基本信息
李思睿  女    中国科学院分子细胞科学卓越创新中心
电子邮件: siruilitree210503@gmail.com
通信地址: 中国上海市徐汇区岳阳路320号
邮政编码: 200031

招生信息

   
招生专业
100102-免疫学
071009-细胞生物学
招生方向
免疫学
肿瘤免疫治疗
核酸识别信号

教育背景

2014-09--2018-01   中国科学院大学   博士学位
2011-09--2014-07   中国科学院大学   硕士学位
2007-09--2011-06   延边大学   学士学位

工作经历

   
工作简历
2023-05~2024-07,北卡罗来纳大学教堂山分校 The University of North Carolina at Chapel Hill, 副研究员
2019-01~2023-04,北卡罗来纳大学教堂山分校 The University of North Carolina at Chapel Hill, 博士后
2018-05~2019-01,德克萨斯大学安德森癌症中心 The University of Texas M.D. Anderson Cancer Center, 博士后

专利与奖励


奖励信息
(1) Joseph S. Pagano Award, 研究所(学校), 2023
专利成果
( 1 ) Compositions and Methods for Treating Cancer, 发明专利, 2023, 第 1 作者, 专利号: PCT/US2023/074642

出版信息

   
发表论文
(1) Advances in the prerequisite and consequence of STING downstream signalosomes, Medical Review, 2024, 通讯作者
(2) The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges, Medical Review, 2024, 通讯作者
(3) Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways, Nature Nanotechnology, 2024, 第 2 作者
(4) A 360° view of the inflammasome: mechanisms of activation, cell death, and disease, Cell, 2023, 第 2 作者
(5) The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates, Proceedings of the National Academy of Sciences, 2023, 第 6 作者
(6) UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders, Cell Metabolism, 2023, 第 5 作者
(7) STING-induced regulatory B cells compromise NK function in cancer immunity, NATURE, 2022, 第 1 作者
(8) Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity, Cell Reports Medicine, 2022, 第 3 作者
(9) Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration, Nature Nanotechnology, 2022, 第 7 作者
(10) ADP-Ribosyltransferase PARP11 Suppresses Zika Virus in Synergy with PARP12, Cell & Bioscience, 2021, 第 3 作者
(11) mRNA Delivery of a Bispecific Single-Domain Antibody to Polarize Tumor-Associated Macrophages and Synergize Immunotherapy against Liver Malignancies, Advanced Materials, 2021, 第 3 作者
(12) TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral innate immune signaling through promoting TBK1 K48 ubiquitination, Nature communications, 2020, 第 5 作者
(13) In vitro inhibition of hepatic stellate cell activation by the autophagy-related lipid droplet protein ATG2A, SCIENTIFIC REPORTS, 2018, 第 2 作者
(14) Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype, JOURNAL OF IMMUNOLOGY, 2015, 第 4 作者
(15) The tumor immunosuppressive microenvironment impairs the therapy of anti-HER2/neu antibody, PROTEIN & CELL, 2012, 第 4 作者

科研活动

   
科研项目
( 1 ) Intracellular Innate Immune Receptors in Cancer Suppression and Immunotherapy, 参与, 其他, 2019-09--2026-08
参与会议
(1)The perspective of STING agonists and IL-35 blockade in solid tumor therapy   2023-12-15