电子邮件： wuzhaofa@genetics.ac.cn
通信地址： 北京市朝阳区北辰西路1号院2号,遗传与发育生物学研究所
邮政编码： 100101
研究领域
本课题组结合荧光探针技术开发、活体荧光成像以及光遗传学/药理学/基因编辑等操控手段研究神经通讯与脑功能。
具体研究内容包括：
1) 嘌呤类分子的检测及其在大脑生理（睡眠等）及病理（癫痫、中风等）过程的功能；
2) 大脑中不同细胞类型的能量代谢调控规律和机制；
3) 结合新型成像工具和操控手段研究神经-肿瘤之间的通讯。
招生信息
招生专业
招生方向
教育背景
工作经历
工作简历
出版信息
# 共同作者; * 通讯作者
代表性论文：
Wu, Z.#, Cui, Y.#, Wang, H.#, …, Xu, M., Luo, M.* & Li, Y.*(2023), Neuronal activity-induced, ENT-dependent, somatodendritic adenosine release revealed by a GRAB sensor. PNAS, 120(14), e2212387120.
Wu, Z.*, He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T., Xi, F., Deng, F., Wang, H., Du, J., Jing, M., & Li, Y.* (2022). A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. Neuron, 110, 770-782 e775.
—See Comments Highlight by: Umpierre, A. D., Haruwaka, K., & Wu, L. J.*(2022). Getting a Sense of ATP in Real Time. Neuroscience Bulletin, 1-3.
—Selected as the “Best of Neuron 2021-2022”.Peng, W.#, Wu, Z.#, Kun, S.#, Zhang, S., Li, Y. & Min, X.* (2020). Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. Science, 369, 1208.
—Highlights by Whalley K., Nature Reviews Neuroscience. 2020 Nov;21(11):593-593.Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics.
Wu, Z., Lin, D. & Li, Y.*. Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. Nature Reviews Neuroscience, 23, 257–274.
Wu, Z.*, & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, 35-43. (Cover).
Qian, C., Wu, Z.#, Sun, R.#, Yu, H., Zeng, J., Rao, Y., & Li, Y.* (2021). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. eLife, 10, e65417.
其它论文：
Zhou, X.#, He, Y.#, Xu, T.#, Wu, Z.#, Guo, W., Xu, X., ... & Chen, J. F.* (2024). 40 Hz light flickering promotes sleep through cortical adenosine signaling. Cell Research, 1-18.
Hatashita, Y., Wu, Z., Fujita H., Kumamoto T., Livet, J., Li, Y., Tanifuji M., & Inoue, T.* (2023). Spontaneous and multifaceted ATP release from astrocytes at the scale of hundreds of synapses. Glia, 71(9), 2250-2265.
Peng, W.#*, Liu, X.#, Ma, G.#, Wu, Z., … Zhang, S.*, & Min, X.* (2023). Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity. Cell Discovery, 9(1), 16.
Li, X., Li, Y., Zhou, Y., …, Wu, Z., ... & Dai, Q.* (2023). Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit. Nature Biotechnology, 41, 282–292.
Pittolo, S., Yokoyama, S., Willoughby, D., ... Wu, Z., … & Poskanzer, K. E.* (2022). Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors. Cell Reports, 40.
Chen, Y.#, Luan, P.#, Liu, J.#, Wei, Y., Wu, Z., & Jing, M.* (2022). Spatiotemporally selective ATP events from astrocytes encode injury information and guide sustained microglial response. bioRxiv preprint, https://doi.org/10.1101/2022.06.21.497103.
Lin, R.#*, Zhou, Y.#, Yan, T.#, Wang, R.#, Li, H., Wu, Z., ... & Luo, M.* (2022). Directed evolution of adeno-associated virus for efficient gene delivery to microglia. Nature Methods, 1-10.
Dai, R., Yu, T., Weng, D., Li, H., Cui, Y., Wu, Z., ... & Luo, M.* (2022). A neuropsin-based optogenetic tool for precise control of Gq signaling. Sci. China Life Sci., 1-14.
Roberts B., Lambert E., Livesey J., Wu, Z., Li, Y. & Cragg S.* (2022). Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol. The Journal of Neuroscience, 42, 1738-1751.
Lu, C.#, Ren, J.#, Mo J., …, Wu, Z., Li, Y., Gao, T., Cao, X.* (2022). Glucocorticoid receptor-dependent astrocytes mediate stress vulnerability. Biological Psychiatry, 92(3), 204-215.
Wang, Q.#, Kong, Y.#, Wu, D. Y., ..., Wu, Z., Li, Y., Yang, J.*, & Gao, T.* (2021). Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice. Nature communications, 12(1), 1-13.
Feng, J., Zhang, C., Lischinsky, J. E., …, Wu, Z., ... Lin, D., Du, J., & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761.
Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., …, Lei, X., Luo, W.* & Li, Y.* (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431.