081703-生物化工

生物材料，核酸药物递送技术，生物医学成像，RNA治疗

2018-09--2021-06   中国科学院过程工程研究所   博士
2014-09--2018-01   中国科学院过程工程研究所   硕士
2010-09--2014-06   青岛科技大学   学士

   

2023-08~现在, 中国科学院过程工程研究所, 副研究员
2023-05~2023-08,中国科学院过程工程研究所, 助理研究员
2021-06~2023-05,中国科学院过程工程研究所, 博士后
2018-09~2021-06,中国科学院过程工程研究所, 博士
2014-09~2018-01,中国科学院过程工程研究所, 硕士
2010-09~2014-06,青岛科技大学, 学士

   

（1） 适配多元化核酸药物治疗的载体输递系统构建与机制研究, 二等奖, 部委级, 2021

（ 1 ） 一种CRISPR/Cas9递送体系及其制备方法和应用, 2022, 第 3 作者, 专利号: CN115068631A

（ 2 ） 一种均三嗪基修饰的空心介孔二氧化硅及其制备方法和应用, 2022, 第 2 作者, 专利号: CN114455592A

（ 3 ） 一种均三嗪基修饰的空心介孔二氧化硅及其制备方法和应用, 2022, 第 2 作者, 专利号: CN114455592A

（ 4 ） 一种活性基团修饰的介孔二氧化硅纳米香料及其制备方法, 2022, 第 2 作者, 专利号: CN113969211A

（ 5 ） 温度和pH双重响应缓释芳香纳米凝胶、制备方法及应用, 2020, 第 2 作者, 专利号: CN110982623A

（ 6 ） 姜黄素香料体系、制备方法及应用, 2019, 第 5 作者, 专利号: CN109771662A

（ 7 ） pH响应缓控释的聚合物纳米香料及其制备方法, 2019, 第 4 作者, 专利号: CN109518463A

（ 8 ） 温控缓释的介孔二氧化硅纳米香料及其制备方法, 2019, 第 4 作者, 专利号: CN109504537A

（ 9 ） 光响应缓释的聚合物纳米香料及其制备方法, 2018, 第 3 作者, 专利号: CN108546595A

（ 10 ） 光控缓释的球形二氧化硅纳米香料及其制备方法, 2018, 第 3 作者, 专利号: CN108531292A

（ 11 ） 光控缓释的棒状二氧化硅纳米香料及其制备方法, 2018, 第 2 作者, 专利号: CN108441323A

   

（1） Smart antioxidant function enhancing (SAFE) nucleic acid therapy for ROS-related chronic diseases and comorbidities, BIOACTIVE MATERIALS, 2024, 第 1 作者
（2） Nucleic acid drug vectors for diagnosis and treatment of brain diseases, Nucleic acid drug vectors for diagnosis and treatment of brain diseases, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 第 1 作者  通讯作者
（3） 两性离子材料在生物化工领域的应用, Application of Zwitterionic Materials in Biochemical Industry, 化学反应工程与工艺, 2023, 第 6 作者
（4） Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs' Spatiotemporal Behaviors, ADVANCED FUNCTIONAL MATERIALS, 2023, 第 13 作者  通讯作者
（5） Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery, THERANOSTICS, 2021, 第 6 作者
（6） Preparation of mesoporous silica nanoparticle with tunable pore diameters for encapsulating and slowly releasing eugenol, Preparation of mesoporous silica nanoparticle with tunable pore diameters for encapsulating and slowly releasing eugenol, CHINESE CHEMICAL LETTERS, 2021, 第 2 作者
（7） Self-Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases, ADVANCED MATERIALS, 2021, 第 9 作者
（8） Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies, MATERIALS HORIZONS, 2021, 第 4 作者
（9） Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment, ADVANCED MATERIALS, 2021, 第 2 作者
（10） Zwitterionic comb-like lipid polymers encapsulating linalool for increasing the fragrance retention time, Zwitterionic comb-like lipid polymers encapsulating linalool for increasing the fragrance retention time, CHINESE CHEMICAL LETTERS, 2021, 第 2 作者
（11） pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery, RSC ADVANCES, 2020, 第 4 作者
（12） Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk, Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk, CHINESE CHEMICAL LETTERS, 2020, 第 1 作者
（13） Nano-Fragrance with pH-Sensitive Release Property for Improvement of Central Nervous System, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2020, 第 2 作者
（14） Effect of mesoporous silica nanoparticles-based nano-fragrance on the central nervous system, ENGINEERING IN LIFE SCIENCES, 2020, 第 1 作者
（15） Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition, Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition, BIOACTIVE MATERIALS, 2020, 第 1 作者
（16） An "Amyloid-beta Cleaner" for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction, ADVANCED SCIENCE, 2020, 第 4 作者
（17） Exosome: a significant nano-scale drug delivery carrier, JOURNAL OF MATERIALS CHEMISTRY B, 2020, 第 5 作者
（18） Cationic Nano-Fragrance with Sustained Release Property for Neuroregulation, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2020, 第 2 作者
（19） Chitosan-based nanofragrance with antibacterial function applied to wallpaper, ENGINEERING IN LIFE SCIENCES, 2020, 第 2 作者
（20） Advances of Nanoparticles for Leukemia Treatment, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 第 2 作者
（21） Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 第 1 作者
（22） Drug Delivery System in the Treatment of Diabetes Mellitus, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 第 2 作者
（23） Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection, NANOMATERIALS, 2020, 第 2 作者
（24） Preparation of hollow mesoporous silica nanorods for encapsulating and slowly releasing eugenol, Preparation of hollow mesoporous silica nanorods for encapsulating and slowly releasing eugenol, CHINESECHEMICALLETTERS, 2020, 第 2 作者
（25） Hollow Mesoporous Silica Nanoparticles Loaded with Eugenol for Regulating the Central Nervous System, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2020, 第 2 作者
（26） Preparation of photo-responsive nanomicelles loaded with sandela 803 for wallpaper application, NANOSCIENCE AND NANOTECHNOLOGY LETTERS, 2019, 第 2 作者
（27） Mesoporous silica nanospheres with the ability of photo-driven releasing sandela 803 for the application to wallpaper, Mesoporous silica nanospheres with the ability of photo-driven releasing sandela 803 for the application to wallpaper, 中国化学快报:英文版, 2019, 第 3 作者
（28） Synthesis and characterization of novel biocompatible nanocapsules encapsulated lily fragrance, Synthesis and characterization of novel biocompatible nanocapsules encapsulated lily fragrance, 中国化学快报(英文版), 2019, 第 3 作者
（29） Mesoporous silica nanospheres with the ability of photo-driven releasing sandela 803 for the application to wallpaper, CHINESE CHEMICAL LETTERS, 2019, 第 3 作者
（30） 高分子纳米香精制备的研究进展, Preparation of polymer nano-fragrance:a review, 中国科学:化学, 2019, 第 3 作者
（31） An "Amyloid-beta Cleaner" for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction, ADVANCED SCIENCE, 2019, 第 4 作者
（32） Light-activated nanoparticles encapsulated with santalum album: a potential therapeutic agent for neurodegenerative disease, NANOSCIENCE AND NANOTECHNOLOGY LETTERS, 2019, 第 4 作者
（33） Synthesis and characterization of novel biocompatible nanocapsules encapsulated lily fragrance, CHINESE CHEMICAL LETTERS, 2019, 第 3 作者
（34） 光敏纳米香料应用于壁纸及香气缓控释的研究, The application of photo-sensitive nano fragrance on wallpaper, 中国科学:化学, 2019, 第 3 作者
（35） Cell-addictive dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway, THERANOSTICS, 2018, 第 3 作者
（36） Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2018, 第 1 作者
（37） Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2018, 第 1 作者
（38） Effects of Wallpaper with the Ability of Photo-Activated Releasing Fragrance on Central Nervous System, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2018, 第 2 作者
（39） CRISPR药物递送系统的研究现状及发展趋势, 中国医药工业杂志, 2018, 第 3 作者
（40） Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 4 作者
（41） Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment, ADVANCED FUNCTIONAL MATERIALS, 2017, 第 1 作者
（42） Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages, THERANOSTICS, 2017, 第 5 作者
（43） Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy, ADVANCED MATERIALS, 2016, 第 4 作者
（44） Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy, SMALL, 2016, 第 3 作者
（45） JOURNAL OF NANOBIOTECHNOLOGY, 第 9 作者

   

（ 1 ） mRNA 药物靶向递释系统构筑、组装机制及构效关系, 参与, 国家任务, 2023-12--2028-11
（ 2 ） 基于“NATURE”设计理念的精准靶向仿生递送平台, 参与, 国家任务, 2023-11--2026-10
（ 3 ） 生物界面微环境适配的CT/MRI多模态成像活体实时示踪siRNA在肿瘤病灶富集-释放过程的研究, 负责人, 国家任务, 2023-01--2025-12