基本信息
杨继榕 女 硕导 中国科学院深圳先进技术研究院
电子邮件: jr.yang@siat.ac.cn
通信地址: 广东省深圳市南山区西丽桃源街道学苑大道1068号
邮政编码: 518055
电子邮件: jr.yang@siat.ac.cn
通信地址: 广东省深圳市南山区西丽桃源街道学苑大道1068号
邮政编码: 518055
招生信息
招生专业
071010-生物化学与分子生物学071009-细胞生物学
招生方向
生物3D打印骨软骨修复再生干细胞分化调控
教育背景
2013-09--2019-06 四川大学 博士/工学博士2009-09--2013-06 四川大学 本科/工学学士
工作经历
工作简历
2023-01~现在, 中国科学院深圳先进技术研究院, 副研究员2019-07~2022-12,中国科学院深圳先进技术研究院, 助理研究员2013-09~2019-06,四川大学, 博士/工学博士2009-09~2013-06,四川大学, 本科/工学学士
专利与奖励
专利成果
( 1 ) 一种力学响应的中空水凝胶支架及其制备方法和在负载细胞中的应用, 2022, 第 2 作者, 专利号: CN202210925915.8( 2 ) 间充质干细胞成骨分化诱导液以及哌嗪的应用, 2022, 第 3 作者, 专利号: CN202210843283.0( 3 ) 水溶性体系的合成高分子生物墨水及其制备方法和应用, 2022, 第 3 作者, 专利号: CN202210291906.8( 4 ) 用于活细胞3D打印的组合物和方法, 2022, 第 5 作者, 专利号: CN114053483A( 5 ) 径向渗透实验装置、方法, 2021, 第 3 作者, 专利号: CN202111236239.5( 6 ) 一种复合细胞的海藻酸钠-明胶双网络水凝胶前驱体及制备方法和带有其的打印墨水及支架, 2021, 第 3 作者, 专利号: CN112646100A( 7 ) 功能化淫羊藿苷衍生物及其制备方法与应用, 2015, 第 3 作者, 专利号: CN104447913A( 8 ) 淫羊藿苷控释型壳聚糖/羟基磷灰石复合支架材料及其制备方法, 2015, 第 2 作者, 专利号: CN104368045A
出版信息
发表论文
(1) Structure driven bio-responsive ability of injectable nanocomposite hydrogels for efficient bone regeneration, Biomaterials, 2024, (2) A mechanical-assisted post-bioprinting strategy for challenging bone defects repair, Nature Communications, 2024, 第 1 作者(3) Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting, Bio-Design and Manufacturing, 2023, 第 1 作者(4) Small-molecule amines: a big role in the regulation of bone homeostasis, Bone Research, 2023, 第 2 作者(5) Digital light processing-bioprinted poly-NAGA-GelMA-based hydrogel lenticule for precise refractive errors correction, Biofabrication, 2023, 第 2 作者(6) In-situ mineralized homogeneous collagen-based scaffolds for potential guided bone regeneration, Biofabrication, 2022, 第 7 作者(7) A universally dispersible graphene-based ink modifier facilitates 3D printing of multi-functional tissue-engineered scaffolds, Materials & Design, 2022, 第 5 作者(8) 3D-printed pre-tapped-hole scaffolds facilitate one-step surgery of predictable alveolar bone augmentation and simultaneous dental implantation, COMPOSITES PART B-ENGINEERING, 2022, 第 5 作者(9) Icariin self-crosslinked network functionalized strontium-doped bioceramic scaffolds synergistically enhanced the healing of osteoporotic bone defects, Composits Part B-Engineering, 2022, 第 2 作者(10) Comparison of chondro-inductivity between collagen and hyaluronic acid hydrogel based on chemical/physical microenvironment, International Journal of Biological Macromolecules, 2021, 第 1 作者(11) Coaxial Scale-Up Printing of Diameter-Tunable Biohybrid Hydrogel Microtubes with High Strength, Perfusability, and Endothelialization, ADVANCED FUNCTIONAL MATERIALS, 2020, 第 4 作者(12) Temperature-programmable and enzymatically solidifiable gelatin-based bioinks enable facile extrusion bioprinting, BIOFABRICATION, 2020, 第 5 作者(13) The negatively charged microenvironment of collagen hydrogels regulates the chondrogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo, Journal of Materials Chemistry B, 2020, 第 1 作者(14) Development of an injectable thiolated icariin functionalized collagen/hyaluronic hydrogel to promote cartilage formation in vitro and in vivo, JOURNAL OF MATERIALS CHEMISTRY B, 2019, 第 2 作者(15) Influence of hydrogel network microstructures on mesenchymal stem cell chondrogenesis in vitro and in vivo, Acta Biomaterialia, 2019, 第 1 作者(16) Methacrylamide-modified collagen hydrogel with improved anti-actin-mediated matrix contraction behavior, JOURNAL OF MATERIALS CHEMISTRY B, 2018, 第 4 作者(17) Collagen structure regulates MSCs behavior by MMPs involved cell-matrix interactions, JOURNAL OF MATERIALS CHEMISTRY B, 2018, 第 3 作者(18) Icariin conjugated hyaluronic acid/collagen hydrogel for osteochondral interface restoration, Acta Biomaterialia, 2018, 第 1 作者(19) Photo-crosslinked mono-component type II collagen hydrogel as a matrix to induce chondrogenic differentiation of bone marrow mesenchymal stem cells, JOURNAL OF MATERIALS CHEMISTRY B, 2017, 第 5 作者(20) Effects of Composition and Mechanical Property of Injectable Collagen I/II Composite Hydrogels on Chondrocyte Behaviors, TISSUE ENGINEERING PART A, 2016, 第 3 作者(21) Conjugated icariin promotes tissue-engineered cartilage formation in hyaluronic acid/collagen hydrogel, PROCESS BIOCHEMISTRY, 2015, 第 3 作者(22) Preparation and characterization of a novel hyaluronic acid���icariin conjugate hydrogel, MATERIALS LETTERS, 2014, 第 2 作者
科研活动
科研项目
( 1 ) 生物3D打印组织工程骨的细胞空间效应及其介导骨质疏松骨折修复的研究, 负责人, 地方任务, 2024-01--2026-12( 2 ) 软组织修复水凝胶结构性能调控及3D打印关键技术, 参与, 国家任务, 2023-01--2025-12( 3 ) 生物打印构建多细胞空间分布的组织工程骨及其细胞交互作用调控骨再生机制研究, 负责人, 国家任务, 2021-01--2023-12( 4 ) 仿骨-软骨差异性功能微环境的一体化支架生物3D打印构建及其促再生机制研究, 参与, 国家任务, 2021-01--2024-12( 5 ) 基2020N035生物打印细胞-生物材料复合的仿髁状突支架及其促再生机制研究, 参与, 地方任务, 2020-12--2023-10
参与会议
(1)Structure driven bio-responsive ability of injectable nanocomposite hydrogels for efficient bone regeneration 2023年中国生物材料大会 2023-10-15