100702-药剂学

结构药剂学理论与新方法，环糊精超分子药用辅料

2013-09--2016-12   吉林大学   博士
2010-09--2013-06   安徽中医药大学   硕士
2006-09--2010-06   安徽中医药大学   本科

   

2021-10~现在, 中国科学院上海药物研究所, 副研究员
2019-07~2021-10,中国科学院上海药物研究所, 助理研究员
2017-01~2019-07,中国科学院上海药物研究所, 博士后
2013-09~2016-12,吉林大学, 博士
2010-09~2013-06,安徽中医药大学, 硕士
2006-09~2010-06,安徽中医药大学, 本科

   

（ 1 ） 过氧化氢敏感的共价环糊精骨架及其制备方法和应用, 2023, 第 4 作者, 专利号: CN116478415A

（ 2 ） 环糊精-金属有机骨架组合物及其制备方法, 2022, 第 2 作者, 专利号: CN115252814A

（ 3 ） 具有肺靶向的肝素-多肽双重接枝环糊精骨架组合物及其制备方法与应用, 2022, 第 4 作者, 专利号: CN114306205A

（ 4 ） 一种环糊精-金属有机骨架晶体材料的制备方法, 2021, 第 2 作者, 专利号: CN111961214B

（ 5 ） 立方形环糊精骨架-RGD组合物及其制备方法, 2021, 第 5 作者, 专利号: CN111440253B

（ 6 ） 基于环糊精-金属有机骨架的呼吸道给药制剂, 2020, 第 3 作者, 专利号: CN111803471A

（ 7 ） 一种提高缬沙坦溶解性的环糊精-金属有机骨架组合物, 2019, 第 3 作者, 专利号: CN110314239A

（ 8 ） 一种缬沙坦环糊精-金属有机骨架组合物及其制备方法, 2019, 第 3 作者, 专利号: CN110314240A

（ 9 ） 一种提高药物溶解性的环糊精-金属有机骨架组合物, 2019, 第 2 作者, 专利号: CN110314241A

（ 10 ） 环糊精‑金属有机骨架材料复合微球及其制备方法, 2018, 第 4 作者, 专利号: CN107837401A

（ 11 ） PTHrP类似物纳米粒, 2018, 第 5 作者, 专利号: CN107773552A

（ 12 ） 一种载三氯蔗糖的环糊精-金属有机骨架复合物及其制备方法, 2017, 第 4 作者, 专利号: CN107151328A

（ 13 ） 环糊精-金属有机骨架材料的快速合成方法, 2017, 第 5 作者, 专利号: CN107151329A

（ 14 ） 蓖麻油环糊精液体分散剂及其制备方法, 2017, 第 3 作者, 专利号: CN106377566A

（ 15 ） 非均相液体沉降自动监测方法及设备, 2016, 第 4 作者, 专利号: CN105987866A

（ 16 ） 非均相液体沉降自动监测设备, 2015, 第 4 作者, 专利号: CN204740186U

（ 17 ） 一种褪黑素仿生释药制剂及其制备方法, 2015, 第 3 作者, 专利号: CN104840439A

（ 18 ） 源自胖大海的天然膨胀性基质在渗透泵制剂中的用途, 2014, 第 2 作者, 专利号: CN104225608A

（ 19 ） 一种药物渗透泵制剂, 2014, 第 2 作者, 专利号: CN104146980A

（ 20 ） 酮洛芬渗透泵片及其制备方法, 2014, 第 2 作者, 专利号: CN103860509A

（ 21 ） 阿奇霉素渗透泵控释片及其制备方法, 2014, 第 3 作者, 专利号: CN103860515A

（ 22 ） 一种药物渗透泵制剂, 2013, 第 2 作者, 专利号: CN102871982A

   

（1） Visualization of nasal powder distribution using biomimetic human nasal cavity model, ACTA PHARMACEUTICA SINICA B, 2024, 第 17 作者  通讯作者
（2） Solvent-Free Loading of Vitamin A Palmitate into beta-Cyclodextrin Metal-Organic Frameworks for Stability Enhancement, AAPS PHARMSCITECH, 2023, 第 13 作者  通讯作者
（3） Diffusion Kinetics-Based Loading of Lipoic Acid into Cyclodextrin Metal-Organic Frameworks via a Solvent-Free Method and Mechanism of Stability Enhancement, JOURNAL OF PHYSICAL CHEMISTRY C, 2023, 第 9 作者  通讯作者
（4） Interactions of Essential Oil Components to Their Payloads in Supramolecular Particulate Carriers of Cyclodextrin Metal-Organic Frameworks, JOURNAL OF OLEO SCIENCE, 2023, 第 7 作者  通讯作者
（5） Hydrogen peroxide responsive covalent cyclodextrin framework for targeted therapy of inflammatory bowel disease, CARBOHYDRATE POLYMERS, 2022, 第 8 作者  通讯作者
（6） Efficient capture and stabilization of iodine via gas-solid reaction using cyclodextrin metal-organic frameworks, CARBOHYDRATE POLYMERS, 2022, 第 13 作者  通讯作者
（7） Particle Design and Inhalation Delivery of Iodine for Upper Respiratory Tract Infection Therapy, AAPS PHARMSCITECH, 2022, 第 12 作者  通讯作者
（8） Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution, ADVANCED SCIENCE, 2021, 第 5 作者
（9） ��-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 第 4 作者
（10） 结构药剂学与中药制剂结构研究进展, The research progress on the structure pharmaceutics and dosage form structures of traditional Chinese medicines, 药学学报, 2021, 第 8 作者
（11） Pulmonary Targeting Crosslinked Cyclodextrin Metal-Organic Frameworks for Lung Cancer Therapy, ADVANCED FUNCTIONAL MATERIALS, 2021, 第 7 作者  通讯作者
（12） Mechanism and optimization of supramolecular complexation-enhanced fluorescence spectroscopy for the determination of SN-38 in plasma and cells, LUMINESCENCE, 2021, 第 6 作者
（13） 载蒿甲醚甘氨胆酸钠/大豆磷脂混合胶束的制备与稳定性评价, Preparation and stability evaluation of artemether-loaded mixed micelles composed of the sodium glycocholate and soybean lecithin, 药学学报, 2021, 第 2 作者
（14） Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets, ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 第 3 作者
（15） Co-delivery of superfine nano-silver and solubilized sulfadiazine for enhanced antibacterial functions, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 第 7 作者
（16） Fabrication of ��-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery, ARABIAN JOURNAL OF CHEMISTRY, 2020, 第 4 作者
（17） Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery, Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery, ACTA PHARMACEUTICA SINICA B, 2020, 第 6 作者
（18） Fabrication of beta-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery, ARABIAN JOURNAL OF CHEMISTRY, 2020, 第 4 作者
（19） Hyaluronic-acid-based beta-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 第 2 作者
（20） Static and dynamic structural features of single pellets determine the release behaviors of metoprolol succinate sustained-release tablets, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 第 2 作者
（21） Facile Synthesis and Size Control of 2D Cyclodextrin-Based Metal-Organic Frameworks Nanosheet for Topical Drug Delivery, PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 2020, 第 4 作者
（22） 基于同步辐射光源显微成像技术原位表征软胶囊结构变化及内部微粒分布, In situ characterization of structural change and internal particle distributions of soft capsules based on synchrotron radiation X-ray micro computed tomography, 药学学报, 2020, 第 2 作者
（23） Hyaluronic-acid-based ��-cyclodextrin grafted copolymers as biocompatible supramolecular hosts to enhance the water solubility of tocopherol, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 第 2 作者
（24） A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of gamma-cyclodextrin metal-organic frameworks, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 第 2 作者
（25） Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 第 5 作者
（26） Optimization of taste-masking on ibuprofen microspheres with selected structure features, Optimization of taste-masking on ibuprofen microspheres with selected structure features, ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 第 5 作者
（27） MOF Capacitates Cyclodextrin to Mega-Load Mode for High-Efficient Delivery of Valsartan, PHARMACEUTICAL RESEARCH, 2019, 第 11 作者  通讯作者
（28） Crystal Transformation of -CD-MOF Facilitates Loading of Dimercaptosuccinic Acid, AAPS PHARMSCITECH, 2019, 第 2 作者
（29） Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan, Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan, ACTA PHARMACEUTICA SINICA B, 2019, 第 12 作者  通讯作者
（30） Folic acid and its metabolite codetermination for pharmacokinetics with circadian rhythms and evaluation of oral bioavailability, Journal of Pharmacy and Pharmacology, 2019, 第 9 作者  通讯作者
（31） CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading, CRYSTAL GROWTH & DESIGN, 2019, 第 2 作者
（32） In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride, BIOMEDICINE & PHARMACOTHERAPY, 2019, 第 3 作者
（33） 利用热熔特征检出混合粉体中目标成分粒径及其分布, Determination of particle size and particle size distribution of selected component in mixed powders by its melting characteristics, 药学学报, 2018, 第 3 作者
（34） Cavities spatial distribution confined by microcrystalline cellulose particles determines tablet disintegration patterns, POWDER TECHNOLOGY, 2018, 第 4 作者
（35） Material distributions and functional structures in probiotic microcapsules, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 第 1 作者
（36） Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability, SCIENTIFIC REPORTS, 2018, 第 3 作者
（37） Synchrotron Radiation Microcomputed Tomography Guided Chromatographic Analysis for Displaying the Material Distribution in Tablets, ANALYTICAL CHEMISTRY, 2018, 第 2 作者
（38） Enhanced stability of vitamin A palmitate microencapsulated by gamma-cyclodextrin metal-organic frameworks, JOURNAL OF MICROENCAPSULATION, 2018, 第 12 作者  通讯作者
（39） Biofunctionalization of beta-cyclodextrin nanosponges using cholesterol, CARBOHYDRATE POLYMERS, 2018, 第 4 作者
（40） 同步辐射X射线显微成像研究环糊精自组装beads的三维结构, Three-dimensional structure of beads self-assembled by cyclodextrin using synchrotron radiation X-ray microcomputed tomography, 药学学报, 2018, 第 2 作者
（41） Solvents effects on crystallinity and dissolution of beta-artemether, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2017, 第 5 作者
（42） Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 第 3 作者
（43） Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload, RSC ADVANCES, 2017, 第 3 作者
（44） Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography, ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 第 1 作者
（45） Moisture resistant and biofriendly CD-MOF nanoparticles obtained via cholesterol shielding, CHEMICAL COMMUNICATIONS, 2017, 第 4 作者
（46） Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 第 8 作者
（47） Ordered and disordered cyclodextrin nanosponges with diverse physicochemical properties, RSC ADVANCES, 2017, 第 3 作者
（48） 基于同步辐射红外显微成像研究层层自组装包衣矫味机制, 药学学报, 2016, 第 3 作者
（49） Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 第 4 作者
（50） Fabrication of non-spherical Pickering emulsion droplets by cyclodextrins mediated molecular self-assembly, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2016, 第 1 作者
（51） 中链甘油三酯环糊精分子自组装介导的pickering乳的形成机制, 药学学报, 2016, 第 2 作者
（52） Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations, JOURNAL OF PHYSICAL CHEMISTRY A, 2016, 第 3 作者
（53） Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting, SCIENTIFIC REPORTS, 2016, 第 2 作者
（54） Three dimensional structural insight of laser drilled orifices in osmotic pump tablets, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 第 1 作者
（55） Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 第 1 作者
（56） Automatic monitoring and quantitative characterization of sedimentation dynamics for non-homogenous systems based on image profile analysis, POWDER TECHNOLOGY, 2015, 第 5 作者
（57） 渗透泵包衣膜结构与释放控制机制研究, 2015, 第 1 作者
（58） Dramatic improvement of the solubility of pseudolaric acid B by cyclodextrin complexation: Preparation, characterization and validation, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 第 6 作者
（59） Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres, ACTA PHARMACEUTICA SINICA B, 2015, 第 6 作者
（60） Bioactivity assay of porcine relaxin based on cAMP accumulation in THP-1 cells quantified by LC���MS/MS, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 第 3 作者
（61） Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population, Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population, ACTA PHARMACEUTICA SINICA B, 2014, 第 3 作者
（62） Quantification of Swelling and Erosion in the Controlled Release of a Poorly Water-Soluble Drug Using Synchrotron X-ray Computed Microtomography, AAPS JOURNAL, 2013, 第 4 作者
（63） Advances in Structure Pharmaceutics from Discovery to Evaluation and Design, MOLECULAR PHARMACEUTICS, 第 2 作者

   

（ 1 ） 缓控释制剂结构的体内/外定量关系研究, 负责人, 国家任务, 2023-01--2026-12