100702-药剂学

新型微针药物、疫苗和细胞递送系统

2010-09--2015-09   浙江大学   博士
2006-09--2010-07   天津大学   学士

   

2021-06~现在, 中国科学院杭州医学研究所, 研究员
2019-06~2021-05,香港城市大学, Senior Research Fellow
2016-04~2019-05,新加坡南阳理工大学, Research Fellow
2010-09~2015-09,浙江大学, 博士
2006-09~2010-07,天津大学, 学士

   

（1） 2022年日内瓦国际发明展银奖, 二等奖, 其他, 2022

   

（1） Microsphere-integrated hydrogel microneedle patch for sustained methotrexate delivery in the long-term management of atopic dermatitis, European Polymer Journal, 2025, 
（2） Ice-pop making inspired photothermal ultra-swelling microneedles to facilitate loading and intradermal vaccination of tumor antigen, Journal of Controlled Release, 2025, 
（3） Microneedles with an anisotropic porous microstructure facilitate the transdermal delivery of small molecules, lipid nanoparticles, and T cells, Matter, 2025, 第 8 作者
（4） Facile minocycline deployment in gingiva using a dissolvable microneedle patch for the adjunctive treatment of periodontal disease, Bioengineering & Translational Medicine, 2025, 
（5） Intradermal implantation of methotrexate-loaded puerarin-gelatin hydrogel via bubble-generating microneedles for psoriasis treatment, International Journal of Biological Macromolecules, 2025, 
（6） Self-Healing Porous Microneedles Fabricated Via Cryogenic Micromoulding and Phase Separation for Efficient Loading and Sustained Delivery of Diverse Therapeutics, Small, 2024, 
（7） An ultraswelling microneedle device for facile and efficient drug loading and transdermal delivery, Advanced Healthcare Materials, 2024, 
（8） Efficient loading and sustained delivery of methotrexate using a tip-swellable microneedle array patch for psoriasis treatment, ACS Biomaterials Science & Engineering, 2024, 
（9） Efficient extraction of interstitial fluid using an ultrasonic-powered replaceable hexagram-shaped hydrogel microneedle patch for monitoring of dermal pharmacokinetics and psoriatic biomarkers, Chemical Engineering Journal, 2024, 
（10） Long-term storage and intradermal vaccination of tumor-derived exosomes via sugar microneedles for improving tumor immunotherapies, Chemical Engineering Journal, 2024, 
（11） A rapidly dissolvable microneedle patch with tip-accumulated antigens for efficient transdermal vaccination, Macromolecular Bioscience, 2024, 
（12） Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses, Acta Biomaterialia, 2024, 
（13） Recent developments in layer���by���layer assembly for drug delivery and tissue engineering applications, Advanced Healthcare Materials, 2024, 第 4 作者
（14） Rapid Correction of the Hypoglycemia State in Nonhuman Primates Using a Glucagon Long-Dissolving Microneedle Patch, ACS Biomaterials Science & Engineering, 2024, 
（15） Co-delivery of dendritic cell vaccine and anti-PD-1 antibody with cryomicroneedles for combinational immunotherapy, Bioengineering & Translational Medicine, 2023, 
（16） Cryomicroneedles for transdermal cell delivery, Nature Biomedical Engineering, 2021, 第 1 作者
（17） A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis, Advanced Materials, 2017, 

   

（ 1 ） 2024眼科联合攻关-视神经微针递药关键技术与应用研究, 负责人, 研究所自主部署, 2025-04--2027-12
（ 2 ） 中国科学院引才计划B类科研经费, 负责人, 中国科学院计划, 2025-01--2027-12
（ 3 ） 功能化各项异性的生物医用补片及其在腹壁缺损场景的应用研究, 负责人, 研究所自主部署, 2025-01--2026-12
（ 4 ） 光热自佐型可自愈多孔微针“空间-时间”控释抗原用于增强适应性免疫反应的研究, 负责人, 地方任务, 2025-01--2027-12
（ 5 ） 载血小板生成素囊泡微针的体内分布以及药代动力学参数测定, 负责人, 境内委托项目, 2023-12--2024-12
（ 6 ） 冷冻水凝胶微针用于树突细胞疫苗和PD-1单抗协同递送与联合免疫治疗的研究, 负责人, 国家任务, 2023-01--2025-12
（ 7 ） 浙江省卫生创新人才, 负责人, 地方任务, 2023-01--2027-12
（ 8 ） 微针透皮给药系统的研发, 负责人, 境内委托项目, 2022-01--2023-12
（ 9 ） 常皓科研与人才启动经费, 负责人, 其他, 2021-06--2026-06

（1）Engineering an Ultra-Swelling Microneedle Device for Facile and Efficient Loading and Delivery of Various Therapeutics   2023-12-03