Our primary research involves studying cell signal transduction and the mechanisms of drug action, with specific directions including the following areas:

1. Study of Cell Signal Transduction Pathways:

• We focus on the roles of kinases and transcription factors in cell signal transduction, especially those signalling pathways that play crucial roles in how cells sense external stimuli, transmit signals to the nucleus, and regulate gene expression. By constructing models of these signaling pathways, we aim to deeply understand how cells respond to external signals and participate in various physiological processes such as inflammation, immune response, and apoptosis.

2. Function of Ion Cotransporters:

• Ion cotransporters play important roles in maintaining ion homeostasis (e.g., sodium, potassium, chloride) within the cellular environment. We study the signal transduction mechanisms of these proteins to explore their specific functions in regulating intracellular ion balance. Through these studies, we hope to reveal how cells regulate ion homeostasis under different physiological and pathological conditions.

3. Inflammation and Immune Mechanisms:

• We investigate how cells perceive and respond to inflammation and immune reactions through specific signaling pathways. The TLR4-NF-κB signaling pathway is particularly important in this regard. By studying this pathway, we aim to delve into its specific mechanisms in immune responses and its regulatory role in apoptosis.

4. Regulation of Apoptosis:

• We explore the signaling pathways and key proteins involved in the process of apoptosis. By studying these processes, we hope to understand how cells eliminate themselves through apoptosis when damaged or stimulated, thereby maintaining tissue health.

5. Intracellular Environment Homeostasis:

• We focus on the mechanisms regulating the homeostasis of ions such as sodium, potassium, and chloride. Ion homeostasis is crucial for normal cellular function. Through our research, we aim to understand the changes in these mechanisms under physiological and pathological conditions and their impact on cellular function.

6. Biological Characteristics of Related Diseases:

• Through the aforementioned research, we hope to uncover the biological characteristics of various diseases (such as cancer, inflammatory diseases, autoimmune diseases, neurodegenerative diseases, etc.). Understanding the occurrence and development mechanisms of these diseases provides scientific bases for their early diagnosis and treatment.

7. Small Molecule Regulation Research:

• By screening and designing small molecule drugs, we study their regulatory effects on the aforementioned signaling pathways and ion cotransporters. Our goal is to develop novel small molecule drugs for the intervention and treatment of related diseases. These studies not only help us understand the molecular mechanisms of drug actions but also provide important theoretical foundations for new drug development.

We look forward to welcoming students who are interested in cell signal transduction, mechanisms of drug action, and related fields of research to join us. Together, we can explore the mysteries of life sciences and contribute to the advancements in biomedical and biopharmaceutical sciences.

现指导学生

耿午珺  硕士研究生  0703Z1-化学生物学