血液学和肿瘤基因组学

血液学和肿瘤基因组学 

071022-基因组学
071021-生物信息学

白血病功能基因组和转录调控
基因转录调控研究的生物信息学方法

2002-09--2006-12   美国加州大学伯克利分校   博士后
1997-09--2002-08   美国约翰霍普金斯大学   博士
1988-09--1993-07   山东医科大学   学士

研究生

博士

   

2009-07~现在, 中国科学院北京基因组研究所, 研究员
2007-01~2009-06,美国芝加哥大学, 研究助理教授

2016-05-01-2019-04-30, 中国医师协会临床精准医疗专业委员会委员,
2016-05-01-2019-04-30, 中国医师协会临床精准医疗专业委员会委员,
2015-01-01-今,科技导报编委,
2014-12-01-今,中国生理学会血液学专业委员会委员,
2014-10-01-今,儿童血液病与肿瘤分子分型北京市重点实验室学术委员会委员,
2011-01-01-今,中国医学科学院血液学国家重点实验室客座研究员,
2010-07-01-今,国家自然科学基金委员会第十三届和第十四届医学科学部血液系统专家评审组成员,
2010-01-01-今,Genomics, Proteomics&Bioinformatics编委,

生命组学
基因组学前沿
基因组前沿
人类基因组学研究-进展与应用
基因组学

   

（1） 天津市自然科学一等奖, 一等奖, 省级, 2015

[1] 胡绍燕, 王前飞, 和夫红, 江姝婷, 张永平. CD69用于白血病耐药性诊断及预后的用途. 202310361808.1, 2023-04-06.
[2] 王前飞, 李玥莹, 陈蕾, 刘景坤. SETD2的医药用途. 202211344979.5, 2022-10-31.
[3] 王前飞, 李玥莹, 孙舒, 金晨. 分子标记物组合及其用途. 202011362907.4, 2020-11-27.

   

[1] Immunity. 2024,   通讯作者  
[2] J Thromb Haemost. 2024,   通讯作者  
[3] Yongping Zhang, Shuting Jiang, Fuhong He, Yuanyuan Tian, Haiyang Hu, Li Gao, Lin Zhang, Aili Chen, Yixin Hu, Liyan Fan, Chun Yang, Bi Zhou, Dan Liu, Zihan Zhou, Yanxun Su, Lei Qin, Yi Wang, Hailong He, Jun Lu, Peifang Xiao, Shaoyan Hu, Qian-Fei Wang. Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML. GENOME BIOLOGY[J]. 2023, 第 22 作者  通讯作者  24(1): 1-41, http://dx.doi.org/10.1186/s13059-023-03031-7.
[4] Xu‑Dong He, Meng‑Fang Xia, Ji‑Yuan Teng, Bin‑Bing S. Zhou, Qian-Fei Wang. Clonal evolution in leukemia: preleukemia, evolutionary models, and clinical implications. Genome Instability & Disease[J]. 2023, 第 5 作者  通讯作者  4: 227-238, 
[5] Hui Luo, Dan Liu, Wenbing Liu, Jin Jin, Xiaoman Bi, Peilin Zhang, Jia Gu, Zheng, Miao, Xiao, Min, Xin Liu, Zhou, Jianfeng, Qian-fei Wang. Clinical and Genetic Characterization of EBV-associated T/NK lymphoproliferativediseases. Journal of Allergy and Clinical Immunology[J]. 2022, 第 12 作者  通讯作者  
[6] Chen Zhang, Xueshuai Han, Jingkun Liu, Lei Chen, Ying Lei, Kunying Chen, Jia Si, Tian-yi Wang, Hui Zhou, Xiaoyun Zhao, Xiaohui Zhang, Yihua An, Yueying Li, Qian-fei Wang. Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells. GENOMICSPROTEOMICSBIOINFORMATICS[J]. 2022, 第 14 作者  通讯作者  
[7] Bi, Xiaoman, Zhang, Qing, Chen, Lei, Liu, Dan, Li, Yueying, Zhao, Xiaoxi, Zhang, Ya, Zhang, Liping, Liu, Jingkun, Wu, Chaoyi, Li, Zhigang, Zhao, Yunze, Ma, Honghao, Huang, Gang, Liu, Xin, Wang, Qianfei, Zhang, Rui. NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis. JOURNAL OF HEMATOLOGY & ONCOLOGY[J]. 2022, 第 16 作者  通讯作者  15(1): http://dx.doi.org/10.1186/s13045-022-01318-z.
[8] Luo, Hui, Liu, Dan, Liu, Wenbing, Wang, Gaoxiang, Chen, Liting, Cao, Yang, Wei, Jia, Xiao, Min, Liu, Xin, Huang, Gang, Wang, Wei, Zhou, Jianfeng, Wang, Qianfei. Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms. EUROPEAN JOURNAL OF HUMAN GENETICS[J]. 2021, 第 13 作者  通讯作者  29(8): 1312-1315, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053565/.
[9] Hu, Yixin, Chen, Aili, Gao, Li, He, Hailong, Jiang, Shuting, Zheng, Xinchang, Xiao, Peifang, Lu, Jun, Wang, Yi, Li, Jie, Li, Jianqin, Fan, Junjie, Yao, Yanhua, Ling, Jing, Fan, Liyan, Cheng, Shengqin, Cheng, Cheng, Fang, Fang, Pan, Jian, Hu, Shaoyan, Wang, Qianfei, Ribeiro, Raul C. Minimally myelosuppressive regimen for remission induction in pediatric AML: long-term results of an observational study. BLOOD ADVANCES[J]. 2021, 第 21 作者  通讯作者  5(7): 1837-1847, http://dx.doi.org/10.1182/bloodadvances.2020003453.
[10] Shu Sun, Chen Jin, Jia Si, Ying Lei, Kunying Chen, Yueli Cui, Zhenbo Liu, Jiang Liu, Meng Zhao, Xiaohui Zhang, Fuchou Tang, Matthew T. Rondina MD, Yueying Li, Qian-fei Wang. Single-Cell Analysis of Ploidy and Transcriptome Reveals Functional and Spatial Divergency in Murine Megakaryopoiesis. BLOOD[J]. 2021, 第 14 作者  通讯作者  138(14): 1211-1224, 
[11] Zhao, Jianxin, Sui, Pinpin, Wu, Bo, Chen, Aili, Lu, Yedan, Hou, Fenxia, Cheng, Xiurong, Cui, Shiwei, Song, Jiayang, Huang, Gang, Xing, Caihong, Wang, Qianfei. Benzene induces rapid leukemic transformation after prolonged hematotoxicity in a murine model. LEUKEMIA. 2021, 第 12 作者  通讯作者  35(2): 595-600, https://www.webofscience.com/wos/woscc/full-record/WOS:000538220500001.
[12] Miao, Xuexia, Li, Yueying, Zheng, Caihong, Wang, Lifei, Jin, Chen, Chen, Lei, Mi, Shuangli, Zhai, Weiwei, Wang, QianFei, Cai, Jun. A promising iPS-based single-cell cloning strategy revealing signatures of somatic mutations in heterogeneous normal cells. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2020, 第 9 作者  通讯作者  18: 2326-2335, http://dx.doi.org/10.1016/j.csbj.2020.08.026.
[13] Yang Xuejing, Lu Yedan, He Fuhong, Hou Fenxia, Xing Caihong, Xu Peiyu, Wang QianFei. Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-κB pathway.. CARCINOGENESIS[J]. 2019, 第 7 作者  通讯作者  
[14] Hu Yixin, Aili Chen, Zheng Xinchang, Lu Jun, He Hailong, Yang Jin, Zhang Ya, Sui Pinpin, Yang Jingyi, He Fuhong, Wang Yi, Xiao Peifang, Liu Xin, Zhou Yinmei, Pei Deqing, Cheng Cheng, Ribeiro Raul C, Hu Shaoyan, Wang Qianfei. Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy. NATIONAL SCIENCE REVIEW[J]. 2019, 第 19 作者6(3): 469-479, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6579868&detailType=1.
[15] Peng Zhang, He, Fuhong, Jie Bai, Shohei Yamamoto, Shi Chen, Lin Zhang, Mengyao Sheng, Lei Zhang, Ying Guo, Na Man, Hui Yang, Suyun Wang, Tao Cheng, Stephen D Nimer, Yuan Zhou, Mingjiang Xu, QianFei Wang, FengChun Yang. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. THE JOURNAL OF CLINICAL INVESTIGATION[J]. 2018, 第 17 作者  通讯作者  128(12): 5383-5398, 
[16] Zhan, Di, Zhang, Yingchi, Xiao, Peifang, Zheng, Xinchang, Ruan, Min, Zhang, Jingliao, Chen, Aili, Zou, Yao, Chen, Yumei, Huang, Gang, Hu, Shaoyan, Wang, Qianfei, Zhu, Xiaofan. Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric acute myeloid leukemia. LEUKEMIA RESEARCH. 2018, 第 12 作者  通讯作者  65: 20-24, http://dx.doi.org/10.1016/j.leukres.2017.12.001.
[17] Huang, Liang, Liu, Dan, Wang, Na, Ling, Shaoping, Tang, Yuting, Wu, Jun, Hao, Lingtong, Luo, Hui, Hu, Xuelian, Sheng, Lingshuang, Zhu, Lijun, Wang, Di, Luo, Yi, Shang, Zhen, Xiao, Min, Mao, Xia, Zhou, Kuangguo, Cao, Lihua, Dong, Lili, Zheng, Xinchang, Sui, Pinpin, He, Jianlin, Mo, Shanlan, Yan, Jin, Ao, Qilin, Qiu, Lugui, Zhou, Hongsheng, Liu, Qifa, Zhang, Hongyu, Li, Jianyong, Jin, Jie, Fu, Li, Zhao, Weili, Chen, Jieping, Du, Xin, Qing, Guoliang, Liu, Hudan, Liu, Xin, Huang, Gang, Ma, Ding, Zhou, Jianfeng, Wang, Qianfei. Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia. CELL RESEARCH[J]. 2018, 第 11 作者28(2): 172-186, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6167939&detailType=1.
[18] Bu, J, Chen, A, Yan, X, He, Fuhong, Dong, Y, Zhou, Y, He, J, Zhan, D, Lin, P, Hayashi, Y, Sun, Y, Zhang, Y, Xiao, Z, Grimes, H L, Wang, Q F, Huang, G. SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. LEUKEMIA[J]. 2018, 32(4): 890-899, https://www.webofscience.com/wos/woscc/full-record/WOS:000429129100005.
[19] Yang, Xuejing, Lu, Bin, Sun, Xueqin, Han, Cuijuan, Fu, Chunling, Xu, Kailin, Wang, Min, Li, Dengju, Chen, Zhichao, Opal, Puneet, Wen, Qiang, Crispino, John D, Wang, Qianfei, Huang, Zan. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. LEUKEMIA[J]. 2018, 第 13 作者  通讯作者  32(7): 1587-1597, https://www.webofscience.com/wos/woscc/full-record/WOS:000438062500011.
[20] Yu, Ruoxi, Liu, Dan, Yang, Yin, Han, Yuanyuan, Li, Lingru, Zheng, Luyu, Wang, Ji, Zhang, Yan, Li, Yingshuai, Wang, QianFei, Wang, Qi. Expression profiling-based clustering of healthy subjects recapitulates classifications defined by clinical observation in Chinese medicine. JOURNAL OF GENETICS AND GENOMICS[J]. 2017, 第 10 作者  通讯作者  44(4): 191-197, http://dx.doi.org/10.1016/j.jgg.2017.01.001.
[21] Jianping Li, Fuhong He, Peng Zhang, Shi Chen, Hui Shi, Yanling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, QunTian Wang, Stephen D Nimer, Peng Yu, QianFei Wang, Mingjiang Xu, FengChun Yang. Loss of Asxl2 leads to myeloid malignancies in mice. NATURE COMMUNICATIONS[J]. 2017, 第 21 作者  通讯作者  8(1): https://doaj.org/article/d8d0621e6a8f4b58bd9d7e748569e036.
[22] Zhang Peng, Xing Caihong, Rhodes Steven D, He Yongzheng, Deng Kai, Li Zhaomin, He Fuhong, Zhu Caiying, Nguyen Lihn, Zhou Yuan, Chen Shi, Mohammad Khalid S, Guise Theresa A, AbdelWahab Omar, Xu Mingjiang, Wang QianFei, Yang FengChun. Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.. STEM CELL REPORTS. 2016, 第 16 作者914-925, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=2&recid=&FileName=SJPDC0B2B5DA6A51DA7CC51D04B5713627B8&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[23] Yueying Li MD, Chen Jin, Hao Bai, Shu Sun, Paul P Liu MD PhD, Linzhao Cheng PhD, Qianfei Wang PhD. Human NOTCH4 Is a Key Target of RUNX1 in Megakaryocytic Differentiation. BLOOD. 2016, 128(22): 425-425, 
[24] Kang, Lan, Wu, Jun, Tao, Yu, Li, Haolan, Liu, Xiaolei, Gao, Shaorong, Wang, QianFei. Cell Type-Specific Expression Profile and Signaling Requirements in Early Hematopoietic Reprogramming. STEM CELLS AND DEVELOPMENT[J]. 2015, 第 7 作者24(12): 1483-1492, https://www.webofscience.com/wos/woscc/full-record/WOS:000360533500010.
[25] CHEN AiLi, YANG JingYi, HU ShaoYan, WANG QianFei. The priming induction regimen of HAG as a low dose chemotherapy strategy in AML clonal evolution. 中国科学:生命科学(英文版). 2015, 第 4 作者https://www.webofscience.com/wos/woscc/full-record/WOS:000368529300016.
[26] WANG QianFei, CHENG Tao. Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development. 中国科学:生命科学(英文版). 2014, 第 1 作者
[27] Wang, Qf, Li, Yj, Dong, Jf, Li, B, Kaberlein, J J, Zhang, L, Arimura, F E, Luo, R T, Ni, J, He, Fuhong, Wu, J, Mattison, R, Zhou, J, Wang, Cz, Prabhakar, S, Nobrega, M A, Thirman, M J. Regulation of MEIS1 by distal enhancer elements in acute leukemia. LEUKEMIA[J]. 2014, 28(1): 138-146, https://www.webofscience.com/wos/woscc/full-record/WOS:000329441200014.
[28] Zhou, J, Wu, J, Li, B, Liu, D, Yu, J, Yan, X, Zheng, S, Wang, J, Zhang, L, Zhang, L, He, Fuhong, Li, Q, Chen, A, Zhang, Y, Zhao, X, Guan, Y, Zhao, X, Yan, J, Ni, J, Nobrega, M A, Loewenberg, B, Delwel, R, Valk, P J M, Kumar, A, Xie, L, Tenen, D G, Huang, G, Wang, Qf. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. LEUKEMIA[J]. 2014, 28(7): 1436-1448, https://www.webofscience.com/wos/woscc/full-record/WOS:000339705500008.
[29] Zhu, Xiaofan, He, Fuhong, Zeng, Huimin, Ling, Shaoping, Chen, Aili, Wang, Yaqin, Yan, Xiaomei, Wei, Wei, Pang, Yakun, Cheng, Hui, Hua, Chunlan, Zhang, Yue, Yang, Xuejing, Lu, Xin, Cao, Lihua, Hao, Lingtong, Dong, Lili, Zou, Wei, Wu, Jun, Li, Xia, Zheng, Si, Yan, Jin, Zhou, Jing, Zhang, Lixia, Mi, Shuangli, Wang, Xiaojuan, Zhang, Li, Zou, Yao, Chen, Yumei, Geng, Zhe, Wang, Jianmin, Zhou, Jianfeng, Liu, Xin, Wang, Jianxiang, Yuan, Weiping, Huang, Gang, Cheng, Tao, Wang, Qianfei. Identification of functional cooperative mutations of SETD2 in human acute leukemia. NATURE GENETICS[J]. 2014, 第 38 作者46(3): 287-+, http://dx.doi.org/10.1038/ng.2894.
[30] Cai, Jun, Miao, Xuexia, Li, Yueying, Smith, Cory, Tsang, Kitman, Cheng, Linzhao, Wang, Qianfei. Whole-Genome Sequencing Identifies Genetic Variances in Culture-Expanded Human Mesenchymal Stem Cells. STEM CELL REPORTS[J]. 2014, 第 7 作者3(2): 227-233, https://doaj.org/article/c40d1277d630445b9132d2280c95f7d3.
[31] Wei, Yingying, Li, Xia, Wang, Qianfei, Ji, Hongkai. iASeq: integrative analysis of allele-specificity of protein-DNA interactions in multiple ChIP-seq datasets. BMC GENOMICS[J]. 2012, 第 3 作者13(1): 681-681, http://www.corc.org.cn/handle/1471x/2374294.
[32] Wang, Qianfei, Wu, George, Mi, Shuangli, He, Fuhong, Wu, Jun, Dong, Jingfang, Luo, Roger T, Mattison, Ryan, Kaberlein, Joseph J, Prabhakar, Shyam, Ji, Hongkai, Thirman, Michael J. MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. BLOOD[J]. 2011, 第 1 作者117(25): 6895-6905, https://www.webofscience.com/wos/woscc/full-record/WOS:000291979800021.
[33] Xing, Caihong, Wang, Qianfei, Li, Bin, Tian, Haoyuan, Ni, Yune, Yin, Songnian, Li, Guilan. Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning. CHEMICO-BIOLOGICAL INTERACTIONS[J]. 2010, 第 2 作者184(1-2): 306-309, http://dx.doi.org/10.1016/j.cbi.2009.12.028.
[34] Wang, ChongZhi, Li, XiaoLi, Wang, QianFei, Mehendale, Sangeeta R, Fishbein, Anna B, Han, Aung H, Sun, Shi, Yuan, ChunSu. The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells. ONCOLOGY REPORTS[J]. 2009, 第 3 作者21(3): 577-584, https://www.webofscience.com/wos/woscc/full-record/WOS:000263584000002.
[35] XiuMin Li, QianFei Wang, Brian Schofield, Jie Lin, ShauKu Huang, Qi Wang. Modulation of Antigen-Induced Anaphylaxis in Mice by a Traditional Chinese Medicine Formula, Guo Min Kang. THE AMERICAN JOURNAL OF CHINESE MEDICINE. 2009, 第 2 作者37(1): 
[36] Wang, Qianfei, Prabhakar, Shyam, Chanan, Sumita, Cheng, JanFang, Rubin, Edward M, Boffelli, Dario. Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons. GENOME BIOLOGY[J]. 2007, 第 1 作者  通讯作者  8(1): R1-R1, https://www.webofscience.com/wos/woscc/full-record/WOS:000244821100006.
[37] Wang, Qianfei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M, Chanan, Sumita, Brown, Myles, Eisen, Michael B, Cheng, JanFang, Rubin, Edward M, Boffelli, Dario. Primate-specific evolution of an LDLR enhancer. GENOME BIOLOGY[J]. 2006, 第 1 作者7(8): R68-R68, https://www.webofscience.com/wos/woscc/full-record/WOS:000241322800013.
[38] Cleaves, R, Wang, QF, Friedman, AD. C/EBP alpha p30, a myeloid leukemia oncoprotein, limits G-CSF receptor expression but not terminal granulopoiesis via site-selective inhibition of C/EBP DNA binding. ONCOGENE[J]. 2004, 23(3): 716-725, https://www.webofscience.com/wos/woscc/full-record/WOS:000188304900010.
[39] Wang, QF, Liu, X, OConnell, J, Peng, Z, Krauss, RM, Rainwater, DL, VandeBerg, JL, Rubin, EM, Cheng, JF, Pennacchio, LA. Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons. HUMAN MOLECULAR GENETICS[J]. 2004, 13(10): 1049-1056, https://www.webofscience.com/wos/woscc/full-record/WOS:000221142700006.
[40] Wang, QF, Cleaves, R, Kummalue, T, Nerlov, C, Friedman, AD. Cell cycle inhibition mediated by the outer surface of the C/EBP alpha basic region is required but not sufficient for granulopoiesis. ONCOGENE[J]. 2003, 22(17): 2548-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000182569000002.
[41] Friedman Alan D, Keefer Jeffrey R, Kummalue Tanawan, Liu Huaitian, Wang Qianfei, Cleaves Rebecca. Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alpha.. BLOOD CELLS, MOLECULES & DISEASES. 2003, 第 5 作者http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD12090202524479&DbName=SJPD_01&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
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[43] Wang, QF, Friedman, AD. C/EBPs are required for granulopoiesis independent of their induction of G1 arrest, PU.1, and the granulocyte-colony stimulating factor receptor.. BLOOD. 2001, 98(11): 284A-285A, https://www.webofscience.com/wos/woscc/full-record/WOS:000172134101204.
[44] Wang, QF, Lauring, J, Schlissel, MS. c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells. MOLECULAR AND CELLULAR BIOLOGY[J]. 2000, 20(24): 9203-9211, https://www.webofscience.com/wos/woscc/full-record/WOS:000168366100011.
[45] Li, XM, Schofield, BH, Wang, QF, Kim, KH, Huang, SK. Induction of pulmonary allergic responses by antigen-specific Th2 cells. JOURNAL OF IMMUNOLOGY[J]. 1998, 160(3): 1378-1384, https://www.webofscience.com/wos/woscc/full-record/WOS:000071915400042.

   

（ 1 ） 血液谱系建立的转录调控研究, 主持, 部委级, 2011-01--2015-12
（ 2 ） 中医健康状态体质辨识法研究, 参与, 国家级, 2011-01--2015-08
（ 3 ） 药物干预下选择肿瘤细胞增殖的基因组变异与进化规律, 主持, 国家级, 2014-01--2016-12
（ 4 ） 肿瘤异质性的基因组和表观遗传机制, 主持, 国家级, 2014-01--2018-08
（ 5 ） 急性白血病的基因组学和表观遗传机制研究, 主持, 国家级, 2015-01--2019-12
（ 6 ） 恶性肿瘤的基因组演化和精准医学研究, 主持, 部委级, 2015-09--2018-12
（ 7 ） 血干细胞的体外扩增以及巨核谱系的发育分化, 主持, 部委级, 2016-01--2018-12
（ 8 ） 儿童白血病化疗耐药基因突变和新靶标SETD2的功能研究, 主持, 部委级, 2016-01--2017-12

（1）The Genome and Transcriptome of MLL Leukemia: Biological Insights Beyond the Fusion Pathway   第十届国际髓系干细胞和白血病分子研讨会   Jun Wu, Xiaofan Zhu, Fuhong He, Huimin Zeng, Bo Li, Shaoping Ling, Aili Chen, Gang Huang, Tao Cheng , Qian-fei Wang   2014-05-04
（2）PU.1 Is Essential For MLL Leukemia Via Activation Of The Meis/HOX Pathway and A Monocytic Cytokine Mediated Anti-Apoptotic Inflammatory Program   Jing Zhou, Jun Wu, Bo Li   2013-12-05
（3）Whole-Genome Sequencing of a Monozygotic Twin Pair Reveals Functional Cooperative Mutations of SETD2 in Acute Leukemia   Xiaofan Zhu, Fuhong He, Huimin Zeng, Shaoping Ling, Xiaomei Yan, Yaqin Wang, Aili Chen,,Wei Wei, Yue Zhang, Hui Cheng, Jun Wu, Xia Li, Lingtong Hao, Lihua Cao, Lili Dong, Wei Zou, Xuejing Yang, Xin Lu   2012-12-08
（4）Essential Role for PU.1 in MEIS1 Activation and MLL Fusion Leukemia   Zhou J, Li B, Wu J, He FH, Li Q, Yan XM, Zhang Y, Zhang LX, Zhao XH, Yan J, Nobrega M, Tenen DG , Huang G and Wang QF   2011-12-10
（5）MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion   Zhang Y, Yan XM, Sashida G, Zhao XH, Rao Y, Goyama S, Whitman SP, Zorko N, Bernot KM, Witte D, Wang QF, Tenen DG, Xiao ZJ, Marcucci G, Mulloy JC, Caligiuri MA and Huang G   2011-12-10
（6）Genome Wide Location Analysis Reveals Deregulated microRNA Genes in MLL Rearragned Leukemic Genome   Mi SL, He FH, Wu J, Zhou J, Wu G, Thirman MJ, Ji HK, Wang QF   2010-12-04
（7）MLL Translocation: Epigenetic Landscapes in the Development of Acute Leukemia   王前飞   2010-04-15
（8）MLL Fusion Proteins Directly Regulate a Small Set of Wild Type MLL Target Genes   Wang QF, Wu G, Mi SL, He FH, Dong JF, Mattison RJ, Kaberlein J , Wang QB, Prabhakar S, Ji HK and Thirman MJ   2009-12-05
（9）Autoregulation of MEIS1 through a Distal Enhancer in Acute Leukemia   Wang QF, Dong JF, Mattison R, Prabhakar S, Arimura FE, Kaberlein J, Wang CZ, Wang QB, Nobrega M and Thirman M.   2008-12-06
（10）Targeted Inhibition of FLT3 Overcomes the Block to Myeloid Differentiation in 32Dcl3 Caused by Expression of FLT3/ITD Mutants   Zheng R, Wang QF, Friedman A, Small D   2001-12-07
（11）C/EBPs Are Required for Granulopoiesis Independent of Their Induction of G1 Arrest, PU.1, and the Granulocyte-Colony Stimulating Factor Receptor   Wang QF, Friedman AD.   2001-12-07

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