基本信息
郑宏毅  男  硕导  中国科学院昆明动物研究所
电子邮件: zhenghongyi@mail.kiz.ac.cn
通信地址: 五华区校场动物32号昆明动物研究所
邮政编码: 650223

招生信息

   
招生方向
病毒免疫学

教育背景

2010-09--2016-06   中国科学技术大学   博士研究生学历,理学博士学位
2006-09--2010-05   安徽医科大学   本科学历,学士学位

工作经历

   
工作简历
2021-01~现在, 中国科学院昆明动物研究所, 副研究员
2016-06~2021-06,中国科学院昆明动物研究所, 博士后
2010-09~2016-06,中国科学技术大学, 博士研究生学历,理学博士学位
2006-09~2010-05,安徽医科大学, 本科学历,学士学位
社会兼职
2023-04-01-2027-03-31,中国免疫学会青年工作委员会, 委员

出版信息

   
发表论文
(1) Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, CELL DISCOVERY, 2023, 第 14 作者
(2) Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFN gamma Secretion of CD8+T Cells, VIRUSES-BASEL, 2022, 第 5 作者
(3) CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity, CELL DISCOVERY, 2022, 第 30 作者
(4) SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury, SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury, SIG TRANSDUCT TARGET THER, 2022, 第 6 作者
(5) Retrospective study of the immunogenicity and safety of the CoronaVac SARS-CoV-2 vaccine in people with underlying medical conditions, COMMUNICATIONS MEDICINE, 2022, 第 16 作者
(6) Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling, Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling, CELLULAR & MOLECULAR IMMUNOLOGY, 2022, 第 1 作者
(7) Jejunal epithelial barrier disruption triggered by reactive oxygen species in early SIV infected rhesus macaques, FREERADICALBIOLOGYANDMEDICINE, 2021, 第 3 作者
(8) Stability of SARS-CoV-2 on the Surfaces of Three Meats in the Setting That Simulates the Cold Chain Transportation, Stability of SARS-CoV-2 on the Surfaces of Three Meats in the Setting That Simulates the Cold Chain Transportation, VIROLOGICA SINICA, 2021, 第 4 作者
(9) Pro-inflammatory microenvironment and systemic accumulation of CXCR3+cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2, Pro-inflammatory microenvironment and systemic accumulation of CXCR3+cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 1 作者
(10) TSA法多重免疫荧光染色在猴艾滋病模型病理研究中的应用, Application of multiple immunofluorescence staining based on TSA method in pathological study of simian acquired immunodeficiency disease syndrome(SAIDS)model, 赣南医学院学报, 2021, 第 2 作者
(11) Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3, JOURNAL OF VIROLOGY, 2021, 第 5 作者
(12) Northern pig-tailed macaques(Macaca leonina)infected with SARS-CoV-2 show rapid viral clearance and persistent immune response, Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response, ZOOLOGICAL RESEARCH, 2021, 第 2 作者
(13) Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy, ACS OMEGA, 2021, 通讯作者
(14) Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, ZOOLOGICAL RESEARCH, 2021, 第11作者
(15) Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients, Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients, CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 第 1 作者
(16) Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques, Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques, ZOOLOGICAL RESEARCH, 2020, 第 2 作者
(17) Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19, Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 1 作者
(18) CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS, ANTIVIRAL RESEARCH, 2018, 其他(合作组作者)
(19) Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, SCIENCE CHINA LIFE SCIENCES, 2018, 第 2 作者
(20) Northern pig-tailed macaques (Macaca leonina) maintain superior CD4 + T-cell homeostasis during SIVmac239 infection, EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 第 2 作者
(21) Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, 中国科学:生命科学英文版, 2018, 第 4 作者
(22) Host restriction factors apobec3g/3f and other interferon-related gene expressions affect early hiv-1 infection in northern pig-tailed macaque (macaca leonina), FRONTIERS IN IMMUNOLOGY, 2018, 第 5 作者
(23) Association of TRIMCyp and TRIM5 alpha from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, SCIENCE CHINA-LIFE SCIENCES, 2018, 第 4 作者
(24) Predict disease progression from T‐cell phenotypes in northern pig‐tailed macaques ( Macaca leonina ) during SIVmac239 infection, IMMUNOLOGY, 2017, 第 2 作者
(25) Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence, SCIENTIFIC REPORTS, 2017, 第 1 作者
(26) HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo, HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo, 科学通报:英文版, 2017, 第 4 作者
(27) 免疫衰老在艾滋病发病中的作用及治疗策略研究进展, 中国免疫学杂志, 2017, 第 1 作者
(28) HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo, SCIENCE BULLETIN, 2017, 第 4 作者
(29) Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239, IMMUNOLOGY, 2016, 第 3 作者
(30) Viral seroprevalence in northern pig-tailed macaques (Macaca leonina) derived from Ho Chi Minh City, Vietnam, PRIMATES, 2016, 第 2 作者
(31) Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque, JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 第 3 作者
(32) High immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infected Chinese rhesus macaques, ARCHIVES OF VIROLOGY, 2015, 第 5 作者
(33) The Effect of Exon 7 Deletion during the Evolution of TRIMCyp Fusion Proteins on Viral Restriction, Cytoplasmic Body Formation and Multimerization, PLOSONE, 2015, 第 4 作者
(34) Longitudinal analysis reveals characteristically high proportions of bacterial vaginosis-associated bacteria and temporal variability of vaginal microbiota in northern pig-tailed macaques (Macaca leonina)., ZOOLOGICAL RESEARCH, 2015, 第 3 作者
(35) Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques (Macaca leonina), ZOOLOGICAL RESEARCH, 2014, 
(36) Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences, EXPERIMENTAL GERONTOLOGY, 2014, 第 1 作者
(37) Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque (Macaca leonina), ZOOLOGICAL RESEARCH, 2014, 第 5 作者
(38) Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5, MOLECULAR BIOLOGY AND EVOLUTION, 2014, 第 6 作者

科研活动

   
科研项目
( 1 ) 基于金黄地鼠模型研究新冠肺炎发病和免疫保护中的T细胞调控机制, 负责人, 地方任务, 2022-04--2025-03