070302-分析化学
0703Z1-化学生物学

动态核极化增强固体核磁共振的方法与应用
GPCR分子机制与药物开发

   

（1） Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways, Nature Communications, 2025, 第 27 作者
（2） Relevance of G protein���coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation, Br. J. Pharmacol., 2024, 第 6 作者
（3） Multitasking Pharmacophores Support Cabotegravir-Based Long-Acting HIV Pre-Exposure Prophylaxis (PrEP), Molecules, 2024, 
（4） Molecular mechanisms and evolutionary robustness of a color switch in proteorhodopsins, Science Advances, 2024, 
（5） Room-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water, Nature Communications, 2021, 
（6） Cysteine oxidation and disulfide formation in the ribosomal exit tunnel, Nature Communications, 2020, 第 1 作者
（7） Light Dynamics of the Retinal���Disease���Relevant G90D Bovine Rhodopsin Mutant, Angewandte Chemie, 2020, 第 1 作者
（8） Exploring Protein Structures by DNPEnhanced Methyl Solid-State NMR Spectroscopy, Journal of the American Chemical Society, 2019, 
（9） The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors, Nature Chemical Biology, 2018, 第 1 作者
（10） Antigenic Peptide Recognition on the Human ABC Transporter TAP Resolved by DNPEnhanced Solid-State NMR Spectroscopy, Journal of the American Chemical Society, 2016, 第 1 作者
（11） Structural Basis of the Green���Blue Color Switching in Proteorhodopsin as Determined by NMR Spectroscopy, Journal of the American Chemical Society, 2014, 第 1 作者
（12） Host���Guest Complexes as Water- Soluble High-Performance DNP Polarizing Agents, Journal of the American Chemical Society, 2013, 第 1 作者

   

（ 1 ） 毛佳飞海外人才项目, 负责人, 研究所自主部署, 2024-10--2026-12
（ 2 ） 毛佳飞引才青年经费补助, 负责人, 研究所自主部署, 2024-05--2027-05
（ 3 ） 毛佳飞国家引才青年项目, 负责人, 其他, 2024-05--2027-05
（ 4 ） 毛佳飞引进人才启动经费, 负责人, 研究所自主部署, 2023-09--2025-12
（ 5 ） 毛佳飞开发基金, 负责人, 研究所自主部署, 2023-09--2035-12

（1）Allosteric ligands induce structural diversity of orthosteric peptide agonist in human bradykinin 1 receptor   2023-06-14
（2）Liquid-state DNP NMR spectroscopy of biological molecules in water   2023-05-20
（3）Room-Temperature DNP NMR spectroscopy of small biological molecules in water   2021-07-15
（4）Decoding GPCR Functions by Sensitivity-Enhanced Solid-State NMR Spectroscopy   2019-05-21
（5）Understanding Ligand Selectivity of GPCR Subtypes – A View of Peptide Ligands from SSNMR Spectroscopy Enhanced by DNP   2016-02-18