基本信息
张亚南 女 中国科学院武汉病毒研究所
电子邮件: ynzhang@wh.iov.cn
通信地址: 武汉市江夏区黄金工业园金龙大街262号
邮政编码:
电子邮件: ynzhang@wh.iov.cn
通信地址: 武汉市江夏区黄金工业园金龙大街262号
邮政编码:
招生信息
招生专业
100103-病原生物学
招生方向
甲病毒复制与包装机制,新型疫苗研究
教育背景
2018-09--2021-06 中国科学院武汉病毒研究所 博士2016-09--2018-06 东北农业大学 硕士2012-09--2016-06 东北农业大学 学士
工作经历
工作简历
2023-11~2025-08,中国科学院武汉病毒研究所, 副研究员2023-08~2023-10,中国科学院武汉病毒研究所, 特别研究员助理2021-07~2023-07,广州市妇女儿童医疗中心, 博士后2018-09~2021-06,中国科学院武汉病毒研究所, 博士2016-09~2018-06,东北农业大学, 硕士2012-09~2016-06,东北农业大学, 学士
社会兼职
2023-12-22-2026-12-21,湖北江夏实验室研究员,
专利与奖励
奖励信息
(1) 中国科学院院长特别奖学金, 院级, 2021(2) 博士国家奖学金, 国家级, 2020(3) 中国科学院朱李月华优秀博士奖学金, 院级, 2020(4) 中国科学院唐立新奖学金, 院级, 2020(5) 博士国家奖学金, 国家级, 2019
出版信息
发表论文
(1) Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster, ANTIVIRAL RESEARCH, 2023, 第 1 作者(2) Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 第 1 作者(3) Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion, PLOS NEGLECTED TROPICAL DISEASES, 2022, 第 2 作者(4) High-Titer Self-Propagating Capsidless Chikungunya Virus Generated in Vero Cells as a Strategy for Alphavirus Vaccine Development, JOURNAL OF VIROLOGY, 2022, 第 1 作者(5) Rational design of West Nile virus vaccine through large replacement of 3 ' UTR with internal poly(A), EMBO MOLECULAR MEDICINE, 2021, 第 1 作者(6) Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2, CELL DISCOVERY, 2021, 第 1 作者(7) Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates, Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates, VIROLOGICA SINICA, 2021, 第 0 作者(8) ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 2 作者(9) Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice, Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 4 作者(10) SARS-CoV-2 replicon for high-throughput antiviral screening, JOURNAL OF GENERAL VIROLOGY, 2021, 第 7 作者(11) A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles, A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles, CELL RESEARCH, 2020, 第 1 作者(12) Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies in Pets in Wuhan, China, JOURNAL OF INFECTION, 2020, 第 3 作者(13) A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice, NPJ VACCINES, 2020, 第 3 作者(14) Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture, EMERGING MICROBES & INFECTIONS, 2020, 第 1 作者(15) A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 2 作者(16) A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon, EBIOMEDICINE, 2020, 第 1 作者(17) Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine, JOURNAL OF VIROLOGY, 2019, 第 1 作者(18) Replication-Defective West Nile Virus with NS1 Deletion as a New Vaccine Platform for Flavivirus, JOURNAL OF VIROLOGY, 2019, 第 2 作者
科研活动
科研项目
( 1 ) 甲病毒病毒样囊泡颗粒(VLV)的包装机制研究, 负责人, 中国科学院计划, 2024-01--2025-12( 2 ) 尼帕病毒的新型载体疫苗技术研究, 负责人, 研究所自主部署, 2023-08--2024-07( 3 ) 衣壳蛋白缺失的基孔肯雅病毒包装机制研究, 负责人, 国家任务, 2023-01--2025-12( 4 ) 利用甲病毒复制型mRNA肺部靶向递送 hACE2 中和抗体的抗新冠病毒感染通用策略研究, 负责人, 国家任务, 2023-01--2023-07( 5 ) 埃博拉病毒、尼帕病毒、拉沙病毒的新型载体疫苗研究, 参与, 国家任务, 2021-01--2024-12