基本信息

曹宏  男  博导  中国科学院水生生物研究所
电子邮件: regancao@ihb.ac.cn
通信地址: 武汉市东湖南路7号
邮政编码:

招生信息

   
招生专业
071007-遗传学
招生方向
鱼类先天性免疫
鱼类肝脏疾病模型

教育背景

2005-09--2008-07   中国科学院水生生物研究所   博士
2000-09--2003-07   中国科学院武汉病毒研究所   硕士
1996-09--2000-06   华中农业大学生命科学技术学院   学士

工作经历

2020-12~现在, 中国科学院水生生物研究所, 研究员

2012-12~2020-12, 中国科学院水生生物研究所, 副研究员

2011-07~2012-12,中国科学院水生生物研究所, 助理研究员
2008-09~2011-07,武汉大学生命科学学院, 博士后

出版信息

   
发表论文
[1] Wang, Bing, Zhou, Man, Lin, Yusheng, Ma, Yuegang, Cao, Hong. TBK1 regulates the induction of innate immune response against GCRV by phosphorylating IRF3 in rare minnow (Gobiocypris rarus ). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2021, 115: http://dx.doi.org/10.1016/j.dci.2020.103883.
[2] Wang Jing, Cao Hong. Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases. International Journal of Molecular Sciences[J]. 2021, 22(19): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509648/.
[3] Hu, Xudong, Wang, Bing, Feng, Haohao, Zhou, Man, Lin, Yusheng, Cao, Hong. Protein Phosphatase PP1 Negatively Regulates IRF3 in Response to GCRV Infection in Grass Carp (Ctenopharyngodon idella). FRONTIERS IN IMMUNOLOGY[J]. 2021, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873974/.
[4] Zhou, Man, Wang, Bing, Lin, Yusheng, Zhang, Chuang, Cao, Hong. Molecular cloning, functional characterization and expression analysis of P65 subunit in response to GCRV infection in rare minnow (Gobiocypris rarus). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2020, 113: http://dx.doi.org/10.1016/j.dci.2020.103786.
[5] Shi, Lixia, Wang, Nenghan, Hu, Xudong, Yin, Dacong, Wu, Chenxi, Liang, Huifang, Cao, Wenxuan, Cao, Hong. Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY[J]. 2020, 78: http://dx.doi.org/10.1016/j.etap.2020.103385.
[6] Shi, Lixia, Hu, Xudong, Wang, Nenghan, Liang, Huifang, Wu, Chenxi, Cao, Hong. Histopathological examination and transcriptome analyses to assess the acute toxic effects of arsenite exposure on rare minnows (Gobiocypris rarus). ECOTOXICOLOGY[J]. 2020, 29(5): 613-624, https://www.webofscience.com/wos/woscc/full-record/WOS:000531129300002.
[7] Li, Zhi, Fan, Sijia, Wang, Jing, Chen, Xiaoyun, Liao, Qian, Liu, Xing, Ouyang, Gang, Cao, Hong, Xiao, Wuhan. Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7. JOURNAL OF IMMUNOLOGY[J]. 2020, 205(7): 1897-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000574415200017.
[8] 王能汉, 邓巧玲, 范垚城, 唐海滨, 雷磊, 曹宏. 长江岸线宜昌江段五种不同类型水样对稀有鲫胚胎的毒性. 水生生物学报[J]. 2020, 44(5): 1064-1069, http://lib.cqvip.com/Qikan/Article/Detail?id=7102946806.
[9] Lin, Yusheng, Wang, Bing, Wang, Nenghan, Ouyang, Gang, Cao, Hong. Transcriptome analysis of rare minnow (Gobiocypris rarus) infected by the grass carp reovirus. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89(1): 337-344, http://dx.doi.org/10.1016/j.fsi.2019.04.013.
[10] Lin, Yusheng, Wang, Bing, Wang, Nenghan, Ouyang, Gang, Cao, Hong. Transcriptome analysis of rare minnow (Gobiocypris rarus) infected by the grass carp reovirus. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89(1): 337-344, http://dx.doi.org/10.1016/j.fsi.2019.04.013.
[11] Lin, Yusheng, Cai, Xiaolian, Wang, Guiping, Ouyang, Gang, Cao, Hong. Model construction of Niemann-Pick type C disease in zebrafish. BIOLOGICAL CHEMISTRY[J]. 2018, 399(8): 903-910, http://ir.ihb.ac.cn/handle/342005/34543, http://www.irgrid.ac.cn/handle/1471x/6853822, http://ir.ihb.ac.cn/handle/342005/34544, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000438949700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[12] Wang, Jing, Leng, Xiaoqian, Wang, Guiping, Wan, Xiaoyang, Cao, Hong. The construction of intrahepatic cholangiocarcinoma model in zebrafish. SCIENTIFIC REPORTS[J]. 2017, 7(1): http://www.irgrid.ac.cn/handle/1471x/1759940.
[13] Liu, Xing, Chen, Zhu, Xu, Chenxi, Leng, Xiaoqian, Cao, Hong, Ouyang, Gang, Xiao, Wuhan. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(10): 5081-5098, http://www.irgrid.ac.cn/handle/1471x/978670.
[14] Yue, Huamei, Ye, Huan, Chen, Xihua, Cao, Hong, Li, Chuangju. Molecular cloning of cDNA of gonadotropin-releasing hormones in the Chinese sturgeon (Acipenser sinensis) and the effect of 17 beta-estradiol on gene expression (vol 166, pg 529, 2013). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGYnull. 2014, 169: 24-24, http://www.irgrid.ac.cn/handle/1471x/852673.
[15] Yue, Huamei, Ye, Huan, Chen, Xihua, Cao, Hong, Li, Chuangju. Molecular cloning of cDNA of gonadotropin-releasing hormones in the Chinese sturgeon (Acipenser sinensis) and the effect of 17 beta-estradiol on gene expression. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY[J]. 2013, 166(4): 529-537, http://www.irgrid.ac.cn/handle/1471x/811651.
[16] Ye, Huan, Du, Hao, Chen, XiHua, Cao, Hong, Liu, Tao, Li, ChuangJu. Identification of a pou2 ortholog in Chinese sturgeon, Acipenser sinensis and its expression patterns in tissues, immature individuals and during embryogenesis. FISH PHYSIOLOGY AND BIOCHEMISTRY[J]. 2012, 38(4): 929-942, http://dx.doi.org/10.1007/s10695-011-9579-8.
[17] Ye, Huan, Chen, Xihua, Wei, Qiwei, Zhou, Li, Liu, Tao, Gui, Jianfang, Li, Chuangju, Cao, Hong. Molecular and expression characterization of a nanos1 homologue in Chinese sturgeon, Acipenser sinensis. GENE[J]. 2012, 511(2): 285-292, http://dx.doi.org/10.1016/j.gene.2012.09.005.
[18] Cao, Hong, Zhou, Li, Zhang, YanZhen, Wei, QiWei, Chen, XiHua, Gui, JianFang. Molecular characterization of Chinese sturgeon gonadotropins and cellular distribution in pituitaries of mature and immature individuals. MOLECULAR AND CELLULAR ENDOCRINOLOGY[J]. 2009, 303(1-2): 34-42, http://dx.doi.org/10.1016/j.mce.2009.01.015.
[19] 曹宏, 周莉, 桂建芳. EXPRESSED SEQUENCE TAG ANALYSIS OF A 4 YEAR-OLD CHINESE STURGEON PITUITARY. Acta Hydrobiologica Sinica[J]. 2009, 33(4): 581-588, http://www.irgrid.ac.cn/handle/1471x/543635.
[20] 曹宏, 周莉, 桂建芳. 4龄中华鲟垂体的EST分析(英文). 水生生物学报[J]. 2009, http://ir.ihb.ac.cn/handle/152342/274.
[21] 曹宏, 周莉, 桂建芳. 雌性性成熟中华鲟垂体SMART cDNA文库的构建及EST分析. 中国海洋湖沼学会第九次全国会员代表大会暨学术研讨会论文摘要汇编null. 2008, http://ir.ihb.ac.cn/handle/342005/14564.
[22] 曹宏. 中华鲟垂体EST分析以及促性腺激素和生长激素的克隆和表达特征研究. 2008, 131-, http://ir.ihb.ac.cn/handle/342005/12274.
[23] 曹宏. 中华鲟垂体EST分析以及促性腺激素和生长激素的克隆和表达特征研究. 2008, 131-, http://ir.ihb.ac.cn/handle/342005/12274.
[24] Han, Ye, Cao, Hong, Jiang, Jiafu, Xu, Yunyuan, Du, Jizhou, Wang, Xin, Yuan, Ming, Wang, Zhiyong, Xu, Zhihong, Chong, Kang. Rice ROOT ARCHITECTURE ASSOCIATED1 binds the proteasome subunit RPT4 and is degraded in a D-box and proteasome-dependent manner. PLANT PHYSIOLOGY[J]. 2008, 148(2): 843-855, http://www.corc.org.cn/handle/1471x/2389669.
[25] 曹宏, 周莉, 桂建芳. 中华鲟垂体SMART cDNA文库的构建及EST分析. 湖北省遗传学会、江西省遗传学会2006年学术年会暨学术讨论会论文摘要集null. 2007, http://ir.ihb.ac.cn/handle/342005/14714.
[26] 曹宏, 周亚凤, 张晓华, 张先恩, 戴和平. 抗对虾白斑综合症病毒单链抗体A1基因在酵母中表达及其与抗原结合活性. 水生生物学报. 2004, 28(5): 531-534, http://lib.cqvip.com/Qikan/Article/Detail?id=10406171.
[27] Xudong Hu, Haorong Li, Yusheng Lin, Zhongkai Wang, Haohao Feng, Man Zhou, Lixia Shi, Hong Cao, Yandong Ren. Genomic deciphering of sex determination and unique immune system of a potential model species rare minnow ( Gobiocypris rarus ). Science Advances. 8(5): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809535/.

科研活动

   
科研项目
( 1 ) 长薄鳅生殖调控关键因子功能验证研究, 主持, 研究所(学校), 2013-01--2016-12
( 2 ) 斑马鱼肝脏肿瘤发生及发展的机制研究, 主持, 国家级, 2015-01--2016-12
( 3 ) 中华鲟促性腺激素释放激素受体, 主持, 院级, 2014-07--2018-07
( 4 ) 雅鲁藏布江、怒江水生生物调查, 主持, 研究所(学校), 2014-11--2017-12
( 5 ) 金沙江中游河段观音岩水电, 主持, 院级, 2014-01--2017-12
( 6 ) 清洁稀有鮈鲫种群和资源保存, 主持, 国家级, 2011-01--2016-12
( 7 ) 鲤耐逆的分子模块解析, 参与, 部委级, 2013-08--2017-12
( 8 ) 渔业水域生境鱼类多样性的环境DNA调查研究, 主持, 国家级, 2018-12--2022-12
( 9 ) 长江干流陆向岸线污染拦截及生态修复技术之子课题, 参与, 部委级, 2019-01--2023-12
( 10 ) 岩原鲤种群遗传结构分析, 主持, 院级, 2017-06--2022-05
( 11 ) 稀有鮈鲫作为水质监测模型的分子机制研究, 主持, 国家级, 2017-09--2019-08

指导学生

现指导学生

周蔓  硕士研究生  085238-生物工程  

封浩浩  硕士研究生  071007-遗传学