基本信息
胡振一 男 博导 中国科学院上海有机化学研究所
电子邮件: Zhenyi.hu@sioc.ac.cn
通信地址: 浦东新区张江高科技园区海科路100号
邮政编码:
电子邮件: Zhenyi.hu@sioc.ac.cn
通信地址: 浦东新区张江高科技园区海科路100号
邮政编码:
招生信息
招生专业
0703Z1-化学生物学100701-药物化学071010-生物化学与分子生物学
招生方向
化学生物学药物化学分子生物学
教育背景
2013-09--2018-08 科罗拉多大学博尔德分校 博士2009-09--2012-07 中科院上海药物所 硕士2005-09--2009-07 中国药科大学 本科
工作经历
工作简历
2018-11~2023-05,耶鲁大学, 博士后2013-09~2018-08,科罗拉多大学博尔德分校, 博士2012-07~2013-07,清华大学, 科研助理2009-09~2012-07,中科院上海药物所, 硕士2005-09~2009-07,中国药科大学, 本科
专利与奖励
专利成果
( 1 ) Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof, 2022, 专利号: US11466010B2( 2 ) TOLL样受体8(TLR8)特异性拮抗剂及其制备方法和用途, 2020, 第 3 作者, 专利号: CN111542515A
出版信息
发表论文
(1) Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 第 1 作者(2) Recent Developments in PROTAC-mediated Protein Degradation: From Bench to Clinic, CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, 2022, 第 1 作者(3) Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic, CHEMBIOCHEM, 2022, 第 1 作者(4) Protocol for evaluation and validation of TLR8 antagonists in HEK-Blue cells via secreted embryonic alkaline phosphatase assay, STAR PROTOCOLS, 2022, 第 1 作者(5) Targeted Degradation of Transcription Factors by TRAFTACs: TRAnscription Factor Targeting Chimeras, CELL CHEMICAL BIOLOGY, 2021, 第 6 作者(6) Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs), ACS CHEMICAL BIOLOGY, 2021, 第 2 作者(7) Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic, CHEMBIOCHEM, 2021, 第 1 作者(8) Sensing of HIV-1 by TLR8 activates human T cells and reverses latency, NATURE COMMUNICATIONS, 2020, 第 6 作者(9) TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria, JOURNAL OF LEUKOCYTE BIOLOGY, 2020, 第 6 作者(10) Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling, FRONTIERS IN IMMUNOLOGY, 2019, 第 8 作者(11) Small-molecule inhibition of TLR8 through stabilization of its resting state, NATURE CHEMICAL BIOLOGY, 2018, 第 2 作者(12) Small-Molecule TLR8 Antagonists via Structure-Based Rational Design, CELL CHEMICAL BIOLOGY, 2018, 第 1 作者(13) Synthesis of withasomnine and pyrazole derivatives via intramolecular dehydrogenative cyclization, as well as biological evaluation of withasomnine-based scaffolds, ORGANIC CHEMISTRY FRONTIERS, 2018, 第 2 作者(14) Dictamins A���C, three unprecedented apotirucallane-type trinortriterpenoids from Dictamnus dasycarpus, TETRAHEDRON LETTERS, 2013, 第 2 作者(15) Self-double-emulsifying drug delivery system (SDEDDS): A new way for oral delivery of drugs with high solubility and low permeability, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 第 4 作者
科研活动
科研项目
( 1 ) 药物化学生物学, 负责人, 国家任务, 2024-01--2027-01( 2 ) 靶向蛋白磷酸化调节分子(PhosTAC)的开发, 负责人, 地方任务, 2023-10--2025-10