研究员，2009年博士毕业于北京协和医学院，主要从事海洋微生物来源药源分子的发现及合成机制等相关研究工作，主持国家基金（3）、广东省基金（1）、广州市科技重点（1）、广州市科技（1）等项目，参与国家重点研发1项。在国际知名期刊Nat Commun、Angew ChemInt Ed、Chem Sci、Chin ChemLett、Org lett等发表论文50多篇（包括第一/通讯作者论文26篇），申请和授权专利17件(含PCT专利1件)，担任J Nat Prod, Mar. Drugs等期刊审稿人。

招收硕士、博士研究生。硕士研究生招生方向为生物工程（本科为微生物学、药物化学专业方向学生），博士研究生招生方向为海洋生物学（本科为微生物学、药物化学专业方向学生）。接收985、211工程院校生物、化学或药学专业硕士推免生。

070703-海洋生物学

微生物天然产物，微生物天然产物生物合成

2006-08--2009-07   中国医学科学院北京协和医学院   博士
2003-08--2006-07   中国医学科学院北京协和医学院   硕士
1996-09--2000-07   内蒙古大学   学士

2020-12~现在, 中国科学院南海海洋研究所, 研究员

2012-08~2020-12,中国科学院南海海洋研究所, 助理研究员、副研究员

2009-09~2012-08,中国科学院南海海洋研究所, 博士后

2000-07~2003-08,内蒙古双奇药业, 质检员

   

国家基金面上项目(41676165)，2022.01-2025.12，主持

国家基金面上项目(42176127)，2017.01--2020.12，主持

国家基金面上项目(31470172)， 2015.01--2018.12，主持

广州市科技项目(2025B03J0088)，2025.11-2028.10，主持

广州市科技项目(201707010181)， 2017.05--2019.04，主持

广东省面上项目(42176127)，2024.01-2026.12，主持

27.    尹苗苗; 丁雪敏; 周天宇; 刘小玉; 张长生; 姜明国*; 张文军*. 深海来源篮状菌SCSIO 40439中苔色酰半胱氨酸二聚体dioscysmycine A及聚酮化合物分离鉴定与活性筛选. 微生物学报 2026, 1-13. DOI: 10.13343/j.cnki.wsxb.20260110

26.    Ye, W.; Liu, K.; Liu, W.; Chen, X.; Ding, X.; Tian, H.*; Zhang,W.*; Zhang, C*. Novel lipopeptides featuring unusual C–C and C–N linkagesbetween cyclic peptides and fatty acyl chains. Chinese Chemical Letters

2025, 112293.

25.    Zhou, T.#; Qiao, Y.#; Wang, L.; Li, Z.; Zhang, H.; Zhang,L.; Liao, S.; Li, M.*; Zhang, C.*; Zhang, W*. Discovery of MK8383s with Antifungal Activity from Mangrove Endophytic Fungi Medicopsis sp. SCSIO 40440

Against Fusarium Wilt of Banana. Marine drugs 2025, 23 (2), 88.

 24.      Chen, Y.#; Jin, H.#; Xiong, W.; Fang, Z.;Sun, W.; Zhu, Y.; Zhang, L.; Zhang, Y.; Zhang, W.*; Zhang, C.*,Discovery of Aburatubolactams Reveals  Biosynthetic Logic for Distinct5/5-Type Polycyclic Tetramate Macrolactams. Organic letters 2024,26, 1677-1682.

23.     Liu, W^#.; Zhai, S^#.; Zhang,L.; Chen, Y.; Liu, Z.; Ma, W.; Zhang, T.; Zhang, W.; Ma, L*.; Zhang, C*;Zhang, W.*, Expanding the Chemical Diversity of Grisechelins via Heterologous Expression. Journal of natural products 2024, 87,371-380.

22.   De, B. C.; Yang, C.; Huang, C.; Zhang, C.; Zhang, W.*,Non-enzymatic synthesis of C-methylated fluostatins: discovery and reaction mechanism. Organic & biomolecular chemistry 2024, 22, 1152-1156.

21.   Ding, X.; Ye, W.; Tan, B.; Song, Q.; Chen, Y.; Liu, W.; Sun, L.; Tang, W.; Qiao, Y.; Zhang, Q.; Zhang, H.; Wang, Y.; Zhang, W.; Zhang, C.*; Zhang, W*. Talachalasins A-C, undescribed cytochalasans with

a 16β-methyl or 2-Oxabicyclo[3.3.1]nonan-3-one unit from the deep-sea-derived Fungus Talaromyces muroii sp. SCSIO 40439. Chinese Journal of Chemistry 2023, 41, 915-923.

20.  De, B. C.;^# Zhang, W.;^# Yang, C.; Mándi, A.; Huang, C.; Zhang, L.; Liu, W.; Ruszczycky, M. W.; Zhu, Y.; Ma, M.; Bashiri, G.; Kurtán, T.; Liu, H.-w*.; Zhang,  C.*, Flavin-enabled reductive and oxidative epoxide ring opening reactions. Nature communications 2022, 13, 4896.

19.  Liu, W.; Ma, L.; Zhang, L.; Chen, Y.; Zhang, Q.; Zhang, H.; Zhang, W.; Zhang, C.^*; Zhang, W.^*, Two New Phenylhydrazone Derivatives fro the Pearl  River Estuary Sediment-Derived Streptomyces sp. SCSIO 40020. Marine drugs 2022,20, 449.

18 .徐慧欣，王 璐，张丽萍，刘威，张庆波，张海波，张长生，张文军^*。Malfilamentoside A 的构型确定与新呋喃糖苷类化合物malfilamentoside。有机化学 2022, 42, 1229-1234.

17. 叶伟霞，赵梦冉，王璐，蒋晓东，张文军，张长生，田海妍^*。南海珊瑚来源真菌Aspergillus sp. SCSIO 40435的分离鉴定及其次级代谢产物研究。  微 生物学报，2022, .62 (5): 1819–1831.

16. 王璐，叶伟霞，赵梦冉，张庆波，张丽萍，张长生，张文军^*。湛江红树林内生真菌分离筛选及Stemphyliums sp. SCSIO 40436代谢产物研究。微生物 学通报，2022, 49, 2995-3007.

15. Wang, L; ^# Huang, YB;^# Zhang, LP.; Liu, ZW.; Liu, W.; Xu, HX.; Zhang, QB.; Zhang, HB.; Yan, Y.; Liu, Z.; Zhang, TY.; Zhang, W;^* Zhang, CS,^* Structures and absolute configurations of phomalones from the coral-associated fungus Parengyodontium album sp. SCSIO 40430. Organic & biomolecular chemistry 2021, 19 (27), 6030-6037.

 14. Yang, CF.;^# Huang, CS.,^# Fang, CY.; Zhang, LP.;Chen, SQ; Zhang, QB; Zhang, CS;^*, Zhang, W.^* Inactivation of Flavoenzyme-Encoding Gene flsO1 in Fluostatin Biosynthesis Leads to Diversified Angucyclinone Derivatives. The Journal of organic chemistry 2021, 86, 11019-11028.

 13.  Xu, H.X.; Yang, T.; Zhang, L.P.; Liu, W.; Zhang, HB.; Zhang, QB.; Zhang, CS;^* Zhang, W,^* Ocauxarthrol A from Auxarthron umbrinum SCSIO 40432 and configurational reassignment of chrysoqueen and auxarthrols. Tetrahedron Letters 2021, 66, 152842.     

 12.  Zhang, L;^# De, BC.;^# Zhang, W;^*Mándi, A; Fang, ZJ; Yang, CF; Zhu, YG; Kurtán, T.; Zhang, CS,^*Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the; α/β-fold epoxide-fold epoxide hydrolase Alp1U. Journal of Biological Chemistry 2020, 295 (50), 16987-16997.  

 11.  Zhang, W.; Zhang, G.; Zhang, L.; Liu, W.; Jiang, X.; Jin, H.; Liu, Z.; Zhang, HB.; Zhou, A.; Zhang, C.,^* New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060. Tetrahedron 2018, 74 (47), 6839-6845. 

 10.  Zhang W;^# Yang, C; ^# Huang, C.; Zhang, L.; Zhang, H.; Zhang, Q.; Yuan, C.; Zhu, Y.; Zhang, C^*.,Pyrazolofluostatins A–C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora

rosaria SCSIO N160. Organic letters, 2017, 19, 592-595.

 9.  Saha, S.;^# Zhang, W.;^# Zhang, G.;^# Zhu, Y.; Chen, Y.; Liu, W.; Yuan, C.; Zhang, Q.; Zhang, H.; Zhang, L.; Zhang, W.; Zhang, C^*., Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams. Chemical Science, 2017, 8, 1607-1612.

 8.  Yang C, Huang C, Zhang W^*, Zhu Y, Zhang C^*,Heterologous Expression of Fluostatin Gene Cluster Leads to a Bioactive Heterodimer, Organic letters, 2015, 17 (21): 5324-5327.

7.  Zhu Y^#, Zhang W^#, Chen Y, Yuan CS, Zhang H, Zhang G, Ma L, Zhang Q, Tian X, Zhang S, Zhang C^*. Characterization of Heronamide Biosynthesis Reveals a  Tailoring Hydroxylase and Indicates Migrated Double Bonds, Chembiochem, 2015, 16 (14): 2086-2093.

6.  Zhang G^#, Zhang W^#, Zhang Q, Shi T, Ma L, Zhu Y, Li S, Zhang H, Zhao YL, Shi R, Zhang C Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis, Angewandte Chemie International Edition, 2014, 53 (19): 4840-4844.

 5. Chen Y^#, Zhang W^#, Zhu Y^*, Zhang Q, Tian X, Zhang S, Zhang C^*, Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis, Organic letters,2014, 16, 736-739

 4.  Zhang W, Ma L, Li S, Liu Z, Chen Y, Zhang HB, Zhang G, Zhang Q, Tian X, Yuan C, Zhang S, Zhang W, Zhang C^* Indimicins A–E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp.

SCSIO 03032, Journal natural Products, 2014, 77 (8): 1887-1892.

3.  Zhang W, Li S, Zhu Y, Chen YC, Chen YL, Zhang HB, Zhang G, Tian X, Pan Y, Zhang S, Zhang WM, Zhang C^*. Heronamides D–F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp.

SCSIO 03032, Journal natural Products, 2014, 77 (2): 388-391.

 2.  Zhang W, Liu Z, Li S, Yang T, Zhang Q, Ma L, Tian X, Zhang H, Huang C, Zhang S, Ju J, Shen Y, Zhang C^*. Spiroindimicins A–D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete, Organic

letters, 2012, 14 (13): 3364-3367. 

 1.  Zhang W^#, Liu Z^#, Li S, Lu Y, Chen Y, Zhang H, Zhang G, Zhu Y, Zhang G, Zhang W, Liu J, Zhang C^* Fluostatins I–K from the South China Sea-Derived Micromonospora rosaria SCSIO N160, Journal natural Products, 2012, 75 (11):1937-1943. 

已指导学生

黄艳冰  硕士研究生  070703-海洋生物学  

徐慧欣  硕士研究生  085238-生物工程  

王璐  硕士研究生  085238-生物工程  

叶伟霞 硕士研究生，天然有机化学（联合培养）

乔宇磊 硕士研究生 086000-生物与医药  

现指导学生

丁雪敏  博士研究生   070703-海洋生物学  

刘小玉 硕士研究生 086000-生物与医药

刘彦兵 硕士研究生 086000-生物与医药