基本信息
王林  男  硕导  中国科学院昆明动物研究所
电子邮件: wanglin2015@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区青松路21号423
邮政编码:

招生信息

   
招生专业
071009-细胞生物学
招生方向
多能干细胞基因组稳态维持

教育背景

2006-09--2011-07   北京协和医学院   博士
2001-09--2005-07   云南大学   本科

工作经历

   
工作简历
2022-01~现在, 中国科学院昆明动物研究所, 副研究员
2015-09~2021-12,中国科学院昆明动物研究所, 助理研究员
2011-09~2015-09,清华大学, 博士后
2006-09~2011-07,北京协和医学院, 博士
2001-09~2005-07,云南大学, 本科

出版信息

   
发表论文
(1) Characterization of long-term ex vivo expansion of tree shrew spermatogonial stem cells., ZOOLOGICAL RESEARCH, 2023, 第 3 作者
(2) Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells, STEM CELL REPORTS, 2023, 第 2 作者
(3) Lnc956 -TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis, SCIENCE ADVANCES, 2023, 第 3 作者
(4) DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 第 2 作者
(5) Lnc956 regulates mouse embryonic stem cell differentiation in response to DNA damage in a p53-independent pathway, SCIENCE ADVANCES, 2023, 第 3 作者
(6) Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system, BIOMATERIALS, 2021, 第 8 作者
(7) A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability, NATURE COMMUNICATIONS, 2021, 第 1 作者
(8) Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair, THERANOSTICS, 2020, 第 1 作者
(9) Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia, SCIENCE ADVANCES, 2020, 第 3 作者
(10) In vitro culture of cynomolgus monkey embryos beyond early gastrulation, SCIENCE, 2019, 第 6 作者
(11) Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells, SCIENCE ADVANCES, 2019, 第 18 作者
(12) Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, ZOOLOGICAL RESEARCH, 2018, 第 2 作者
(13) Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells, STEM CELL RESEARCH & THERAPY, 2018, 第 5 作者
(14) Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program, PROTEIN & CELL, 2018, 第 2 作者
(15) Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes, 动物学研究, 2018, 第 2 作者
(16) Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring, CELL RESEARCH, 2017, 第 6 作者
(17) Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells, STEM CELL RESEARCH & THERAPY, 2017, 第 2 作者
(18) Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2011, 第 1 作者

科研活动

   
科研项目
( 1 ) 胚胎干细胞特异基因Dppa5通过可变剪接调控基因组稳态的分子机制研究, 负责人, 地方任务, 2023-06--2026-05
( 2 ) 中国科学院西部之光, 负责人, 其他国际合作项目, 2023-01--2025-12
( 3 ) 云南省兴滇英才支持计划-青年人才, 负责人, 其他国际合作项目, 2022-11--2027-10
( 4 ) Filia泛素化修饰在胚胎干细胞遗传物质稳定性中的调控作用及其分子机理研究, 负责人, 国家任务, 2019-01--2021-12
( 5 ) 胚胎干细胞特异基因Filia通过调节Atm的可变剪接维持基因组稳定的机制研究, 负责人, 地方任务, 2018-06--2021-05
( 6 ) 自噬和DNA损伤修复维持PSC稳态的机制研究, 负责人, 国家任务, 2016-06--2021-05