My research interests are mainly focus on development of CNS drugs targeting at organellar ion channels. My group is trying to hunting drugs for neural degenerative diseases, including Alzheimer`s disorder and Parkinson`s disorder and so on. Our study feature is we have well established ion channel pharmacology, especially the intracellular ion channels, such as membrane proteins on lysosome, endoplasmic reticulum, mitochondria membrane. And patch-clamp recording and other eletrophysiological recordings are key skills for our work. Also, we have created a series of transgenic animal model with these neural degenerative diseases for evaluation of effects of CNS drugs tested in our hands both in vivo and in vitro.

September, 2005~June, 2009      Bachelor in Chemical Biology          Hubei University

September, 2009~July, 2014       Ph.D in Neuropharmacology           Shanghai Institute of Materia Medica, CAS

   

July, 2014~June, 2015                     Postdoctoral                Shenzhen Institute of Advanced Technology, CAS, China

October, 2015~September, 2020    Postdoctoral               University of Michigan, USA

January, 2021~                           Principal Investigator       Shanghai Institute of Materia Medica, CAS, China

（1） LRRC8 family proteins within Lysosomes Regulate Cellular Osmoregulation and Enhance Cell Survival to Multiple Physiological Stresses, PNAS, 2020, 
（2） Lysosomal ion channels as decoders of cellular signals., Trends in Biochemical Sciences, 2019,
（3） Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels, eLife, 2019, 
（4） A statistical thermodynamic model for ligands interacting with ion channels: theoretical model and experimental validation of the KCNQ2 channel., Frontier in Pharmacology, 2018, 
（5） A voltage-dependent K channel in the lysosome is required for refilling lysosomal Ca2+ stores., Journal of Cell Biology, 2017, 
（6） The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels, J Pharmacol Exp Ther, 2014, 
（7） Biomodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage dependent inactivation., Pflugers Arch., 2014, 
（8） The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands, Cell Research, 2013, 
（9） The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel, Toxicology Letters, 2013, 
（10） Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models., J Ethnopharmacol, 2013, 
（11） The inhibitory effects of DC031050，a class III antiarrhythmic agent with high selectivity for hERG channels, on three neuronal potassium channels., Acta Pharmacologica Sinica, 2012, 
（12） A theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2 Potassium Channel., Biophysical Journal, 2012, 
（13） Kv1.2 potassium channel inhibitors from Chukrasia tabularis, Organic Biomolecular Chemistry, 2012, 
（14） Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis., Organic Letters, 2012,