基本信息
李恺  男  硕导  中国科学院上海硅酸盐研究所
电子邮件: likai@mail.sic.ac.cn
通信地址: 上海市定西路1295号
邮政编码: 200050

研究领域

1)病理状态下骨植入物表面生物涂层基础研究。基于骨微量营养元素和生物抗氧化剂在治疗骨质疏松、糖尿病和风湿性关节炎等方面的功能性,对涂层生物学性能进行改性研究。 

2)具生物响应能力的功能性骨修复材料研究。通过骨修复材料组分与拓扑结构的调控,实现光电/光热/声电等功能,以满足对骨折微环境下特定骨修复细胞的生物刺激。

3)骨修复与替代材料产品研发。采用等离子喷涂技术和新型合金制备技术研发具有自主知识产权的骨修复与替代材料产品(例如,人工关节、外固定螺钉和脊柱融合器等)。


招生信息

   
招生专业
080502-材料学
080501-材料物理与化学
招生方向
生物医用材料
纳米生物材料
无机涂层材料

教育背景

2008-09--2013-07   中国科学院上海硅酸盐研究所   博士学位
2004-09--2008-07   北京科技大学   学士学位
学历
研究生

学位

博士

工作经历

   
工作简历
2016-07~现在, 中国科学院上海硅酸盐研究所, 副研究员
2013-07~2016-06,中国科学院上海硅酸盐研究所, 助理研究员
社会兼职
2020-01-01-今,《热喷涂技术》期刊编委, 编委

专利与奖励

   
奖励信息
(1) 2019中国医疗器械创新创业大赛优秀奖, 三等奖, 其他, 2019
(2) 中国科学院第一届“率先杯”未来技术创新大赛复赛优胜奖, 二等奖, 院级, 2018
专利成果
( 1 ) 一种具有优良生物相容性的微米/纳米多级结构二氧化钛涂层及其制备方法, 专利授权, 2020, 第 3 作者, 专利号: CN108588626B

( 2 ) 一种具有微纳结构的促体外成骨分化钽基涂层及其制备方法, 专利授权, 2020, 第 3 作者, 专利号: CN109989089B

( 3 ) 一种制备碳/纳米二氧化锰复合电极材料的方法, 发明专利, 2020, 第 1 作者, 专利号: CN111223683A

( 4 ) 一种抗氧化生物涂层及其制备方法, 专利授权, 2020, 第 1 作者, 专利号: CN106913906B

( 5 ) 一种抗降解和抗菌性能良好的二氧化铈掺杂硅酸钙涂层及其制备方法和应用, 专利授权, 2020, 第 1 作者, 专利号: CN106913905B

( 6 ) 一种生物抗氧化性能良好的二氧化铈掺杂羟基磷灰石涂层及其应用, 专利授权, 2019, 第 1 作者, 专利号: CN107638591B

( 7 ) 一种兼具良好生物相容性和光热转换效果的氧化钽涂层及其制备方法和应用, 发明专利, 2019, 第 3 作者, 专利号: CN110129712A

( 8 ) 一种具有显著促细胞成骨分化性能的钽基涂层及其制备方法和应用, 发明专利, 2019, 第 3 作者, 专利号: CN110075354A

( 9 ) 一种具促成骨分化和抗炎功能的纳米结构含硼硅酸钙生物涂层及其制备方法, 发明专利, 2019, 第 1 作者, 专利号: CN109793923A

( 10 ) 一种具免疫调节功能的骨植入体及其制备方法和应用, 发明专利, 2019, 第 3 作者, 专利号: CN109745150A

( 11 ) 一种二氧化钛薄膜及其制备方法和应用, 发明专利, 2018, 第 3 作者, 专利号: CN107815665A

( 12 ) 一种掺硼硅酸钙生物活性涂层的制备方法, 发明专利, 2017, 第 2 作者, 专利号: CN106668942A

( 13 ) 一种银掺杂的氧化铝陶瓷涂层及其制备方法, 发明专利, 2015, 第 1 作者, 专利号: CN104388874A

( 14 ) 用于陶瓷涂层的复合粉体组合物与陶瓷涂层及其制备方法, 发明专利, 2015, 第 5 作者, 专利号: CN104725038A

( 15 ) 一种抗降解和抗菌性能良好的生物涂层及其制备方法, 发明专利, 2013, 第 1 作者, 专利号: CN103285425A

( 16 ) 一种抗降解、抗菌型生物涂层及其制备方法和应用, 发明专利, 2011, 第 1 作者, 专利号: CN101972490A

出版信息

   
发表论文
(1) Electroactive MnO2-poly(3,4-ethylenedioxythiophene) composite nanocoatings enhance osteoblastic electrical stimulation, APPLIED SURFACE SCIENCE, 2021, 通讯作者
(2) Boron-incorporated micro/nano-topographical calcium silicate coating dictates osteo/angio-genesis and inflammatory response toward enhanced osseointegration, BIOLOGICAL TRACE ELEMENT RESEARCH, 2021, 第 1 作者
(3) Titania nanotube array supported nanoceria with redox cycling stability ameliorates oxidative stress-inhibited osteogenesis, CHEMICAL ENGINEERING JOURNAL, 2021, 通讯作者
(4) Preparation and characteristics of a novel oxygen-releasing coating for improved cell responses in hypoxic environment, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2021, 第 4 作者
(5) Zn-doped MnO2 nanocoating with enhanced catalase-mimetic activity and cytocompatibility protects pre-osteoblasts against H2O2-induced oxidative stress, COLLOIDS AND SURFACES B-BIOINTERFACES, 2021, 通讯作者
(6) Dual enzyme-like activities of transition metal-doped MnO2 nanocoatings and their dependence on the electronic band structure and ionic dissolution, APPLIED SURFACE SCIENCE, 2020, 通讯作者
(7) Optimized Nanointerface Engineering of Micro/Nanostructured Titanium Implants to Enhance Cell-Nanotopography Interactions and Osseointegration, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 第 1 作者
(8) Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability, BIOSCIENCE REPORTS, 2020, 第 3 作者
(9) Macrophage polarization by plasma sprayed ceria coatings on titanium-based implants: Cerium valence state matters, APPLIED SURFACE SCIENCE, 2020, 通讯作者
(10) Controlling Preosteoblast Behavior through Manganese Vacancy-Rich Birnessite with Enhanced Divalent Cation Modulation of Fibronectin-Integrin Interactions, ADVANCED MATERIALS INTERFACES, 2020, 通讯作者
(11) Cerium Oxide Nanoparticles Regulate Osteoclast Differentiation Bidirectionally by Modulating the Cellular Production of Reactive Oxygen Species, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 
(12) The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 第 1 作者
(13) Room-temperature facile synthesis of MnO2on carbon film via UV-photolysis for supercapacitor, Room-temperature facile synthesis of MnO_2 on carbon film via UVphotolysis for supercapacitor, 自然科学进展:英文版, 2019, 通讯作者
(14) Synthesis of carbon coated-ceria with improved cytocompatibility, CERAMICS INTERNATIONAL, 2019, 第 3 作者
(15) Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2019, 通讯作者
(16) A COMPARATIVE STUDY ON VACUUM AND ATMOSPHERIC PLASMA SPRAYED TANTALUM COATINGS FOR THE MODIFICATION OF TITANIUM IMPLANTS, SURFACE REVIEW AND LETTERS, 2019, 第 3 作者
(17) Chemical Stability and Antimicrobial Activity of Plasma-Sprayed Cerium Oxide-Incorporated Calcium Silicate Coating in Dental Implants, IMPLANT DENTISTRY, 2019, 通讯作者
(18) The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 第 1 作者
(19) 等离子喷涂生物涂层对病理性骨缺损愈合的应用研究, Application Research of Plasma Sprayed Bioactive Coatings for Bone Regeneration under Pathological Conditions, 表面技术, 2019, 第 2 作者
(20) Room-temperature facile synthesis of MnO_2 on carbon film via UVphotolysis for supercapacitor, PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, 2019, 通讯作者
(21) A hydrogenated black TiO2 coating with excellent effects for photothermal therapy of bone tumor and bone regeneration, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 第 3 作者
(22) Adhesion Behavior of Escherichia coli on Plasma-Sprayed Zn and Ag Co-incorporated Calcium Silicate Coatings with Varying Surface Roughness, JOURNAL OF THERMAL SPRAY TECHNOLOGY, 2018, 通讯作者
(23) Unveiling the Mechanism of Surface Hydrophilicity-Modulated Macrophage Polarization, ADVANCED HEALTHCARE MATERIALS, 2018, 通讯作者
(24) Sr-doped nanowires modification of Ca-Si based coatings for improved osteogenic activities and reduced inflammatory reactions, Nanotechnology, 2018, 
(25) Black plasma-sprayed Ta2O5 coatings with photothermal effect for bone tumor therapy, CERAMICS INTERNATIONAL, 2018, 第 3 作者
(26) Sr-doped nanowire modification of Ca-Si-based coatings for improved osteogenic activities and reduced inflammatory reactions, NANOTECHNOLOGY, 2018, 第 1 作者
(27) Incorporation of Cerium Oxide into Hydroxyapatite Coating Protects Bone Marrow Stromal Cells Against H2O2-Induced Inhibition of Osteogenic Differentiation, BIOLOGICAL TRACE ELEMENT RESEARCH, 2018, 第 1 作者
(28) Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells, MATERIALS, 2018, 第 3 作者
(29) Improved Mechanical Compatibility and Cytocompatibility of Ta/Ti Double-Layered Composite Coating, JOURNAL OF THERMAL SPRAY TECHNOLOGY, 2017, 第 3 作者
(30) Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis, Biomedical Materials (Bristol), 2017, 第 4 作者
(31) Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway, RSC ADVANCES, 2017, 第 4 作者
(32) YAP-mediated mechanotransduction regulates osteogenic and adipogenic differentiation of BMSCs on hierarchical structure, COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 第 4 作者
(33) Optimal Zn-Modified Ca-Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering, JOURNAL OF NANOMATERIALS, 2017, 第 4 作者
(34) Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits, Scientific Reports, 2017, 第 3 作者
(35) Incorporation of cerium oxide into hydroxyapatite coating regulates osteogenic activity of mesenchymal stem cell and macrophage polarization, JOURNAL OF BIOMATERIALS APPLICATIONS, 2017, 第 1 作者
(36) The effects of cerium valence states at cerium oxide coatings on the responses of bone mesenchymal stem cells and macrophages, BIOLOGICAL TRACE ELEMENT RESEARCH, 2017, 通讯作者
(37) Enhanced osteogenic activity of anatase TiO2 film: Surface hydroxyl groups induce conformational changes in fibronectin, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 第 2 作者
(38) The Effects of Cerium Oxide Incorporation in Calcium Silicate Coating on Bone Mesenchymal Stem Cell and Macrophage Responses, BIOLOGICAL TRACE ELEMENT RESEARCH, 2017, 第 1 作者
(39) The effects of cerium oxide incorporation in calcium silicate coating on bone mesenchymal stem cell and macrophage response, Biological Trace Element Research, 2017, 第 1 作者
(40) Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin, Materials Science and Engineering C, 2017, 第 2 作者
(41) The combined effects of nanotopography and Sr ion for enhanced osteogenic activity of bone marrow mesenchymal stem cells (BMSCs), JOURNAL OF BIOMATERIALS APPLICATIONS, 2017, 通讯作者
(42) Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis, BIOMEDICAL MATERIALS, 2017, 第 4 作者
(43) Zinc-modified calcium silicate coatings promote osteogenic differentiation through tgf-beta/smad pathway and osseointegration in osteopenic rabbits, SCIENTIFIC REPORTS, 2017, 第 3 作者
(44) 镁、锌和锶离子掺杂硅酸钙涂层成骨行为比较研究, 热喷涂技术, 2016, 第 2 作者
(45) Plasma-Sprayed Titanium Patterns for Enhancing Early Cell Responses, JOURNAL OF THERMAL SPRAY TECHNOLOGY, 2016, 第 7 作者
(46) Different response of osteoblastic cells to Mg2+, Zn2+ and Sr2+ doped calcium silicate coatings, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2016, 通讯作者
(47) Covalently immobilised type I collagen facilitates osteoconduction and osseointegration of titanium coated implants, JOURNAL OF ORTHOPAEDIC TRANSLATION, 2016, 第 5 作者
(48) Chemical stability and osteogenic activity of plasma-sprayed boron-modified calcium silicate-based coatings, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2016, 通讯作者
(49) Cerium Oxide-Incorporated Calcium Silicate Coating Protects MC3T3-E1 Osteoblastic Cells from H2O2-Induced Oxidative Stress, BIOLOGICAL TRACE ELEMENT RESEARCH, 2016, 第 1 作者
(50) Plasma sprayed cerium oxide coating inhibits H2O2-induced oxidative stress and supports cell viability, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2016, 第 1 作者
(51) ROCK-regulated synergistic effect of macropore/nanowire topography on cytoskeletal distribution and cell differentiation, RSC ADVANCES, 2015, 第 3 作者
(52) ROCK-regulated synergistic effect of macrophage/nanowire topography on cytoskeletal distribution and cell differentiation, RSC Advances, 2015, 第 1 作者
(53) Effects of graphene plates’ adoption on the microstructure, mechanical properties, and in vivo biocompatibility of calcium silicate coating, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 第 5 作者
(54) Effects of graphene plates’ adoption on the microstructure, mechanical properties, and in vivo biocompatibility of calcium silicate coating, International Journal of Nanomedicine, 2015, 
(55) Microstructure and wear behavior of graphene nanosheets-reinforced zirconia coating, CERAMICS INTERNATIONAL, 2014, 第 3 作者
(56) Preparation and Characterization of Calcium-Magnesium Phosphate Cements, 医用生物材料, 2014, 第 1 作者
(57) Antibacterial mechanism of plasma sprayed Ca2ZnSi2O7 coating against Escherichia coli, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2013, 第 1 作者
(58) Effects of Zn Content on Crystal Structure, Cytocompatibility, Antibacterial Activity, and Chemical Stability in Zn-Modified Calcium Silicate Coatings, JOURNAL OF THERMAL SPRAY TECHNOLOGY, 2013, 通讯作者
(59) In Vitro and In Vivo Evaluation of Zinc-Modified Ca–Si-Based Ceramic Coating for Bone Implants, PLOS ONE, 2013, 第 2 作者
(60) Antibacterial mechanism of plasma sprayed Ca2ZnSi2O7 coating against Escherichia, Journal of Materials Science: Materials in Medicine, 2013, 第 1 作者
(61) The enhanced bactericidal effect of plasma sprayed zinc-modified calcium silicate coating by the addition of silver, CERAMICS INTERNATIONAL, 2013, 第 1 作者
(62) Fabrication and in vitro evaluation of stable collagen/hyaluronic acid biomimetic multilayer on titanium coatings, JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2013, 第 5 作者
(63) 抗菌型硅酸钙基复合涂层研究, 2013, 第 1 作者
(64) Chemical stability and antimicrobial activity of plasma sprayed bioactive Ca2ZnSi2O7 coating, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2011, 第 1 作者

科研活动

   
科研项目
( 1 ) 氧化铈纳米涂层对氧化应激状态下骨修复影响机制研究, 负责人, 国家任务, 2016-01--2018-12
( 2 ) 抗菌型XXX研制, 负责人, 国家任务, 2017-08--2018-07
( 3 ) 适用于骨质疏松症的骨科植入器械研制, 负责人, 地方任务, 2017-06--2020-09
( 4 ) 适用于XXX环境的XXX器械技术, 负责人, 国家任务, 2018-10--2019-10
( 5 ) 钛植入体对骨免疫和神经再生微环境的光致调控机制和效果研究, 负责人, 国家任务, 2020-01--2023-12
( 6 ) 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2020-01--2023-12
( 7 ) 主动调控成骨微环境的骨科植入物涂层研究, 负责人, 地方任务, 2021-07--2024-06

指导学生

现指导学生

张昕玮  硕士研究生  080500-材料科学与工程