071005-微生物学

病毒学，合成生物学

2017-09--2022-06   中国科学院武汉病毒研究所   博士学位
2013-09--2017-06   华中农业大学   学士学位

   

2025-10~现在, 中国科学院武汉病毒研究所, 副研究员
2024-11~2025-09,中国科学院武汉病毒研究所, 助理研究员
2022-07~2024-10,中国科学院武汉病毒研究所, 博士后

   

（ 1 ） 一种转运载体, 发明专利, 2023, 第 2 作者, 专利号: CN116042720A

   

（1） Structural insights into hybridoma-derived neutralizing monoclonal antibodies against Omicron BA.5 and XBB.1.16 variants of SARS-CoV-2, JOURNAL OF VIROLOGY, 2025, 第 1 作者
（2） Discovery of novel non-retroviral endogenous viral elements reveals their long-term integration history in spiders, NATURE COMMUNICATIONS, 2025, 第 1 作者
（3） Mucin-like protein of Crimean-Congo hemorrhagic fever virus is a key virulence factor and a potent target for developing novel attenuated vaccine, Mucin-like protein of Crimean-Congo hemorrhagic fever virus is a key virulence factor and a potent target for developing novel attenuated vaccine, CELL RESEARCH, 2025, 第 4 作者
（4） Genome-Wide Simplification of the AcMNPV Genome Using Synthetic Biology, ACS SYNTHETIC BIOLOGY, 2025, 第 2 作者
（5） Assembly of ascovirus HvAV-3h long DNA fragment using the Transformation-Associated Recombination (TAR) approach in yeast cells, BMC BIOTECHNOLOGY, 2025, 第 3 作者
（6） Crucial role played by CK8+cells in mediating alveolar injury remodeling for patients with COVID-19, VIROLOGICA SINICA, 2024, 第 2 作者
（7） Efficient Strategy for Synthesizing Vector-Free and Oncolytic Herpes Simplex Type 1 Viruses, ACS SYNTHETIC BIOLOGY, 2024, 第 2 作者
（8） Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo, VIROLOGICA SINICA, 2023, 第 8 作者
（9） 抗SARS-CoV-2变异株的广谱mRNA疫苗RQ3013的临床前研究, Preclinical evaluation of RQ3013,a broad-spectrum mRNA vaccine against SARS-CoV-2 variants, SCIENCE BULLETIN, 2023, 第 22 作者
（10） SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts, STEM CELL RESEARCH & THERAPY, 2023, 第 2 作者
（11） Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection In Vitro, VIRUSES-BASEL, 2023, 第 3 作者
（12） Construction and characterization of a synthesized herpes simplex virus H129-Syn-G2, Construction and characterization of a synthesized herpes simplex virus H129-Syn-G2, VIROLOGICA SINICA, 2023, 第 2 作者
（13） Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants, SCIENCE BULLETIN, 2023, 第 22 作者
（14） Antiviral effects and tissue exposure of tetrandrine against SARS-CoV-2 infection and COVID-19, MEDCOMM, 2023, 第 7 作者
（15） Multiloci Manipulation of Baculovirus Genome Reveals the Pivotal Role of Homologous Regions in Viral DNA Replication, Progeny Production, and Enhancing Transcription, ACS SYNTHETIC BIOLOGY, 2022, 第 1 作者
（16） Successful Rescue of Synthetic AcMNPV with a ∼17 kb Deletion in the C1 Region of the Genome, VIRUSES-BASEL, 2022, 第 2 作者
（17） Covalently Engineered Protein Minibinders with Enhanced Neutralization Efficacy against Escaping SARS-CoV-2 Variants, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 第 3 作者
（18） Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries, CELL DISCOVERY, 2021, 第 20 作者
（19） Systematic Analysis of 42 Autographa Californica Multiple Nucleopolyhedrovirus Genes Identifies An Additional Six Genes Involved in the Production of Infectious Budded Virus, Systematic Analysis of 42 Autographa Californica Multiple Nucleopolyhedrovirus Genes Identifies An Additional Six Genes Involved in the Production of Infectious Budded Virus, Virologica Sinica, 2021, 第 3 作者
（20） Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes, PLOS BIOLOGY, 2021, 第 5 作者
（21） Construction and Characterization of a Novel Bacmid AcBac-Syn Based on a Synthesized Baculovirus Genome, Construction and Characterization of a Novel Bacmid AcBac-Syn Based on a Synthesized Baculovirus Genome, Virologica Sinica, 2021, 第 2 作者
（22） Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq, Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 10 作者
（23） Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro, VIROLOGICA SINICA, 2020, 第 11 作者
（24） The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro, CELL DISCOVERY, 2020, 第 6 作者
（25） Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discovery, 2020, 第 6 作者
（26） Infection of human sweat glands by SARS-CoV-2, CELL DISCOVERY, 2020, 第 6 作者
（27） Anti-SARS-CoV-2 Potential of Artemisinins InVitro, ACS INFECTIOUS DISEASES, 2020, 第 2 作者
（28） Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2In Vitro, Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro, Virologica Sinica, 2020, 第 11 作者
（29） Baculovirus Per Os Infectivity Factor Complex: Components and Assembly, JOURNAL OF VIROLOGY, 2019, 第 7 作者

   

（ 1 ） 国际关注与难培养病毒的关键技术工具库的建立与应用研究, 负责人, 国家任务, 2025-12--2028-11
（ 2 ） 基于蛋白结构和基因组特征鉴定新型节肢动物内源性大DNA病毒, 负责人, 国家任务, 2025-01--2027-12