100706-药理学
100701-药物化学

核酸药物设计；核酸结构生物学
核酸药物化学

2012-08--2016-12   香港中文大学   博士
2008-09--2012-06   华中师范大学   学士

   

2022-07~现在, 中国科学院杭州医学研究所, 副研究员
2019-05~2022-07,华南理工大学, 副研究员
2016-12~2019-05,香港中文大学, 博士后研究员
2012-08~2016-12,香港中文大学, 博士
2008-09~2012-06,华中师范大学, 学士

   

（1） Structural investigation of pathogenic RFC1 AAGGG pentanucleotide repeats reveals a role of G-quadruplex in dysregulated gene expression in CANVAS, Nucleic Acids Research, 2024, 
（2） High-Resolution NMR Structures of Intrastrand Hairpins Formed by CTG Trinucleotide Repeats, ACS Chemical Neuroscience, 2024, 
（3） A spatially localized DNA linear classifier for cancer diagnosis, Nature Communications, 2024, 
（4） Structure-based investigation of a DNA aptamer targeting PTK7 reveals an intricate 3D fold guiding functional optimization, Proceedings of the National Academy of Sciences of the United States of America, 2024, 
（5） Structures and conformational dynamics of DNA minidumbbells in pyrimidine-rich repeats associated with neurodegenerative diseases, Computational and Structural Biotechnology Journal, 2023, 
（6） Targeting pathogenic DNA and RNA repeats: a conceptual therapeutic way for repeat expansion diseases, Chemistry–A European Journal, 2022, 
（7） NMR solution structures of d (GGCCTG) n repeats associated with spinocerebellar ataxia type 36, International Journal of Biological Macromolecules, 2022, 
（8） Solution nuclear magnetic resonance structures of ATTTT and ATTTC pentanucleotide repeats associated with SCA37 and FAMEs, ACS Chemical Neuroscience, 2022, 
（9） 5���Methylcytosine substantially enhances the thermal stability of DNA minidumbbells, Chemistry–A European Journal, 2021, 
（10） Rational design of a reversible Mg 2+/EDTA-controlled molecular switch based on a DNA minidumbbell, Chemical Communications, 2021, 
（11） Minidumbbell structures formed by ATTCT pentanucleotide repeats in spinocerebellar ataxia type 10, Nucleic Acids Research, 2020, 
（12） An extraordinarily stable DNA minidumbbell, The Journal of Physical Chemistry Letters, 2017, 第 1 作者
（13） The competing mini-dumbbell mechanism: new insights into CCTG repeat expansion, Signal Transduction and Targeted Therapy, 2016, 第 1 作者
（14） Minidumbbell: a new form of native DNA structure, Journal of the American Chemical Society, 2016, 第 1 作者

   

（ 1 ） 脊髓小脑共济失调36型相关DNA和RNA六核苷酸重复序列的结构与功能研究, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 核酸适体药物序列-结构协同设计的预训练基座模型开发与论证, 参与, 国家任务, 2024-01--2026-12
（ 3 ） 核酸适体结构解析, 负责人, 地方任务, 2023-01--2025-12