Discovery of Therapeutic Targets for Reproductive and Metabolic Diseases and Development/Application of Targeted Delivery Tools

University of Chinese Academy of Science, Ph.D. Candidate, 2019.09-2022.06

University of Science and Technology of China, Master's Student, 2012.09-2015.06

   

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , Senior Engineer, 2026-01 onwards；

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Postdoctoral Researcher, 2022.07-2025.06

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Assistant Researcher, 2018.01-2019.08

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Research Assistant, 2015.07-2017.12

   

1. Zhendong Zhu#, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang*, Yali Yang*, J.V. Zhang*. Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Middle-Age Testicular Macrophages.Adv Sci (Weinh). 2026 Mar;13(14):e15166.

2. Xiao,Zhonglin#, Wang,Feng#, Yang,Yali#, Xiao,Tianxia, Chen,Jie, Li,Mengxia, Liao,Haizhen, Chu,Chiawei*, Fan,Xiujun*, Zhang,Jian V*. Low-dose letrozole-HMG regimen reverses letrozole-induced endometrial impairment and improves frozen embryo transfer outcomes. Front. Cell Dev. Biol., 16 December 2025. 13:1725350

3. Lei Ge#, Yuqing Gao, Feifei Du, Chiyuan Ma, Tianxia Xiao, Yali Yang*, Xiaohua Lei*, Jian V. Zhang* ; The critical role of enhanced OXPHOS and mitochondrial hyperpolarization in simulated microgravity induced oocyte maturation arrest. Adv Sci 2025 Jul 18:e05570.

4. Ge L#, Yang Y#, Xiao T, Gao Y, Chang W, Du F, Yu M, Zhang JV*. Ovarian Endometriosis Accelerates Premature Ovarian Failure and Contributes to Osteoporosis and Cognitive Decline in Aging Mice. International Journal of Molecular Sciences. 2025; 26(7):3313.

5. Ge L#, Yang Y#, Gao Y#, Xiao T, Chang W, Wang H, Xiao Z, Chen J, Li M, Yu M, Jin P, Zhang JV*. Ovarian Endometrioma Disrupts Oocyte-Cumulus Communication and Mitochondrial Function, With Melatonin Mitigating the Effects. Cell Prolif. 2025 Jan 21:e13800.

6. Yang Y#, Zhao H#, Wu M#, et al. 3D-printed scaffolds with controlled-releasing compounds for ectopic activation of dormant ovarian follicles. Int J Bioprint. 2024. doi: 10.36922/ijb.4941

7. Ani Ma#, Yali Yang#, Lianbao Cao, Lijun Chen & Jian V. Zhang. FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes. Commun Biol 2024；1099(7). （IF：5.9）

8. Yu M#, Yang Y#, Zhao H, Li M, Chen J, Wang B, Xiao T, Huang C, Zhao H, Zhou W, Zhang JV. Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression. Front Pharmacol. 2022 Nov 29;13:985618. （IF：5.988）

9. Yu M#, Yang Y#, Huang C, Ge L, Xue L, Xiao Z, Xiao T, Zhao H, Ren P, Zhang JV. Chemerin: A Functional Adipokine in Reproductive Health and Diseases. Biomedicines. 2022 Aug 7;10(8):1910. （IF：4.757）

10. Sun LF#, Yang YL#, Wang MY, Zhao HS, Xiao TX, Li MX, Wang BB, Huang C*, Ren PG*, Zhang JV*. Inhibition of Col6a5 Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogenic Mice. Front Cell Dev Biol. 2021 May 24;9:669189（IF：6.684）