejia, Shi, Xiaoke, Huang, Wenge, Li, Sheng, Zhang, Jizhou, Wang, Huan, Wang, Fei, Meng, Xianli. Sennoside A is a novel inhibitor targeting caspase-1. FOOD & FUNCTION[J]. 2022, 第 8 作者 通讯作者 13(19): 9782-9795, http://dx.doi.org/10.1039/d2fo01730j.[36] 席芮颖, 付乃洁, 李润择, 张国林, 王飞. 氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡. 应用与环境生物学报[J]. 2022, 第 5 作者28(2): 365-371, http://lib.cqvip.com/Qikan/Article/Detail?id=7107199027.[37] Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorganic & Medicinal Chemistry[J]. 2022, 第 14 作者 通讯作者 66: 116811, [38] Nai-jie Fu, Rui-ying Xi, Xiao-ke Shi, Run-ze Li, Zhong-hui Zhang, Ling-yu Li, Guo-lin Zhang, Fei Wang. Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways. Toxicology and Applied Pharmacology[J]. 2022, 第 8 作者 通讯作者 441: 115988, [39] Zhang, Xuejian, Luo, Guoyong, Cao, Yu, Mishig, Dumaa, Lodonjav, Munkhgerel, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang. (±)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa. BIOORGANIC CHEMISTRY[J]. 2021, 第 8 作者116: http://dx.doi.org/10.1016/j.bioorg.2021.105364.[40] Xiao-Yu Hou, Yu Cao, Bing-Lan Wu, Bin Chen, Fu Li, Fei Wang, Ming-Kui Wang, Lun Wang. New 2-isobutylmalates from the tubers of Bletilla striata and their potential anti-pulmonary fibrosis activities. Phytochemistry Letters[J]. 2021, 第 6 作者46: 95-99, [41] Peng, Ting, Wonganan, Orawan, Zhang, Zhonghui, Yu, Jialing, Xi, Ruiying, Cao, Yu, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei. A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating beta-TrCP E3 Ubiquitin Ligase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 第 9 作者 通讯作者 22(7): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000638678600001.[42] Zhou, Zongyuan, Li, Yiming, Ma, Xiaofang, Cao, Biyun, Peng, Ting, Sheng, Yuwen, Peng, Huipan, Li, Runze, Cao, Yu, Xi, Ruiying, Li, Fu, Wang, Mengru, Sun, Handong, Zhang, Guolin, Zhang, Hongbin, Hu, Kaifeng, Xiao, Weilie, Wang, Fei. Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 第 18 作者 通讯作者 64(11): 7404-7421, http://dx.doi.org/10.1021/acs.jmedchem.1c00018.[43] 席芮颖, 付乃洁, 李润择, 张国林, 王飞. 氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡. 应用与环境生物学报[J]. 2021, 第 5 作者 通讯作者 28: 365-371, https://t.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKHTPvOGrUOOqX1coEOzL8AFqhlmu-o6sXjzYJdv148CfTKvdryZMFAk5AWFaMJpGIVQ9Jw4CizvT.[44] Laura, Gertrude Foudjo Melacheu, Njoya, Emmanuel Mfotie, Jouda, JeanBosco, Kweka, Brussine Nadege Wakeu, Mbazoa, Celine Djama, Wang, Fei, Seguin, Elisabeth, Wandji, Jean. A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf. NATURAL PRODUCT RESEARCH[J]. 2021, 第 6 作者35(10): 1590-1595, http://dx.doi.org/10.1080/14786419.2019.1628749.[45] Wisanwattana, Wisanee, Wongkrajang, Kanjana, Cao, Dongyi, Shi, Xiaoke, Zhang, Zhonghui, Zhou, Zongyuan, Li, Fu, Mei, Qinggang, Wang, Chun, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei. Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway. FRONTIERS IN ENDOCRINOLOGY[J]. 2021, 第 12 作者 通讯作者 12: https://doaj.org/article/5be6f442dd374776b11afcae1eb91b69.[46] Xu, Jian, Li, Runze, Xu, Nian, Liu, Xiaohua, Wang, Fei, Feng, Xiaoming. Enantioselective 4+2 Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids. ORGANIC LETTERS[J]. 2021, 第 5 作者 通讯作者 23(5): 1856-1861, http://dx.doi.org/10.1021/acs.orglett.1c00260.[47] Zhang, Zhonghui, Du, Guoyuan, Gong, Guidong, Sheng, Yuwen, Lu, Xiangyu, Cai, Wentao, Wang, Fei, Zhao, Gang. A novel ferrocene-palladium metal complex: synthesis, single crystal structure, in vitro cytotoxicity study and molecular docking. JOURNAL OF MOLECULAR STRUCTURE[J]. 2021, 第 7 作者 通讯作者 1232: http://dx.doi.org/10.1016/j.molstruc.2021.130021.[48] Wang, Dongmei, Yang, Yun, Shi, Xiaoke, Yang, Kaitai, Yin, Kaipu, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Viburnumfocesides A - D, 1-O-isovaleroylated iridoid 11-O-alloside derivatives from Viburnum foetidum var. ceanothoides. FITOTERAPIA[J]. 2020, 第 6 作者143: http://dx.doi.org/10.1016/j.fitote.2020.104601.[49] Lian, Xufan, Zhang, Xiuli, Wang, Fei, Wang, Xiaoning, Xue, Zheyong, Qi, Xiaoquan. Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway ofMelia toosendan. PHYSIOLOGIA PLANTARUM[J]. 2020, 第 3 作者170(4): 528-536, http://dx.doi.org/10.1111/ppl.13189.[50] Xiong, Wei, Wang, Xiaohong, Shen, Xianyan, Hu, Cuifang, Wang, Xin, Wang, Fei, Zhang, Guolin, Wang, Chun. Synthesis of Flavonols via Pyrrolidine Catalysis: Origins of the Selectivity for Flavonol versus Aurone. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 第 6 作者85(20): 13160-13176, http://dx.doi.org/10.1021/acs.joc.0c01869.[51] Zhang, PuZhao, Zhang, YaMei, Lin, Yuan, Wang, Fei, Zhang, GuoLin. Three new diterpenes from Dysoxylum lukii and their NO production inhibitory activity. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2020, 第 4 作者22(6): 531-536, https://www.webofscience.com/wos/woscc/full-record/WOS:000469740600001.[52] Fei Wang. Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp.CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways. Planta Medica. 2020, 第 1 作者 通讯作者 [53] Du, BaoWen, Zhang, XingJie, Shi, Nan, Peng, Ting, Gao, JunBo, Azimova, Bahtigul, Zhang, Ruihan, Pu, DeBing, Wang, Chun, Abduvaliev, Anvar, Rakhmanov, Alisher, Zhang, GuoLin, Xiao, WeiLie, Wang, Fei. Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2020, 第 14 作者 通讯作者 879: http://dx.doi.org/10.1016/j.ejphar.2020.173154.[54] Zhang, Xuejian, Peng, Ting, Shi, Xiaoke, Fang, Dongmei, Tang, Lin, Chen, Fang, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa. PHYTOCHEMISTRY[J]. 2020, 第 7 作者180: http://dx.doi.org/10.1016/j.phytochem.2020.112534.[55] Liu Deming, Yang Dong, Zhou Chunyan, Wu Jiasi, Zhang Guolin, Wang Ping, Wang Fei, Meng Xianli. Aloe-emodin induces hepatotoxicity by the inhibition of multidrug resistance protein 2. PHYTOMEDICINE[J]. 2020, 第 7 作者 通讯作者 68: http://dx.doi.org/10.1016/j.phymed.2019.153148.[56] Ebokaiwe, Azubuike Peter, Njoya, Emmanuel Mfotie, Sheng, Yuwen, Zhang, Zhonghui, Li, Sheng, Zhou, Zongyuan, Qiang, Zhe, Peng, Ting, Hussein, Ahmed A, Zhang, Guolin, Lu, Xiaoxia, Li, Lin, Wang, Fei. Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2020, 第 13 作者 通讯作者 404: http://dx.doi.org/10.1016/j.taap.2020.115203.[57] Zhang, Puzhao, Lin, Yuan, Wang, Fei, Fang, Dongmei, Zhang, Guolin. Diterpenes from Dysoxylum lukii Merr. PHYTOCHEMISTRY LETTERS[J]. 2019, 第 3 作者29: 53-56, http://dx.doi.org/10.1016/j.phytol.2018.09.012.[58] Huang, Xin, Zhao, Yongyun, Pu, Qinlin, Liu, Getong, Peng, Yan, Wang, Fei, Chen, Gangyi, Sun, Meiling, Du, Feng, Dong, Juan, Cui, Xin, Tang, Zhuo, Mo, Xianming. Intracellular selection of trans-cleaving hammerhead ribozymes. NUCLEIC ACIDS RESEARCH[J]. 2019, 第 6 作者47(5): 2514-2522, [59] Zhao, Xingwang, Xie, Hengyi, Zhao, Meng, Ahsan, Asma, Li, Xinxin, Wang, Fei, Yi, Junyang, Yang, Zhiyong, Wu, Chuan, Raman, Indu, Li, QuanZhen, Kim, Tae Jin, Liu, Wanli. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. SCIENCE ADVANCES[J]. 2019, 第 6 作者5(7): [60] Li, Rui, Liu, Fang, Yang, Xiao, Chen, Lianqi, Wang, Fei, Zhang, Guolin, Zhang, Qian, Zhang, Liang, He, Yuxin, Li, Yufeng, Lai, Peng, Chen, Xianggui, Ye, Min, Xiao, Hongtao, Xiao, Hang. Analysis of bisabolocurcumin ether (a terpene-conjugated curcuminoid) and three curcuminoids in Curcuma species from different regions by UPLC-ESI MS/MS and their in vitro anti-inflammatory activities. JOURNAL OF FUNCTIONAL FOODS[J]. 2019, 第 5 作者52: 186-195, http://dx.doi.org/10.1016/j.jff.2018.11.008.[61] Wu, Jiasi, Luo, Yu, Jiang, Qing, Li, Sheng, Huang, Wenge, Xiang, Li, Liu, Deming, Hu, Yingfan, Wang, Ping, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, Meng, Xianli. Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1. PHARMACOLOGICAL RESEARCH[J]. 2019, 第 12 作者 通讯作者 147: 104348, http://dx.doi.org/10.1016/j.phrs.2019.104348.[62] 史楠, 史小可, Jovliqizi, Azimova, Bahtigul, Abduvaliev, Anvar, Rakhmanov, Alisher, 王飞. Eryxin通过抑制芳香化酶表达调控雌激素生物合成. 应用与环境生物学报[J]. 2019, 第 10 作者25(5): 1205-1210, http://lib.cqvip.com/Qikan/Article/Detail?id=7100213343.[63] Fei Wang. wo new indole alkaloids from Tabernaemontana contorta Stapf. Phytochemistry Letters. 2019, 第 1 作者[64] Yang, Lingling, Chen, Yang, He, Junlin, Njoya, Emmanuel Mfotie, Chen, Jianjun, Liu, Siyan, Xie, Congqiang, Huang, Wenze, Wang, Fei, Wang, Zhouyu, Li, Yuzhi, Qian, Shan. 4,6-Substituted-1 H-Indazoles as potent IDO1/TDO dual inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2019, 第 9 作者27(6): 1087-1098, http://dx.doi.org/10.1016/j.bmc.2019.02.014.[65] Melacheu, Gertrude Laura Foudjo, Njoya, Emmanuel Mfotie, Jouda, JeanBosco, Kweka, Brussine Nadege Wakeu, Mbazoa, Celine Djama, Wang, Fei, Wandji, Jean. Two new indole alkaloids from Tabernaemontana contorta Stapf. PHYTOCHEMISTRY LETTERS[J]. 2019, 第 6 作者30: 116-119, http://dx.doi.org/10.1016/j.phytol.2019.01.028.[66] 李晟, 李焱鑫, Emmanuel, Mfotie, Njoya, 蒋黎, 李霖, 王飞. 瑞香素及噁唑类小分子抑制吲哚胺-2,3-双加氧酶1(IDO1)的研究. 天然产物研究与开发[J]. 2018, 第 8 作者30(12): 2128-2132, http://lib.cqvip.com/Qikan/Article/Detail?id=7001044758.[67] Pu, DeBing, Du, BaoWen, Chen, Wen, Gao, JunBo, Hu, Kun, Shi, Nan, Li, YiMing, Zhang, XingJie, Zhang, RuiHan, Li, XiaoNian, Zhang, HongBin, Wang, Fei, Xiao, WeiLie. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva. ORGANIC LETTERS[J]. 2018, 第 12 作者 通讯作者 20(19): 6314-6317, https://www.webofscience.com/wos/woscc/full-record/WOS:000447118200072.[68] Han, Xiaojuan, Chen, Honghan, Zhou, Jiao, Tai, Haoran, Gong, Hui, Wang, Xiaobo, Huang, Ning, Qin, Jianqiong, Fang, Tingting, Wang, Fei, Xiao, Hengyi. The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2018, 第 10 作者233(5): 3945-3954, http://dx.doi.org/10.1002/jcp.26169.[69] JeanBosco Jouda, Emmanuel Mfotie Njoya, Cline Djama Mbazoa, ZongYuan Zhou, Alain Meli Lannang, Jean Wandji, Yoshihito Shiono, Fei Wang. Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways. BIOORGANIC CHEMISTRY. 2018, 第 8 作者80: 216-222, http://dx.doi.org/10.1016/j.bioorg.2018.06.021.[70] Qiang, Zhe, Zhou, Zongyuan, Peng, Ting, Jiang, Puzi, Shi, Nan, Njoya, Emmanuel Mfotie, Azimova, Bahtigul, Liu, Wanli, Chen, Weihua, Zhang, Guolin, Wang, Fei. Inhibition of TPL2 by interferon- suppresses bladder cancer through activation of PDE4D. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH[J]. 2018, 第 11 作者 通讯作者 37(1): http://ir.imde.ac.cn/handle/131551/24538.[71] Wang, Junyi, Lin, Feng, Wan, Zhengpeng, Sun, Xiaolin, Lu, Yun, Huang, Jianyong, Wang, Fei, Zeng, Yingyue, Chen, YingHua, Shi, Yan, Zheng, Wenjie, Li, Zhanguo, Xiong, Chunyang, Liu, Wanli. Profiling the origin, dynamics, and function of traction force in B cell activation. SCIENCE SIGNALING[J]. 2018, 第 7 作者11(542): http://dx.doi.org/10.1126/scisignal.aai9192.[72] Wan, Zhengpeng, Xu, Chenguang, Chen, Xiangjun, Xie, Hengyi, Li, Zongyu, Wang, Jing, Ji, Xingyu, Chen, Haodong, Ji, Qinghua, Shaheen, Samina, Xu, Yang, Wang, Fei, Tang, Zhuo, Zheng, JiShen, Chen, Wei, Lou, Jizhong, Liu, Wanli. PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation. JOURNAL OF CELL BIOLOGY[J]. 2018, 第 12 作者217(7): 2565-2582, http://dx.doi.org/10.1083/jcb.201711055.[73] Ebokaiwe, Azubuike P, Ijomone, Omamuyovwi M, Osawe, Sharon O, Chukwu, Chukwuma J, Ejike, Chukwunonso E C C, Zhang, Guolin, Wang, Fei. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. REDOX REPORT[J]. 2018, 第 7 作者23(1): 194-205, https://doaj.org/article/6099c37be82d488e84ed627cf01bc5e3.[74] Gong, Guidong, Cao, Yuan, Wang, Fei, Zhao, Gang. Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells. ORGANOMETALLICS[J]. 2018, 第 3 作者 通讯作者 37(7): 1103-1113, https://www.webofscience.com/wos/woscc/full-record/WOS:000429886300003.[75] Gong, Guidong, Cao, Yuan, Qian, Hongyun, Zhou, Yangyang, Zhao, Haihang, Li, Ling, Wang, Fei, Zhao, Gang. Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system. CHEMICAL COMMUNICATIONS[J]. 2018, 第 7 作者 通讯作者 54(60): https://www.webofscience.com/wos/woscc/full-record/WOS:000439702200002.[76] Fu Li, BaoWen Du, DanFeng Lu, WenXuan Wu, Kanjana Wongkrajang, Lun Wang, WenChen Pu, ChangLu Liu, HanWei Liu, MingKui Wang, Fei Wang. Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects. SCIENTIFIC REPORTS[J]. 2017, 第 11 作者 通讯作者 7(1): https://doaj.org/article/cdbf79c242b5456e9d71bb62e04b9411.[77] Orawan Wonganan, Yu-jiao He, Xiao-fei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. TOXICOLOGY AND APPLIED PHARMACOLOGY. 2017, 第 7 作者336: 31-39, http://dx.doi.org/10.1016/j.taap.2017.10.004.[78] Wonganan, Orawan, He, Yujiao, Shen, Xiaofei, Wongkrajang, Kanjana, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2017, 第 7 作者 通讯作者 336: 31-39, https://www.webofscience.com/wos/woscc/full-record/WOS:000416880000004.[79] Fei Wang. Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Oncotarget. 2017, 第 1 作者 通讯作者 [80] Shaheen, Samina, Wan, Zhengpeng, Li, Zongyu, Chau, Alicia, Li, Xinxin, Zhang, Shaosen, Liu, Yang, Yi, Junyang, Zeng, Yingyue, Wang, Jing, Chen, Xiangjun, Xu, Liling, Chen, Wei, Wang, Fei, Lu, Yun, Zheng, Wenjie, Shi, Yan, Sun, Xiaolin, Li, Zhanguo, Xiong, Chunyang, Liu, Wanli. Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKC beta and focal adhesion kinase. ELIFE[J]. 2017, 第 14 作者6: http://dx.doi.org/10.7554/eLife.23060.[81] Sheng Li, Lijuan Yang, Ping Wang, Yujiao He, Junmei Huang, Hanwei Liu, Xiaofei Shen, Fei Wang. Dietary apigenin potentiates the inhibitory effect of interferon-α on cancer cell viability through inhibition of 26S proteasome-mediated interferon receptor degradation. FOOD & NUTRITION RESEARCH[J]. 2016, 第 8 作者60: 1-12, https://doaj.org/article/bd73899fe81f49e386ad5d46963c156d.[82] Wu, Jiasi, Zhang, Hai, Hu, Boyang, Yang, Lijuan, Wang, Ping, Wang, Fei, Meng, Xianli. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2016, 第 6 作者 通讯作者 780: 106-114, http://dx.doi.org/10.1016/j.ejphar.2016.03.037.[83] Pu, Wenchen, Yuan, Yun, Lu, Danfeng, Wang, Xin, Liu, Hanwei, Wang, Chun, Wang, Fei, Zhang, Guolin. 2-Phenylbenzobfurans: Synthesis and promoting activity on estrogen biosynthesis. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 第 7 作者26(22): 5497-5500, http://dx.doi.org/10.1016/j.bmcl.2016.10.013.[84] Chen, Lianqi, Shen, Xiaofei, Hu, Boyang, Lin, Yuan, Igbe, Ighodaro, Zhang, Chenggang, Zhang, Guolin, Yuan, Xiaohong, Wang, Fei. Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 第 9 作者 通讯作者 26(10): 2521-2525, http://dx.doi.org/10.1016/j.bmcl.2016.03.088.[85] Gao, ZhongHua, Shi, YiMing, Qiang, Zhe, Wang, Xia, Shang, ShanZhai, Yang, Yan, Du, BaoWen, Peng, HuiPan, Ji, Xu, Li, Honglin, Wang, Fei, Xiao, WeiLie. Plasiatine, an Unprecedented Indole-Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2. SCIENTIFIC REPORTS[J]. 2016, 第 11 作者 通讯作者 6: http://ir.kib.ac.cn/handle/151853/26238.[86] He, Yujiao, Huang, Junmei, Wang, Ping, Shen, Xiaofei, Li, Sheng, Yang, Lijuan, Liu, Wanli, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei. Emodin potentiates the antiproliferative effect of interferon alpha/beta by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. ONCOTARGET[J]. 2016, 第 10 作者 通讯作者 7(4): 4664-4679, https://www.webofscience.com/wos/woscc/full-record/WOS:000369952400076.[87] Luo, Guoyong, Ye, Qi, Du, Baowen, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Iridoid Glucosides and Diterpenoids from Caryopteris glutinosa. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 第 4 作者79(4): 886-893, http://dx.doi.org/10.1021/acs.jnatprod.5b00946.[88] Wang, WeiHua, Nian, Yin, He, YuJiao, Wan, LuoSheng, Bao, NiMan, Zhu, GuoLei, Wang, Fei, Qiu, Minghua. New cycloartane triterpenes from the aerial parts of Cimicifuga heracleifolia. TETRAHEDRON[J]. 2015, 第 7 作者 通讯作者 71(42): 8018-8025, http://dx.doi.org/10.1016/j.tet.2015.08.057.[89] 邓腾, 杨莉娟, 罗国勇, 李晟, 杜宝文, 王飞. 蛋白酪氨酸磷酸酶SHP2抑制剂体外筛选模型的建立及应用. 应用与环境生物学报[J]. 2015, 第 6 作者21(4): 602-606, http://210.75.237.14/handle/351003/27720.[90] Sornkaew, Nilubon, Lin, Yuan, Wang, Fei, Zhang, Guolin, Chokchaisiri, Ratchanaporn, Zhang, Ailian, Wongkrajang, Kanjana, Suebsakwong, Parichat, Piyachaturawat, Pawinee, Suksamrarn, Apichart. Diarylheptanoids of Curcuma comosa with Inhibitory Effects on Nitric Oxide Production in Macrophage RAW 264.7 Cells. NATURAL PRODUCT COMMUNICATIONS[J]. 2015, 第 3 作者10(1): 89-93, http://210.75.237.14/handle/351003/27608.[91] Wan, Zhengpeng, Chen, Xiangjun, Chen, Haodong, Ji, Qinghua, Chen, Yingjia, Wang, Jing, Cao, Yiyun, Wang, Fei, Lou, Jizhong, Tang, Zhuo, Liu, Wanli. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. ELIFE[J]. 2015, 第 8 作者4: https://doaj.org/article/4dd3978ba64a4f358e4353f822caa50b.[92] Guo, Jiajia, Yuan, Yun, Lu, Danfeng, Du, Baowen, Xiong, Liang, Shi, Jiangong, Yang, Lijuan, Liu, Wanli, Yuan, Xiaohong, Zhang, Guolin, Wang, Fei. Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3 beta,5 alpha,8 alpha-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19). TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2014, 第 11 作者279(1): 23-32, http://210.75.237.14/handle/351003/26671.[93] Jiajia Guo, Yun Yuan, Danfeng Lu, Baowen Du, Liang Xiong, Jiangong Shi, Lijuan Yang, Wanli Liu, Xiaohong Yuan, Guolin Zhang, Fei Wang. Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19). TOXICOLOGY AND APPLIED PHARMACOLOGY. 2014, 第 11 作者279(1): 23-32, http://dx.doi.org/10.1016/j.taap.2014.05.008.[94] Lin, Yuan, Wang, Fei, Zhang, GuoLin. Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2014, 第 2 作者16(7): 800-812, http://210.75.237.14/handle/351003/26703.[95] Hu, Boyang, Zhang, Hai, Meng, Xianli, Wang, Fei, Wang, Ping. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2014, 第 4 作者 通讯作者 153(3): 846-853, http://210.75.237.14/handle/351003/26683.[96] Chunyan Yang, Fu Li, Baowen Du, Bin Chen, Fei Wang, Mingkui Wang. Isolation and characterization of new phenolic compounds with estrogen biosynthesis-inhibiting and antioxidation activities from Broussonetia papyrifera leaves.. PLOS ONE[J]. 2014, 第 5 作者 通讯作者 9(4): https://doaj.org/article/c1edc48d0f334efb920a09bc046fa2df.[97] 袁韵, 林之蔚, 郭加加, 王飞, 袁小红. 细胞膜结合的雌激素受体的特异性标记. 应用与环境生物学报[J]. 2014, 第 4 作者20(2): 227-232, http://www.irgrid.ac.cn/handle/1471x/1028564.[98] Tai, Zhengfu, Lin, Yuan, He, Yujiao, Huang, Junmei, Guo, Jiajia, Yang, Lijuan, Zhang, Guolin, Wang, Fei. Luteolin sensitizes the antiproliferative effect of interferon alpha/beta by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. CELLULAR SIGNALLING[J]. 2014, 第 8 作者26(3): 619-628, http://210.75.237.14/handle/351003/26695.[99] Zhengfu Tai, Yuan Lin, Yujiao He, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang, Fei Wang. Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. CELLULAR SIGNALLING. 2014, 第 8 作者26(3): 619-628, http://dx.doi.org/10.1016/j.cellsig.2013.11.039.[100] Chen, Qianfeng, Yang, Lijuan, Zhang, Guolin, Wang, Fei. Bioactivity-guided Isolation of Antiosteoporotic Compounds from Ligustrum lucidum. PHYTOTHERAPY RESEARCH[J]. 2013, 第 4 作者27(7): 973-979, http://www.irgrid.ac.cn/handle/1471x/900548.[101] Yang, Lijuan, Lu, Danfeng, Guo, Jiajia, Meng, Xianli, Zhang, Guolin, Wang, Fei. Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19). JOURNAL OF ETHNOPHARMACOLOGY[J]. 2013, 第 6 作者145(3): 715-721, http://www.irgrid.ac.cn/handle/1471x/900498.[102] Fei Wang. Trichinenlides A-T, Mexcicanolide-Type Limonoids from Trichilia sinensis. Journal of Natural Products. 2013, 第 1 作者[103] Zhang, Puzhao, Wang, Fei, Yang, Lijuan, Zhang, Guolin. Pregnane alkaloids from Sarcococca hookeriana var. digyna. FITOTERAPIA[J]. 2013, 第 2 作者89: 143-148, http://www.irgrid.ac.cn/handle/1471x/900537.[104] Xu, JinBiao, Lin, Yuan, Dong, ShiHui, Wang, Fei, Yue, JianMin. Trichinenlides A-T, Mexicanolide-Type Limonoids from Trichilia sinensis. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 第 4 作者76(10): 1872-1880, http://www.irgrid.ac.cn/handle/1471x/900533.[105] Liu, HanWei, Yu, XiuZhu, Padula, Daniele, Pescitelli, Gennaro, Lin, ZhiWei, Wang, Fei, Ding, Kai, Lei, Ming, Gao, JinMing. Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 第 6 作者59: 265-273, http://dx.doi.org/10.1016/j.ejmech.2012.11.003.[106] Lin, Yuan, Wang, Fei, Yang, Lijuan, Chun, Ze, Bao, Jinku, Zhang, Guolin. Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum. PHYTOCHEMISTRY[J]. 2013, 第 2 作者95(2013): 242-251, http://dx.doi.org/10.1016/j.phytochem.2013.08.008.[107] 丹枫, Azimova Bahtigul Jovliqizi, 张国林, 王飞. 采用磁微粒分离酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型. 天然产物研究与开发[J]. 2013, 第 4 作者25(1): 27-30, http://210.75.237.14/handle/351003/24044.[108] 郭加加, 黄君梅, 王飞. 冰乙酸水解法提高女贞子提取物中红景天苷含量. 应用与环境生物学报[J]. 2013, 第 3 作者19(4): 723-726, http://210.75.237.14/handle/351003/24058.[109] Hua, Lei, Li, Ya, Wang, Fei, Lu, Danfeng, Gao, Kun. Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd. FITOTERAPIA[J]. 2012, 第 3 作者83(6): 1036-1041, http://www.irgrid.ac.cn/handle/1471x/656376.[110] Guo-Lin Zhang. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological Pharmaceutical Bulletin. 2012, [111] Lu, Danfeng, Yang, Lijuan, Wang, Fei, Zhang, Guolin. Inhibitory Effect of Luteolin on Estrogen Biosynthesis in Human Ovarian Granulosa Cells by Suppression of Aromatase (CYP19). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2012, 第 3 作者 通讯作者 60(34): 8411-8418, http://www.irgrid.ac.cn/handle/1471x/656377.[112] 林之蔚, 邰正福, 万忠民, 王飞, 雷泞菲. 荧光光谱法研究木栓酮与牛血清白蛋白的相互作用. 应用与环境生物学报[J]. 2012, 第 4 作者18(2): 287-291, http://lib.cqvip.com/Qikan/Article/Detail?id=41871147.[113] Lu, Danfeng, Yang, Lijuan, Li, Qilin, Gao, Xiaoping, Wang, Fei, Zhang, Guolin. Egonol gentiobioside and egonol gentiotrioside from Styrax perkinsiae promote the biosynthesis of estrogen by aromatase. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2012, 第 5 作者 通讯作者 691(1-3): 275-282, http://dx.doi.org/10.1016/j.ejphar.2012.07.005.[114] Fei Wang. Aqueous extract of Fructus Ligustri Lucidi regulates the proliferation and differentiation of UMR-106. Nat Prod Res Dev. 2011, 第 1 作者 通讯作者 [115] Pu, Wenchen, Wang, Fei, Wang, Chun. Bioactivities and Synthetic Methods of 2-Arylbenzobfurans. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 第 2 作者31(2): 155-165, http://www.irgrid.ac.cn/handle/1471x/517902.[116] 王星, 吕广颖, 杨利娟, 王飞, 王淳. 7-羟基异黄酮及其衍生物的合成与选择性雌激素受体结合的构效关系研究. 有机化学[J]. 2011, 第 4 作者31(8): 1245-1251, https://sioc-journal.cn/Jwk_yjhx/CN/Y2011/V31/I08/1245.[117] 王玉梅, 陈前锋, 杨莉娟, 王飞. 女贞子对大鼠成骨细胞增殖与分化的影响. 天然产物研究与开发[J]. 2011, 第 4 作者23(2): 232-235, http://lib.cqvip.com/Qikan/Article/Detail?id=37802565.[118] Pu, Wenchen, Wang, Fei, Wang, Chun. Bioactivities and Synthetic Methods of 2-Arylbenzobfurans. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 第 2 作者31(2): 155-165, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000288184700001.[119] Yang, Lijuan, Chen, Qianfeng, Wang, Fei, Zhang, Guolin. Antiosteoporotic compounds from seeds of Cuscuta chinensis. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2011, 第 3 作者 通讯作者 135(2): 553-560, http://www.irgrid.ac.cn/handle/1471x/517887.[120] Fei Wang. Selective Estrogen Receptor Binding Affinity of Synthetic 7-hydroxylisoflavones and their Structure-Activity Relationship. CHINESE J ORG CHEM. 2011, 第 1 作者[121] Wang, Xing, Lu, Guangying, Yang, Lijuan, Wang, Fei, Wang, Chun. Synthesis and Selective Estrogen Receptor Binding Affinity of 7-Hydroxylisoflavones. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 第 4 作者31(8): 1245-1251, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000294738900013.[122] Fei Wang. Estrogenic activity of egonol gentiotrioside and its effect on HepG2 cells proliferation. Nat Prod Res Dev. 2010, 第 1 作者 通讯作者 [123] 杨笛笑, 李麒麟, 张国林, 王飞. 齐墩果醇-龙胆三糖苷雌激素样作用及其对肝癌HepG2细胞增殖的影响. 天然产物研究与开发[J]. 2010, 第 4 作者22(4): 697-700, http://lib.cqvip.com/Qikan/Article/Detail?id=36381352.[124] Qiao, H, Wang, F, Zhao, L, Zhou, JL, Lai, Z, Zhang, YS, Robbins, TP, Xue, YB. The F-Box protein AhSLF-S-2 controls the pollen function of S-RNase-based self-incompatibility. PLANT CELL[J]. 2004, 16(9): 2307-2322, https://www.webofscience.com/wos/woscc/full-record/WOS:000223927000007.[125] Zhou, JL, Wang, F, Ma, WS, Zhang, YS, Han, B, Xue, YB. Structural and transcriptional analysis of S-locus F-box genes in Antirrhinum. SEXUAL PLANT REPRODUCTION[J]. 2003, 16(4): 165-177, https://www.webofscience.com/wos/woscc/full-record/WOS:000186202900002.[126] Chen QFbrYang LJbrZhang GLbrWang F. Bioactivity-guided Isolation of Antiosteoporotic Compounds from Ligustrum lucidum. PHYTOTHERAPY RESEARCH. 10.1002/ptr.4820.
科研活动
科研项目
( 1 ) 女贞子抗高原反应的研究, 主持, 部委级, 2013-01--2015-12( 2 ) 蛋白激酶A介导的磷酸化调控芳香化酶降解机制的化学生物学研究, 主持, 国家级, 2014-01--2017-12( 3 ) 基于共轭聚合物纳米粒子的蛋白质-蛋白质相互作用药物筛选新方法的研究及其应用, 主持, 部委级, 2014-01--2016-12( 4 ) 青年研究员人才支持项目, 主持, 市地级, 2013-01--2017-12( 5 ) 四川省杰出青年学术技术带头人计划, 主持, 省级, 2014-01--2016-12( 6 ) α7尼古丁乙酰胆碱受体激动剂治疗类风湿性关节炎的研究, 主持, 省级, 2016-03--2019-06( 7 ) 治疗老年性疾病的天然产物药物发现研究, 参与, 国家级, 2015-10--2018-09( 8 ) 苯基噁唑类化合物通过TRBP调控microRNA生物合成抑制肝癌转移的化学生物学研究, 主持, 国家级, 2017-01--2020-12( 9 ) 二苯庚烷类化合物作为α7尼古丁乙酰胆碱受体激动剂治疗心律失常的研究, 主持, 部委级, 2016-09--2018-09( 10 ) 基于天然产物的老年性疾病候选药物研究, 参与, 国家级, 2019-01--2021-12( 11 ) 黄烷酮类小分子靶向蛋白酪氨酸磷酸酶SHP2调控RAS信号通路抑制肺癌的化学生物学研究, 主持, 国家级, 2020-01--2023-12
指导学生
已指导学生
郭加加 硕士研究生 077901-药物化学
邓腾 硕士研究生 078001-药物化学
李晟 硕士研究生 085238-生物工程
彭辉盼 硕士研究生 105500-药学
盛钰雯 硕士研究生 085238-生物工程
史楠 硕士研究生 077804-病理学与病理生理学
现指导学生
史小可 硕士研究生 100104-病理学与病理生理学
周宗元 博士研究生 100706-药理学
李润择 硕士研究生 077804-病理学与病理生理学
曹东怡 博士研究生 100701-药物化学
靳钰洁 硕士研究生 078006-药理学
盛钰雯 博士研究生 100706-药理学