基本信息
毛雨丰 男 硕导 中国科学院天津工业生物技术研究所
电子邮件: maoyf@tib.cas.cn
通信地址: 天津空港经济区西七道32号
邮政编码:
电子邮件: maoyf@tib.cas.cn
通信地址: 天津空港经济区西七道32号
邮政编码:
招生信息
招生专业
071005-微生物学081703-生物化工
招生方向
工程菌种自动化设计与构建代谢工程与系统生物学多基因同步编辑技术
教育背景
2011-09--2018-06 天津大学 生物化工,工学硕士与博士学位2007-09--2011-06 天津大学 生物工程,工学学士学位
工作经历
工作简历
2022-07~现在, 中国科学院天津工业生物技术研究所, 高通量编辑与筛选平台实验室,副研究员2018-07~2022-07,中国科学院天津工业生物技术研究所, 生物设计中心平台实验室,博士后2011-09~2018-06,天津大学, 生物化工,工学硕士与博士学位2007-09~2011-06,天津大学, 生物工程,工学学士学位
专利与奖励
奖励信息
(1) 中国科学院第四届“科苑名匠”(团队), , 院级, 2023
专利成果
( 1 ) 一种6-磷酸阿洛糖、乙酰磷酸和乙酰辅酶A的制备方法, 2022, 第 3 作者, 专利号: CN114369633A( 2 ) 利用丙酮酸合成β-丙氨酸的方法, 2022, 第 2 作者, 专利号: CN113943691A( 3 ) 谷氨酸棒杆菌转录调控因子IpsA突变体及应用, 2020, 第 3 作者, 专利号: CN111607601A( 4 ) 一种谷氨酸棒杆菌高强度启动子P sod-sx 及应用, 2020, 第 3 作者, 专利号: CN111549027A( 5 ) 发酵木糖生产琥珀酸的谷氨酸棒杆菌及用途, 2019, 第 3 作者, 专利号: CN110551648A( 6 ) 高产手性D-(-)-2,3-丁二醇的谷氨酸棒杆菌菌株及构建方法及应用, 2018, 第 2 作者, 专利号: CN108611311A( 7 ) 一种体外酶反应生产D‑(‑)‑乙偶姻的方法, 2018, 第 4 作者, 专利号: CN107653259A( 8 ) 一种体外酶反应生产L(+)‑乙偶姻的方法, 2017, 第 3 作者, 专利号: CN106967741A( 9 ) 高产手性D‑(‑)‑乙偶姻的谷氨酸棒杆菌菌株及构建及应用, 2017, 第 4 作者, 专利号: CN106868033A
出版信息
发表论文
(1) Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in Escherichia coli, Synthetic and Systems Biotechnology, 2024, (2) 多基因同步调控结合高通量筛选构建高产L-苯丙氨酸的谷氨酸棒杆菌工程菌株, Construction of L-phenylalanine High-producing Corynebacterium glutamicum Engineered Strains via Multi-gene Simultaneous Regulation Combined with High-throughput Screening, 生物技术通报, 2023, 第 7 作者(3) ecBSU1: A Genome-Scale Enzyme-Constrained Model of Bacillus subtilis Based on the ECMpy Workflow, MICROORGANISMS, 2023, 第 3 作者(4) Reconstruction of a Genome-Scale Metabolic Network for Shewanella oneidensis MR-1 and Analysis of its Metabolic Potential for Bioelectrochemical Systems, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 第 3 作者(5) Construction and Analysis of an Enzyme-Constrained Metabolic Model of Corynebacterium glutamicum, BIOMOLECULES, 2022, 第 3 作者(6) Global Cellular Metabolic Rewiring Adapts Corynebacterium glutamicum to Efficient Nonnatural Xylose Utilization, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2022, 第 2 作者(7) 工程菌种自动化高通量编辑与筛选研究进展, Advances in automated high-throughput editing and screening of engineered strains, 生物工程学报, 2022, 第 2 作者(8) Enhanced 3-Hydroxypropionic Acid Production From Acetate via the Malonyl-CoA Pathway in Corynebacterium glutamicum, FRONTIERSINBIOENGINEERINGANDBIOTECHNOLOGY, 2022, 第 3 作者(9) 麦角硫因生物合成研究的新进展, Recent progress in ergothioneine biosynthesis:a review, 生物工程学报, 2022, 第 2 作者(10) Natural 5-Aminolevulinic Acid: Sources, Biosynthesis, Detection and Applications, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 第 3 作者(11) 面向微生物遗传操作的编辑序列设计工具的研究进展, 合成生物学, 2022, 第 2 作者(12) AutoESD: a web tool for automatic editing sequence design for genetic manipulation of microorganisms, NUCLEIC ACIDS RESEARCH, 2022, 第 2 作者(13) Advances in biotechnological production of beta-alanine, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2021, 第 2 作者(14) GEDpm-cg: Genome Editing Automated Design Platform for Point Mutation Construction in Corynebacterium glutamicum, FRONTIERSINBIOENGINEERINGANDBIOTECHNOLOGY, 2021, 第 2 作者(15) Non-natural Aldol Reactions Enable the Design and Construction of Novel One-Carbon Assimilation Pathways in vitro, FRONTIERS IN MICROBIOLOGY, 2021, 第 1 作者(16) Engineering central pathways for industrial-level (3 R )-acetoin biosynthesis in Corynebacterium glutamicum, MICROBIAL CELL FACTORIES, 2020, 第 2 作者(17) Substrate profiling and tolerance testing of Halomonas TD01 suggest its potential application in sustainable manufacturing of chemicals, JOURNAL OF BIOTECHNOLOGY, 2020, 第 3 作者(18) One-pot efficient biosynthesis of (3R)-acetoin from pyruvate by a two-enzyme cascade, CATALYSIS SCIENCE & TECHNOLOGY, 2020, 第 2 作者(19) Efficient solid-state fermentation for the production of 5-aminolevulinic acid enriched feed using recombinant Saccharomyces cerevisiae, JOURNAL OF BIOTECHNOLOGY, 2020, 第 1 作者(20) Engineering Corynebacterium glutamicum for the Efficient Production of 3-Hydroxypropionic Acid from a Mixture of Glucose and Acetate via the Malonyl-CoA Pathway, CATALYSTS, 2020, 第 11 作者(21) In vitro biosynthesis of optically pure d-(-)-acetoin from meso-2,3-butanediol using 2,3-butanediol dehydrogenase and NADH oxidase, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2019, 第 3 作者(22) Screening, expression, purification and characterization of CoA-transferases for lactoyl-CoA generation, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2019, 第 2 作者(23) Systematic design and in vitro validation of novel one-carbon assimilation pathways, METABOLIC ENGINEERING, 2019, 第 5 作者(24) Metabolic engineering of Corynebacterium glutamicum for efficient production of succinate from lignocellulosic hydrolysate, BIOTECHNOLOGY FOR BIOFUELS, 2018, 第 1 作者(25) Concomitant cell-free biosynthesis of optically pure D-(-)-acetoin and xylitol via a novel NAD(+) regeneration in two-enzyme cascade, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2018, 第 2 作者(26) Model-based reconstruction of synthetic promoter library in Corynebacterium glutamicum, BIOTECHNOLOGY LETTERS, 2018, 第 4 作者(27) 生物法生产3-羟基丙酸研究进展, Recent progress in microbial production of 3-hydroxypropionic acid, 化工进展, 2018, 第 2 作者(28) 生物法合成双乙酰的研究进展, Recent advances for microbial production of diacetyl, 生物加工过程, 2017, 第 2 作者(29) 乙酸合成途径阻断及NADH氧化酶表达对于谷氨酸棒杆菌生产乙偶姻的影响, Effects of inactivation of acetate synthetic pathway genes and overexpression of NADH oxidase on acetoin production in Corynebacterium glutamicum, 微生物学通报, 2017, 第 2 作者(30) Systematic metabolic engineering of Corynebacterium glutamicum for the industrial-level production of optically pure D-(-)-acetoin, GREEN CHEMISTRY, 2017, 第 1 作者(31) Metabolic engineering of Corynebacterium glutamicum for efficient production of 5-aminolevulinic acid, BIOTECHNOLOGYANDBIOENGINEERING, 2016, 第 4 作者(32) Metabolic engineering of Bacillus subtilis for chiral pure meso-2,3-butanediol production, BIOTECHNOLOGY FOR BIOFUELS, 2016, 第 4 作者(33) Development of a markerless gene replacement system in Corynebacterium glutamicum using upp as a counter-selection marker, BIOTECHNOLOGY LETTERS, 2015, 第 3 作者(34) Engineering microorganisms based on molecular evolutionary analysis: a succinate production case study, EVOLUTIONARY APPLICATIONS, 2014, 第 4 作者
科研活动
科研项目
( 1 ) 基因编辑技术与自动化设施的适配整合, 负责人, 国家任务, 2023-12--2028-11( 2 ) 营养化学品生物合成途径与底盘细胞的构建, 参与, 国家任务, 2023-01--2026-12( 3 ) 非天然β-丙氨酸合成途径的系统设计与构建研究, 负责人, 国家任务, 2022-01--2024-12( 4 ) 谷氨酸棒杆菌新一代网络模型的构建与优化, 负责人, 国家任务, 2021-12--2024-12( 5 ) 快速代谢木糖的谷氨酸棒杆菌的逆向代谢工程研究及应用, 负责人, 其他国际合作项目, 2019-01--2022-07( 6 ) 枯草芽孢杆菌微氧代谢木糖机理及产乙偶姻的代谢工程研究, 参与, 国家任务, 2016-01--2019-12( 7 ) 基于高产核黄素枯草芽孢杆菌全基因组突变分析的逆向代谢工程研究, 参与, 国家任务, 2013-01--2015-12